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| Number | Title | Issue Date |
| 4695454 | Process for preparing hepatitis B surface antigen containing particles in novel forms which are highly immunogenic There is disclosed a process for producing a proteinaceous mass containing particles of HBsAg in a morphological form not found in nature while inactivating any live virus contained therein. The process comprises subjecting a concentrated mass thereof fre... | 09/22/1987 |
| 4683136 | Proteinaceous antigens with conformation-independent and conformation-dependent determinants A single polypeptide antigen that includes the amino acid residue sequence and epitope of a conformation-independent antigenic determinant and the amino acid residue sequence but lacks the epitope of a conformation-dependent antigenic determinant is discl... | 07/28/1987 |
| 4675400 | Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids Bifunctional derivatives of a 3-carboxhydrazide of an antineoplastic dimeric indole-dihydroindole alkaloids, useful both in forming conjugates with immunoglobulins and as anti-tumor agents.... | 06/23/1987 |
| 4673634 | Purified antigen from non-A, non-B hepatitis causing factor The present invention discloses an isolated and purified antigen specific to non-A, non-B hepatitis (NANBH) causing agent. The utility of the antigen as a diagnostic serologic marker and as a screening device for detecting the carrier or source of non-A, ... | 06/16/1987 |
| 4666713 | Relating to hepatitis B vaccine Immunogenically active fragments of hepatitis B surface antigen, which are a glycoprotein of molecular weight about 28,000 (gp 28) and a protein of molecular weight about 23,000 (p 23), obtained by known methods by treatment of surface antigen with deterg... | 05/19/1987 |
| 4659568 | Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom This invention discloses a novel process for the solubilization, purification and characterization of a protein or proteins from insoluble protein aggregates or complexes. The novel process comprises the use of a dissociating step gradient which can be fo... | 04/21/1987 |
| 4649192 | Method for the isolation and purification of hepatitis B surface antigen using polysorbate The supernatant of engineered yeast cells having produced hepatitis B surface antigaen and disrupted in the presence of a polysorbate non-ionic detergent is clarified by addition of urea and adsorbed on colloidal silica from which the purified antigen is ... | 03/10/1987 |
| 4614793 | Hepatitis A--subunit antigen A surface structural protein of Hepatitis A Virus (HAV) has been isolated and characterized from virus grown in tissue culture. This 33,000 dalton viral protein (VP-1) reacts with immune HAV sera and monoclonal antibodies that neutralize HAV infectivity. ... | 09/30/1986 |
| 4563423 | Products displaying the antigenicity of hepatitis B virus e antigens and methods of producing those antigens Polypeptides displaying the antigenicity of hepatitis B virus e antigens, DNA sequences coding for those polypeptides, antibodies to those polypeptides and methods of producing and using those polypeptides, antibodies and DNA sequences. The polypeptides a... | 01/07/1986 |
| 4545985 | Pseudomonas exotoxin conjugate immunotoxins A method of modifying Pseudomonas exotoxin (PE) with methyl-4-mercaptobutyrimidate is disclosed so that after conjugating the exotoxin to a monoclonal antibody (ab) such as the antibody to the transferrin receptor, the PE-ab conjugate becomes a highly pot... | 10/08/1985 |
| 4534972 | Protein compositions substantially free from infectious agents Compositions containing therapeutically or immunologically active proteins are rendered substantially free from infectious agents such as viable viruses and bacteria without substantial loss of therapeutic or immunologic activity by mixing the protein com... | 08/13/1985 |
| 4518526 | Purification and activity assurance of precipitated heterologous proteins A process for isolating and purifying a precipitated heterologous protein from a host cell culture, including treating the host cell culture with a buffered solution of ionic strength suitable to solubilize most of the host protein but in which refractile... | 05/21/1985 |
| 4512922 | Purification and activity assurance of precipitated heterologous proteins A process for maintaining refractile proteins in solubilized form by replacing the strongly denaturing solution with a weakly denaturing solution.... | 04/23/1985 |
| 4511503 | Purification and activity assurance of precipitated heterologous proteins A process for dissolving refractile proteins from their insoluble form by using a strongly denaturing solution.... | 04/16/1985 |
| 4511502 | Purification and activity assurance of precipitated heterologous proteins A process for purifying heterologous proteins from higher molecular weight components, including dissolving the heterologous protein in a strong denaturing solution and removing the higher molecular weight components using a molecular sieve or high speed ... | 04/16/1985 |
| 4478823 | Immunological preparations containing purified MHC antigens bonded to other antigens An immunologically active preparation for human or veterinary use comprises an antigenic material in combination with an MHC antigen.... | 10/23/1984 |
| 4474757 | Synthetic vaccine and process for producing same There is provided a synthetic vaccine against influenza virus infections consisting of a synthetic peptide corresponding to a relevant antigenic fragment of the virus, which fragment is attached to a suitable carrier, such as a macromolecule. Effective va... | 10/02/1984 |
| 4452734 | Herpes subunit vaccine Herpes virus subunit antigens suitable for vaccine use are prepared by (1) treating virus-infected cells with a surfactant and varying concentrations of salt to extract and solubilize viral-directed glycoproteins, (2) fractionating the solubilized materia... | 06/05/1984 |
| 4428941 | Nucleotidic sequence coding the surface antigen of the hepatitis B virus, vector containing said nucleotidic sequence, process allowing the obtention thereof and antigen obtained thereby Nucleic acid of reduced size and vector containing said nucleotidic sequence of which DNA codes an immunogenic peptidic sequence capable of inducing the generation of antibodies to the virus of viral hepatitis B. It comprises totally or partly the sequenc... | 01/31/1984 |
| 4377513 | Process for the production of human erythropoietin The present invention relates to a process for the production of human erythropoietin. More precisely, the invention relates to a process for the mass production of human erythropoietin, comprising in vivo multiplication of human lymphoblastoid cells capa... | 03/22/1983 |
| 4372883 | Process for the production of vaccine The present invention relates to a process for the production of vaccine, characterized by covalent attachment of a biologically toxic substance to a saccharide both to form a biologically toxic substance-saccharide conjugate and to detoxify said substanc... | 02/08/1983 |
| 4357272 | Recovering purified antibodies from egg yolk Immunological preparations are prepared by immunizing hens with an antigen, preferably to a stage of hyperimmunization. The eggs of the immunized hens are collected, the yolk is separated from the eggs, followed by separation of the lipid content of the y... | 11/02/1982 |
| 4335105 | Specific antigen vaccine for TGE in swine A vaccine for protecting swine against transmissible gastroenteritis (TGE) is prepared from a specific antigenic protein (SPA) obtained by separation from TGE virus. The SPA is characterized by a buoyant density of 1.02 to 1.03 gms/ml in a solution of suc... | 06/15/1982 |
| 4331589 | Deoxyribonucleic acid synthesis using binding protein extracted from chick embryo fibroblasts Described is a method of obtaining complete copying of the entire length of single stranded ribonucleic acid (RNA) into its complementary deoxyribonucleic acid (cDNA) by reverse transcription using binding protein. The method can be used in recombinant DN... | 05/25/1982 |
| 4228068 | Peptide complexes of DNA-containing organisms DNA peptide complexes are prepared from organisms containing DNA to produce specific peptide complexes in a substantially pure state and useful for diagnostic, therapeutic and prophylactic purposes. The complexes can be prepared from bacteria, fungi, plan... | 10/14/1980 |
| 4206014 | Process for removing detergents from virus-antigen suspensions A method for isolating a detergent-free virus-antigen from a suspension of said virus-antigen containing detergent, which method comprises precipitating said virus-antigen by adding a polyethylene glycol to said suspension and then isolating the detergent... | 06/03/1980 |
| 4199450 | Process of separating from an aqueous medium a protein or a morphologically organized unit by liquid exclusion chromatography A novel process of separating from an aqueous medium at least one protein or at least one morphologically organized unit by liquid exclusion chromatography on a solid support previously passivated by treatment with an aqueous solution of a non-proteinic p... | 04/22/1980 |
| 4195074 | Process for producing a soluble rubella antigen Purified soluble antigen, specific for rubella virus, is isolated from growth media of rubella-infected cell cultures by affinity and gel permeation chromatography and characterized, inter alia, by its specific activity. Antigen-sensitized particles are e... | 03/25/1980 |
| 4172827 | Method for concentration and purification of antigens and antibodies In carrying out a purification and/or concentration step of antigens or antibodies, a substrate is immersed in a first aqueous medium containing a specifically reacting antigen to coat said substrate with a monomolecular layer of said specifically reactin... | 10/30/1979 |
| 4168300 | Method of removal of hepatitis virus Hepatitis virus is removed from a biological material contaminated with the virus by contact with a preparation. The preparation may be agarose gel or beaded polyacrylamide plastic coupled with a variety of hydrophobic ligands.... | 09/18/1979 |
| 4126671 | Method for detecting bovine leukemia viral infection A new immunodiffusion test method for determining the presence of bovine leukemia viral infection in cattle. The method relies upon the formation of a precipitin line resulting from the reaction of glycoprotein antigen with an antibody. The reaction is co... | 11/21/1978 |
| 3994870 | Purification of hepatitis B surface antigen After a polyethylene glycol purification procedure, virus particles, viral components and virus associated particles having concanavalin A binding sites are further purified by subjecting such particles or components to affinity chromatography utilizing i... | 11/30/1976 |
| 3975344 | Interferon purification Interferon and interferon-like proteins isolated from animal cells are purified by means of zonal density gradient centrifugation.... | 08/17/1976 |
