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| Number | Title | Issue Date |
| 7220727 | Aminoglycosides as antibiotics The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human). ... | 05/22/2007 |
| 7196209 | Continuous process for the preparation of fructopyranose sulfamate derivatives The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein R1, R3, R | 03/27/2007 |
| 7183261 | Galactosylceramide analogs, and β-glucocerebrosidase activators, external skin preparations and method of activating β-glucocerebrosidase using the analogs Galactosylceramide analogues represented by the following formula (1) or (2). (wherein X and Y each represent S or O, R1 and R2 each represent an alkyl group or an alkenyl group each having ... | 02/27/2007 |
| 7102023 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention ... | 09/05/2006 |
| 7060685 | Compounds and methods for inhibiting selectin-mediated function Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-med... | 06/13/2006 |
| 6887689 | Immobilized carbohydrate biosensor The present invention refers to a biosensor in which an immobolized carbohydrate or a derivative thereof is used to generate a detectable signal when a protein, a virus or a cell is bound to the carbohydrate surface. The sensor is an optical sensor, a piezoelectric ... | 05/03/2005 |
| 6887854 | Compounds as dynamic organ function monitoring agents Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 05/03/2005 |
| 6875755 | Antithrombotic compound The present invention relates to compounds of the formula (I), wherein R is independently SO3− or CH3; the spacer is a flexible spacer of a length of 13-25 atoms; the charge of the pentasaccharide residue is compensated by positive... | 04/05/2005 |
| 6841536 | Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof Disclosed is a prodrug of the formula: where A is a sulfur or a selenium, and R is derived from a mono- di- or oligo- saccharide. Also disclosed is a prodrug of the formula: | 01/11/2005 |
| 6774112 | Amino acid complexes of C-aryl glucosides for treatment of diabetes and method Crystalline complexes are obtained from a 1:1 or 2:1 mixtures of either the (D) or (L) enantiomer of natural amino acids and compounds of formula wherein R1, R2 and R2a are indepen... | 08/10/2004 |
| 6765089 | Protecting and linking groups for organic synthesis on solid supports This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and ... | 07/20/2004 |
| 6723831 | Neoglycoproteins Polyamide conjugates comprising either (a) a xenoantigenic group; or (b) a biologically active group and a macromolecular, macro- or microscopic entity; bound to a polyamide backbone, processes for their preparation and the use of these conjugates in therapeutic com... | 04/20/2004 |
| 6683056 | O-aryl glucoside SGLT2 inhibitors and method ##STR1## wherein when Y is ##STR2## or heteroaryl; A is --O(CH2)m, S, --NH(CH2)m, or (CH2)n where n is 0-3 and m is 0-2; and R1 to R6 are as defined herein... | 01/27/2004 |
| 6590085 | Derivatives of monosaccharides as cell adhesion inhibitors This invention relates generally to compounds and processes for synthesizing derivatives of 2-3-O-isopropylidene--L-xylo-2-hexulofuranosonic acid. The compounds of this invention are useful, inter-alia, for the inhibition and prevention of cel... | 07/08/2003 |
| 6541614 | Polysaccharide derivative Polysaccharide derivatives derived from a polysaccharide or a derivative thereof by substituting a part or all of the hydrogen atoms of the hydroxyl groups of the polysaccharide or the derivative thereof with the groups represented by the following formul... | 04/01/2003 |
| 6534637 | Synthesis of chlorophenol red glucuronic acid This invention provides ଲ-D-Glucuronidase substrates of the formula: ##STR1## wherein R1, R2, and R7 -R12 are independently selected from the group consisting of: hydrogen, fluorine, chlorine, bromine, iodine, ... | 03/18/2003 |
| 6492337 | Galactosylceramide, glucosylceramide, lactosylceramide, and specific catchers therefor for use in the prophylaxis or therapy of prediabetes, diabetes and/or associated complication The use of glycolipids, in particular galactosylceramide, glucosylceramide and lactosylceramide, and specific catchers therefor (antibodies or lectins), in particular monoclonal antibodies, for use in the prophylaxis or therapy of prediabetes, diabetes an... | 12/10/2002 |
| 6486129 | Antithrombotic compounds ##STR1## The present invention relates to compounds of formula (1), wherein R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso)quinolinyl, tetrahydro(iso)quinolinyl, 3,4-dihydro-1H-isoquinolinyl, chromanyl or the camphor group, which grou... | 11/26/2002 |
| 6465625 | Taxol derivatives Highly specific biocatalytic reactions have been used to create a population of taxol derivatives.... | 10/15/2002 |
| 6399578 | Conjugates comprising galactose 댑,3 galactosyl epitopes and methods of using same This invention provides conjugates useful for xenotransplantation which comprise a galactose 댑,3 galactosyl (Gal) epitope conjugated to a valency platform molecule, preferably a chemically defined valency platform molecule which allows preci... | 06/04/2002 |
| 6399071 | Neoglycoproteins Polyamide conjugates comprising either (a) a xenoantigenic group; or (b) a biologically active group and a macromolecular, macro- or microscopic entity, bound to a polyamide backbone, processes for their preparation and the use of these conjugates in ther... | 06/04/2002 |
| 6340746 | Prodrugs and conjugates of thiol- and selenol- containing compounds and methods of use thereof Disclosed are prodrugs as follows: (I) a prodrug of the formula ##STR1## where A is a sulfur or a selenium, and R is a mono- di- or oligo-saccharide; (II) a prodrug of the formula ##STR2## where A is sulfur or selenium, R' is a sugar, or .dbd.O, and the R... | 01/22/2002 |
| 6306837 | Heavy metal chelating agent for oral administration, its synthesis and its uses in medicine and health protection The present invention relates to a new kind of heavy metal chelating agents and a preparation process and uses thereof. The said heavy metal chelating agents are expressed in -[D(+)glucose-1-yl-amino]-댣-mercapto-(S)-propanoic acid (abbr... | 10/23/2001 |
| 6258784 | Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure ##STR1## wherein W is S, SO, SO2, NR; Y is O, S, NR, or CH2 ; R is hydrogen or alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon ... | 07/10/2001 |
| 6235720 | Acid-functionalized saccharide polymers The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. The monomer can have a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a s... | 05/22/2001 |
| 6183994 | N-containing saccharides and method for the synthesis of N-containing saccharides from amino-deoxy-disaccharides and amino-deoxy-oligosaccharides Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted wi... | 02/06/2001 |
| 6184366 | Substituted liposaccharides useful in the treatment and prevention of endotoxemia Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing ... | 02/06/2001 |
| 6136961 | Biocatalytic methods for synthesizing and identifying biologically active compounds Highly specific biocatalytic reactions have been used to create a population of derivatives from a single starting compound. Examples demonstrate synthesis of derivatives of taxol, taxol-2'-adipate, taxol-2'-vinyl adipate, 2,3-(methylenedioxy) benzaldehyd... | 10/24/2000 |
| 6107284 | Water-soluble derivatives of epipodophyllotoxin, process for their preparation, their use as medicinal products and their intended use in anti-cancer treatments Water-soluble derivatives of epipodophyllotoxin, process for their preparation and their use for the treatment of rheumatoid arthritis, complaints caused by human papilloma virus and cancer.... | 08/22/2000 |
| 6087339 | Saccharide derivatives Disclosed are novel saccharide derivatives which inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. Additionally, disclosed are compounds which inhibit binding of enterovirulent orga... | 07/11/2000 |
| 6084081 | Lewis X derivatives A novel fluorine-containing Lewis X derivative represented by the following formula (I): ##STR1## wherein R represents hydrogen, a hydroxyl-protective group, --PO(OH)2, --SO3 H or sialylate; R1 represents hydrogen, hy... | 07/04/2000 |
| 6063769 | 1-thiogalactose derivatives Disclosed are novel 1-thiogalactose derivatives which inhibit binding of heat labile toxin (LT) and/or chlorea toxin (CT) to cell surface receptors either in vitro or in vivo. Additionally, disclosed are compounds which inhibit binding of enterovirulent m... | 05/16/2000 |
| 6007823 | Simmondsin concentrate from jojoba A process for the isolation of simmondsins from jojoba meal is disclosed. Simmondsins are first extracted from defatted jojoba meal with water. After separation from the meal, this water extract is subsequently dried, leaving the simmondsins in the result... | 12/28/1999 |
| 5968907 | 1-thiogalactose derivatives Disclosed are novel 1-thiogalactose derivatives which inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. Additionally, disclosed are compounds which inhibit binding of organisms (e.g... | 10/19/1999 |
| 5939537 | Acid-functionalized saccharide monomers The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. The monomer can have a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a s... | 08/17/1999 |
| 5932554 | 1-galactose derivatives Disclosed are novel 1-galactose derivatives which inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. Additionally, disclosed are compounds which inhibit binding of enterovirulent org... | 08/03/1999 |
| 5929037 | Modified -D-Glc.rho.-(1-2)--D-Glc.rho.-(1-3)--D-Glc.rho.-ana logues Disclosed is the trisaccharide -D-Glcp-(1-2)--D-Glcp-(1-3)--D-Glcp and compounds related thereto as well as pharmaceutical compositions thereof.... | 07/27/1999 |
| 5925622 | Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same An aryl glucuronide of 2-hydroxy-N-(5-nitro-2-thiazolyl)benzamide, preferably an O-aryl glucuronide, as well as methods for the convenient synthesis of these aryl glucuronides, highly stable and low toxicity pharmaceutical composition containing these ary... | 07/20/1999 |
| 5886143 | Hepatic-directed compounds and reagents for preparation thereof Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are discussed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic me... | 03/23/1999 |
| 5877157 | Modified kojibioside analogues Disclosed are novel analogues of kojibiose and pharmaceutical compositions comprising such analogues.... | 03/02/1999 |
