Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 5545328 | Purification of hemoglobin by displacement chromatography A preselected hemoglobin species is separated from contaminants having a different acidity from that of the preselected hemoglobin species, by an overload displacement chromatography process. To remove more acidic contaminants, the process is conducted un... | 08/13/1996 |
| 5530098 | Human B-cell differentiation factor and process of producing said factor A cDNA and a chromosomal DNA coding for the human B-cell differentiation factor were provided and the entire nucleotide sequence of said DNAs as well as the entire amino acid sequences of the polypeptide portion of mature human B-cell differentiation fact... | 06/25/1996 |
| 5530103 | Method for the purification of PC protein from Borrelia burgdorferi A method of purifying B. burgdorferi proteins comprising the steps of (a) disrupting a B. burgdorferi cell and fractionating the disrupted cell into membrane and cytoplasmic components; (b) resuspending the membrane component in a non-denaturing detergent... | 06/25/1996 |
| 5525508 | Haemonchus contortus vaccine A substantially purified antigen derived from a first species of parasitic nematodes, which antigen is capable of providing protection to a host from parasitism by a second nematode species, which may be the same as or different from the first nematode sp... | 06/11/1996 |
| 5525497 | Recombinant poly(A) polymerase Purified nucleic acid encoding a yeast, human, or bovine poly(A) polymerase, where the bovine nucleic acid consists essentially of that nucleic acid sequence shown as nucleotide SEQ. ID. NO.: 1; the resulting recombinant poly(A) polymerase expressed from ... | 06/11/1996 |
| 5525500 | Chromatographic process for the copurification of chondroitinase I and II proteins from Proteus vulgaris A chromatographic process for the copurification of chondroitinase proteins useful in ocular surgery for non-surgical disruption of chondroitin sulfate, the molecule which mediates the attachment between the retina and vitreous body in the human eye. The ... | 06/11/1996 |
| 5521287 | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatm... | 05/28/1996 |
| 5512657 | Detection of complexes which include basement membrane components as diagnostic of cancer and other diseases Isolated complexes (which include basement membrane components), antibodies to such complexes or polypeptide constituents thereof, and methods for detecting such complexes or constituents are disclosed. Detection of such complexes in a biological sample b... | 04/30/1996 |
| 5508177 | Process for purification of water soluble penicillin binding protein 2a The present invention provides processes for isolating in substantially purified form water-soluble penicillin binding protein 2a of Staphylococcus aureus.... | 04/16/1996 |
| 5496802 | Control of milk secretion A protein which inhibits milk secretion by lactating cows and which is present in the eighth (6B, Figure) significant peak when a nominally 10-30 KDa fraction of the whey proteins of the milk is resolved on a "Mono Q" anion exchange column using 10 mM imi... | 03/05/1996 |
| 5496926 | Process of preparing a soluble LDL receptor A soluble LDL receptor protein is provided. It can be isolated from cells that have been treated with an interferon, isolated from the urine of healthy human individuals or produced by recombinant techniques. The soluble LDL receptor protein is useful in ... | 03/05/1996 |
| 5484890 | Antihemophilic factor stabilization A method of recovering a purified and stabilized protein having antihemophilic factor activity (Factor VIII), from a biological sample containing Factor VIII, at least one destabilizing protease impurity, i.e. thrombin, and optionally one or more proprote... | 01/16/1996 |
| 5482924 | Proteinaceous compositions having an activity on erythropoiesis The invention relates to proteinaceous compositions capable of modulating the development of erythroid progenitors such as obtainable from a biological material selected from bone marrow culture supernatants, or kidney cell lysates by contacting said biol... | 01/09/1996 |
| 5478924 | Displacement chromatography of proteins using low molecular weight displacers A method for the purification of proteins by displacement chromatography on ion exchange media using low molecular weight displacers is disclosed. Several classes of low molecular weight, charged species are exemplified, including aminoacids, peptides, an... | 12/26/1995 |
| 5470954 | Ultrapurification process for factor VIII A process for purifying Factor VIII:C comprising contacting an immobilized antibody specifically binding a Factor VIII:C with Factor VIII: C, desorbing Factor VIII:C from the antibody which had adsorbed it, eluting Factor VIII:C from the presence of the a... | 11/28/1995 |
| 5468847 | Method of isolating and purifying a biomacromolecule The invention provides a method of separating a biomacromolecule which comprises the steps of providing a separation system including a filter element which comprises a composite filtration medium, the composite filtration medium comprising a filtration l... | 11/21/1995 |
| 5464939 | Highly purified protein, production and use thereof A substantially pure non-glycosylated human interleukin-2 protein having a specific activity of not less than 104 U/mg is obtained by growing a transformant carrying a DNA having a base sequence coding for human interleukin-2 to cause productio... | 11/07/1995 |
| 5463029 | Purification of fusion proteins comprising GM-CSF and IL-3 A process for purifying a fusion protein comprising GM-CSF and IL-3 is disclosed.... | 10/31/1995 |
| 5461034 | Osteogenic growth polypeptides identified from regenerating bone marrow A biochemically pure polypeptide(s), termed osteogenic growth polypeptide (OGP), which exhibits stimulatory effects on osteoblastic cells, in vivo bone formation and hemopoietic reconstruction. OGP, identified from regenerating bone marrow, has an amino a... | 10/24/1995 |
| 5459052 | Method of producing IGF-1 Ala-Glu-IGF-I is a novel compound which exerts IGF-I activity and is a precursor for the preparation of IGF-I. Ala-Glu-IGF-I may by converted to IGF-I by renaturation after recombinant production in E. coli under specified conditions and then cleaving Ala... | 10/17/1995 |
| 5457181 | Preparation of a high-purity human factor IX concentrate and other plasmatic proteins and their therapeutic use The present invention relates to a method for preparing a high purity Factor IX concentrate. The starting material for the process is the supernatant fraction of a cryoprecipitated human plasma. A pre-purification step is performed by DEAE-Sephadex chroma... | 10/10/1995 |
| 5453490 | Production of recombinant human interleukin-1 inhibitor A method for the production of commercial quantities of highly purified interleukin-1 inhibitor (IL-1i) from a recombinant host is disclosed. A preferred recombinant E. coli host for use in this method is also disclosed.... | 09/26/1995 |
| 5451662 | Method of purifying protein An ion-exchange chromatography technique for purifying crude proteins containing closely related impurities, wherein the isoelectric points of the desired protein and the impurities are determined, is disclosed. In performing this technique, the pH for th... | 09/19/1995 |
| 5449757 | Mammalian adipogenic factors Mammalian adipogenic factors, including purified proteins or glycoproteins, capable of inducing the adipose differentiation of adipogenic cells are disclosed, as are antibodies to such proteins, DNA encoding the proteins and host cells expressing the prot... | 09/12/1995 |
| 5447840 | Receptor of the small rhinovirus receptor group A substantially pure receptor with binding activity for rhinoviruses of the small receptor group is disclosed, which has the following characteristics: (a) a molecular weight of 120 kD on a polyacrylamide gel in the presence of SDS; (b) a sedimentation co... | 09/05/1995 |
| 5445958 | Process for purifying blood clotting factors A method for at least partially separating vitamin K-dependent blood clotting factors from a mixture containing at least one such factor, e.g. a prothrombin complex concentrate, which comprises adsorption of said mixture on to a chelate of a polyvalent me... | 08/29/1995 |
| 5444159 | Purification of a pertussis outer membrane protein Pertactin (formerly 69 kDa protein) is recovered in stable biologically pure form having no detectable adenylate cyclase activity from fermentation broth from the fermentation of Bordetella pertussis as well as from the cells. The broth is processed to se... | 08/22/1995 |
| 5444046 | Amylase inhibitors An amylase inhibitor consisting essentially of a protein constructed of 248 amino acid residues having two subunits, each identified as SEQ ID NO:1, in which a single band is observed at a mobility of 0.26 by polyacrylamide gel electrophoresis. The amylas... | 08/22/1995 |
| 5440018 | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatm... | 08/08/1995 |
| 5439591 | Displacement chromatography process Hemoglobin is purified from a crude solution thereof, to obtain an aqueous solution containing at least 99% of a preselected hemoglobin species, by a two stage displacement chromatography process. One of the stages is conducted under anionic exchange cond... | 08/08/1995 |
| 5439807 | Methods for the preparation of endotoxin-binding proteins Disclosed are improvements in methods for the isolation of endotoxin-binding proteins which are secreted by transfected host cells in appropriate cell culture media. In its preferred embodiment, the invention comprises addition of a cation exchange materi... | 08/08/1995 |
| 5430129 | Purified, native dystrophin The invention pertains to pure, native dystrophin of mammalian skeletal muscle and a method of purifying dystrophin from mammalian skeletal muscle. The invention further pertains to a method of diagnosing muscular dystrophy by detecting the loss or abnorm... | 07/04/1995 |
| 5424401 | Process for the preparation of a stable factor VIII A process for the preparation of a pasteurized factor VIII concentrate with high specific activity and stability is described, which comprises adsorbing impurities from the solution containing the factor VIII by at least two-fold adsorption with Al(OH) | 06/13/1995 |
| 5417863 | Quantitative measurement of LDL Disclosed is a method for the rapid quantitative determination of low density lipoprotein (LDL) in a biological fluid sample containing LDL, very low density lipoprotein (VLDL) and high density lipoprotein (HDL). The sample is first passed through a matri... | 05/23/1995 |
| 5417970 | Drugs containing a glycosylated interleukin-2 An interleukin-2 preparation suitable for pharmaceutical purposes, consisting essentially of disialilated glycosylated interleukin-2, monosialilated glycosylated interleukin-2, or a mixture thereof, and substantially free of organic solvents, is isolated ... | 05/23/1995 |
| 5415859 | Production and use of antheimintic agents and protective antigens The protein doublet H110D, the individual components thereof, and the production and use thereof in a vaccine against a nematode infection. This protein doublet is a plasma membrane-associated protein material of the intestinal microvilli of Haemonchus co... | 05/16/1995 |
| 5413989 | Method and activin compositions for inducing bone growth Activin is administered systemically and locally to induce the growth of mature bone. Activin enhances the level of bone formation and the quality of the bone formed when administered locally with BMP or bone marrow. Administration of activin by subcutane... | 05/09/1995 |
| 5410025 | Unmodified intravenously administered immunoglobulin preparations containing immunoglobulin M and/or A Intravenously administered chemically unmodified immunoglobulin preparation containing more than 5% of its total immunoglobulin by weight consisting of IgM and/or more than 10% of its total immunoglobulin of IgA and with a low anticomplementary activity, ... | 04/25/1995 |
| 5408039 | Process for an industrial-scale preparation of a standardized human von Willebrand factor concentrate of very high purity and suitable for therapeutic use The invention relates to a process for purifying human von Willebrand factor from a cryoprecipitated plasma fraction, which comprises a combination of three chromatographic separation steps. The first chromatographic separation step comprises contacting a... | 04/18/1995 |
| 5408041 | Process of purifying antler-derived bone growth factors The present invention relates to the development of bone growth factors as therapeutics for the prevention and treatment of pathological conditions involving bone tissue. The present invention provides biologically active proteinaceous factors comprising ... | 04/18/1995 |
