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| Number | Title | Issue Date |
| 8026347 | Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I: ... | 09/27/2011 |
| 7943750 | Process for obtaining pure monosialoganglioside GM1 for medical use A process for preparing pure monosialoganglioside GM1 in the form of its sodium salt. There is provided a process for the isolation and purification of monosialoganglioside GM1 comprising (a) separation of GM1 from a lipidic mixture containing the monosialogangliosi... | 05/17/2011 |
| 7888487 | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same Pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group selected from the following groups: ... | 02/15/2011 |
| 7605241 | Synthesis of inhibitors of p90Rsk The synthesis of the naturally occurring kaempferol glycoside SLO1O1-1, as well as analogs thereof, has been accomplished, as has its biochemical evaluation. SLO1O1-1 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhib... | 10/20/2009 |
| 7572898 | Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside A process of preparing an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonate, which is useful as an intermediate in the preparation of a beta nucleoside, such as gemcitabine, an anti-tumor agent. A beta-2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonat... | 08/11/2009 |
| 7439352 | Process for the production of anhydrosugar alcohols A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst, and subsequent purification of the anhydrosugar alcohol. In some emb... | 10/21/2008 |
| 7439344 | Selective O-acylation of nucleosides The present invention relates to a one-step process for the selective O-acylation of the hydroxy groups of a nucleoside under basic conditions utilizing DMAP and a carboxylic acid anhydride in aqueous heterogenous solvent mixture. ... | 10/21/2008 |
| 7435816 | Synthesis of solanum glycosides The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solasonine as well as to novel β-monosaccharide intermediate compounds, of Formula (2), where R1 is a benzylidene, 4-nitrobenzylidene or 4-me... | 10/14/2008 |
| 7432368 | Photolabile protecting groups The present invention relates to novel nucleoside derivatives of general formula (I) wherein R1=H, halogen, NO2, CN, OCH3, an alkyl, alkoxy or alkoxyalkyl residue having 1 to 4 C atoms, pref... | 10/07/2008 |
| 7396925 | Volatilizable solid phase supports for compound synthesis A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved p... | 07/08/2008 |
| 7375090 | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof The present invention relates to glucopyranosyloxy-pyrazoles of general formula wherein R1 to R6 and R7a, R7b, R7c are defined as in claim 1, the tauto... | 05/20/2008 |
| 7365055 | Derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses The invention relates to novel derivatives of morphine-6-glucuronide, the preparation method thereof and the uses of same in therapy, for example, as analgesics. ... | 04/29/2008 |
| 7361744 | Oligosaccharide derivative Compounds having the formula (I): wherein A represents a group such as a cyclic group, R1 and R2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologic... | 04/22/2008 |
| 7361644 | Specific antagonist for both E- and P-selectins Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-med... | 04/22/2008 |
| 7361745 | Process for the preparation of 1-chloro-3,5-di-o-acyl-2-deoxy-l-ribofuranoside derivatives Herein described is a process for the preparation of 1-chloro-3,5-di-O-acyl-2-de-oxy-L-ribofuranoside derivatives of general formula (I) useful as intermediates in processes for preparing nucleotides of the L series having antiviral activity | 04/22/2008 |
| 7351809 | Glycerol carbonate glycoside A process is provided for the selective and convenient production of a glycerol glycoside, which has been glycosidated at the 1-hydroxyl group of glycerol and is useful as a glyceroglycolipid precursor, humectant or the like. A glycerol carbonate glycoside re... | 04/01/2008 |
| 7341746 | Chinese herbs extract This application relates to a material which is suitable for the treatment of atopic disease, non-atopic eczema or psoriasis. The material can be extracted from a freeze-dried decoction of a mixture comprising the following Chinese herbs: Radix Ledebouriella, Fru... | 03/11/2008 |
| 7335627 | Polymeric alkylpolyglycoside carboxylates The products of the invention are polymers of carboxylated alkylpolyglycosides. The products are very mild surfactants that are useful in personal care applications. ... | 02/26/2008 |
| RE40040 | Process of use in converting the 4″(S)-OH functional group of the cladinose unit of an azamacrolide to 4″(R)-NH2 The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula I by stereoselective displacement by a nitrogenous nucleophilic compound of the activated alcohol functional gr... | 01/29/2008 |
| 7282150 | Method of extracting and method of purifying an effective substance A method for extracting a hydrophobic group-containing water-soluble organic compound, comprising the step of bringing an aqueous solution containing the hydrophobic group-containing water-soluble organic compound and a saccharide into contact with a polar organic s... | 10/16/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7241875 | Method for the production of surface active agent mixtures An aqueous surfactant mixture comprised of an alkyl and/or alkenyl oligoglycoside ether carboxylic acid is made by a process comprising reacting in an aqueous solution an alkyl and/or alkenyl oligoglycoside and an ω-halocarboxylic acid or a salt or ester thereof in... | 07/10/2007 |
| 7235646 | Process for the preparation of azithromycin monohydrate isopropanol clathrate The present invention relates to an improved, cost effective and easy process for the preparation of azithromycin monohydrate isopropanol clathrate. The process provides a one-step method of preparing azithromycin monohydrate isopropanol clathrate directly from 9-de... | 06/26/2007 |
| 7211663 | Synthesis of oligosaccharides, reagents and methods related thereto One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the present invention, glycosyl phosph... | 05/01/2007 |
| 7205394 | Clathrate of azithromycin hydrate with 1,2-propyleneglycol, method for the manufacture thereof and pharmaceutical composition comprising same A clathrate of azithromycin hydrate with 1,2-propyleneglycol is much less hygroscopic than azithromycin hydrate or crystals known in the art, therefore, it can be useful for the preparation of a medicine for treating various microbial infections. ... | 04/17/2007 |
| 7205395 | Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin A hydrate used therein Azithromycin is prepared in a high yield by a simple process using a crystalline 9-deoxo-9a-aza-9a-homoerythromycin A hydrate. ... | 04/17/2007 |
| RE39560 | Erythromycin A derivatives and method for preparing same Erythromycin A derivatives represented by the general formula wherein R1 is a 2-alkenyl group having 3 to 15 carbon atoms, an arylmethyl group, or an arylmethyl group substituted by 1 to 3 of a halogen atom, an alkoxy ... | 04/10/2007 |
| RE39531 | 9-hydrazone and 9-azine erythromycin derivatives and a process for making the same Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin. Also disclosed are the processes for converting the compounds into 6... | 03/27/2007 |
| 7196179 | Method for manufacturing calcium gluconolcatate compositions, processes and uses A method to manufacture calcium gluconolactate as a single molecule, compositions formed thereby, and uses therefor are disclosed and described. In one embodiment, a method of manufacturing calcium gluconolactate by reacting a gluconic acid reaction or an equivalent... | 03/27/2007 |
| 7196180 | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, ... | 03/27/2007 |
| 7160517 | Apparatus and methods for the automated synthesis of oligosaccharides One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the p... | 01/09/2007 |
| 7148223 | 4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or... | 12/12/2006 |
| 7138377 | Topoisomerase inhibitors The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells. ... | 11/21/2006 |
| RE39383 | Process for 6-O-alkylation of erythromycin derivatives A procedure for preparing 6-O-alkyl erythromycin compounds having the formula: wherein R1 is a loweralkyl group, R2 and R3 an independently hydrogen or a hydroxy-protecting group, except that R | 11/07/2006 |
| 7122204 | Antibiotic composition with inhibitor Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. I... | 10/17/2006 |
| 7109182 | Synthetic oligomannosides, preparation and uses thereof A pharmaceutical composition including a therapeutically effective amount of at least one oligomannoside produced by chemical synthesis which is homologous to a wall oligomannoside of an infectious organism or pathogen, or a derivative thereof, and a pharmaceuticall... | 09/19/2006 |
| 7101858 | Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same The present invention relates to processes for preparing protected silylated clarithromycin oxime, preferably 6-O-methyl-2′,4″-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime (“S-MOP oxime”), and for converting protected silylated clarithrom... | 09/05/2006 |
| 7083814 | Antiviral substances from plant cuticular and epicuticular material Substances having antiviral activity against one or more human disease-causing viruses are disclosed. These antiviral substances are obtained from the cuticular and extracuticular layers of plants. Pharmaceutical and nutraceutical formulations comprising the antivir... | 08/01/2006 |
| 7071314 | Arylation method for the functionalization of O-allyl erythromycin derivatives An efficient arylation technique for use in the synthesis of erythromycin derivatives, involving a modified Heck reaction which employs less than six mole percent of palladium catalyst and no phosphine is disclosed. With this modified Heck reaction, an O-alkenylaryl... | 07/04/2006 |
| 7060685 | Compounds and methods for inhibiting selectin-mediated function Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-med... | 06/13/2006 |
