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| Number | Title | Issue Date |
| 7211240 | Multivalent constructs for therapeutic and diagnostic applications The invention provides compositions and methods for therapeutic and diagnostic applications. ... | 05/01/2007 |
| 7179450 | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane o... | 02/20/2007 |
| 7147838 | Gastrin receptor-avid peptide conjugates A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a n... | 12/12/2006 |
| 7090828 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. Th... | 08/15/2006 |
| 7048907 | Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products Stable isotope labeling and neutron activation to measure biological functions are provided, as are the use and method of adding a chemical monitor to correct for neutron flux to sample vials prior to the addition of sample is presented, and the use of stable isotop... | 05/23/2006 |
| 6995247 | Ac-HEHA and related compounds, methods of synthesis and methods of use The present invention provides an α-particle-emitting radioisotope chelation complex comprising 225Actinium (225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N′,N′,N′,N′-hexaacetic acid (HEHA) (225Ac-HEHA). Also provi... | 02/07/2006 |
| 6808699 | Methods for imaging pulmonary and cardiac vasculature and evaluating blood flow using dissolved polarized 129Xe MR spectroscopy and imaging methods for imaging pulmonary and cardiac vasculature and the cardiac region and evaluating blood flow or circulatory deficits use dissolved phase polarized 129Xe gas and large flip angle excitation pulses. Pulmonary and cardia... | 10/26/2004 |
| 6696551 | 225Ac-HEHA and related compounds, methods of synthesis and methods of use The present invention provides an -particle-emitting radioisotope chelation complex comprising 225 Actinium (225 Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N',N",N'",N"",N'""-hexaacetic acid (HEHA) (225 Ac-HEHA... | 02/24/2004 |
| 6607709 | Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melonoma A compound for use as a diagnostic or therapeutic pharmaceutical and method of using the same where the compound consists essentially of an alpha-melanotropin stimulating hormone analog which has integrally located a radionuclide. The radionuclide is admi... | 08/19/2003 |
| 6495118 | Lipophilic metal complexes for necrosis and infarction imaging This invention describes the use of metal complexes that have a plasma protein bond of at least 10% as imaging diagnostic agents for locating an infarction or a necrosis using lasting positive visualization.... | 12/17/2002 |
| 6491895 | Methods for imaging pulmonary and cardiac vasculature and evaluating blood flow using dissolved polarized 129Xe MR spectroscopy and imaging methods for imaging pulmonary and cardiac vasculature and the cardiac region and evaluating blood flow or circulatory deficits use dissolved phase polarized 129 Xe gas and large flip angle excitation pulses. Pulmonar... | 12/10/2002 |
| 6488910 | Methods for dissolving hyperpolarized 129 Xe gas using microbubbles Methods for increasing the T1 of injectable microbubble formulations of hyperpolarized 3 He include the step of introducing the hyperpolarized 3 He to a quantity of microbubbles held in a chamber and increasing the pressur... | 12/03/2002 |
| 6461587 | Perfluoroalkylamides, their production and their use in diagnosis The invention relates to macrocyclic perfluoroalkylamides, their production and their use in diagnosis.... | 10/08/2002 |
| 6359120 | Rhenium and technetium complexes containing a hypoxia-localizing moiety Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined ... | 03/19/2002 |
| 6338834 | Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma A compound for use as a diagnostic or therapeutic pharmaceutical and method of using the same where the compound consists essentially of an alpha-melanotropin stimulating hormone analog which has integrally located a radionuclide. The radionuclide is admi... | 01/15/2002 |
| 6299859 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuab... | 10/09/2001 |
| 6284222 | Hyperpolarized helium-3 microbubble gas entrapment methods Methods for increasing the T1 of injectable microbubble formulations of hyperpolarized 3 He include the step of introducing the hyperpolarized 3 He to a quantity of microbubbles held in a chamber and increasing the pressur... | 09/04/2001 |
| 6241966 | Magnetic resonance imaging using Hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 06/05/2001 |
| 6183722 | Somatostatin analogs This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to cyclic p... | 02/06/2001 |
| 6123919 | Magnetic resonance imaging using hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 09/26/2000 |
| 6017511 | Glycopeptide-chelator conjugates A peptide-chelator conjugate that is useful for imaging sites of inflammation in humans comprises a metal chelator coupled to a glycopeptide antibiotic. The metal chelator and the glycopeptide are coupled by a linking group. The linking group may be the d... | 01/25/2000 |
| 5785953 | Magnetic resonance imaging using hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 07/28/1998 |
| 5545396 | Magnetic resonance imaging using hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 08/13/1996 |
| 3959455 | Labeling of indocyanine green with carrier-free iodine-123 The method of labeling indocyanine green (ICG) with carrier-free iodine-123 comprising the steps of condensing xenon-123 on crystals of ICG followed by permitting decay of the 123 Xe a sufficient length of time to produce 123 I-elect... | 05/25/1976 |
