Quotables
"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8173784 | Enzymatic substrates for multiple detection systems An inventive substrate is provided which includes a substrate compound of formula A-B1-B2-B3-B4: wherein A is a sugar moiety; B1 is a linker moiety allowing the conjugation of moiety A and the remaining structur... | 05/08/2012 |
| 8168766 | Process of making 2-deoxy-2,2-difluoro-D-ribofuranosyl nucleosides and intermediates therefor A compound of formula (A) or salt thereof: wherein each of R1, R2, and R3 independently represents hydrogen, alkyl, aryl, acyl, sulfonyl, or silyl; P represents hydr... | 05/01/2012 |
| 8101732 | Methods of producing validamycin A analogs and uses thereof This disclosure relates to validamycin A biosynthesis and in particular, to methods of producing validamycin A analogs and uses thereof. In a particular example, a method for making a validamycin A analog includes transforming a host cell with one or more recombinan... | 01/24/2012 |
| 8034908 | Glycolipids and synthetic method thereof as well as their synthetic intermediates, and synthetic method thereof Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient s... | 10/11/2011 |
| 7960522 | Certain aminoalkyl glucosaminide phosphate compounds and their use Compounds that are adjuvants and immunoeffectors are described and claimed. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvant... | 06/14/2011 |
| 7772380 | Ceramide derivatives as modulators of immunity and autoimmunity α-Galactosylceramides and glycosylceramides (“ceramide-like glycolipids”) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the antigen-presenting cells that are capable of efficiently presenting the... | 08/10/2010 |
| 7718782 | Charged sophorolipids and sophorolipid containing compounds A sophorolid produced by a method involving reacting a compound of formula I with a compound of formula II wherein R1 and R2 are H, C1 | 05/18/2010 |
| 7683163 | Colchicoside analogues The present invention relates to colchicine derivatives, in particular to the 3-demethyl and 3-demethylthio-colchicine of the general formula (I) in which X is oxygen or sulfur, a method for the preparation thereof and pharmaceutical compositions containing them. Th... | 03/23/2010 |
| 7632930 | Oligosaccharide derivative Compounds having the formula (I): wherein A represents a group such as a cyclic group, R1 and R2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologic... | 12/15/2009 |
| 7491805 | Conjugates and compositions for cellular delivery This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including galactosamine and N-acetyl galactosamine derived conjugates of biologically active compounds, including antibodies, antivirals, chemothera... | 02/17/2009 |
| 7439343 | Aminoglycoside-polyamine displacers and methods of use in displacement chromatography Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides an... | 10/21/2008 |
| 7375088 | Polyene polyketides, processes for their production and their use as a pharmaceutical This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensi... | 05/20/2008 |
| 7365055 | Derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses The invention relates to novel derivatives of morphine-6-glucuronide, the preparation method thereof and the uses of same in therapy, for example, as analgesics. ... | 04/29/2008 |
| 7285298 | Use of a dihydrochalcone-rich phenolic fraction in a cosmetic treatment The use of a dihydrochalcone-rich polyphenolic fraction in the cosmetic treatment of mammals in order to limit the weight, to improve the aesthetic appearance of the body, and to treat certain non-pathological forms of obesity. The use of a dietary or nutraceutical ... | 10/23/2007 |
| 7244712 | Aminoglycoside antibiotics and methods of using same The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses antibiotic activity and are not susceptible to development of resistant... | 07/17/2007 |
| 7241875 | Method for the production of surface active agent mixtures An aqueous surfactant mixture comprised of an alkyl and/or alkenyl oligoglycoside ether carboxylic acid is made by a process comprising reacting in an aqueous solution an alkyl and/or alkenyl oligoglycoside and an ω-halocarboxylic acid or a salt or ester thereof in... | 07/10/2007 |
| 7238842 | Covalent tethering of functional groups to proteins A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 07/03/2007 |
| 7220727 | Aminoglycosides as antibiotics The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human). ... | 05/22/2007 |
| 7211663 | Synthesis of oligosaccharides, reagents and methods related thereto One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the present invention, glycosyl phosph... | 05/01/2007 |
| 7138372 | Agent for preventing and/or treating cachexia The present invention provides an agent for preventing and/or treating cachexia comprising TCF-II as an effective ingredient. An agent for preventing and treating cachexia caused by cancer, acquired immunodeficient syndrome (AIDS), cardiac diseases, infectious disea... | 11/21/2006 |
| 7115568 | Methods using TCF II The present invention provides an agent for preventing and/or treating cachexia comprising TCF-II as an effective ingredient. An agent for preventing and treating cachexia caused by cancer, acquired immunodeficient syndrome (AIDS), cardiac diseases, infectious disea... | 10/03/2006 |
| 7115721 | Microorganism, its product and utilization thereof There are provided a novel microorganism Enterobacter sp. B20 strain which produces (E)-4-(2-isocyanovinyl)phenyl α-rhamnopyranoside having a favorable effect of inhibiting melanogenesis and α-L-rhamnopyranoside produced thereby. This novel microorganism is... | 10/03/2006 |
| 7105491 | Biosynthesis of enediyne compounds by manipulation of C-1027 gene pathway This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced by Streptomyces globisporus). Methods are provided for the biosynthesis of enediynes, enediyne analogs an... | 09/12/2006 |
| RE39245 | Galactopyranosides and their use The present invention relates to simplified synthesis, new carbohydrate-based products and practical use of different carbohydrate-based products. Examples of these are (Galα1-3Gal), GlcNAcβ1-3Gal, α- or β-glycosides thereof, Galα1-3Gal- containing tri-, or hig... | 08/22/2006 |
| 7087560 | Personal care composition with salts of dihydroxypropyltri(C-Calkyl) ammonium monosubstituted polyols A personal care product is provided which includes a composition a quaternary ammonium salt wherein a cation of the salt is a dihydroxypropyltri(C1–C3 alkyl)ammonium monosubstituted polyol in a carrier. The cation should have a molecular weig... | 08/08/2006 |
| 7071170 | Macrolide antibiotics This invention relates to compounds of the formula wherein a, R1, R2, R3, R4, R5, R6 and X are each as defined above, and to pharmaceutically acce... | 07/04/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7019131 | Programmable one-pot oligosaccharide synthesis The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach for a facile ... | 03/28/2006 |
| 6960566 | Compositions and methods for treatment of cancer Compositions containing one or more peptido-mimetics or modified peptido-mimetics of a carbohydrate ligand of an adhesion molecule in a physiologically acceptable carrier are useful for methods of reducing metastasis in a mammal and for inhibiting inflammatory respo... | 11/01/2005 |
| 6958314 | Alkylated alkyl polyglucoside non-ionic surfactants A petro-chemical free nonionic surfactant is prepared by the alkylation of an alkyl polyglucoside (APG). Under suitable alkylation reaction conditions, the surfactants are preferably prepared by the reaction of an APG with either alkyl halide or an alkyl tosylate. T... | 10/25/2005 |
| 6921810 | Bifunctional antibiotics Bifunctional antibiotics that target both bacterial RNA and resistance-causing enzymes are disclosed. The A-site of bacterial 16S rRNA serves as the target site for most aminoglycoside antibiotics. Resistance to this class of antibiotics is frequently developed by m... | 07/26/2005 |
| 6916920 | Process for producing hydrazinomonosaccharide derivatives and use thereof A process for producing hydrazinomonosaccharide derivatives and use of hydrazines in determining the structures of aldose and ketose monosaccharides located at the reducing ends of saccharides. ... | 07/12/2005 |
| 6905856 | Soluble GlcNAc phosphotransferase The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same. ... | 06/14/2005 |
| 6887854 | Compounds as dynamic organ function monitoring agents Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 05/03/2005 |
| RE38723 | Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells The subject invention provides substrates useful for analyzing the metabolic activity in cells by improving the retention of a detectable reporter molecule only in intact cells where a particular enzyme is present. In particular, improved retention results from a tw... | 04/12/2005 |
| 6872820 | Finely divided polysaccharide derivatives Finely divided polysacharide derivatives are described. The finely divided polysacharide derivatives are prepared by a process comprising: a) forming an aqueous composition comprising a polysaccharide derivative and water, in which the polysaccharide derivative is s... | 03/29/2005 |
| 6867230 | Hygromycin A derivatives This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3 and R10 | 03/15/2005 |
| 6858233 | Simmondsin processing methods and products The invention provides a process for reducing odour, bitterness, astringency and pungency of a Simmondsins extract by dissolving the Simmondsins extract in a solvent if the Simmondsins extract is in a dry form, reacting the liquid Simmondsins extract with a carbonac... | 02/22/2005 |
| 6844346 | Chromogenic substrates of sialidase and methods of making and using the same The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-ac... | 01/18/2005 |
| 6841536 | Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof Disclosed is a prodrug of the formula: where A is a sulfur or a selenium, and R is derived from a mono- di- or oligo- saccharide. Also disclosed is a prodrug of the formula: | 01/11/2005 |
