Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7375090 | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof The present invention relates to glucopyranosyloxy-pyrazoles of general formula wherein R1 to R6 and R7a, R7b, R7c are defined as in claim 1, the tauto... | 05/20/2008 |
| 7375213 | Methods of producing C-aryl glucoside SGLT2 inhibitors Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents. ... | 05/20/2008 |
| 7375087 | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group repre... | 05/20/2008 |
| 7238514 | Diterpene-producing unicellular organism The present invention is directed to a unicellular organism system, such as a yeast, for producing geranylgeranyl pyrophosphate and a diterpene in vivo. The yeast cell preferably comprises an inducible nucleic acid sequence encoding geranylgeranyl pyrophosphate synt... | 07/03/2007 |
| 7229629 | Carboxylate-gated-nitroxide (CGN) compounds and compositions and methods of use thereof Carboxylic-gated-nitroxide (CGN) compounds and their esterified derivatives are discovered and disclosed as compositions and shown to have the potential in treating a variety of acute and chronic diseases and disorders resulting from reactive oxygen species (ROS) in... | 06/12/2007 |
| 7217697 | Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 is a hydrogen atom or a hydroxyalkyl group; one of Q and T is a group represented by ... | 05/15/2007 |
| 7148223 | 4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or... | 12/12/2006 |
| 7129261 | Cytotoxic agents The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 10/31/2006 |
| 7129220 | Substituted indole-O-glucosides Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed. ... | 10/31/2006 |
| 7129219 | Immunoeffector compounds This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to a cyclic aminoalkyl (aglycon) group. The invention further provides methods for inducing an immune response using the compounds of the present in... | 10/31/2006 |
| 7112671 | Non-symmetric tripyrranes in the synthesis of novel macrocycles The present invention provides certain non-symmetric tripyrranes; that is, tripyrranes that do not contain a mirror plane of symmetry perpendicular to the plane containing the tripyrrane. Further, the invention includes texaphyrin compounds and sapphyrin compounds, ... | 09/26/2006 |
| 7097995 | Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-PFormula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached an... | 08/29/2006 |
| 7094764 | Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X. ... | 08/22/2006 |
| RE39245 | Galactopyranosides and their use The present invention relates to simplified synthesis, new carbohydrate-based products and practical use of different carbohydrate-based products. Examples of these are (Galα1-3Gal), GlcNAcβ1-3Gal, α- or β-glycosides thereof, Galα1-3Gal- containing tri-, or hig... | 08/22/2006 |
| 7087600 | Peptidyl prodrugs and linkers and stabilizers useful therefor The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 08/08/2006 |
| 7084124 | Substituted indazole-O-glucosides Substituted indazole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed. ... | 08/01/2006 |
| 6946283 | Ginkgo biloba levopimaradiene synthase The present invention is directed to nucleic acid sequences of Ginkgo biloba diterpene synthases, particularly of a levopimaradiene synthase. More specifically, the invention is directed to a cell of a unicellular organism, such as Saccharomyces cerevisiae... | 09/20/2005 |
| 6939858 | Malto-oligosaccharide derivatives and use thereof The present invention provides a substance which strongly inhibits human α-amylase and is effective for the prevention and treatment of hyperglycemia, for example, diabetes and the diseases caused thereby, and an α-amylase inhibitor and a prophylactic or therapeut... | 09/06/2005 |
| 6914061 | 4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3,... | 07/05/2005 |
| 6911434 | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ cyclic AGPs for selectively stimulating immune responses in animals and plants. ... | 06/28/2005 |
| 6887854 | Compounds as dynamic organ function monitoring agents Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 05/03/2005 |
| 6867194 | Enzyme activated nitric oxide donors Sugar-modified SIN-1 compositions are provided. The compositions are useful for generating NO in response to hydrolytic activity of a glycosidase specific for the O-glycosidic bond between the sugar and SIN-1 moieties. Pharmaceutical compositions containing the suga... | 03/15/2005 |
| 6849607 | Galectin recognized photosensitizers for photodynamic therapy Purpurin-carbohydrate conjugates and their method of preparation and use for treatment of cancer cells. The conjugates have the general formula: wherein R6 and R7 taken together are ═NR11 | 02/01/2005 |
| 6844346 | Chromogenic substrates of sialidase and methods of making and using the same The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-ac... | 01/18/2005 |
| 6812332 | Chromogenic substrates of sialidase and methods of making and using the same The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provi... | 11/02/2004 |
| 6683056 | O-aryl glucoside SGLT2 inhibitors and method ##STR1## wherein when Y is ##STR2## or heteroaryl; A is --O(CH2)m, S, --NH(CH2)m, or (CH2)n where n is 0-3 and m is 0-2; and R1 to R6 are as defined herein... | 01/27/2004 |
| 6683061 | Enzyme catalyzed therapeutic activation This invention provides novel substrate compounds that selectively inhibit the proliferation of pathological cells, for example, pathological calls that endogenously overexpress a target enzyme that confers resistance to biologic and chemotherapeutic agen... | 01/27/2004 |
| 6673907 | Methods and compositions for the manufacture of C-3' and C-4' anthracycline antibiotics The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3' of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4' of the sugar moiety. It also d... | 01/06/2004 |
| 6610502 | Compound 2-amino-3-[2-(-mannopyranosyl)indol-3-yl]propionic acid, process for preparing the same, and method for inspecting function of living body with the novel compound The present invention relates to a novel endogenous compound 2-amino-3-[2-(-mannopyranosyl)indole-3-yl]propionic acid; to a method for testing a biological function by quantitating 2-amino-3-[2-(-mannopyranosyl)indole-3-yl]propionic acid in ... | 08/26/2003 |
| 6596696 | Malto-oligosaccharide derivatives and uses thereof Maltoligosaccharide derivatives represented by the general formula: ##STR1## wherein n is an integer of 0 to 3 and X is a hydrogen atom or a hydrophobic group) or their hydrates or physiologically acceptable salts, and an -amylase inhibitor and a p... | 07/22/2003 |
| 6545134 | Method for the production of pentopyranosyl nucleosides Processes for the preparation of 3',4'-cyclic acetals of pentopyranosylnucleosides, in which the pentopyranosyl nucleoside is reacted with an aldehyde, ketone, acetal, or ketal under reduced pressure of less than about 500 mbar.... | 04/08/2003 |
| 6525028 | Immunoeffector compounds This invention provides compounds containing a 2-deoxy-2-amino-ଲ-D-glucopyranose (glucosamine) glycosidically linked to an cyclic aminoalkyl (aglycon) group. The invention further provides methods for inducing an immune response using the compounds ... | 02/25/2003 |
| 6515117 | C-aryl glucoside SGLT2 inhibitors and method An SGLT2 inhibiting compound is provided having the formula ##STR1## A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or in combination with another antidiabetic agent or... | 02/04/2003 |
| 6512100 | Chromogenic substrates of sialidase and methods of making and using the same The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this inve... | 01/28/2003 |
| 6512101 | Branched hydrazone linkers Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferr... | 01/28/2003 |
| 6506734 | 20(S) camptothecin glycoconjugates The present invention relates to glycoconjugates of 20(S)-camptothecin, in which a 3-O-methylated ଲ-L-fucose unit is linked to the 20-hydroxyl group of a camptothecin derivative via a thiourea-modified peptide spacer. The invention furthermore relat... | 01/14/2003 |
| 6495528 | 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.... | 12/17/2002 |
| 6472541 | Protecting groups with increased photosensitivities Protecting groups derived from a halogenated coumarin group, a quinoline-2-one group, a xanthene group, a thioxanthene group, a selenoxanthene group, or an anthracene group are described. The protecting groups is photolabile and can be removed by irradiat... | 10/29/2002 |
| 6455593 | Method of dynamic retardation of cell cycle kinetics to potentiate cell damage The invention relates to a method of potentiating cell damage in a target cell population by administering a "restraining agent" and concomitantly or subsequently applying a "targeted cytotoxic insult." The restraining agent is administered at a concentra... | 09/24/2002 |
| 6455507 | Benzimidazole derivatives Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of preparing these benzimidazole derivatives and pharmaceutical co... | 09/24/2002 |
