Did You Know...
...that two musicians were responsible for the invention of color print film? Fascinated by photography, Leopold Godowsky and Leopold Mannes worked together to produce an easy-to-use, practical color film. They worked full time as music teachers and gave concerts while experimenting during their off hours in Mannes' kitchen. Their success earned them full-time, well-paying jobs at Kodak and their efforts resulted in Kodachrome film, which was introduced in 1935.
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| Number | Title | Issue Date |
| 4136254 | Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby Selective blocking of some amino groups in a polyamino organic compound having at least one pair of available neighboring hydroxyl and amino groups is effected by first preparing in situ transition metal salt complexes of available neighboring amino and h... | 01/23/1979 |
| 4130709 | Pleuromutilin glycoside derivatives Pleuromutilin glycoside derivatives which are useful agents against gram-positive and gram-negative bacteria, anaerobic bacteria, and mycoplasma.... | 12/19/1978 |
| 4129720 | Aminoeverninomicin and derivatives thereof Everninomicin B, C or D may be converted to amino derivatives by reductive means. The amino derivatives may, subsequently, be converted to novel N-acyl, N-alkyl or N,N-dialkyl derivatives. Alternatively, everninomicins B, C or D may be converted to N-acyl... | 12/12/1978 |
| 4129721 | A-40104 antibiotics and process for production thereof A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of Clitopilus pseudo-pinsitus. Individual factors, A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-4... | 12/12/1978 |
| 4117221 | Aminoacyl derivatives of aminoglycoside antibiotics Disclosed herein are novel 1-N-X-aminoglycoside anti-bacterial agents produced from antibiotics elaborated by species of the genus Micromonospora wherein X is a member selected from the group consisting of S-3-amino-2-hydroxypropionyl and S-4-amino-2-hydr... | 09/26/1978 |
| 4107435 | Process for ω-amino-2-hydroxyalkyl derivatives of aminoglycoside antibiotics 1-N-(ω-Amino-2-hydroxyalkyl) derivatives of aminoglycoside antibiotics are prepared by reductive alkylation of the parent antibiotic, or a partially protected derivative thereof, with a 6-dihydroxymethyltetrahydro-1, 3-oxazin-2-one or 5-dihydroxymet... | 08/15/1978 |
| 4085208 | Process for preparing 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 1-epimers and 1-N-alkyl derivatives produced thereby; methods for the use of the 1-epimer derivatives as antibacterial agents and compositions useful therefor This invention relates to the preparation of novel 1-epi-aminoglycosides, useful as antibacterial agents, and also relates to the process for the preparation of known as well as novel 1-N-substituted aminoglycoside antibacterial agents.... | 04/18/1978 |
| 4078139 | Process for deoxygenating secondary alcohols The process for removing a secondary hydroxyl group from an organic compound having at least one secondary hydroxyl group and having any amino groups protected, comprises the reaction of a reactive ester of said secondary hydroxyl group selected from the ... | 03/07/1978 |
| 4071560 | Diaminoalditols useful in the preparation of antibacterial antibiotics AM31, AM31ଲ, and AM31γ This disclosure describes a novel class of antibiotics, three of which have been designated AM31, AM31ଲ, and AM31γ and are produced in a microbiological fermentation under controlled conditions using a new strain of Streptoverticillium netro... | 01/31/1978 |
| 4066752 | 1-Desamino-1-hydroxy and 1-desamino-1-epi-hydroxy-4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols; 1-desamino-1-oxo-4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols, intermediates and use as antibacterial agents This invention relates to the preparation of novel 1-desamino-1-oxo-aminoglycosides and their use as intermediates in the preparation of novel 1-desamino-1-hydroxy and 1-desamino-1-epi-hydroxyaminoglycoside antibacterial agents.... | 01/03/1978 |
| 4065615 | Deoxyaminoglycoside antibiotic derivatives A new deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups other than the amino group at the 1-position of the deoxystreptamine moiety are formylated is obtained in a high yield by treating a deoxystreptamine-cont... | 12/27/1977 |
| 4064341 | Nogalamycinic acid and derivatives thereof Novel antibiotic, nogalamycinic acid (U-51,205) prepared by the chemical modification of the known antibiotic nogalamycin. Nogalamycinic acid is active against various microorganisms, for example, Mycobacterium avium, Bacillus subtilis, Lactobacillus case... | 12/20/1977 |
| 4064012 | Process for producing antibacterial antibiotics AM31, AM31ଲ, and AM31γ with Streptoverticillium netropsis This disclosure describes a novel class of antibiotics, three of which have been designated AM31, AM31ଲ, and AM31γ and are produced in a microbiological fermentation under controlled conditions using a new strain of Streptoverticillium netro... | 12/20/1977 |
| 4064340 | Nogamycin and process of preparation Novel antibiotic, nogamycin (U-51,204) prepared chemically from nogalamycinic acid. Nogamycin is active against various microorganisms, for example, Mycobacterium avium, Bacillus subtilis, Lactobacillus casei, Staphylococcus aureus, and Sarcina lutea. Thu... | 12/20/1977 |
| 4064339 | Antibiotic aminoglycosides, processes of preparation and pharmaceutical compositions There are disclosed pharmaceutically-active aminoglycosides comprising 4-O-(2',6'-diamino 2',6'-didesoxy ,D-glucopyrannosyl) 6-O-(3"-amino 3",4",6"-tridesoxy , D-xylohexopyrannosyl) 2-desoxy streptamine of the formula: ##STR1## and... | 12/20/1977 |
| 4062947 | Di-N-alkylaminoglycosides, methods for their manufacture and novel intermediates useful therein, method for their use as antibacterial agents and pharmaceutical compositions useful therefor 1,2'-di-N-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and 1,6'-di-N-alkyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and their acid addition salts are valuable as antibacterial agents. Also disclosed are 2'-N-alkyl-4,6-di-O-(aminoglycosyl)-1,3-diamin... | 12/13/1977 |
| 4053591 | 5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, method for their use as antibacterial agents and compositions useful therefor 5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, useful antibacterial agents, are prepared by the reaction of the corresponding 5-O-thioformyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol having all amino functions and all primary and secondary hydr... | 10/11/1977 |
| 4048430 | Mercaptopseudotrisaccharides Novel pseudodisaccharide compounds which are related to neamine are prepared. These compounds have a mercapto group or a derivative thereof at position 3 or 4 of the glucose moiety of neamine. The compounds have antibacterial activity and have utility as ... | 09/13/1977 |
| 4044123 | 6'-N-alkyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods for their use as antibacterial agents and compositions useful therefor Described are 6'-N-alkyl derivatives of antibacterially active 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols having a primary carbinamine at C-5' of which a preferred group are 6'-N-alkyl derivatives having 2 to 4 carbon atoms of 4-O-aminoglycosyl-6-O-gar... | 08/23/1977 |
| 4029548 | Process for producing antibiotics U-50,147 and U-51,738 Microbiological process for preparing the known antibiotics, antibiotic A-396-1 also known as U-50,147 and L-dihydrophenylalanine also known as U-51,748, by use of the new microorganism Streptomyces lemensis, NRRL 8170 using controlled fermentation condit... | 06/14/1977 |
| 4029882 | Selective acylation of the C-1 amino group of aminoglycoside antibiotics A novel process for preparing novel 1-N-acyl-4,6-di-(aminoglycosyl)aminocyclitols is disclosed. The compounds are useful as antibacterial agents.... | 06/14/1977 |
| 4027016 | Everninomicin antibacterial derivatives, electrochemical method for their manufacture, method for their use as antibacterial agents, and pharmaceutical compositions useful therefor Everninomicin derivatives devoid of a nitro group and having antibacterial activity are prepared by electrochemically reducing the corresponding everninomicin having a nitro function or salts thereof in an aprotic anhydrous solvent in the absence of carbo... | 05/31/1977 |
| 4024251 | Antibiotic FR-02A and therapeutic compositions thereof This invention relates to a new antibiotic agent which also possesses growth promoting activity. The antibiotic is isolated from the fermentation broth of Streptomyces lactamdurans by solvent extraction and designated Efrotomycin.... | 05/17/1977 |
| 4020269 | Epiminodeaminodeoxyaminoglycoside antibiotics and intermediates Deoxyaminoglycoside antibiotics are prepared in a high yield from phosphorylated aminoglycosides by reacting a phosphorylated aminoglycoside (a) with a silylating agent, or (b) successively with (i) a silylating or acylating agent and (ii) a halogenating ... | 04/26/1977 |
| 4012576 | Antibiotic complex Bu 2183 A novel aminoglycoside antibiotic complex designated herein as Bu-2183 is produced by fermentation of Pseudomonas sp. strain D946-B83, A.T.C.C. 31086. Complex Bu-2183 is known to consist of at least five components, said components being herein designated... | 03/15/1977 |
| 4011391 | Validamycin C, D, E and F antibiotics Novel antibiotics, termed validamycins C, D, E and F, and acid salts thereof, are prepared by cultivating a validamycin-producing strain of microorganism of the genus Streptomyces, and optionally converting the free base to its acid salt.... | 03/08/1977 |
| 4009328 | Aminoglycoside 66-40C, method for its manufacture, method for its use as an intermediate in the preparation of known antibiotics and novel antibacterials Aminoglycoside 66-40C, a minor product produced by the fermentation of Micromonospora inyoensis, is separated from said fermentation mixture, and is used as an intermediate in preparing the known antibiotic, sisomicin, as well as 6' -N-alkylsisomicins hav... | 02/22/1977 |
| 4008218 | 1-N-((S)--substituted-ω-aminoacyl)-neamine or -ribostamycin and the production thereof An 1-N-((S)--substituted-ω-aminoacyl)-neamine or -ribostamycin of the formula: ##STR1## wherein R is a hydrogen atom or ଲ-D-ribofuranosyl group of the formula ##STR2## and R3 is hydroxyl, amino-NH2 or acy... | 02/15/1977 |
| 4008362 | 1-N-((S)--substituted-ω-aminoacyl)-neamine or -ribostamycin and the production thereof An 1-N-((S)--substituted-ω-aminoacyl)-neamine or -ribostamycin of the formula ##STR1## wherein R is a hydrogen atom or ଲ-D-ribofuranosyl group of the formula ##STR2## and R3 is hydroxyl, amino-NH2 or acyl... | 02/15/1977 |
| 4006225 | Method of using reduction products of everninomicins as antibacterial agents and pharmaceutical compositions useful therefor Everninomicin antibiotics having a nitro function, e.g. everninomicin B, everninomicin C, and everninomicin D, upon treatment with aluminum amalgam in aqueous alkanol are converted to a mixture of at least two reduction products having antibacterial activ... | 02/01/1977 |
| 4002742 | 1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor 1-N-Alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, valuable as antibacterial agents, are prepared by treating an acid addition salt of a 4,6-di-(aminoglycosyl)-1,3-diamonocyclitol antibacterial agent in an inert solvent, preferably a protic solvent co... | 01/11/1977 |
| 4001209 | Antibiotic G-52 and method for the production thereof A novel actinomycete herein designated Micromonospora zionensis elaborates a product having substantial antibacterial activity, said activity being due to sisomicin and the novel antibiotic substance coproduced therewith. The disclosure sets forth methods... | 01/04/1977 |
| 4001208 | 1-N-[(S)--hydroxy-ω-aminoacyl] A new and useful 1-N-[(S)--hydroxy-ω-aminoacyl]derivative of an aminoglycosidic antiobiotic, including its deoxy derivative, such as kanamycin B, 3'-deoxyneamine, 3',4'-dideoxyneamine, 3',4'-dideoxyribostamycin or 3', 4'-dideoxykanamycin B is now ... | 01/04/1977 |
| 4000262 | 5-Epi-amino and 5-epi-azido-4,6-di-O-(aminoglycosyl)-2,5-dideoxystreptamines 1-N-alkyl-5-epi-amino and 1-N-alkyl-5-epi-azido-4,6-di-O-(aminoglycosyl)-2,5-dideoxystreptamines 5-Epi-azido- and 5-epi-amino-4,6-di-O-(aminoglycosyl)-2,5-dideoxystreptamines and 1-N-alkyl derivatives thereof, valuable as antibacterial agents, are prepared from the corresponding 5-O-hydrocarbonsulfonyl (or substituted hydrocarbonsulfonyl)-4,6-di... | 12/28/1976 |
| 4000261 | 5-Epi-4,6-di-O-(aminoglycosyl)-2-deoxystreptamines, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor 5-Epi-4,6-di-O-(aminoglycosyl)-2-deoxystreptamines and 1-N-alkyl-5-epi-4,6-di-O-(aminoglycosyl)-2-deoxystreptamines, valuable as antibacterial agents, are prepared from the corresponding 5-O-hydrocarbonsulfonyl (or substituted hydrocarbonsulfonyl)-4,... | 12/28/1976 |
| 3998708 | Electrochemical process for preparing hydroxylaminoeverninomicins Hydroxylaminoeverninomicins having antibacterial activity are prepared by electrochemically reducing the corresponding everninomicin having a nitro function or the corresponding nitrosoeverninomicin in an aqueous miscible organic solvent under an inert at... | 12/21/1976 |
| 3997403 | Antibiotic G-418 and the production thereof A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods... | 12/14/1976 |
| 3997524 | Process for the manufacture of 6'-N-alkyl derivatives of sisomicin and verdamicin; novel intermediates useful therein, and novel 6'-N-alkylverdamicins prepared thereby 1,3,2',3"-tetra-N-acyl-5'-deaminomethyl-5'-formylsisomicin and 1,3,2',3"-tetra-N-acyl-5'-de--aminoethyl-5'-acetylverdamicin are prepared from the 1,3,2',3"-tetra-N-acyl-6'-N-(2,4-dinitrophenyl) derivatives of sisomicin and verdamicin, respectively,... | 12/14/1976 |
| 3996205 | Aminoglycoside antibiotics and intermediates 6-0- AND 3'-0-D-glycosyl analogs of neamine, 6-0- and 3'-0-D-glycosyl ortho esters of neamine, novel aminoglycoside antibiotics, and novel intermediates are prepared by a new chemical process. The compounds have utility as antibacterial agents or as inter... | 12/07/1976 |
| 3988316 | Antibiotics sisomicin and verdamicin I and complex containing same A novel composition having antibiotic activity is produced by fermentation of the new species of microorganism, Micromonospora grisea. The antibiotic complex is composed of four components, Verdamicin I, sisomicin, Antibiotic G-418, and gentamicin A, of w... | 10/26/1976 |
