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| Number | Title | Issue Date |
| 8114970 | Synthetic heparin monosaccharides Preparation of synthetic monosaccharides, for use in the preparation of synthetic heparinoids. ... | 02/14/2012 |
| 7919599 | Production of L-iduronate containing polysaccharides The present invention provides processes for the production of polysaccharides containing the L-iduronate subunit, for example, heparin-type polysaccharides. New intermediate compounds and processes developed during the production of said polysaccharides are also pr... | 04/05/2011 |
| 7875708 | Sialic acid derivatives An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a usefu... | 01/25/2011 |
| 7667012 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 02/23/2010 |
| 7504489 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof The present invention provides compounds having the formula: wherein A is chosen from a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group; both B and C are hydrogen, or either B or C is a halog... | 03/17/2009 |
| 7419958 | Method of attenuating reactions to skin irritants The present invention is directed to a method of inhibiting CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Compositions of the invention are useful for the attenuation of CD1d-restricted immune responses, including tr... | 09/02/2008 |
| 7417129 | Combinatorial libraries of monosaccharides A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I. ... | 08/26/2008 |
| 7393937 | N-acetylglucosamine derivatives and use thereof The present invention relates to An N-acetylglucosamine derivative represented by the following formula (1), and a hyaluronic acid production promoting agent containing the same and a skin external preparation containing the same: | 07/01/2008 |
| 7375087 | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group repre... | 05/20/2008 |
| 7375213 | Methods of producing C-aryl glucoside SGLT2 inhibitors Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents. ... | 05/20/2008 |
| 7375088 | Polyene polyketides, processes for their production and their use as a pharmaceutical This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensi... | 05/20/2008 |
| 7375090 | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof The present invention relates to glucopyranosyloxy-pyrazoles of general formula wherein R1 to R6 and R7a, R7b, R7c are defined as in claim 1, the tauto... | 05/20/2008 |
| 7371732 | Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture The present invention relates to glucopyranosyloxy-substituted aromatic groups of general formula wherein R1 to R6 and R7a, R7b, R7c are defined as in clai... | 05/13/2008 |
| 7351408 | Glycoconjugates and methods Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosacch... | 04/01/2008 |
| 7345031 | Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use Hydrophilic transportable N-linked glycosyl dopaminergic prodrug compounds according to FORMULA V and methods of their use, wherein, Ring 1 comprises an aryl or heteroaryl ring having 4 to... | 03/18/2008 |
| 7288528 | Aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which ... | 10/30/2007 |
| 7288640 | Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-sily... | 10/30/2007 |
| 7253278 | Purification process for manufacturing a high pure acarbose A process for purifying and preparing highly pure acarbose from acarbose-containing fermentation broth. The acarbose is purified through steps of alcohol precipitation, a strongly acidic cation exchanger chromatography and an immobolized enzyme affinity chromatograp... | 08/07/2007 |
| 7244712 | Aminoglycoside antibiotics and methods of using same The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses antibiotic activity and are not susceptible to development of resistant... | 07/17/2007 |
| 7238483 | Method for detecting catalytic activity This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent... | 07/03/2007 |
| 7235533 | Compounds and their uses Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. I... | 06/26/2007 |
| 7232900 | Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors and intermediates therefor This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-sily... | 06/19/2007 |
| 7220727 | Aminoglycosides as antibiotics The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human). ... | 05/22/2007 |
| 7217697 | Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 is a hydrogen atom or a hydroxyalkyl group; one of Q and T is a group represented by ... | 05/15/2007 |
| 7199159 | Use of biguanide derivatives for making a medicine having a wound healing effect The present invention relates to the use of biguanide derivatives of general formula I below: in which: the groups R1 and R2 represent, independently of each other, a hydrogen a... | 04/03/2007 |
| 7196178 | Sugar-derived gellant for hydrogel formation A gelatinizer having gel-forming capability in both organic solvents and water, is provided. The hydrogelatinizer is represented by: (where, A is a sugar residue, and R is an alkyl group). ... | 03/27/2007 |
| 7189702 | Glucopyranosyloxypyrazole derivatives and medicinal use thereof The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula: | 03/13/2007 |
| 7183261 | Galactosylceramide analogs, and β-glucocerebrosidase activators, external skin preparations and method of activating β-glucocerebrosidase using the analogs Galactosylceramide analogues represented by the following formula (1) or (2). (wherein X and Y each represent S or O, R1 and R2 each represent an alkyl group or an alkenyl group each having ... | 02/27/2007 |
| 7179792 | Combination product of a 1,4-benzothiepine 1,1-dioxide compound with at least one other active ingredient and the use of the product The present invention is directed to a 1,4-benzothiepine 1,1-dioxide compound of formula I in which the radicals have the meanings defined herein, or a pharmaceutically acceptable salt or physiologically function... | 02/20/2007 |
| 7169761 | Azulene derivatives and salts thereof The present invention provides an azulene derivative and a salt thereof, wherein an azulene ring is bonded to a benzene ring directly or via a lower alkylene which may be substituted with a halogen atom and the benzene ring is directly bonded to the glucose residue,... | 01/30/2007 |
| 7166611 | Pharmaceutical compositions having appetite suppressant activity A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1... | 01/23/2007 |
| 7150793 | Method of reducing materials contained in juice A process system that uses a reduced amount of lime or other base to clarify or purify juice obtained from plant material such as sugar cane, sugar beets, or sweet sorghum. Specifically, apparatus and methods to reduce volatile materials in juice providing a product... | 12/19/2006 |
| 7148223 | 4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or... | 12/12/2006 |
| 7129220 | Substituted indole-O-glucosides Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed. ... | 10/31/2006 |
| 7128897 | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis Pharmaceutical compositions are described that contain one agent for treatment of sinusitis and a surfactant. The compositions are prepared to have a surface tension that renders the composition effective for treatment of sinusitis. ... | 10/31/2006 |
| 7129219 | Immunoeffector compounds This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to a cyclic aminoalkyl (aglycon) group. The invention further provides methods for inducing an immune response using the compounds of the present in... | 10/31/2006 |
| 7119079 | Bioadhesive pharmaceutical compositions Disclosed are compounds having the formula wherein R2 is hydrogen, a monomeric glycoside or an oligomeric glycoside, R3 is hydrogen, a monomeric glycoside, an oligomeric glycoside, or a grou... | 10/10/2006 |
| 7109177 | Methods and compositions for the manufacture of C-3′ and C-4′ anthracycline antibiotics The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also disclose... | 09/19/2006 |
| 7105492 | Camptothecin derivatives having antitumor activity Camptothecin derivatives of camptothecin of formula (I) exhibit antitumor activity and show a good therapeutic index and are used in the treatment of tumors, viral infections and antiplasmodium falciparum. ... | 09/12/2006 |
| 7105491 | Biosynthesis of enediyne compounds by manipulation of C-1027 gene pathway This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced by Streptomyces globisporus). Methods are provided for the biosynthesis of enediynes, enediyne analogs an... | 09/12/2006 |
