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| Number | Title | Issue Date |
| 7261891 | Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease Methods are described for treating inflammatory bowel disease in animals, including humans. Specific avian polyclonal antibodies directed to proinflammatory cytokines (such as IL-6 and TNF) are shown to have a beneficial effect in animal models predictive of human t... | 08/28/2007 |
| 7128904 | Material containing metal ion ligand complex producing nitric oxide in contact with blood Biocompatible materials that have the ability to release nitric oxide (NO) in situ at the surface-blood interface when in contact with blood. The materials which may be polymers (e.g., polyurethane, poly(vinyl chloride), silicone rubbers), metals, such as stainless ... | 10/31/2006 |
| 7109300 | Extraction of collagen from calcified tissues A method is disclosed for extracting collagen from calcified tissue without a prior decalcification step. The method may be used with calcified tissues such as fish skin with scales, alligator skeletons, and crustacean exoskeletons. It does not require the use of ED... | 09/19/2006 |
| 6649740 | Hydratable form of keratin for use as a soil amendment A hydratable oxidized keratin composition comprising one or more metal ion species capable of absorbing water to form a hydrogel. The keratin material is useful as a soil amendment providing organic and inorganic nutrients. The keratin material is also us... | 11/18/2003 |
| 6537550 | Use of avian antibodies The present invention relates to use of avian antibodies and/or antigen binding fragments thereof, for the production of a drug for treatment and/or prevention of respiratory tract infection. The drug is administered through local application at the oral ... | 03/25/2003 |
| 6335430 | Process of producing polyphenolic adhesive proteins and proteins produced in accordance with the process The invention relates to a process of producing MAP-products from mussel feet. The process is characterised by extracting the mussel feet in a weakly acid aqueous solution containing, for instance, 1-10 percent by weight of a weak acid and 0.5-3 percent b... | 01/01/2002 |
| 6316598 | Water absorbent keratin and gel formed therefrom A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a c... | 11/13/2001 |
| 6107468 | Highly soluble protein, method for making, and food products made thereof Disclosed is a method of obtaining a highly soluble protein which method generally includes at least the step of contacting the protein with an amount of antioxidant suitable to raise the solubility of the protein, which method may also be utilized to rai... | 08/22/2000 |
| 5849886 | Extraction of myelin basic protein A process for extraction of myelin basic protein from myelin containing tissue, such as central nervous system tissue, which process comprises the following steps: extraction of the myelin basic protein from myelin containing tissue with an organic solven... | 12/15/1998 |
| 5808006 | Refolding of polypeptides like recombinant insulin-like growth factor IGF-I A composition is provided comprising about 0.1 to 15 mg/ml of a polypeptide in a buffer having a pH of about 7-12 comprising about 5-40% (v/v) of an alcoholic or polar aprotic solvent, about 0.2 to 3M of an alkaline earth, alkali metal, or ammonium salt, ... | 09/15/1998 |
| 5798446 | Method of extracting proteins utilizable in foodstuff from a protein-containing substance In the method described, a protein-containing substance is first taken up in an alkaline solvent to give a solution. Insoluble constituents of the substance are separated off, the solution is neutralized and desalinated, and then the proteins contained in... | 08/25/1998 |
| 5777080 | Highly soluble protein, method for making, and food products made thereof Disclosed is a method of obtaining a highly soluble protein which method generally includes at least the step of contacting the protein with an amount of antioxidant suitable to raise the solubility of the protein, which method may also be utilized to rai... | 07/07/1998 |
| 5756672 | Refolding of polypeptides A composition is provided comprising about 0.1 to 15 mg/mL of a polypeptide in a buffer having a pH of about 7-12 comprising about 5-40% (v/v) of an alcoholic or polar aprotic solvent, about 0.2 to 3M of an alkaline earth, alkali metal, or ammonium salt, ... | 05/26/1998 |
| 5530100 | Methods for purification of recombinantly produced proteins Recovery of the 52/48 kDa tryptic fragment of vWF or peptide subfragments thereof produced in the form of inclusion bodies from recombinant host cells is carried out by providing a washed recombinant host cell suspension, adding a detergent and subjecting... | 06/25/1996 |
| 5420253 | Method for purifying egg yolk immunoglobulins The present invention provides a method for purifying high yields of IgG immunoglobulins from an egg yolk by a single phase separation step using a nonionic detergent.... | 05/30/1995 |
| 5380826 | Supercritical fluid disruption of and extraction from microbial cells The invention involves the supercritical or near-critical fluid disruption of microbial cells and extraction of intracellular components. First, a solvent that is a gas at ambient conditions and that has a critical temperature of between 0° and 100° C. ... | 01/10/1995 |
| 5349052 | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor The invention relates to fractionating a mixture of polyethylene glycol (PEG)-protein adducts having different degrees of PEG substitution by partitioning the PEG-protein adducts in a PEG-containing aqueous biphasic system according to the degree of PEG s... | 09/20/1994 |
| 5340926 | Process for the recovery of recombinantly produced protein from insoluble aggregate In a process for the production of a soluble native protein, such as immunoglobulin or methionine-prochymosin, in which an insoluble form of the protein is produced by a host organism transformed with a vector including a gene coding for the protein, the ... | 08/23/1994 |
| 5334704 | Glycoprotein isolated from ganoderma having immunosuppressive activity Disclosed herein is a novel glycoprotein derived from Ganoderma mycelia. The glycoprotein is free of human hemagglutination ability, and has immunosuppressive activities and a molecular weight of 16,000-18,000 as measured by SDS gel electrophoresis or 12,... | 08/02/1994 |
| 5332805 | Process for the recovery of recombinantly produced chymosin from insoluble aggregate The production of recombinant chymosin is disclosed in which an insoluble form of chymosin precursor is produced by a bacterial host cell transformed by a vector including a coding sequence for said precursor. Solubilization of said insoluble form of chym... | 07/26/1994 |
| 5284937 | Process for the extraction and purification of human recombinant gamma interferon An extraction and purification process for human gamma interferon (HuIFN-gamma) from recombinant host cells producing the same in insoluble form is described, which comprises suspending the cells in a buffer solution having pH from 6.0 to 8.5, optionally ... | 02/08/1994 |
| 5276138 | Process for solubilizing animal hair The present invention provides the process for treating the animal hairs by solubilization wherein the animal hairs can be treated in a short time without any complicated operations and special apparatuses, and the process for recovering the solubilized p... | 01/04/1994 |
| 5275954 | Process for demineralization of bone using column extraction A process and apparatus are disclosed for the demineralization of ground bone particles or pieces of cancellous or cortical bone. The apparatus includes multiple solution reservoirs which supply solutions to be pumped into one or more columns filled with ... | 01/04/1994 |
| 5264555 | Process for hemoglobin extraction and purification Methods are disclosed for separating hemoglobin from erythrocytes by contacting erythrocytes with a hypotonic buffer solution at a rate sufficient to render the release of hemoglobin from said erythrocytes without significant lysis. The hemoglobin is then... | 11/23/1993 |
| 5258497 | Process for purifying annexines The present invention relates to processes for purifying annexines. The overall process includes the steps of preparing a homogenized cell preparation and adjusting the pH to about 8.0 to 10.0, adding at least one bivalent cation, adding a phospholipid, w... | 11/02/1993 |
| 5235041 | Purification of structurally ordered recombinant protein polymers Recombinant structural and functional polymers are purified by lysing of the cellular host, separation of the solid materials, washing and extraction of contaminants using a detergent solution at elevated temperatures.... | 08/10/1993 |
| 5187260 | Process for the preparation of a high purity protamine-DNA complex and process for use of same A process is disclosed in which high purity protamine-DNA complexes are prepared by collecting nucleoprotamines specific developmental stages of a life form, specifically, amphibian, egg by low temperature processing. The process also includes the steps o... | 02/16/1993 |
| 5093254 | Aqueous two-phase protein extraction An aqueous two-phase protein partitioning system is disclosed which employs polyvinylpyrrolidone as the upper phase and maltodextrin as the lower phase and provides a low-cost system for protein partitioning. The system can also be employed with the amion... | 03/03/1992 |
| 5008377 | Production of proteins in active forms A method for the preparation of a protein in a physiologically active or native form, which method includes providing a source of protein in a solubilized form, and a cationic exchange medium; contacting the source of protein and cationic exchange medium; and recov... | 04/16/1991 |
| 4966963 | Production of proteins in active forms A method for the preparation of proteins in biologically active form including providing a source of protein solubilized from inclusion bodies with a cationic surfactant; providing a weak denaturing agent; and contacting the solubilized protein with the w... | 10/30/1990 |
| 4958007 | Extraction of human interleukin-4- from bacteria A method is provided for extracting human interleukin-4 (IL-4) from IL-4 expressing bacterial cells. The method comprises treating the bacterial cells with a deactivating agent, disrupting the cell membrane and recovering the IL-4.... | 09/18/1990 |
| 4883865 | Recovery of pres2+s antigen A liquid phase containing preS2+S antigen is separated into two phases after which the desired antigen is concentrated, washed and adsorbed and desorbed from a fumed silica to produce a product that is purified and concentrated in antigen:protein ratio an... | 11/28/1989 |
| 4873317 | Method of separating or purifying proteins and other biopolymers A method for the separation or purification of biopolymers comprises adsorbing the biopolymer on the surface of liquid oil droplets; and separating the adsorbed biopolymer from the oil droplets. The adsorbed biopolymer is separated from the oil droplets b... | 10/10/1989 |
| 4859464 | Method for the purification of parasite antigenic factors A method for the solubilization and recovery of insoluble parasite protective antigenic factors associated with parasite material comprising solubilizing the antigenic factors with a non-ionic detergent and separating the solubilized material from undispe... | 08/22/1989 |
| 4830969 | Process for the rapid and simple isolation of nucleic acids A process for the separation from other cellular materials of heat agglomeration resistant water soluble nitrogen containing organic compounds such as plasmids, RNA's, mitochondrial DNA's, viral DNA's, chloroplast DNA's, other episomal DNA's and certain p... | 05/16/1989 |
| 4824939 | Process for leaching particulate solid materials A novel leaching process for separating extractable material from a particulate solid material that comprises extractable and non-extractable portions includes the steps of introducing the particulate solid material and a liquid solvent to an extraction z... | 04/25/1989 |
| 4797474 | Solubilization of protein aggregates A method for the recovery of proteins which method includes providing a source of protein in an insoluble form, a source of at least one cationic surfactant; treating the insoluble protein with the at least one cationic surfactant in an amount sufficient ... | 01/10/1989 |
| 4744983 | Immunogenic protein or peptide complex, method of producing said complex and the use thereof as an immune stimulant and as a vaccine The invention relates to an immunogenic complex containing antigenic membrane proteins or peptides from viruses mycoplasmas, bacteria, parasites or animal cells or prepared synthetically or with hybride DNA technique and glycoside. The invention also rela... | 05/17/1988 |
| 4743583 | Sustained release protein compositions and method for making Lewis acid-Lewis base high molecular weight salt microparticulate material of the type referred to in U.S. Pat. No. 3,959,457, which include biologically active peptides and proteins solubilized in a non-aqueous, non-denaturing manufacturing solvent.... | 05/10/1988 |
| 4675387 | Method for extracting protein with organic acid A method for extracting protein produced by procaryotic or eucaryotic cells comprising contacting said cells with a solution containing from about 50 to about 100 volume percent of an organic acid having from 1 to 5 carbon atoms and mixtures thereof is di... | 06/23/1987 |
