Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 5807847 | Nitrate esters Aliphatic Nitrate esters having a sulfur or phosphorus atom ଲ or γ to a nitrate group having efficacy as vasodilators are described. Preferred nitrate esters may be synthesized by nitration of a 3-bromo-1,2-propanediol, and subsequent reaction to y... | 09/15/1998 |
| 5804564 | Antitumor indolopyrrolocarbazole derivatives This invention relates to compounds of the general formula ##STR1## or pharmaceutically salts thereof, wherein R1 and R2 each represent an OH group, R1 is located at the 1- or 2-position, R2 is located at t... | 09/08/1998 |
| 5795749 | Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives Processes using 2-deoxyribose-5-phosphate aldolase (DERA) are described for the preparation of 2-deoxyfucose and related compounds. In one embodiment, DERA is used to catalyze the condensation of acetaldehyde as donor and a 2(R)-hydroxy-3-(hydroxy or merc... | 08/18/1998 |
| 5792842 | Ganglioside GM3 derivative having fluorine atom at 9-position of sialic acid and intermediates therefor A ganglioside GM3 derivative having a fluorine atom at the 9-position of sialic acid represented by the formula: ##STR1## wherein R is an aliphatic lower acyl group, R1 is a hydrogen atom or a lower alkyl group, R2 to R5 | 08/11/1998 |
| 5786461 | Peptide nucleic acids having amino acid side chains A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligan... | 07/28/1998 |
| 5780606 | Neisseria meningitidis capsular polysaccharide conjugates Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant reactive residues of heterobifunctional linker molecules ... | 07/14/1998 |
| 5780442 | Orthosomycins from micromonospora carbonacae Orthosomycins have been isolated from the fermentation broth of the microorganism Micromonospora Carbonacea var Africana designated SCC 2146. These compounds are antibacterial agents. Compositions and methods for treating bacterial infections are also des... | 07/14/1998 |
| 5763413 | Lewis-associated compound, process for producing the same, and anti-inflammatory A Lewis-associated compound, represented by general formula (I), a process for producing the same, and an anti-inflammatory, wherein R1 and R3 represent each hydrogen, m SO3 H or CH2 COOH; R2 represen... | 06/09/1998 |
| 5759993 | Modified sialyl Lewisx compounds The present invention is drawn to methods for the synthesis of sialyl Lewisx derivatives modified at the C-2 and/or C-6 position of GlcNAc employing chemo-enzymatic synthesis. The derivatives find use in the treatment and prevention of diseases... | 06/02/1998 |
| 5760199 | Polysaccharide acid amide comprising fatty alkyl group in amide Polysaccharide acid amide compositions are disclosed which contains one extra carbon atom as compared to the polysaccharide and which comprises an acid amide of the formula --C(O)N(R)(R') where R is selected from the group consisting of hydrogen and alkyl... | 06/02/1998 |
| 5753631 | Intercellular adhesion mediators The present invention is directed towards compositions and methods for reducing or controlling inflammation and for treating inflammatory disease processes and other pathological conditions mediated by intercellular adhesion. The compositions of the inven... | 05/19/1998 |
| 5753630 | Method for treating and inhibiting gastric and duodenal ulcers A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I (NeuAc-(2-3)-pGal-ଲ(1)--(--X--)m --(--Y--)n --)p... | 05/19/1998 |
| 5750664 | Substituted liposaccharides useful in the treatment and prevention of endotoxemia Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing ... | 05/12/1998 |
| 5744596 | Nucleoside analogues and synthetic intermediates The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.... | 04/28/1998 |
| 5741897 | Process for preparing an N-substitued aldonamide The present invention generally relates to a process for preparing an N-substituted aldonamide by reacting an aldonic acid in a polar organic solvent with an amine of the formula HNR1 (X--NR1)nR2, wherein R1 and R~ may be ... | 04/21/1998 |
| 5739304 | Process for the preparation of water-soluble aminoalkyl derivatives of polysaccharides Water-soluble polysaccharides which contain a) substituents selected from the group consisting of alkyl, hydroxyalkyl, carboxyalkyl and sulfoalkyl, b) N,N-disubstituted aminoalkyl groups, are prepared by alkylation of a polysaccharide in the presence of a base ... | 04/14/1998 |
| 5733892 | Metastasis inhibitor composition comprising a phospholipid-linked glycosaminoglycan and method for inhibiting metastasis employing the same This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their excellent function to inhibit adhesion of cancer cells to b... | 03/31/1998 |
| 5723504 | Amadori reaction compounds and products, process for their manufacture, and their use as cytokine inducers Novel Amadori reaction compounds have the formula R1 --NH--R2, wherein R1 comprises the D-form of a 1-amino-1-deoxy-2-ketose radical derived from a sugar radical selected from the group of glucose, xylose, galactose, rhamn... | 03/03/1998 |
| 5721357 | Preparation of sulfated polysaccharides for treatment or prevention of thromboses The invention relates to new mixtures of sulfated oligosaccharides having the general structure of heparin constitutive oligosaccharides, having an average molecular mass of 6&#b1;0.6 kD, a polydispersiveness close to 1 and the capacity of inhibiting the ... | 02/24/1998 |
| 5719020 | 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens Chromogenic and fluorogenic 4,7-dialkoxy-N-acetylneuraminic acid substrates of the general formula ##STR1## are provided wherein R1 and R2 are alkyl groups containing 1 to 4 carbon atoms and R3 is a chromogenic or flu... | 02/17/1998 |
| 5700918 | Moranoline derivative The present invention has for its object to provide a trisaccharide Lewis sugar-chain epitope derivative of the following structural formula, which is of value as a medicine and has a novel structure containing moranoline. ##STR1## wherein R1 | 12/23/1997 |
| 5700917 | Aldehyde cationic derivatives of galactose containing polysaccharides used as paper strength additives Aldehyde cationic derivatives of galactose containing polysaccharides which are obtained by oxidizing galactose containing polysaccharides with the enzyme galactose oxidase. The enzyme oxidized products have an aldehyde function at a specific position of ... | 12/23/1997 |
| 5693623 | Topical preparations for the treatment of acne and acneiform dermatitis Topical Preparations for the treatment of acne and acneiform dermatitis containing as active principle therapeutically active quantities of N,N'bis (2-hydroxyethyl) nonandiamide together with dermatansulfate lithium salt, having molecular weight ranging f... | 12/02/1997 |
| 5691423 | Polysaccharide-bound nitric oxide-nucleophile adducts A polymeric composition capable of releasing nitric oxide comprises a polysaccharide including a nitric oxide-releasing N2 O2- functional group bound to the polymer; pharmaceutical compositions including the polymeric comp... | 11/25/1997 |
| 5686439 | Chelate complexes and processes for their preparation Phthalocyanine-chelate complexes of formula I ##STR1## are described which contain as central atom M aluminium, gallium, indium, tin, ruthenium or preferably germanium and in which the remaining symbols are as defined in claim 1. The complexes can be... | 11/11/1997 |
| 5683699 | Meningococcal polysaccharide conjugate vaccine Neisseria meningitidis group B polysaccharide (GBMP) modified by having sialic acid residue N-acetyl groups replaced by N-acyl groups exhibits enhanced immuno response thereto. In addition, induction of antibodies which cross-react with unmodified group B... | 11/04/1997 |
| 5684141 | Aminated cellulosic synthetic fibers Aminated cellulosic synthetic fibers are produced by adding an amine-substituted cellulose derivative to a viscose or an alkali cellulose and spinning fibers by the viscose spinning process, or by adding said cellulose derivative to a cellulose solution a... | 11/04/1997 |
| 5681947 | Oligonucleotides having universal nucleoside spacers Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each Rn is H, OH, F... | 10/28/1997 |
| 5679654 | Capsular polysaccharide immunomodulator Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto als... | 10/21/1997 |
| 5677285 | Derivatives of neuraminic acid Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including carboxylic amides, their 2-hydrocarbyl-glycosides, and their ... | 10/14/1997 |
| 5665574 | Method for preparing N-acetylneuraminic acid A method for preparing N-acetylneuraminic acid characterized in reacting N-acetylglucosamine with pyruvic acid in an alkaline condition by the action of N-acetylneuraminic acid lyase.... | 09/09/1997 |
| 5665876 | 3-(aminoacyl-amino)-saccharides and processes for their preparation The invention pertains to 3-(aminoacyl-amino)-saccharides of the general formula (I), ##STR1## wherein R' is selected from the group consisting of hydrogen, a carboxyl group, a phenyl group and an alkyl group with 1-10 C-atoms which is optionall... | 09/09/1997 |
| 5663311 | Polysaccharide derivative and separation agent The present invention provides a novel polysaccharide derivative in which part or the whole of the hydroxyl groups or the amino groups contained in a polysaccharide are displaced by two or more kinds of substituents, and a separating agent and a separatin... | 09/02/1997 |
| 5658880 | Sialic acid/fucose based medicaments Compounds that exhibit selectin binding activity are described and have the following structural formula: ##STR1## where W is selected from a group including structures a-d below ##STR2## wherein p is an integer of from 0-2, q is an integer of f... | 08/19/1997 |
| 5654282 | Selectin binding glycopeptides Glyco-amino acids and glycopeptides having three-dimensionally stable configurations are described. These glyco-amino acids and glycopeptides have glycoside functional groups, such as fucose and analogues and derivatives thereof, covalently bound to an am... | 08/05/1997 |
| 5652335 | Physiologically active substance well capable of permeating biomembrane A physiologically active substance well capable of permeating biomembrane according to the present invention is represented by: ##STR1## where R represents a residue of a physiologically active substance comprising a peptide, amino acid, aliphatic am... | 07/29/1997 |
| 5648343 | Method for treating LPS-mediated disorders A purified lipid A from Rhizobium leguminosarum biovar phaseoli CE3, as well as analogs and derivatives of the purified lipid A are provided. Compositions containing heterogenous mixtures of lipid A from R. leguminosarum bv. phaseoli CE3 are also provided... | 07/15/1997 |
| 5643780 | Compositions and methods for modulating RNA activity through modification of the 5' cap structure of RNA Methods for regulating gene expression in biological experimental systems via modification or removal of the 5' cap structure of targeted ribonucleic acids are disclosed. Modification or removal of the 5' cap structure is achieved in accordance with prefe... | 07/01/1997 |
| 5643884 | Lupane triterpenoid derivatives This invention relates generally to the field of medicinal chemistry, and more specifically to derivatives of a subclass of triterpenoid acids that have multi-medicament properties, that is derivatives of the lupane, betulinic acid, formulations containin... | 07/01/1997 |
| 5644049 | Biomaterial comprising hyaluronic acid and derivatives thereof in interpenetrating polymer networks (IPN) Provided is a biomaterial comprising an interpenetrating polymer network (IPN), wherein one of the polymer components is an acidic polysaccharide or a semi-synthetic derivative thereof. The polysaccharide can be hyaluronic acid, and the second polymer com... | 07/01/1997 |
