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| Number | Title | Issue Date |
| 7414111 | Engineered templates and their use in single primer amplification Methods of amplifying nucleic acid have now been discovered which include the steps of: a) annealing a primer to a template nucleic acid sequence, the primer having a first portion which anneals to the template and a second portion of predetermined sequence; b) synt... | 08/19/2008 |
| 7311912 | Epithelial tissue targeting agent Targeting molecules for use in delivering biological agents to epithelial tissue are disclosed. Upon delivery, the biological agent(s) may remain within an epithelial cell or may undergo transepithelial transport via transcytosis. The targeting molecules may be used... | 12/25/2007 |
| 6967108 | Human monoclonal antibodies to the islet cell antigen IA-2 The invention concerns human monoclonal antibodies to the islet cell antigen IA-2, a process for their production, the use of human monoclonal antibodies in a method for detecting antibodies to IA-2, a method for detecting antibodies to the islet cell antigen IA-2 a... | 11/22/2005 |
| 6949627 | Plasmodium falciparum antigens inducing protective antibodies The present invention relates, in part, to a purified polyclonal or monoclonal antibody which recognizes an epitope of a protein of 48,000 dalton, where the protein recognizes is a surface protein of a merozoite of Plasmodium falciparum which has a peptide of... | 09/27/2005 |
| 6767711 | Treatment and diagnosis of prostate cancer The present invention is directed to the use of antibodies or binding portions thereof or probes which recognize an antigen of normal, benign, hyperplastic, and cancerous prostate epithelial cells or portions thereof. These antibodies or binding portions thereof or ... | 07/27/2004 |
| 6764827 | Anti-human medullasin monoclonal antibody process for producing the same and immunoassay using the same A monoclonal antibody by which medullasin that is a kind of serine proteases existing in granulocytes, production process thereof and an immunoassay of human medullasin using the antibody are disclosed. The monoclonal antibody specifically recognizes human medullasi... | 07/20/2004 |
| 6680376 | Process for selectively isolating avian immunoglobulins This invention relates to a method for selectively isolating IgY(ƊFc) avian antibodies from IgY avian antibodies. For example, the method includes: (a) providing an aqueous fraction from yolk of an egg of an anseriform bird; (b) precipitation IgY antibod... | 01/20/2004 |
| 6646108 | Process for isolating IgG and IgA A method for the separation of IgG and IgA from an immunoglobulin-containing starting material is described, whereby the method is characterized in that (i) IgG and optionally IgA are adsorbed to a solid inorganic carrier material, (ii) IgA is isolated fr... | 11/11/2003 |
| 6608172 | Isolation of IgY (ƊFc) antibodies The present invention relates to a method for the preparation and purification of IgY(ƊFc) antibody from avian yolk, generally comprising the steps of immunization of a fowl hen with an antigen, a partial purification of the whole antibodies from the egg... | 08/19/2003 |
| 6395273 | Prevention and treatment of inflammatory bowel disease Methods are described for treating inflammatory bowel disease in animals, including humans. Specific avian polyclonal antibodies directed to TNF are shown to have a beneficial effect in animal models predictive of human therapy for the treatment of coliti... | 05/28/2002 |
| 6346247 | Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies The prevention and treatment of autoimmune disease in humans (as well as other animals) is described through the use of ligands directed to cytokines. Antibodies and receptors to the proinflammatory cytokines IL-2, TNF, IL-12 and IFN-gamma are employed (a... | 02/12/2002 |
| 6251392 | Epithelial cell targeting agent Targeting molecules for use in delivering biological agents to non-polarized epithelial cells are disclosed. Upon delivery, the biological agent(s) are lethal to the epithelial cell. The targeting molecules may be used, for example, for the eradication of... | 06/26/2001 |
| 6093400 | Modified HGP-30 peptides, conjugates, compositions and methods of use An antigenic peptide fragment from the p17 gag protein of HIV includes a portion from HGP-30 and a contiguous portion from HGP-35 such that the peptide fragment is capable of inducing a TH1 immune response when administered to a person suffering from AIDS... | 07/25/2000 |
| 5977318 | CTLA4 receptor and uses thereof The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybri... | 11/02/1999 |
| 5965713 | Dye labeled protein conjugate its preparing method and sensor using the same It is intended to present a sensor capable of labeling with more dyes, applying the labeled protein in immunochromatography making use of antigen-antibody reaction, and having an excellent sensitivity. In a buffer, a protein and a first covalent bonding c... | 10/12/1999 |
| 5965378 | Antibody class-specific interference eliminating reagent The invention concerns a composition composed of several different antibodies or/and antibody fragments which is suitable as a reagent to reduce interferences in an immunological method for the class-specific detection of antibodies from one or several of... | 10/12/1999 |
| 5895811 | Artificial positive controls derived from bifunctional conjugates The invention relates to an artificial positive control reagents based on antibody conjugates that are used in immunochemical detection methods and to processes for the preparation of these reagents.... | 04/20/1999 |
| 5833984 | Composition and method for preventing and treating inflammation with Immunoglobulin A Inflammation can be treated or prevented altogether by administering a preparation comprising IgA. These preparations also can effect immunomodulation. Preferably, the preparation includes multimeric IgA and is essentially free of IgG in its various forms... | 11/10/1998 |
| 5672688 | Immunoglobulin Fc fragment bound to an alkylating, antibiotic, or antimetabolic antitum or substance A composition comprising as an active ingredient a compound consisting of an immunoglobulin Fc fragment and an alkylating, antibiotic, or antimetabolic antitumor substance bound thereto, and a pharmaceutically acceptable carrier is disclosed. T... | 09/30/1997 |
| 5670623 | Methods of use of cellulose binding domain proteins A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewis... | 09/23/1997 |
| 5585098 | Oral administration of chicken yolk immunoglobulins to lower somatic cell count in the milk of lactating ruminants A method for lowering somatic cell count in the milk of a lactating ruminant is disclosed. IgY antibodies are first obtained from the egg of a hen which has been actively immunized against one or more mastitis-causing pathogenic organisms by injection wit... | 12/17/1996 |
| 5548066 | Failure of passive transfer immune serum and method of making same An immunological serum and method of making same. The serum essentially consists of purified and concentrated materials, sometimes known as transfer factor, and immunoglobulins, expressed from the clotted blood of a donor group having known immunity. To p... | 08/20/1996 |
| 5496802 | Control of milk secretion A protein which inhibits milk secretion by lactating cows and which is present in the eighth (6B, Figure) significant peak when a nominally 10-30 KDa fraction of the whey proteins of the milk is resolved on a "Mono Q" anion exchange column using 10 mM imi... | 03/05/1996 |
| 5491218 | Artificial positive controls derived from bifunctional conjugates The invention relates to artificial positive control reagents based on antibody conjugates that are used in immunochemical detection methods and to processes for the preparation of these reagents.... | 02/13/1996 |
| 5420253 | Method for purifying egg yolk immunoglobulins The present invention provides a method for purifying high yields of IgG immunoglobulins from an egg yolk by a single phase separation step using a nonionic detergent.... | 05/30/1995 |
| 5371196 | Process for producing secretory immunoglobulin A preparations Secretory immunoglobulin A preparations substantially not containing virus are produced by a process wherein secretory immunoglobulin A which might be contaminated with viruses is (1) heated about 60° C. for about 10 hours, or (2) subjected to the reacti... | 12/06/1994 |
| 5359038 | Method for isolating immunoglobulin compounds in the feces A method for isolating the immunoglobulin compounds in the feces of animals and humans including the steps of placing said feces in a container with a buffer solution, homogenizing the feces in a phosphate buffer saline solution thereby forming a homogeni... | 10/25/1994 |
| 5340923 | Methods for making and purifying antivenoms Antivenoms suitable for treatment of humans and animals as well as for analytical use. A method wherein individual venoms are used to immunize and the resulting antivenoms are, thereafter, purified individually prior to mixing. Immunization is performed i... | 08/23/1994 |
| 5310875 | Peptides corresponding to membrane-bound IgA The invention relates to a method of stimulating IgA production through administering a peptide which has the sequence of epitopes which are present on B cell-bound but not secreted IgA. This induces production of the antibody itself. These extracellular ... | 05/10/1994 |
| 5308614 | Methods for the production of antibodies and induction of immune responses to tumor-associated gangliosides by immunization with ganglioside lactones The present invention relates to an improved method for the production of antibodies to tumor-associated gangliosides using ganglioside lactones. The resulting antibodies are useful in the detection and treatment of tumors containing gangliosides. The pre... | 05/03/1994 |
| 5258177 | IgA preparation and process of making the same A method of preparing an IgA rich preparation comprising exposing a plasma fraction to an amino acid, organic salt or inorganic salt with optional chromatographic treatment yielding a product suitable for use in medical conditions treatable with IgA.... | 11/02/1993 |
| 5202422 | Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use The present invention contemplates glycopolypeptide multimers having a polypeptide that contain an immunoglobulin amino acid residue sequence and an oligosaccharide that comprises a core pentasaccharide and N-acetylglucosamine-containing outer branches, s... | 04/13/1993 |
| 5198342 | DNA encoding IgA Fc receptors The present invention provides an isolated DNA sequence encoding soluble and membrane bound forms of a mammalian IgA Fc receptor, as well as recombinant expression vectors and host cells suitable for expressing the protein.... | 03/30/1993 |
| 5179197 | Secretory component-containing composition A secretory component-containing composition which is obtainable by contacting a milk or a whey with a cation exchange resin to allow the resin to absorb a secretory component contained in the milk or the whey and then eluting the secretory component and ... | 01/12/1993 |
| 5171667 | Hybridomas producing monoclonal antibodies to mono-, di- and trifucosylated type 2 chain Hybridoma cell lines that produce monoclonal antibodies that differentially recognize glycolipids with mono-, di-, and trifucosylated type 2 chain structures are disclosed. The monoclonal antibodies can be used to detect specific types of tumor cells that... | 12/15/1992 |
| 5171666 | Monoclonal antibodies reactive with a cell-surface gylcoprotein expressed on human carcinomas The present invention relates to a novel tumor-associated antigen that is a cell-surface glycoprotein having a molecular weight in the range of 110,000-140,000 daltons that is present in a variety of carcinomas, including squamous cell carcinomas and aden... | 12/15/1992 |
| 5153118 | Monoclonal antibodies having binding specificity to human prostate tumor-associated antigens and methods for employing the same Monoclonal antibodies having binding specificity to human prostate tumor-associated antigens but not to prostate-specific antigen (PSA) or prostatic acid phosphatase (PAP); and methods of diagnosis and treatment employing the same.... | 10/06/1992 |
| 5151266 | Use of anionic detergents with conjugates of monoclonal or polyclonal antibodies Methods are disclosed for increasing the solubility of antibodies and their radioisotope, toxin, or drug immunoconjugates and for reducing the non-specific uptake of antibody, either conjugated or unconjugated, into the RES organs such as via Fc receptor-... | 09/29/1992 |
| 5128451 | Protein V:AIgG binding factor A novel bacterial proteinaceous immunoglobulin G receptor is disclosed. The proteinaceous factor binds all four subclasses of human IgG, as well as rabbit, swine, equine, bovine, sheep, and goat IgG. The proteinaceous factor is obtained from biologically ... | 07/07/1992 |
| 5093261 | Cancer-related antigen-specific human immunoglobulins and human/human hybridomas having the ability to produce said human immunoglobulins A new human/human fused cell clone derived from human B cells having the ability to produce immunoglobulins and human B cells substantially lacking the ability to produce immunoglobulins, antigen-specific human immunoglobulins produced by the human/human ... | 03/03/1992 |
