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| Number | Title | Issue Date |
| 8119779 | Phosphoramidate derivatives The present invention provides a phosphoramidate compound having the structure (I) wherein X comprises a monosaccharide group comprising the structure (II) or (III) or a pharmaceu... | 02/21/2012 |
| 7960523 | Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-sily... | 06/14/2011 |
| 7906633 | Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof The present invention provides methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic ... | 03/15/2011 |
| 7893226 | Use of lipid conjugates in the treatment of diseases This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothi... | 02/22/2011 |
| 7893225 | Crosslinked polysaccharide sponge A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtain... | 02/22/2011 |
| 7700747 | Crosslinked polysaccharide sponge A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtain... | 04/20/2010 |
| 7439352 | Process for the production of anhydrosugar alcohols A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst, and subsequent purification of the anhydrosugar alcohol. In some emb... | 10/21/2008 |
| 7411055 | Attractin/mahogany-like polypeptides, polynucleotides, antibodies and methods of use thereof The present disclosure provides attractin/mahogany-like polypeptides and fragments thereof, polynucleotides encoding such polypeptides and fragments, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides ... | 08/12/2008 |
| 7405214 | Nucleoside derivatives and therapeutic use thereof The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disord... | 07/29/2008 |
| 7393938 | Use of lipid conjugates in the treatment of diseases This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothi... | 07/01/2008 |
| 7385051 | Fluorescent N,N3-etheno-purine (2′-deoxy) riboside derivatives and uses thereof The invention relates to fluorescent N2,N3-etheno-purine (2′-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and uses thereof for staining DNA/RNA and for detection and quanti... | 06/10/2008 |
| 7371403 | Wound dressing and method for controlling severe, life-threatening bleeding This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing for controlling severe blee... | 05/13/2008 |
| 7368551 | DNA cytosine methyltransferase genes, polypeptides and uses thereof De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, ... | 05/06/2008 |
| 7358353 | Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnos... | 04/15/2008 |
| 7342109 | Human kinase interacting protein 2 (KIP2)-related gene variant associated with cancers Nucleic acid and polypeptide sequences of one novel human KIP2-related gene variant (KIP2V), and the processes for producing the same are provided. Use of the nucleic acid and polypeptide sequences of the gene variant in diagnosing cancers is also provided. ... | 03/11/2008 |
| 7342108 | De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, ... | 03/11/2008 |
| 7338932 | Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments Attachment of O-glycans to proteins is controlled by a large family of homologous polypeptide GalNAc-transferases. Polypeptide GalNAc-transferases contain a C-terminal sequence with similarity to lectins. This invention discloses that the putative lectin domains of ... | 03/04/2008 |
| 7335766 | Method for producing a chitosan containing salt having a function of lowering blood pressure The present invention relates to a method for producing a chitosancontaining salt having the function of lowering blood pressure. The method comprises the steps of: (a) dissolving an acid-soluble chitosan in organic acid, or dissolving a water-soluble chitosan deriv... | 02/26/2008 |
| 7312194 | Delivery systems The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical... | 12/25/2007 |
| 7309437 | Compositions and methods for removal of toxic metals and radionuclides The present invention relates to compositions and methods for the removal of toxic metals or radionuclides from source materials. Toxic metals may be removed from source materials using a clay, such as attapulgite or highly cationic bentonite, and chitin or chitosan... | 12/18/2007 |
| 7306910 | Breast cancer prognostics A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expresson profiles in a variety of medium such as microarrays are included as are kits that contain them. ... | 12/11/2007 |
| 7304148 | Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain, and processes for producing these An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose ... | 12/04/2007 |
| 7301016 | Human transferase family members and uses thereof The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention... | 11/27/2007 |
| 7291462 | TADG-15: an extracellular serine protease overexpressed in carcinomas The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression... | 11/06/2007 |
| 7288640 | Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-sily... | 10/30/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7276595 | DNA sequence encoding a retinoic acid regulated protein The present invention concerns a novel retinoic acid regulated gene whose expression product displays useful morphogenic/mitogenic properties. The present invention further concerns an isolated nucleic acid of SEQ ID NO:1 encoding a retinoic acid regulated expressio... | 10/02/2007 |
| 7270980 | Compounds for immunodiagnosis of prostate cancer and methods for their use Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and moni... | 09/18/2007 |
| 7262179 | Wound care compositions Compositions for the treatment of wounds and skin injuries are described. The compositions, which include gellan gum, increases in viscosity once applied to the wound to form an immobile gel. The composition may be in sprayable form or dispersed in an aqueous soluti... | 08/28/2007 |
| 7259152 | Methods and compositions using sulodexide for the treatment of diabetic nephropathy The present invention provides oral formulations of Sulodexide for the treatment of diabetic nephropathy in patients with both insulin dependent and non-insulin dependent diabetes mellitus. Oral formulations containing doses adapted for administration to obtain a re... | 08/21/2007 |
| 7256275 | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ... | 08/14/2007 |
| 7253278 | Purification process for manufacturing a high pure acarbose A process for purifying and preparing highly pure acarbose from acarbose-containing fermentation broth. The acarbose is purified through steps of alcohol precipitation, a strongly acidic cation exchanger chromatography and an immobolized enzyme affinity chromatograp... | 08/07/2007 |
| 7247722 | Polysaccharide aldehydes prepared by oxidation method and used as strength additives in papermaking Polysaccharide aldehydes are prepared using selective oxidation involving the use of nitroxyl radical mediated aqueous oxidation with a limited amount of oxidant and defined reaction conditions. These polysaccharide aldehyde derivatives having maximum effective alde... | 07/24/2007 |
| 7244830 | Glycopolymers and free radical polymerization methods A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a saccharide moiety connected to said linking group, optionally a second penden... | 07/17/2007 |
| 7235647 | Intermediate and process for preparing of β- anomer enriched 21-deoxy,21,21-difluoro-D-ribofuranosyl nucleosides The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 21-deoxy-21,21-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically accept... | 06/26/2007 |
| 7235533 | Compounds and their uses Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. I... | 06/26/2007 |
| 7235370 | Site-specific aminoglycoside derivatives for use in immunodiagnostic assays A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups wit... | 06/26/2007 |
| 7227019 | Process for the preparation of rebeccamycin and analogs thereof The present invention relates to a method for making an indolopyrrolocarbazole of the general formula [I], where the method includes the step of reacting a bisindolylmaleimide compound with an oxidizing agent in the presence of an oxygen containing gas at a temperat... | 06/05/2007 |
| 7217696 | Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof Disclosed are glycosides, orthoester glycosides and glycuronamides of fluoxetine and analogs thereof to treat conditions and diseases such as depression. ... | 05/15/2007 |
| 7211663 | Synthesis of oligosaccharides, reagents and methods related thereto One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the present invention, glycosyl phosph... | 05/01/2007 |
