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| Number | Title | Issue Date |
| 6841644 | Biopolymers obtained by solid state irradiation in an unsaturated gaseous atmosphere Disclosed are modified naturally occurring biocompatible biopolymers of plant and animal origin made by subjecting same to ionizing radiation in the presence of a mediating gas, typically acetylene to enable one to selectively enhance and modify one or more of the p... | 01/11/2005 |
| 6566496 | Neurogenin The invention relates to novel neurogenin proteins, nucleic acids and antibodies.... | 05/20/2003 |
| 6429296 | Complex of human growth hormone and zinc and use The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and ... | 08/06/2002 |
| 6310040 | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs Disclosed is a method for promoting retinal neuronal survival in a mammal, wherein the neuronal cells are at risk of dying. The method comprises administering to the mammal an effective dose of at least one of the following substances: IGF-I; a functional... | 10/30/2001 |
| 6294340 | Method of binding material to the ଲ-amyloid peptide The present invention relates to the finding that antibodies bind to the ଲ-amyloid peptide, and that ଲ-amyloid peptide binds the hinge region of the immunoglobulin heavy chain, thereby preserving the ability of the immunoglobulin to bind antig... | 09/25/2001 |
| 6277828 | Pharmaceutical formulations of nerve growth factor Stable, aqueous pharmaceutical formulations of human nerve growth factor (NGF) in aqueous isotonic solutions, buffered to maintain the pH from about 4.5 to about 6.0, and optionally containing a carrier such as human serum albumin are provided. Also provi... | 08/21/2001 |
| 6191107 | Complex of human growth hormone and zinc The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and ... | 02/20/2001 |
| 6168926 | Protein inhibitor of neuronal nitric oxide synthase An nNOS associated protein designated PIN-1 (Protein Inhibitor of nNOS) has been identified. It physically interacts with nNOS and inhibits its activity. Multiple lines of evidence indicate that PIN-1 is a regulator of nNOS: it is physiologically associat... | 01/02/2001 |
| 6159746 | Solid phase immunoassay to detect inhibitors of proteolytic enzymes Solid phase immunoassay for detecting specific inhibitors of proteolytic enzymes in biological fluids, which comprises: a) contacting a tubulin peptide covalently linked to a support with a solution containing a proteolytic activity together with a protea... | 12/12/2000 |
| 6124430 | Human brain natriuretic peptides The present invention provides reagents and assays for the quantification of hBNP in biological fluid samples such as plasma or serum. Antibodies are provided which are monospecific to epitopes comprising the amino acid sequences 5-13, 1-10 and 15-25 of h... | 09/26/2000 |
| 6114502 | Gene family associated with neurosensory defects Nucleic acid compositions are provided that encode a family of mammalian proteins expressed in the retina and brain. Members of the gene family are genetically linked to various neurosensory defects, including cochlear degeneration, peripheral retinal deg... | 09/05/2000 |
| 6051259 | Composition for sustained release of human growth hormone The method of the invention for producing a composition for the sustained release of biologically active hGH includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, metal ca... | 04/18/2000 |
| 6043222 | Two new human DnaJ-like proteins The invention provides a two new human DnaJ-like proteins (HSPJ1 or HSPJ2) and polynucleotides which identify and encode HSPJ1 or HSPJ2. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also p... | 03/28/2000 |
| 5981704 | Kainate-binding, human CNS receptors of the EAA2 family Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors, of the kainate binding type of EAA receptors, has now been isolated and the receptor prote... | 11/09/1999 |
| 5965699 | Assay for the proteolytic activity of serotype a from clostridium botulinum A label-based assay is described, through modifications of substrate strure and derivatization of serum albumin, which can be used to determine type A proteolytic activity without separation of products.... | 10/12/1999 |
| 5948888 | Neural thread protein gene expression and detection of Alzheimer's disease The present invention is directed to recombinant hosts expressing novel proteins associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. This invention is specifically directed to the recombinant hosts and v... | 09/07/1999 |
| 5945510 | Substantially pure zonulin, a physiological modulator of mammalian tight junctions A substantially pure mammalian protein, hereinafter "zonulin", that is a physiological modulator of mammalian tight junctions is disclosed, as well as methods for the use of the same.... | 08/31/1999 |
| 5935795 | Glial cell line-derived neurotrophic factor antibody A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequ... | 08/10/1999 |
| 5891478 | Composition for sustained release of human growth hormone The method of the invention for producing a composition for the sustained release of biologically active hGH includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, metal ca... | 04/06/1999 |
| 5883227 | Multiple sclerosis associated polypeptide The present invention relates to the diagnosis of multiple sclerosis. More specifically, this invention relates to an assay for detecting antigen(s) associated with multiple sclerosis. The present invention also relates to the generation of hybridomas whi... | 03/16/1999 |
| 5859197 | Neurogene Disclosed are DNA and amino acid sequences for a novel polypeptide termed Neuritin which is expressed primarily in selected regions of the brain.... | 01/12/1999 |
| 5849886 | Extraction of myelin basic protein A process for extraction of myelin basic protein from myelin containing tissue, such as central nervous system tissue, which process comprises the following steps: extraction of the myelin basic protein from myelin containing tissue with an organic solven... | 12/15/1998 |
| 5849988 | Rat comprising straight filaments in its brain Methods of generating a rat having Aଲ deposits in the brain of the rat by injecting an amount of human A68 protein sufficient to result in formation of the deposits and subsequently examining the rat for the formation of the deposits are disclosed. ... | 12/15/1998 |
| 5849869 | Delta fragments and derivatives and methods based thereon The present invention relates to nucleotide sequences of the Delta genes, and amino acid sequence of the encoded protein, fragments and derivatives which retain binding activity are also provided.... | 12/15/1998 |
| 5837473 | Methods of screening for agents affecting the deposition of ଲ-amyloid peptides on amyloid plaques in human tissue The present invention provides a labelled ଲ-amyloid peptide or a labelled active fragment of ଲ-amyloid peptide and methods of using the labelled peptides to screen for agents which affect the deposition of the labelled peptide onto amyloid pla... | 11/17/1998 |
| 5770577 | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol Derivatives of the neurotrophic factors BDNF and NT-3 have been prepared by attachment of these polypeptides to a water soluble polymer, for instance, polyethylene glycol.... | 06/23/1998 |
| 5767240 | Activity-dependent neurotrophic factor The present invention relates to a purified non-neuronal activity-dependent neurotrophic factor (ADNF) protein that increase the survival of spinal cord neuron cells, cerebral cortical cells and hippocampal neuron cells which has a molecular weight of 16,... | 06/16/1998 |
| 5747033 | Method of enhancing the biological activity of Eph family ligands Novel ligands that bind Eph family receptors are identified, and methods for making the soluble ligands in biologically active form are described. cDNA clones encoding these novel proteins enable production of the recombinant proteins, which are useful to... | 05/05/1998 |
| 5703209 | Amyloid precursor proteins and method of using same to assess agents which down-regulate formation of ଲ-amyloid peptide This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, abou... | 12/30/1997 |
| 5693476 | Methods of screening for compounds capable of modulating vesicular release Methods of identifying compounds capable of affecting binding of a SNAP-25, -SNAP, n-sec1 or VAMP to syntaxin are disclosed. Compounds identified by such methods are useful for modulating vesicular release, such as release at neural synapses.... | 12/02/1997 |
| 5667978 | Antibody to the neural cell adhesion molecule and methods of use The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous syst... | 09/16/1997 |
| 5656477 | Amyloid precursor proteins and method of using same to assess agents which down-regulate formation of ଲ-amyloid peptide This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, abou... | 08/12/1997 |
| 5654010 | Composition for sustained release of human growth hormone A composition, and methods of forming and using said composition, for the sustained release of biologically active, stabilized human growth hormone (hGH). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible ... | 08/05/1997 |
| 5651969 | Antibody to the neural cell adhesion molecule and methods of use The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous syst... | 07/29/1997 |
| 5652092 | Amyloid precursor proteins and method of using same to assess agents which down-regulate formation of ଲ-amyloid peptide This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, abou... | 07/29/1997 |
| 5648464 | Human Notch and Delta binding domains in toporythmic proteins, and methods based thereon The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The invention ... | 07/15/1997 |
| 5624905 | Merosin fragments and uses thereof This invention provides a purified protein, having an apparent molecular weight of about 800 kDa, designated merosin. Also provided is an isolated nucleic acid sequence which encodes merosin. The invention further provides antibodies, vectors, and the exp... | 04/29/1997 |
| 5625040 | Phosphacan: a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell adhesion molecules A phosphacan proteoglycan molecule, or a functional derivatives thereof, binds to brain cells and to a number of cell adhesion molecules including Ng-CAM and N-CAM. Such proteoglycan molecules or functional derivatives, as well as nucleic acids coding the... | 04/29/1997 |
| 5591629 | Monoclonal antibodies which promote central nervous system remyelination Monoclonal IgM antibodies which promote central nervous system remyelination when given to a mammal afflicted with a demyelinating disease are disclosed. These antibodies show multi-organ autoreactivity, and recognize both surface and cytoplasmic determin... | 01/07/1997 |
| 5576191 | Cytokine that binds ST2 ST2 ligand polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing ST2 ligand polypeptides. The ST2 ligand polypeptide binds to a receptor that is expressed on cell types that include certain ... | 11/19/1996 |
