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| Number | Title | Issue Date |
| 6231864 | Strategically modified hepatitis B core proteins and their derivatives A strategically modified hepatitis B core protein is described, where an insert is provided, preferably in an immunodominant region of the nucleocapsid protein, containing a chemically reactive amino acid residue. The modified hepatitis B core protein or ... | 05/15/2001 |
| 6231862 | Purified new epididymal forward motility protein and a process for the isolation of the said epididymal forward motility protein useful as a fertility prometer/blocker The subject invention relates to a new forward motility protein isolated from goat epididymal plasma and a process for the isolation of the said epididymal forward motility protein useful as a fertility promoter/blocker comprising subjecting goat epididym... | 05/15/2001 |
| 6228372 | Compounds and methods for the detection and prevention of T. cruzi infection Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays f... | 05/08/2001 |
| 6225073 | Immunoassay for mycophenolic acid The present invention provides antibodies useful in assays for mycophenolic acid (MPA). These antibodies bind MPA and are able to distinguish MPA from its esters, such as morpholinoethyl E-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofurany... | 05/01/2001 |
| 6224880 | Immunization against Streptococcus pneumoniae using conjugated and unconjugated pneumoccocal polysaccharide vaccines A method of immunizing against disease caused by Streptococcus pneumoniae is provided in which children are immunized at age 2 and again at age 4 months with a conjugated pneumococcal polysaccharide vaccine. These immunizations are followed by an immuniza... | 05/01/2001 |
| 6217873 | Polyoxime compounds and their preparation Provided by this invention are essentially homogeneous, defined compositions of matter and hetero-polyoximes of defined structure comprising a baseplate structure having a plurality of oxime bonds, wherein each oxime bond links a specifically active molec... | 04/17/2001 |
| 6214346 | GidB from Streptococcus pneumoniae The invention provides gidB polypeptides and DNA (RNA) encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.... | 04/10/2001 |
| 6210908 | Activated peptides and conjugates Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.... | 04/03/2001 |
| 6210674 | GreA from Staphylococcus aureus The invention provides greA polypeptides and DNA (RNA) encoding greA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing greA polypeptides to screen for antibacterial compounds.... | 04/03/2001 |
| 6210673 | gidB from Staphylococcus aureus The invention provides gidB polypeptides and DNA (RNA) encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.... | 04/03/2001 |
| 6207802 | Stem cell factor and compositions Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.... | 03/27/2001 |
| 6207396 | Immunoassay reagents and methods for determination of LSD and LSD metabolites To improve the detection of LSD in biological samples, antibodies are raised to LSD conjugated to a protein carrier, preferably through the indole ring. Selected antibodies are matched with an immunoassay reagent in which the LSD is conjugated in the same... | 03/27/2001 |
| 6207160 | aPL immunoreactive peptides, conjugates thereof and methods of treatment for aPL antibody-mediated pathologies aPL analogs that (a) bind specifically to B cells to which an aPL epitope binds and are disclosed. Optimized analogs lack T cell epitope(s) are useful as conjugates for treating aPL antibody-mediated diseases. Methods of preparing and identifying said ana... | 03/27/2001 |
| 6207159 | Methods for the diagnosis and treatment of insulin-dependent diabetes mellitus Methods for detecting the status of an insulin-dependent diabetes mellitus (IDDM)-associated autoimmune response in a mammal are provided. Specifically, the ratio of the frequency of T helper 1 cells to T helper 2 cells specific for a pancreatic ଲ-c... | 03/27/2001 |
| 6201110 | Polypeptide with reduced respiratory allergenicity The invention relates to modified polypeptides with reduced respiratory allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer with a molecular weight (Mr) in the range of 1... | 03/13/2001 |
| 6197301 | Compositions and methods for the prevention and diagnosis of Lyme disease Methods and compositions for the prevention and diagnosis of Lyme disease. OspA and OspB polypeptides and serotypic variants thereof, which elicit in a treated animal the formation of an immune response which is effective to treat or protect against Lyme ... | 03/06/2001 |
| 6190916 | Troponin I composition The present invention relates to stable compositions useful as primary standards and calibrators and controls comprising a cardiac troponin I (cTnI) such as native, recombinant, addition and deletion forms thereof, whether or not complexed with other trop... | 02/20/2001 |
| 6190723 | Neutralization of food allergens by thioredoxin Thioredoxin, a small dithiol protein, is a specific reductant for major allergenic proteins present in widely used foods from animal and plant sources. All targeted allergenic proteins contain disulfide (S--S) bonds that are reduced to the sulfhydryl (SH)... | 02/20/2001 |
| 6190659 | Bacterial plasmin binding protein and methods of use thereof The present invention describes a novel polypeptide, and methods of its use in effective thrombolytic therapy in the treatment of coronary and pulmonary thrombosis. Its use is also disclosed in vaccines to abrogate a streptococcal infection. Pharmaceutica... | 02/20/2001 |
| 6183754 | Anticytomegalovirus monoclonal antibodies and processes for the in vitro diagnosis of infections by human cytomegaloviruses and a protein-kinase inducible by cytomegaloviruses and recognizable by aforesaid monoclonal antibodies The invention relates to a process for in vitro diagnosis of an infection by human cytomegaloviruses. The process consists of contacting cells, possibly carrying the infection, with a monoclonal antibody reacting with a polypeptide of molecular weight 68,... | 02/06/2001 |
| 6183745 | Subunit papilloma virus vaccine and peptides for use therein The invention relates to a subunit papillomavirus vaccine which is protective against anogenital human Papillomavirus (HPV) infection. Peptides are also provided, which constitute an antigenic component of the vaccine. The peptide includes the sequence DR... | 02/06/2001 |
| 6180763 | Cyclin D binding factor, and uses thereof The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in ... | 01/30/2001 |
| 6180096 | Formulations for protection of peg-interferon alpha conjugates The present invention provides formulations that prevent loss and damage of PEG-interferon alpha conjugates during and following lyophilization. The formulations of the present invention protect PEG-interferon alpha conjugates from loss and degradation du... | 01/30/2001 |
| 6177085 | Generation of immune response using immunogenic conjugate of molecules Immunogenic conjugate molecules comprising at least a portion of a capsular polysaccharide of a Streptococcus strain linked to at least a portion of an outer membrane protein of a Haemophilus strain are provided in which the immunogenicity of the capsular... | 01/23/2001 |
| 6174530 | Homogeneous polyoxime compositions and their preparation by parallel assembly Provided by this invention are essentially homogeneous, defined compositions of matter comprising a baseplate structure having a plurality of oxime bonds, wherein each oxime bond links a specifically active molecule to the baseplate. Also provided are nov... | 01/16/2001 |
| 6171598 | GTP cyclohydrolase II (RIBA) The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.... | 01/09/2001 |
| 6168786 | Chimeric immunogens Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. Th... | 01/02/2001 |
| 6166187 | Method of concentrating prion proteins in blood samples A sample is prepared from blood in a manner which makes it possible to further analyze proteins in the sample, e.g. to detect prions in the sample. Blood is extracted, allowed to clot and subjected to separation processing (e.g. centrifugation) to obtain ... | 12/26/2000 |
| 6162436 | Compositions and methods using complexes of heat shock protein 90 and antigenic molecules for the treatment and prevention of neoplastic diseases The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases. The methods of the invention comprise administering a compos... | 12/19/2000 |
| 6162434 | Cytomodulating peptide for inhibiting lymphocyte activity Novel oligopeptides comprising a sequence associated with HLA-B 댑 domain, but comprising a tyrosine-tyrosine-tryptophan triad are provided for use in inhibiting cytotoxic activity of CTLs and natural killer cells. By combining the subjec... | 12/19/2000 |
| 6150327 | Conjugate of an active agent, a polyether and possibly a native protein regarded as acceptable by the body This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation for treating and/or diagnosing inflammatory, infectious and/... | 11/21/2000 |
| 6149911 | Method for enhancing the immunogenicity of an immunogenic compound or hapten, and use thereof for preparing vaccines The present invention relates to a process for improving the immunogenicity of an immunogen, an antigen or a hapten, when it is administered to a host, independently of the mode of administration, characterized in that the said antigen or hapten is couple... | 11/21/2000 |
| 6146633 | Method for treatment of antigenically modified polypeptides Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protei... | 11/14/2000 |
| 6143493 | HCMV-specific peptides, agents therefor and the use thereof The invention relates to peptides for the immunochemical determination of human cytomegalovirus (HCMV)-specific antibodies and HCMV antigens, and to agents suitable for this method and to the use thereof.... | 11/07/2000 |
| 6140137 | Conjugates and specific immunoassays for the methadone metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine Novel chemical analogs of the methadone metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) are disclosed. The derivatives can be used for formation of EDDP-protein conjugates. The conjugates can be used in turn to raise antibodies reactiv... | 10/31/2000 |
| 6133433 | Method for detection and prevention of human cytomegalovirus infection A DNA probe has been isolated which is capable of hybridizing to an oligonucleotide sequence coding for a polypeptide from a major 64 Kilodalton protein of human cytomegalovirus (HCMVgp64). The probe has a sequence of at least seventeen (17) to as many as... | 10/17/2000 |
| 6133429 | Chromophores useful for the preparation of novel tandem conjugates The inventors herein disclose new heterobifunctional chromophores that are capable of coupling with two distinct moieties. One moiety may be either a signal-enhancing agent or a blocking agent. The second moiety may be one member of a specific binding pai... | 10/17/2000 |
| 6132723 | Immunogenic oligosaccharide compositions The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier protein, wherein the resultant conjugate has been shown to contai... | 10/17/2000 |
| 6132721 | Non-Toxic immunogens derived from a retroviral regulatory protein, antibodies, preparation method therefor, and pharmaceutical compositions containing same A non-toxic immunogenic compound, which may be administered to humans, is derived from an HIV-1, HIV-2, HTLV-1 or HTLV-2 viral regulatory protein by chemical processing using a coupling agent such as an aldehyde, or from a carrier protein activated by pre... | 10/17/2000 |
| 6129921 | Viral ribonucleocapsid as an immunological enhancer Methods of enhancing an antigen-induced immune response through use of a ribonucleocapsid complex are provided. Composition containing a ribonucleocapsid complex and an antigen which are capable of enhancing the immune response to the antigen are also pro... | 10/10/2000 |
