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| Number | Title | Issue Date |
| 7425339 | CD8alpha mutants The present invention provides modified CD8 molecules whose binding to MHC is enhanced compared to wild-type CD8, wherein Ser53 of at least one CD8α chain thereof is mutated to another amino acid. It also provides nucleic acids encoding such molecules an... | 09/16/2008 |
| 7399471 | Polypeptides capable of forming antigen binding structures with specificity for the Rhesus D antigens, the DNA encoding them and the process for their preparation and use Polypeptides capable of forming antigen binding structures specific for Rhesus D antigens include the sequences indicated in the FIGS. 1a to 16b. The obtained polypeptides, being Fab fragments, MAY be used directly as an active ingredient... | 07/15/2008 |
| 7393529 | Methods and compositions for inhibiting binding of IgE to a high affinity receptor The invention provides methods and compositions for inhibiting binding of IgE to a high affinity receptor. The methods and compositions are useful in the treatment of allergic diseases and allergy symptoms in mammals. ... | 07/01/2008 |
| 7368542 | Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can... | 05/06/2008 |
| 7326769 | Method for isolating and purifying grass pollen allergens The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chroma... | 02/05/2008 |
| 7320873 | Use of antibodies against specific MHC-peptide complexes The invention describes a method to diagnose the autoimmune disease activity by detecting the presence of an autoimmune specific MHC-peptide complex in a patient suffering from an autoimmune disease. The MHC-peptide complex is associated with rheumatoid arthritis. M... | 01/22/2008 |
| 7279158 | Methods for the treatment of inflammatory joint disease The use of compounds that block complement component C5 or its active fragments C5a and/or C5b (such compounds collectively referred to as “C5 blockers”) to treat established joint inflammation (arthritis) is disclosed. Administration of such C5 bl... | 10/09/2007 |
| 7252826 | Modified mite allergen and pharmaceutical uses thereof The present invention provides a modified Dermatophagoides pteronyssinus allergen Der p 5 protein which has ability to inhibit IgE binding when exposed against to the antigen. A method for treating allergy comprising administrating a therapeutically effective... | 08/07/2007 |
| 7244431 | Allergy vaccines and their preparation The present invention relates to a pharmaceutical composition containing a peptide and a pharmaceutically acceptable carrier or diluent wherein the peptide has a length of 8 to 50 amino acids, at least three preferably consecutive amino acids of the peptide are iden... | 07/17/2007 |
| 7226996 | Equine Fc epsilon receptor alpha protein The present invention relates to equine Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and inhibitors of such proteins. The present invention also includes methods to ... | 06/05/2007 |
| 7211408 | Recombitope peptides The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes derived from the same or from different protein antigens, and more preferab... | 05/01/2007 |
| 7204981 | Methods of treating diseases with activated protein C Method of treating a disease or pathological condition with activated protein C or a compound having activated protein C activity by direct regulation of the expression of specific genes associated with the disease or pathological condition. ... | 04/17/2007 |
| 7173108 | Peptide epitopes recognized by disease promoting CD4+ T lymphocytes The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includ... | 02/06/2007 |
| 7166693 | Ectoparasite saliva proteins The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention includes a saliva protein collection appa... | 01/23/2007 |
| 7112333 | T cell epitopes of ryegrass pollen allergen The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne. Therapeutic peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a p... | 09/26/2006 |
| 7108858 | Non-anaphylactic forms of allergens and their use The present invention is drawn to an immunogen derived from a protein allergen, which is a) a non-anaphylactic immunogenic recombinant fragment of the protein allergen which contains an IgG epitope partly but not wholly overlapping an IgE epitope of the protein alle... | 09/19/2006 |
| 7074904 | MHC complexes and uses thereof The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In particular, the invention relates to MHC fusion complexes that contain a MHC molecule with a peptide-binding groove and a presenting pep... | 07/11/2006 |
| 7060274 | Receptor specific transepithelial transport of therapeutics The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to metho... | 06/13/2006 |
| 7041289 | Method for treating established spontaneous auto-immune diseases in mammals A method of treating spontaneous and ongoing auto-immune diseases in mammals, comprising administering to a mammal, in need of such a treatment, a therapeutically effective amount of one or more non mitogenic anti-CD3 active principles to achieve permanent disease r... | 05/09/2006 |
| 7029686 | Variants of Phleum pratense allergenic proteins Hypoallergenic variants of the major allergen Ph1 p 1 of Phleum pratense plants and their use in the therapy of the allergic diseases is disclosed. ... | 04/18/2006 |
| 7011834 | Immunomodulating dimers Peptide-like compounds and their variants having immunomodulating activity including the N-terminal acylated and/or C-terminal amidated or esterified forms thereof of up to 60 amino acids wherein the peptide-type compound comprises the formula: α−β | 03/14/2006 |
| 6967108 | Human monoclonal antibodies to the islet cell antigen IA-2 The invention concerns human monoclonal antibodies to the islet cell antigen IA-2, a process for their production, the use of human monoclonal antibodies in a method for detecting antibodies to IA-2, a method for detecting antibodies to the islet cell antigen IA-2 a... | 11/22/2005 |
| 6932969 | Ig fractions having immunomodulatory activity The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The in... | 08/23/2005 |
| 6866846 | Patient-specific immunoadsorbers for the extracorporeal apheresis and methods for their preparation A process for preparing a patient-specific immunoadsorber, which comprises (i) extracting a body fluid from a patient having an immunopathological condition, the fluid containing immune complexes that are relevant to that immunopathological condition, (ii) contactin... | 03/15/2005 |
| 6818622 | Selective MMP inhibitors having reduced side-effects The subject invention pertains to matrix metalloproteinase (MMP) inhibitors that exhibit an IC50 of below 10−4M against MMP and have substantially no activity against non-MMP metalloproteinase-related events. The MMP inhibitors of the inventi... | 11/16/2004 |
| 6800290 | Variants of allergenic proteins of the group 2 of dermatophagoides Variants of allergens of Dermatophagoides pteronyssinus species with reduced allergenic activity. ... | 10/05/2004 |
| 6759517 | Allergenic proteins of natural rubber latex, their production and use in assays This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative dete... | 07/06/2004 |
| 6649165 | Method of blocking cytotoxic activity in patients with amyotrophic lateral sclerosis using soluble FcγRIII receptors The present invention is directed to a method of blocking the cytotoxic activity of FcγRIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis using an effective amount of soluble FcγRIII receptors. The soluble FcγRIII recep... | 11/18/2003 |
| 6627194 | Activated immunoglobulin Activated immunoglobulin which is useful as an eosinophilia-suppressing agent, immunomodulating agent, therapeutic agent for autoimmune diseases, anfiinflammatory agent and antiallergic agent is obtained by admixing immunoglobulin with a histamine compone... | 09/30/2003 |
| 6596687 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 07/22/2003 |
| 6579688 | Stabilizing diluent for polypeptides and antigens Compositions for stabilizing polypeptides or antigens are described. These compositions are useful for stabilizing polypeptides or antigens stored in aqueous formulations. Such formulations can be used for various analytical or other methods.... | 06/17/2003 |
| 6566082 | T-cell antigens, and their use in diagnosis and treatment of T-cell mediated conditions The OX-40 antigen is characterized and claimed together with variants and derivatives thereof. Also described are binding agents for the antigen and the use of these in diagnosis and therapy. Examples of such use include a method for the selective depleti... | 05/20/2003 |
| 6566386 | Immunomodulating and antiinflammatory agent In the present invention, pharmaceutical compositions containing a histamine-added gamma-globulin as an effective component are used as an immunomodulating agent, a suppressive agent for eosinophilia, and as an antiinflammatory agent. The immunomodulating... | 05/20/2003 |
| 6558961 | Immunodiagnostics using particle delivery methods Methods for assessing immunocompetence, cellular or humoral immunity, antigen exposure, or allergic conditions in an individual by accelerating diagnostic particles into a target skin site in the individual are provided.... | 05/06/2003 |
| 6551593 | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through 4 ଲ 7 and its ligands and madcam The invention relates to the treatment of individuals suffering from a disease associated with leukocyte recruitment to the gastrointestinal tract or other tissues as a result of binding of leukocytes to gut-associated endothelium expressing the molecule ... | 04/22/2003 |
| 6531133 | Pseudomonas exotoxin-myelin basic protein chimeric proteins A chimeric protein comprising a Pseudomonas aeruginosa exotoxin (PE) moiety linked to a myelin basic protein (MBP) moiety is disclosed. The MBP moiety is selected from the group comprising: (a) MBP; (b) amino acids 69-88 of guinea-pig myelin basic protein... | 03/11/2003 |
| 6509165 | Detection methods for type I diabetes Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived from a region of proinsulin that spans the junction between... | 01/21/2003 |
| 6468532 | Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates Provided are methods for treating inflammatory diseases in a patient comprising administering to the patient an effective amount of a conjugate consisting essentially of one or more antibody fragments covalently attached to one or more nonproteinaceous po... | 10/22/2002 |
| 6423512 | Fusion polypeptides Fusion polypeptides and salts thereof comprising at least one IgE-binding domain fused to at least one human serum albumin component, optionally via a peptide linker, and in particular, dimeric fusion polypeptides comprising HSA protein fused, at each of ... | 07/23/2002 |
| 6413738 | House dust mite allergen, Der f VII, and uses therefor Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular wei... | 07/02/2002 |
