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| Number | Title | Issue Date |
| 5534499 | Lipophilic drug derivatives for use in liposomes The present invention provides novel lipophilic drug derivatives which are capable of being formulated in liposomes or micelles. These drug derivatives are known therapeutic agents which are covalently attached to a fatty acid chain of a phospholipid, gly... | 07/09/1996 |
| 5530113 | Anti-endotoxin compounds Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection.... | 06/25/1996 |
| 5527890 | Derivatives of triterpenoid acids and uses thereof Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have significant applications for the treatment or prevention of certai... | 06/18/1996 |
| 5521293 | Heteroatom containing alkyl aldonamide compounds as superior foaming, more soluble nonionic surfactants and a process for their manufacture The present invention relates to a process for producing amido heteroatom containing alkyl aldonamides comprising reacting an amino heteroatom containing alkyl aldonamide and an acid anhydride in water or solvent; heating the mixture and recovering. A sec... | 05/28/1996 |
| 5519008 | Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin) Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/endothelial cell... | 05/21/1996 |
| 5519010 | Sulfated polysaccharide, pharmaceutically acceptable salt thereof, process for preparing same and medicament containing same as effective component The present invention provides a sulfated polysaccharide (D-HG), a pharmaceutically acceptable salt thereof, a process for preparing the same and a medicament containing the same as the effective component for DIC (disseminated intravascular coagulation) ... | 05/21/1996 |
| 5512470 | Method for inhibiting sialidase activity Novel NeuAc-Gal dissacharide sialidase substrates and inhibitors which are locked into rigid conformation by the attachment of an alkyl group at the C-6 arm of the galactose core are provided. Also provided is a method for the inhibition of sialidase acti... | 04/30/1996 |
| 5508268 | Parenteral elsamitrucin formulations Stable parenteral antitumor formulations contain elsamitrucin salt, a stabilizer and a buffer. The formations are optionally stored in sealed containers under air or nitrogen headspace.... | 04/16/1996 |
| 5508392 | Use of vitamin D glycosides, vitamin D orthoester glycosides, vitamin D analog glycosides and vitamin D analog orthoester glycosides for the treatment of osteoporosis The present invention relates to methods for the treatment of prevention of osteoporosis by the administration of a vitamin D glycoside or vitamin D orthoester glycoside, or an analog thereof.... | 04/16/1996 |
| 5504196 | Removal of color, polysaccharides, phenolics and turbidity from sugar-containing solutions and derivated fibrous residues therefore Unwanted color and turbidity are removed from sugar solutions during the processing of raw sugar by the use of bagasse treated with a dialkylaminoalkyl compound in a basic aqueous medium, and with regenerated treated bagasse, including sugarcane bagasse, ... | 04/02/1996 |
| 5496931 | Insecticide and miticide A83543 compounds and their method of production by fermentation Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components... | 03/05/1996 |
| 5489675 | Disaccharide sialidase substrates and inhibitors Novel NeuAc-Gal dissacharide sialidase substrates and inhibitors which are locked into rigid conformation by the attachment of an alkyl group at the C-6 arm of the galactose core are provided. Also provided is a method for the inhibition of sialidase acti... | 02/06/1996 |
| 5489578 | Sulfated ligands for l-selectin and methods of treating inflammation Sulfated oligosaccharides which bind to L-selectin receptors and act as agonists are formulated into pharmaceutical formulations and administered by injection to treat inflammation. Compounds which act as metabolic inhibitors of carbohydrate sulfation and... | 02/06/1996 |
| 5473058 | Process and reagent for the specific determination of pancreatic -amylase The present invention provides a process for the specific determination of pancreatic -amylase in the presence of salivary -amylase in body fluids by reaction with a system for the detection of -amylase with the use of an inhibitor fo... | 12/05/1995 |
| 5470962 | Oligosialyl-1,2-dialkyl-sn-glycerols and synthetic intermediates for their preparation An oligosialyl-1,2-dialkyl-sn-glycerol represented by the following formula (I): ##STR1## wherein each R1 independently represents a group selected from the group consisting of a hydrogen atom and alkali metal atoms, each R2 ... | 11/28/1995 |
| 5470843 | Carbohydrate-containing polymers, their preparation and use Carbohydrate-containing polymers which can have an HLB* of from about 10 to about 20 are disclosed. The compounds comprise a hydrophilic polymer portion, a carbohydrate portion comprising from 1 to about 20 naturally occurring, identical or different, mon... | 11/28/1995 |
| 5464821 | Small peptidic compounds useful for the treatment of glaucoma Small peptidic compounds containing a small and branched chained amino acid residue, pharmaceutical compositions containing at least one such compound active against glaucoma and intraocular hypertension and a method for treating glaucoma and intraocular ... | 11/07/1995 |
| 5464942 | Phospholipid- or lipid-linked glycosaminoglycan and process for producing the same This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their excellent function to inhibit adhesion of cancer cells to b... | 11/07/1995 |
| 5463034 | Polysaccharides, process for their preparation and their use New polysaccharides have recurring units I or a salt thereof. ##STR1##... | 10/31/1995 |
| 5461143 | Oligosaccharide enzyme substrates and inhibitors: methods and compositions Oligosaccharide compounds that are substrates and inhibitors of glycosyltransferase and glycosidase enzymes and compositions containing such compounds are disclosed. A method of glycosylation is also disclosed. An E. coli transformed with phagemid CMPSIL-... | 10/24/1995 |
| 5445944 | Methods for determining peroxidately active substances Methods and compositions are disclosed for determining a peroxidatively active substance (PAS). The methods comprise the step of detecting a fluorescent signal produced upon cleavage of a compound of the formula F-L-Q, wherein F is a fluorescer capable of... | 08/29/1995 |
| 5444050 | Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa This invention relates to compounds that inhibit the binding of E-selectin and/or P-selectin to sialyl-Lewisx or sialyl-Lewisa presented on a cell surface having the general structure ##STR1## wherein X is selected from the grou... | 08/22/1995 |
| 5444174 | 16-membered macrolide derivative having sustained antibacterial activity in plasma, synthesis intermediate thereof and process for producing the same 16-membered macrolide compounds wherein both of hydroxyl groups at the 3"- and 4"-positions form ether bonds together with two alkyl groups which are either the same or different from each other is useful as an antibacterial agent. The macrolide compounds... | 08/22/1995 |
| 5441932 | Sugar compounds for inhibition of the biosynthesis of sugar chains containing sialic acid An inhibitor of the biosynthesis of sugar chains containing sialic acid that is excellent in the suppression of inflammation or allergy, which comprises as an active ingredient a sugar compound of the formula (1): ##STR1## wherein R1 is a ... | 08/15/1995 |
| 5438069 | Glucohydrolase inhibitors useful as antidiabetic agents The invention provides the compounds 1,2-dideoxy-2-(hydroxymethyl)-1-(methylamino)-myo-inositol hydrochloride, 1,2-dideoxy-2-(hydroxymethyl)-1-(methylamino)-scyllo-inositol, 1,6-dideoxy-6-(hydroxymethyl)-1-(methylamino)-myo-inositol.... | 08/01/1995 |
| 5432163 | Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides Compounds of this invention are derivatives of pentose monosaccharides which exhibit anti-proliferative and anti-inflammatory activity as well as intermediates for the synthesis of these compounds. Methods of preparation, pharmaceutical compositions conta... | 07/11/1995 |
| 5426184 | Cyclodextrin glycosides and processes for their preparation The invention relates to cyclodextrin glycosides and processes for their preparation. The cyclodextrin glycosides according to the invention are cyclodextrins substituted by 2-acetamido-2-deoxyaldoses. These cyclodextrin glycosides are prepared by a proce... | 06/20/1995 |
| 5415855 | Cosmetic composition Modified ceramides are defined, together with their synthesis and compositions comprising them for topical application to human skin, hair and nails. The modified pseudoceramides have a structure: ##STR1## and an approximate summary is that R and R | 05/16/1995 |
| 5414073 | Pradimic acids, amides, and novel pradimicin derivatives The present invention relates to intermediates, pradimic acids and pradimic acid amides of the formula (II) ##STR1## wherein R is OH or NH2 ; R1 is hydrogen or a group of the formula ##STR2## with the proviso that when... | 05/09/1995 |
| 5412080 | Enterobactin compounds Enterobactin analogs prepared from scyllo-inositol mono-orthoformate and having the following formula: ##STR1## wherein each X1, X2 and X3, independently, is H, C1-20 alkyl, phenyl, naphthyl, C7-20 | 05/02/1995 |
| 5412118 | Thickened foam stable compositions comprising alkyl(alkyl glycosid)uronamides The present invention relates to liquid and powdered surfactant compositions comprising alkyl (alkyl glycosid) uronamide compounds. Compositions comprising these compounds have been found to provide significant benefits such as stable, aqueous foam (in sh... | 05/02/1995 |
| 5412082 | Conversion of amines to hydroxylamines Oxidation of primary amines to primary hydroxylamines using a dialkyl dioxirane is described. This new method is utilized to prepare aliphatic non-axial hydroxylamines from corresponding primary amino-substituted sugar derivatives and hydroxylamino acid d... | 05/02/1995 |
| 5401426 | Lactobionic acid amide compositions and their use Lactobionic acid amide compositions synthesized from lactobionic acid and a mixture of primary fatty amines, which contains at least 30 percent by weight of fatty amines having a chain length of 14 to 18 carbon atoms, and their use as softening, detergent... | 03/28/1995 |
| 5401839 | Process of preparing N-substituted aldonamides having improved color and color stability A process of preparing N-substituted aldonamides, the process including the steps of mixing and reacting an aldonolactone and an amine in an organic polar solvent, in the presence of an antioxidant and a reducing agent. The aldonamides have improved color... | 03/28/1995 |
| 5399488 | Method for assaying enzyme activity using N-acetyl-ଲ-D-glucosamine derivatives Novel N-acetyl-ଲ-D-glucosamine derivatives and a method for assaying N-acetyl-ଲ-D-glucosaminidase activity using the same as substrate are provided. N-Acetyl-ଲ-D-glucosamine derivatives represented by general formula (I): ##STR1## ... | 03/21/1995 |
| 5393875 | Amino acid derivatives having renin inhibiting activity The compounds of the formula ##STR1## wherein A, R1, R2, R3, R4 and R5 have the significance given in claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomer... | 02/28/1995 |
| 5385685 | Compositions comprising glyceroglycolipids having an ether linkage as a surfactant or cosurfactant The present invention relates to detergent compositions comprising a glyceroglycolipid having one or two ether linkages for use as a surfactant or cosurfactant in the detergent compositions.... | 01/31/1995 |
| 5384334 | Alkoxylated alkyl glucoside ether quaternaries useful in personal care Alkoxylated alkyl glucosides having quaternary nitrogen-containing ether substituents possess cationics utility combined with extreme mildness to skin and hair along with stable personal care compositions and processes.... | 01/24/1995 |
| 5380716 | Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation Highly sulfated oligosaccharides in the form of hexasaccharide and octasaccharide compounds which have antiproliferative activity with respect to smooth muscle cells are useful in treatment of conditions characterized by unwanted smooth muscle cell prolif... | 01/10/1995 |
| 5380832 | Ganglioside GM3 analogs Disclosed are ganglioside GM3 analogs represented by the formula ##STR1## in which X represents a radical of the following formula ##STR2## wherein at least one of R1, R2, R3 and R4 is hydrogen ... | 01/10/1995 |
