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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 6113914 | Osp A proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines The invention relates to novel Borrelia, and OspA antigens derived therefrom. These antigens show little homology with known OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borreli... | 09/05/2000 |
| 6113906 | Water-soluble non-antigenic polymer linkable to biologically active material Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologicall... | 09/05/2000 |
| 6111071 | Recombinant fusion protein comprising PDC-E2, BCOADC-E2 and OGDC-E2 and uses thereof The present invention provides a fusion protein which comprises the E2 subunits of PDC, BCOADC, and OGDC and uses thereof.... | 08/29/2000 |
| 6110750 | Rapid detection method of Mycobacterium bovis by fluorescence polarization An assay for the detection of antibodies to the MPB70 protein secreted by Mycobacterium bovis utilizes a tracer consisting of the MPB70 protein conjugated to a fluorophore such as fluorescein. Upon mixing with the antibodies specific for MPB70 protein con... | 08/29/2000 |
| 6106840 | MHC conjugates useful in ameliorating autoimmunity The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.... | 08/22/2000 |
| 6103873 | Isolated renal cancer specific antigen The invention described methods for identifying a molecule of interest, as well as nucleic acid molecules which encode it, and binding partners for it. A cDNA library from a cell expressing the target is prepared, and expressed in host cells. Lysates of t... | 08/15/2000 |
| 6096825 | Electrically conductive electroactive functionalized conjugated polymers, and uses thereof There are electrically conductive, electroactive functionalized conjugated polymers having formula (I): ##STR1## These electrically conducive, electroactive conjugated polymers may be covalently bonded to a first biological molecule or antiligand. Po... | 08/01/2000 |
| 6096315 | Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same The present invention relates to a heterofunctional cellular immunological reagent comprising at least two T cell specific binding ligands covalently linked together, wherein one of the T cell specific binding ligands binds to a specific class or subclass... | 08/01/2000 |
| 6096314 | Peptides and pharmaceutical compositions comprising them The present invention relates generally to peptide sequences, and method of their use, which sequences modulate the activity of anti-idiotypic T cells. The activity of the anti-idiotypic T cells of interest is related to the ability of these T cells to re... | 08/01/2000 |
| 6090387 | Vaccination and methods against diseases resulting from pathogenic responses The present invention provides vaccines and a means of vaccinating a vertebrate so as to prevent or control specific T cell mediated pathologies, including autoimmune diseases and the unregulated replication of T cells. The vaccine is composed of a T cell... | 07/18/2000 |
| 6086880 | Rotavirus peptide compositions and methods of use A number of subunits of various rotaviral proteins have been shown to be useful in diagnosis, therapy, and prevention of rotaviral infection. Specifically, the subunits represented by positions 40-60 of VP6, 232-255 and 240-248 of VP4, and 247-259 and 275... | 07/11/2000 |
| 6066621 | Synthetic peptides for the treatment of myasthenia gravis Peptides having at least nine amino acid residues each including an amino acid sequence which corresponds to position p200-208 or p262-266 of the human acetylcholine receptor -subunit, but differing therefrom by one or more amino acid substitutions... | 05/23/2000 |
| 6057160 | Methods for preparation and use of a coomassie brilliant blue/protein complex A rapid and simple method for making a hydrophobically associated, Coomassie Brilliant Blue (CBB) dye/protein complex comprising CBB and a protein, and a method for detecting analytes using the CBB dye/protein complex are disclosed. The method for making ... | 05/02/2000 |
| 6054303 | Cyclosporin immunoassay A method of measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is disclosed. A method of inactivating interfering cross-reactive material in an assay for measuring the amount of cyclosporin in a sample suspected of contain... | 04/25/2000 |
| 6054127 | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition... | 04/25/2000 |
| 6054126 | Cloning and expression of host-protective immunogens of IBDV This invention relates to the cloning and characterization of the infectious bursal disease virus (IBDV) genome, to the identification of cloned genes for host-protective antigens of IBDV, to the expression of cDNA inserts encoding the whole or part of ho... | 04/25/2000 |
| 6048531 | Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies An essentially pure immunogenic composite capable of selectively inducing antibody production in an animal to a peptide that if administered by itself to the animal without being conjugated to or mixed with additional substance does not stimulate producti... | 04/11/2000 |
| 6045805 | Oligosaccharide derived from an antigenic polysaccharide obtained from a pathogenic agent An oligosaccharide derived from an antigen polysaccharide obtained from a pathogenic agent, a method for its preparation, and its use particularly as a vaccinal agent. The oligosaccharide is prepared by oxidation-reduction depolymerization reaction.... | 04/04/2000 |
| 6045799 | Chimeric contraceptive vaccines The invention is directed to contraceptive vaccines comprising a carrier protein or fragment thereof in peptide linkage with a reproduction related polypeptide, protein or fragment thereof, and to DNAs encoding the chimeric proteins. The invention also in... | 04/04/2000 |
| 6043094 | Therapeutic liposome composition and method A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic ... | 03/28/2000 |
| 6042833 | Cellular internalization of pIgR stalk and associated ligands Compositions and methods for specific binding to the stalk of a polymeric immunoglobulin receptor (pIgR) of a cell with the proviso that the ligand does not substantially bind to secretory component of pIgR under physiological conditions. The ligand may b... | 03/28/2000 |
| 6039948 | Method for treatment of antigenically modified polypeptides Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protei... | 03/21/2000 |
| 6033668 | Chimeric protein which confers protection against parainfluenza virus and respiratory syncytial virus Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. Th... | 03/07/2000 |
| 6030626 | Method for preparing the fimbrin protein of Haemophilus influenzae It has been discovered that a vaccine comprised of fimbrin, a filamentous protein derived from the bacterial surface appendages of non-typable Haemophilus influenzae is useful in studying, preventing or reducing the severity of, otitis media. The gene seq... | 02/29/2000 |
| 6025163 | DNA coding for a peptide of a papilloma virus main capside protein and use thereof This invention relates to a DNA encoding a peptide of a papilloma virus major capsid protein. Furthermore, this invention deals with a papilloma virus genome containing such a DNA. In addition, this invention concerns proteins encoded by the papilloma vir... | 02/15/2000 |
| 6025325 | Pegylated obese (ob) protein compositions Polyethylene and polypropylene protein conjugates which modulate body weight of animals and humans for the treatment, prevention and control of obesity and associated diseases or conditions, and the recombinant expression of these biologically active prot... | 02/15/2000 |
| 6025324 | Pegylated obese (ob) protein compositions Polyethylene and polypropylene protein conjugates which modulate body weight of ani is and humans for the treatment, prevention and control obesity and associated diseases or conditions, and the recombinant expression of these biologically active proteins... | 02/15/2000 |
| 6025141 | Immunofluorescence assay for the detection of antibodies using recombinant antigens in insoluble form The present invention relates to the use of insoluble forms of recombinant proteins in a flow cytometric immunofluorescence assay for the detection of given antibodies.... | 02/15/2000 |
| 6022544 | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry The invention features a method for reducing an undesired antibody response in a mammal by administering to the mammal a non-immunogenic construct which is free of high molecular weight immunostimulatory molecules. The construct which contains at least tw... | 02/08/2000 |
| 6017539 | Chimeric protein which confers protection against parainfluenza virus and respiratory syncytial virus Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. Th... | 01/25/2000 |
| 6017540 | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases. The methods of the invention comprise administering a compos... | 01/25/2000 |
| 6015567 | HER2 extracellular domain A method of treating a human patient via active immunotherapy comprising administrating an effective amount of extracellular portion of human HER2 receptor to the patient wherein the method provokes a cell-mediated immune response to HER2 receptor in the ... | 01/18/2000 |
| 6013770 | Chimeric contraceptive vaccines The invention is directed to contraceptive vaccines comprising a carrier protein or fragment thereof in peptide linkage with a reproduction related polypeptide, protein or fragment thereof, and to DNAs encoding the chimeric proteins. The invention also in... | 01/11/2000 |
| 6013262 | Recombinant papilloma virus L1 This invention relates to a recombinant papilloma virus L1 protein which can elicit an immune response which recognises papilloma virus VLP including L1 protein and can form extracellularly a multimeric structure or VLP wherein the multimeric structure co... | 01/11/2000 |
| 6007818 | Oligosaccharide derived from an antigenic polysaccharide obtained from a pathogenic agent An oligoside derived from an antigen polyoside obtained from a pathogenic agent, a method for its preparation, and its use particularly as a vaccinal agent. The oligoside is prepared by oxidation-reduction depolymerisation reaction.... | 12/28/1999 |
| 6001360 | Method and compositions for early detection and treatment of insulin dependent diabetes mellitus Compositions and methods for the treatment or prevention of insulin dependent diabetes (IDD) are provided. Specifically, glutamic acid decarboxylase (GAD) proteins, and fragments. thereof, can be administered to an animal in order to the reduce the severi... | 12/14/1999 |
| 6001364 | Hetero-polyoxime compounds and their preparation by parallel assembly Provided by this invention are defined compositions of hetero-polyoximes of defined structure comprising a baseplate structure having a plurality of oxime bonds, wherein each oxime bond links a specifically active molecule to the baseplate. Also provided ... | 12/14/1999 |
| 5998368 | Derivatives of structurally modified VIP and pharmaceutical compositions containing them There are provided novel compounds for the treatment of male impotence. The compounds are derived from vasoactive intestinal peptide (VIP) in which the natural amino acid sequence is modified by replacement of any of the 5, 17 and 19 amino acid residues b... | 12/07/1999 |
| 5998154 | Somatostatin receptor peptide antigens and antibodies Peptide antigens derived from the carboxy terminus of somatostatin receptors and antibodies produced using the peptide antigens. The anti-somatostatin receptor antibodies are specific for a receptor subtype and are useful in characterizing receptor subtyp... | 12/07/1999 |
| 5998588 | Interactive molecular conjugates The combination of the capabilities of stimuli-responsive components such as polymers and interactive molecules to form site-specific conjugates which are useful in a variety of assays, separations, processing, and other uses is disclosed. The polymer cha... | 12/07/1999 |
