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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8039601 | Crystalline forms of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-α-D-mannopyranosyloxy)-phenyl] hexane The novel crystalline and polymorphic forms of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-α-D-mannopyranosyloxy)-phenyl] hexane have advantageous properties and can be used in pharmaceutical and dermatological compositions. ... | 10/18/2011 |
| 7767798 | Loganin analogues and a process for the preparation thereof The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit pulp of Strychnos nux-vomica and its bioactive semi-sy... | 08/03/2010 |
| 7419960 | Hemiterpene glycosides with anti-platelet aggregation activities from Two hitherto unreported novel hemiterpene glycosides were isolated in substantially pure form from the root of Ilex pubescens. The chemical structures and some properties of these hemiterpenes have been elucidated. These hemiterpene glycosides possess anti-pl... | 09/02/2008 |
| 7417129 | Combinatorial libraries of monosaccharides A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I. ... | 08/26/2008 |
| 7396818 | Sulfotransferase inhibitor The hexuronic acid derivative represented by the following formula 1 or a salt thereof is used as an active ingredient of a heparin/heparan sulfate sulfotransferase inhibitor. In the formula, each of R1, R2 | 07/08/2008 |
| 7365174 | Azalide and azalactam derivatives and method for producing the same Compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof, effective in the prevention and/or treatment of infections with microbes: (1) (a) wherein R1 is hydrogen or straight-chain C1-6 alkylcarbonyl; R... | 04/29/2008 |
| 7262285 | Anticancer biangeloyl saponins Novel compounds such as compounds designated herein as Xanifolia-Y or -Y3, -Y1, -Y2, -Y8, -Y9 and -Y10 are disclosed. These compounds have anticancer activity. The compounds of the present invention are obtainable from plants in the sapindaceae family, such as Xa... | 08/28/2007 |
| 7258823 | Flame retardants with high halogen content and low viscosity Flame retardant formulations comprised of at least one bromine-containing polyol are produced by a process which comprises: A) heating a mixture formed from components comprised of (i) tetrabromophthalic anhydride, (ii) at least one aliphatic polyol, an... | 08/21/2007 |
| 7151186 | Method for the direct esterification of sorbitol with fatty acids Mixtures of sorbitol fatty acid esters useful as low calorie fat substitutes are prepared through a direct esterification process. The process entails the direct esterification of sorbitol with free fatty acids, optionally in the presence of an esterification cataly... | 12/19/2006 |
| 7074907 | Compound, process for producing the same and use thereof The compound of the present invention is a component originated from a natural material, camu camu (Myrciaria dubia), has strong antioxidative activity and stable whitening effect, and is represented by the formula (1). The antioxidant, whitening agent, skin ... | 07/11/2006 |
| 7033619 | Method for making herbal extracts using percolation The present invention comprises an apparatus and methods for making herbal extracts. The apparatus employs a percolation vessel having a filter and discharge valve. A heater is provided to heat the contents of the vessel to up to about 60° C. during the cold percol... | 04/25/2006 |
| 6987182 | Process for producing cold-gelling hydrocolloids A dry hydrocolloid powder with cold-gel capabilities is produced by: dissolving a hydrocolloid comprising polysaccharide chains in an aqueous solution; heating the dissolved hydrocolloid solution to a temperature and for a time sufficient to induce a substantial alt... | 01/17/2006 |
| 6949640 | Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy... | 09/27/2005 |
| 6916857 | Hydrogel-forming system with hydrophobic and hydrophilic components A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g. dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is con... | 07/12/2005 |
| 6916920 | Process for producing hydrazinomonosaccharide derivatives and use thereof A process for producing hydrazinomonosaccharide derivatives and use of hydrazines in determining the structures of aldose and ketose monosaccharides located at the reducing ends of saccharides. ... | 07/12/2005 |
| 6875746 | Anticancer anthraquinones and method of use thereof Anthraquinones are described which have anticancer or antitumor activity and which are useful for inhibiting cancer cells and cells comprising tumors in vitro or in vivo. Preferably, the anthraquinones have the chemical formula: ... | 04/05/2005 |
| 6864241 | Amine salt of lignan compounds The present invention provides an amine salt of a lignan compound, i.e., [1-O-[4-(3,4-dimethoxyphenyl)-2-(3-ethylpentanoyl)-5,6,7-trimethoxy-3-(methoxycarbonyl)naphthalen-1-yl]-beta-D-glucopyranoside]uronic acid, which is useful as a medicament. The present inventio... | 03/08/2005 |
| 6838450 | Drug complex A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C1-4)alkyldextran polyalcohol obtained by treating a dextran under conditions that enable substantially complete polyalcoholization are bound to ... | 01/04/2005 |
| 6818657 | Bioprecursors of a retinoic derivative and pharmaceutical and/or cosmetic compositions The present invention relates to a ternary glucosyl complex which is a bioprecursor of at least one retinoic active ingredient for percutaneous application, having formula (I), wherein E represents a linear hydrocarbon spacer group that is branched or cyclized and h... | 11/16/2004 |
| 6800742 | Method for producing β-D-ribofuranose derivatives or optical isomers thereof The present invention provides a method for efficiently producing β-D-ribofuranose derivatives or optical isomers thereof, useful as synthetic intermediates of pharmaceutical nucleic acid-series products. The method comprises a step of producing 1-O-benzyl-β-D-rib... | 10/05/2004 |
| 6693085 | Macrolide compound JK Compound JK represented by the general formula (1): ##STR1## wherein R is H or --CH3 ; or a pharmaceutically acceptable salt thereof. Compound JK has an excellent antimicrobial activity even against resistant strains including MRSA and is useful as ... | 02/17/2004 |
| 6664235 | Medicaments comprising sialic acid derivatives as active ingredients A medicament for treatment of a viral infection which comprises as an active ingredient a compound represented by the following formula (I) or its Pharmaceutically acceptable salt, or a hydrate thereof or a solvate thereof. ##STR1## wherein R1 | 12/16/2003 |
| 6649172 | Amphipathic aldehydes and their uses as adjuvants and immunoeffectors This invention relates to novel aldehyde containing compounds and their uses as adjuvants and immunoeffectors.... | 11/18/2003 |
| 6624317 | Taxoid conjugates as antimitotic and antitumor agents Compounds according to formula I: wherein T1 is a taxoid group, preferably of Formula II: ##STR1## wherein R1 is C6 H5 ; R2 is O; L is a linking group; and T2 is a substituent selected from the ... | 09/23/2003 |
| 6610835 | Sphingolipid derivatives and their methods of use Derivatives of sphingolipids of the formula: ##STR1## are provided wherein the substituents are as defined in the specification and wherein there is at least one R2 substituent in the sphingolipid derivative. The compounds are useful in the tre... | 08/26/2003 |
| 6534637 | Synthesis of chlorophenol red glucuronic acid This invention provides ଲ-D-Glucuronidase substrates of the formula: ##STR1## wherein R1, R2, and R7 -R12 are independently selected from the group consisting of: hydrogen, fluorine, chlorine, bromine, iodine, ... | 03/18/2003 |
| 6531582 | 2-O-(9z,12z-octadecadienoyl)-3-O-[-D-galactopyranosyl-(1"-6')-O-.alp ha.-D-galactopyranosyl]glycerol and pharmaceutical composition containing the same The present invention relates to the novel compound 2-O-(9z,12z-octadecadienoyl)-3-O-[-D-galactopyranosyl-(1"-6')-O-.al pha.-D-galactopyranosyl]glycerol (Generic name: shinbarometin) having the chemical structure represented by the following formula... | 03/11/2003 |
| 6498269 | Method for the oxidation of aldehydes, hemiacetals and primary alcohols A method for the oxidation of substrates comprising treating an aqueous, basic solution of a substrate having an oxidizable functionality using an elemental halogen as terminal oxidant in the presence of an oxoammonium catalyst/halide co-catalyst system. ... | 12/24/2002 |
| 6476204 | Dextran-maleic acid monoesters and hydrogels based thereon Biodegradable hydrogels are formed by photocrosslinking dextran-maleic acid monoesters in which the average degree of substitution of each glucose unit of each -D-glucopyranosyl of dextran by maleic acid ranges from 0.60 to 1.6 and which have a wei... | 11/05/2002 |
| 6455512 | Water-soluble esterified hydrocolloids Emulsifiers based on the reaction product of hydrocolloid and dicarboxylic anhydrides, especially useful in the preparation of oil-in-water emulsions.... | 09/24/2002 |
| 6436912 | Drug complexes A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C1-4)alkyldextran polyalcohol obtained by treating a dextran under conditions that enable substantially complete polyalcoholization ar... | 08/20/2002 |
| 6384201 | Synthetic method for the preparation of the antineoplastic agent etoposide A synthetic method for the preparation of the anti-tumor drug Etoposide. In one embodiment, the method includes the direct condensation of 4'-demethyl-epipodophylloxin with 2,3-di-O-dichloroacetyl-(4,6-O-ethylidene)-ଲ-D-glucopyranose in the pre... | 05/07/2002 |
| 6329377 | Ketomethylene group-containing cysteine and serine protease inhibitors The present invention is directed to novel ketomethylene group-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.... | 12/11/2001 |
| 6174863 | Carbohydrate derivatives The invention relates to a carbohydrate derivative having formula I ##STR1## wherein R1 is (1-4C)alkoxy; R2, R3 and R4 are independently (1-4C)alkoxy or OSO3-, the total number of sulfate g... | 01/16/2001 |
| 6121430 | Regiospecific synthesis of glucose-based surfactants New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants are economical to prepare and have excellent surface-active ... | 09/19/2000 |
| 6030951 | Chrysomycin derivative compounds and use as antitumor agents Disclosed are the novel C-glycoside compounds Mer-1020dA, Mer-1020dB, Mer-1020dC and Mer-1020dD which have a chromophore group in common with well-known chrysomycins A and B, but can be distinguished from the chrysomycins and the like in that the novel C-... | 02/29/2000 |
| 6018033 | Hydrophilic, hydrophobic, and thermoreversible saccharide gels and forms, and methods for producing same Polymerizable saccharide monomers are made by the reaction of a saccharose and a (meth)acrylate. Hydrophilic, hydrophobic and thermoreversible gels and foams are formed upon polymerization of the saccharide monomers. Hydrophilic sucrose monomers are synth... | 01/25/2000 |
| 5919768 | Di- and trivalent small molecule selectin inhibitors The present invention provides compounds having structure (II), and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof.... | 07/06/1999 |
| 5869460 | Sulfated and phosphated saccharide derivatives, process for the preparation of the same and use thereof There are described sulfated and phosphated saccharide erivatives of the Formula ##STR1## wherein R1 is hydrogen atom or a residue of sulfate, phosphate or L-fucose; R2, R3 and R4 are hydrogen atom or a res... | 02/09/1999 |
| 5866376 | Production of oily emulsions mediated by a microbial tenso-active agent The present invention is directed to biosurfactant stabilized emulsions of high viscosity hydrocarbons such as high viscosity crude oil wherein the biosurfactant is a metabolite of Pseudomonas aeruginosa (USB-CS1) and two methods for making the same. Pref... | 02/02/1999 |
