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| Number | Title | Issue Date |
| 7317086 | Basal cell carcinoma tumor suppressor protein This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene. ... | 01/08/2008 |
| 7001987 | Hydrogel with controllable mechanical, chemical, and biological properties and method for making same Networks, hydrogels, and methods for networks and hydrogels comprising proteinaceous material consisting essentially of water soluble proteins and covalent interprotein crosslinks other than disulfide crosslinks. ... | 02/21/2006 |
| 6989437 | Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks Methods for producing biocompatible heterogeneous proteinaceous networks crosslinked with a heterogeneous crosslinking agent, and novel heterogeneous crosslinked networks. Preferred heterogeneous crosslinking agents are silicone-based. ... | 01/24/2006 |
| 6914126 | Methods for producing, films comprising, and methods for using heterogenous crosslinked protein networks Methods for producing biocompatible heterogeneous proteinaceous networks crosslinked with a heterogeneous crosslinking agent, and the novel crosslinked networks. ... | 07/05/2005 |
| 6841644 | Biopolymers obtained by solid state irradiation in an unsaturated gaseous atmosphere Disclosed are modified naturally occurring biocompatible biopolymers of plant and animal origin made by subjecting same to ionizing radiation in the presence of a mediating gas, typically acetylene to enable one to selectively enhance and modify one or more of the p... | 01/11/2005 |
| 6649740 | Hydratable form of keratin for use as a soil amendment A hydratable oxidized keratin composition comprising one or more metal ion species capable of absorbing water to form a hydrogel. The keratin material is useful as a soil amendment providing organic and inorganic nutrients. The keratin material is also us... | 11/18/2003 |
| 6379690 | Keratin-based hydrogel for biomedical applications and method of production A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide l... | 04/30/2002 |
| 6316598 | Water absorbent keratin and gel formed therefrom A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a c... | 11/13/2001 |
| 6165496 | Keratin-based sheet material for biomedical applications and method of production A sheet wound dressing formed of cross linked keratin. An insoluble, largely Beta keratin fraction from human hair is acidified to a low pH, preferably less than about 3, which partially solubilizes the keratin by weakening hydrogen bonds. The suspension ... | 12/26/2000 |
| 6159496 | Keratin-based hydrogel for biomedical applications and method of production A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide l... | 12/12/2000 |
| 6124265 | Method of making and cross-linking keratin-based films and sheets Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separat... | 09/26/2000 |
| 5770562 | Products and methods for improving keratinocyte adhesion to the dermis The isolated proteins kalinin and k-laminin are disclosed to provide adhesion between epidermal keratinocytes and the underlying dermis. Purified kalinin localizes to the anchoring filaments of basement membranes of human subepithelial skin, trachea, esop... | 06/23/1998 |
| 5580960 | KS-laminin and methods of use KS-laminin and a KS-laminin-kalinin adduct are disclosed. The molecules of the invention are useful for promoting the adhesion of keratinocytes to a substrate.... | 12/03/1996 |
| 5567806 | Collagen crosslinked with a crosslinking agent for the manufacture of a suturable, biocompatible slowresorbing membrane, and such a membrane Suturable, biocompatible, control-resorbing membranes are disclosed for use in guided tissue regeneration, comprising a cross-linked collagen material either obtained by crosslinking a starting collagen material in the coagulated state produced by coagula... | 10/22/1996 |
| 5549904 | Biological adhesive composition and method of promoting adhesion between tissue surfaces A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment... | 08/27/1996 |
| 5358935 | Nonantigenic keratinous protein material The present invention is a new nonantigenic keratinous protein material that may be used as a number of purposes, including correction of soft tissue deficiencies and the creation of biomedical implants and implant coatings. The present invention also inc... | 10/25/1994 |
| 5352668 | Product and method for improving keratinocyte adhesion to the dermis A purified protein kalinin is disclosed that provides adhesion between epidermal keratinocytes and the underlying dermis. Purified kalinin localizes to the anchoring filaments of basement membranes or human subepithelial skin, trachea, esophagus, cornea a... | 10/04/1994 |
| 5276138 | Process for solubilizing animal hair The present invention provides the process for treating the animal hairs by solubilization wherein the animal hairs can be treated in a short time without any complicated operations and special apparatuses, and the process for recovering the solubilized p... | 01/04/1994 |
| 5234911 | Substance with interleukin-8 inhibiting activity and process for its preparation A substance is prepared having interleukin-8 inhibiting activity by extracting psoriatic scales and separating the extract on several successive HPLC columns, using an assay for IL-8i activity based on the inhibition of myeloperoxidase release and/or of t... | 08/10/1993 |
| 5221664 | Composition and treatment with biologically active peptides and toxic cations A composition comprising a biologically active amphiphilic ion channel-forming peptide or ion channel forming protein and a toxic cation, such as a silver cation. Such compositions may be employed as pharmaceuticals, particularly for the treatment and pre... | 06/22/1993 |
| 5102663 | Vaccine for stimulating or enhancing production of antibodies against 9-O-acetyl GD3 The present invention provides a vaccine for stimulating or enhancing in a subject to whom the vaccine is administered, production of antibodies directed against 9-O-acetyl GD3 ganglioside comprising an amount of purified 9-O-acetyl GD3 ganglioside effect... | 04/07/1992 |
| 5068315 | Composition for the regulation of hair growth Disclosed is a composition for regulating hair growth comprising a safe and effective amount of a polypeptide having the structure of those derived from dermal papilla cells with characteristics of apparent isoelectric pH/molecular weight selected from th... | 11/26/1991 |
| 4980403 | Collagen products Collagen in tactoid form obtained by forming an aqueous solution containing dissolved collagen and a water soluble or miscible polymer adapted to precipitate collagen out of solution in the form of tactoids.... | 12/25/1990 |
| 4959213 | Pharmaceutical composition for treatment and/or prevention of diseases of the skin involving an inflammatory process A pharmaceutical composition for the treatment and prevention of erythma and acne comprises in a pharmaceutically acceptable carrier from about 1 to 10 weight percent based on the total weight of the composition of a delipidized and purified keratin polym... | 09/25/1990 |
| 4894441 | Process for the preparation of collagen and obtained product A process for the preparation of undenaturated triple helix collagen, starting form animal tendons or cutis, by extraction with diluted organic acids, precipitation with salts, optional gelation and/or lyophilization, tangential filtration. The obtained c... | 01/16/1990 |
| 4789734 | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue A method of isolating cell surface receptors utilizing a short peptide sequence bound to an affinity column. Cell surface receptors which bind selectively to the short peptide and which are specific to various adhesion proteins may be isolated therewith f... | 12/06/1988 |
| 4732891 | Placenta-derived anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component Novel human placenta-derived anticoagulating substances having the following properties: (1) molecular weight of 34,000&#b1;2,000 determined by SDA-polyacrylamide gel electrphoresis under reduced state; (2) isoelectric point of 4.7&#b1;0.1 determined by isoele... | 03/22/1988 |
| 4548608 | Depilating composition and method A composition for removing hair from full hair whole carcasses, skins, hides and pelts comprising:... | 10/22/1985 |
| 4507229 | Tissue protein PP4, a process for isolating it and its use The protein PP4 which has (a) an electrophoretic mobility in the range between that of 댑 and 댒 globulins; (b) an isoelectric point of 4.85&#b1;0.15; (c) a sedimentation coefficient s20,w0 of 3.3&#... | 03/26/1985 |
| 4505855 | Transparent non-fibrilized collagen material by ultracentrifugation A transparent native, non-fibrilized collagen material is described having an absorbence at a wavelength of 900 nm of less than 5% in a sample 5 mm thick. This collagen material is useful for a prosthetic replacement of the cornea because of the high tran... | 03/19/1985 |
| 4488911 | Non-antigenic collagen and articles of manufacture Collagen, available from domestic animals, is freed of noncollagen proteins, glycosaminoglycans and lipids by enzymatic treatment with a proteolytic enzyme to yield a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS).... | 12/18/1984 |
| 4483829 | Process for recovering proteins and chromium from chrome-tanning waste Waste products from the chrome-tanning of hides are washed and then chopped in water, with subsequent hydrolyzation at a pH of at least 10.5 and at boiling or near-boiling temperature. The resulting suspension is filtered to yield a polypeptide solution a... | 11/20/1984 |
| 4424208 | Collagen implant material and method for augmenting soft tissue An injectable implant material for soft tissue augmentation comprising a dispersion of (a) particles of cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen in a (c) physiological aqueous carrier. Implants of this materi... | 01/03/1984 |
| 4378311 | Method for hydrolyzing keratinaceous material An apparatus for effecting the continuous conversion of feathers, hair, and other keratinaceous material into usable products, including a first vessel, said first vessel being jacketed and capable of heating the material therein without subjecting it to ... | 03/29/1983 |
| 4374063 | Process for the preparation and purification of gelatin and pyrogen-free gelatin so prepared A process of preparing an essentially pyrogen-free gelatin solution from cattle hides and/or tanner's stock is described. The essentially pyrogen-free gelatin solution and the use of the pyrogen-free gelatin solution for various pharmaceutical, surgical a... | 02/15/1983 |
| 4374121 | Macromolecular biologically active collagen articles Macromolecular reconstituted collagen is prepared by treating natural insoluble collagen with an aqueous solution comprised of an alkali sulfate salt and an alkali metal hydroxide for at least 48 hours to saponify fats suspended within the natural insolub... | 02/15/1983 |
| 4312853 | Radioimmunological determination of procollagen (type III) and procollagen peptide (type III) For the radioimmunological determination of procollagen (type III) and procollagen peptide (type III) a certain amount of radioactively tagged procollagen (type III) or procollagen peptide (type III) and a highly specific anti-procollagen (type III) serum... | 01/26/1982 |
| 4151306 | Process for hydrolyzing proteinaceous derivatives of the skin A process for hydrolyzing keratinous materials, comprising the steps of mechanically dewatering raw keratinous material to reduce the water content while maintaining the water in its liquid phase, applying heat and pressure to the dewatered material to hy... | 04/24/1979 |
| 4097234 | Method for preparing dispersion of collagen fiber A method for preparing an aqueous dispersion of collagen fibers from various materials containing insoluble collagen and various products prepared from the dispersion are disclosed.... | 06/27/1978 |
| 4049684 | Process for the separation of fat from animal skins Raw or partially cooked animal skins containing fats and oils from which the surface hair has been removed are ground into particles and fed into the end of a perforated conduit that has a conveyor screw therein which progressively decreases in conveying ... | 09/20/1977 |
