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| Number | Title | Issue Date |
| 7129337 | Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents The present invention relates to new genomic nucleotide sequences and amino acid sequences corresponding to the coding region of these genomes. The invention relates to new HCV types and subtypes sequences which are different from the known HCV types and subtypes se... | 10/31/2006 |
| 5260278 | Diol-containing renin inhibitors The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the pe... | 11/09/1993 |
| 4985407 | Dipeptide compounds, processes for their preparation and compositions containing them There are described new compounds of formula (1) ##STR1## wherein R1 represents an acyl group; X1 represents phenylalanine or p-methoxyphenylalanine bonded N-terminally to R1 and C-terminally to X2 ; X2 | 01/15/1991 |
| 4983743 | 5-alkyl tetramic acids A process for the production of 5-alkyl tetramic acids from 4-alkoxy-3-pyrrolin-2-ones and aldehydes or ketones. By basic catalysis, 5-alkylidene-4-alkoxy-3-pyrrolin-2-ones are first formed, which are converted into the target compounds by cleavage of the... | 01/08/1991 |
| 4981843 | N-heterocyclic alcohol derivatives Compounds of the formula ##STR1## wherein R1 is an N-heterocyclic group as defined herein and Y can be --NH--, --O-- or --CH2 --, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agen... | 01/01/1991 |
| 4980283 | Renin-inhibitory pepstatin phenyl derivatives A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and c... | 12/25/1990 |
| 4978759 | Process for the stereospecific synthesis of optically pure 4-amino-3-hydroxycarboxylic acid derivatives The process described makes it possible to obtain optically pure 4-amino-3-hydroxycarboxylic acids by means of a series of stereoselective steps. The starting material is an alpha-amino acid in the L or D configuration, with which Meldrum's acid is reacte... | 12/18/1990 |
| 4977277 | Functionalized peptidyl aminodiols and -triols 4-amino-5-cyclohexyl-3-hydroxy-1,2-oxopentane and derivatives thereof The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is hydrogen; loweralkyl; arylalkyl; OR8 or SR8 wherein R8 is hydrogen, loweralkyl or aminoalkyl; NR9 R10 wherein ... | 12/11/1990 |
| 4977141 | Peptidyl -aminoacyl aminodiol carbamates as anti-hypertensive agents Non-peptidyl compounds characterized generally as aminoacyl aminodiol carbamates are useful as renin inhibitors for the treatment of hypertension.... | 12/11/1990 |
| 4965372 | Process and intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates Process and intermediates for isopropyl 3S-amino-4-cyclohexyl-2R-hydroxybutyrate and 3S-amino-2R-hydroxy-5-methylhexanoate from R-malic acid. These products are of known utility in the synthesis of certain renin inhibitors.... | 10/23/1990 |
| 4963530 | Renin inhibitor peptide compounds, a process for the preparation thereof and pharmaceutical composition comprising the same A compound of the formula: ##STR1## wherein R1 is aryl optionally substituted with a substituent selected from the group consisting of halogen and halo(lower)alkyl; lower alkyl or cyclo(lower)alkyl; and R2 is hydrogen or lower a... | 10/16/1990 |
| 4948913 | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these c... | 08/14/1990 |
| 4935405 | Nor-statine and nor-cyclostatine polypeptides Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.... | 06/19/1990 |
| 4931429 | -aminoacyl ଲ-aminoacyl aminodiols as anti-hypertensive agents Compounds characterized generally as -aminoacyl ଲ-aminoactyl aminodiols are useful as renin inhibitors for the treatment of hypertension.... | 06/05/1990 |
| 4931591 | Novel 5-amino-4-hydroxyvaleryl derivatives Compounds of the formula ##STR1## in which R1 represents hydrogen or acyl, A represents an optionally N-alkylated -amino acid residue which is bonded N-terminally to R1 and C-terminally to the group --NR2 --, R... | 06/05/1990 |
| 4927565 | 5-substituted amino-4-hydroxy-pentenoic acid derivatives and their use A 5-substituted amino-4-hydroxy-pentenoic acid or its salt represented by the formula: ##STR1## wherein each of R1 and R2 which may be the same or different is a hydrogen atom, a lower alkyl group, an aralkyl group, a lower ... | 05/22/1990 |
| 4927807 | Glaucoma treatment A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH and U is CH | 05/22/1990 |
| 4923864 | Certain heterocyclic-hexanamides useful for treating hypertension Simple amides and derivatives thereof useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.... | 05/08/1990 |
| 4921855 | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same A compound of the formula: ##STR1## wherein R1 is lower alkyl optionally substituted with a substituent selected from the group consisting of acyl, hydroxy, lower alkoxy, aryl, lower alkylthio and a group of the formula: ##STR2## ... | 05/01/1990 |
| 4914129 | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups Compounds of the formula ##STR1## in which R1 represents acyl substituted by a thio, sulphinyl or sulphonyl group, A represents an optionally N-alkylated -amino acid residue that is bonded N-terminally to R1 and C-termina... | 04/03/1990 |
| 4906613 | Antiglaucoma compositions and methods The present invention relates to ophthalmological pharmaceutical compositions comprising a renin inhibitor and to methods for using said composition in the treatment of glaucoma.... | 03/06/1990 |
| 4904660 | Histidine derivatives as superior renin inhibitors Novel compounds of the following formula (I) and their salts: A compound of the formula (I) ##STR1## These compounds are expected to be useful for renin inhibitors. Thus, the compounds are useful medical agents, in particular, anti-hypertensive ... | 02/27/1990 |
| 4902706 | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as antihypertensive agents Non-peptidyl compounds characterized generally as aminoalkylaminocarbonyl aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension.... | 02/20/1990 |
| 4900745 | Poly(aminoalkyl)aminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents Non-peptidyl compounds characterized generally as poly(aminoalkyl)aminocarbonyl aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension.... | 02/13/1990 |
| 4900746 | Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents Non-peptidyl compounds characterized generally as ethereal N-terminal aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension.... | 02/13/1990 |
| 4898977 | Processes for the preparation of 5-amino-4-hydroxyvaleric acid derivatives The invention relates to novel processes and intermediates for the preparation of 5-amino-4-hydroxyvaleric acid derivatives of the formula ##STR1## in which R1 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower... | 02/06/1990 |
| 4895834 | Renin inhibitors III The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension, hyperaldosternoism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using t... | 01/23/1990 |
| 4894437 | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties The present invention provides novel renin-inhibiting peptides of the formula X-A6 -B5 -C8 -D9 -E10 -F11 -G12 -H13 -I14 -Z, wherein X and Z are terminal groups, ... | 01/16/1990 |
| 4889869 | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups Compounds of the formula ##STR1## in which R1 represents acyl substituted by a thio, sulphinyl or sulphonyl group, A represents an optionally N-alkylated -amino acid residue that is bonded N-terminally to R1 and C-termina... | 12/26/1989 |
| 4885292 | N-heterocyclic alcohol renin inhibitors Compounds of the formula ##STR1## are disclosed wherein R1 is N-heterocyclic moiety. These compounds intervene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.... | 12/05/1989 |
| 4882420 | Dihalo-statine substituted renin inhibitors The present invention provides novel renin inhibitory peptides of the formula X--A--B--C--D--E--F--G--H--Z wherein E--F is a dihalo-substituted statine group, X and Z are terminal groups, and the remaining variables are absent or amino acid residues. Thes... | 11/21/1989 |
| 4880781 | Renin inhibitory peptides containing an N-alkyl-histidine moiety The present invention provides novel renin-inhibiting peptides and novel processes and intermediates for the preparation of both novel and known renin-inhibiting peptide analogs. Such inhibitors are useful for the diagnosis and control of renin-dependent ... | 11/14/1989 |
| 4877785 | Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents Non-peptidyl compounds characterized generally as ଲ-succinamidoacyl aminodios are useful as renin inhibitors for the treatment of hypertension.... | 10/31/1989 |
| 4876343 | Process for statine and statine analogs An improved process for the preparation of statine, the phenyl analog of statine, the cyclohexyl analog of statine and derivatives thereof is described, as well as other valuable intermediates used in the process.... | 10/24/1989 |
| 4874745 | Renin-inhibitory pepstatin phenyl derivatives A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and c... | 10/17/1989 |
| 4870183 | Novel amino acid derivatives Novel amino acid derivatives useful as a therapeutic agent are disclosed. These amino acid derivatives and the pharmaceutically acceptable salts thereof have a human renin inhibitory effect when administered orally and are useful for treatment of hyperten... | 09/26/1989 |
| 4863903 | Substituted 5-amino-4-hydroxyvaleryl derivatives Compounds of the formula ##STR1## in which R1 represents hydrogen or acyl, X1 represents an optionally N-alkylated amino acid residue that is bonded N-terminally to R1 and C-terminally to X2, X2 ... | 09/05/1989 |
| 4863905 | Renin inhibitors II The invention concerns novel renin-inhibiting peptides which are modified as isosteres. These peptides are useful for treating renin-associated hypertension and hyperaldosteronism. Processes for preparing the peptides, compositions containing them and met... | 09/05/1989 |
| 4864017 | Novel renin inhibiting peptides having a dihyroxyethylene isostere transition state insert The present invention provides novel renin-inhibiting peptides of the formula X-A6 -B7 -C8 -D9 -E10 -F11 -G12 -H13 - I14 -Z, wherein the E10 -F11... | 09/05/1989 |
| 4863904 | Dipeptides as renin inhibitors Dipeptides are described which are represented by the formula ##STR1## wherein the various substituents are defined hereinbelow. These compounds have a strong inhibitory efect on human renin, and are useful as a therapeutically active agent for the t... | 09/05/1989 |
