Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 4493793 | Soluble immunoassay reagent comprising lectin covalently bonded to reactive component A lectin is covalently bonded to an immunological conjugate such as an antibody-antigen or its equivalent. Then, the lectin-conjugate is isolated from the reaction product mixture by one of a number of alternative techniques involving one or more of the f... | 01/15/1985 |
| 4481136 | Alkyl substituted fluorescent compounds and conjugates Fluorescent antigen conjugates are provided comprising antigens covalantly bonded to at least one 2,7-dialiphatic substituted-9-phenyl-6-hydroxy-3H-xanthen-3-one, wherein the 1- and 8-positions are unsubstituted. Also provided are novel fluorescent c... | 11/06/1984 |
| 4473495 | Albumin-solubilized hymenoptera venoms for vaccine use Hymenoptera venoms for vaccine immunization of human subjects are prepared by copolymerizing the venom with albumin using glutaraldehyde as the polymerizing reagent. Sufficient albumin is used to produce water-soluble copolymers of high molecular weight. ... | 09/25/1984 |
| 4456553 | Vitamin D3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom The present invention relates to novel vitamin D3 derivatives which have a carboxyl group or its ester group at the 22-position, processes for the preparation thereof, and antigens, which comprise said vitamin D3 derivative and an im... | 06/26/1984 |
| 4436727 | Refined detoxified endotoxin product A refined detoxified endotoxin (RDE) product is disclosed which, when combined with cell wall skeleton (CWS), results in a composition useful for the treatment of cancerous tumors. Methods of making RDE as well as methods of using the combination of RDE a... | 03/13/1984 |
| 4430318 | Immunoassay utilizing 125 I Protein A An improved method for the preparation of 125 I-labelled Protein A (125 I PA) of high specific and functional activity. 125 I PA has been used in combination with purified rabbit IgG (immunoglobulin G) bound to a solid sup... | 02/07/1984 |
| 4428941 | Nucleotidic sequence coding the surface antigen of the hepatitis B virus, vector containing said nucleotidic sequence, process allowing the obtention thereof and antigen obtained thereby Nucleic acid of reduced size and vector containing said nucleotidic sequence of which DNA codes an immunogenic peptidic sequence capable of inducing the generation of antibodies to the virus of viral hepatitis B. It comprises totally or partly the sequenc... | 01/31/1984 |
| 4397779 | Preparation of xanthine tracers Compounds useful as tracers in the radioimmunoassay of xanthine derivatives such as theophylline and pharmacologically related drugs: ##STR1## wherein at least one R1, R3, R7 or R8 is a radioiodinated radic... | 08/09/1983 |
| 4351761 | Purified antigen to test for Neisseria gonorrhoeae antibodies Serological method for determining the presence of Neisseria gonorrhoeae antibodies in human sera and products utilized in such testing.... | 09/28/1982 |
| 4344938 | Agent for the treatment of allergic reactions What are disclosed are a method for the prophylaxis and therapy of allergic reactions and an agent therefor, said agent containing immunoglobulins of class IgG or fragments thereof which have been immunologically modified in their Fc part.... | 08/17/1982 |
| 4314993 | Immunogenic E. coli ST enterotoxin derivatives and compositions containing them E. coli heat stable (ST) enterotoxin derivatives are prepared by reaction of E. coli ST enterotoxin with crosslinking agents for proteins. The so-obtained crosslinked ST enterotoxins show immunogenic activity; they are valuable prophylactic agent for prot... | 02/09/1982 |
| 4313871 | Antigen for early pregnancy test and contraceptive vaccine Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the ଲ-subunit of human chorionic gonadotropin which has been modified by ... | 02/02/1982 |
| 4310455 | Antigen for early pregnancy test and contraceptive vaccine Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the ଲ-subunit of human chorionic gonadotropin which has been modified by ... | 01/12/1982 |
| 4290944 | Antigenic peptide compound The novel antigenic peptide compound of this invention comprises a sequence of seven amino acids, namely, methionine-glutamine-lysine-aspartic acid-leucine-glutamic acid-leucine, all of the amino acids being in their L-forms. The compound has utility in v... | 09/22/1981 |
| 4275000 | Peptide macromolecular complexes Macromolecular complexes which comprise a first and a second macromolecular moiety joined by a link derived from a linking agent having two or more reactive groups, one of these reactive groups being an activated acyl group, an isocyanate, an isothiocyana... | 06/23/1981 |
| 4273865 | Insolubilized biochemical materials Stabilized, insolubilized biochemical materials are prepared by covalently bonding a biochemical material such as an antigen, antibody, hormone, or enzyme to a silicic acid heteropolycondensate layer which is applied to a mechanically stable support. The ... | 06/16/1981 |
| 4268435 | Chorionic gonadotropin derived antigen for early pregnancy test and contraceptive vaccine Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the ଲ-subunit of human chorionic gonadotropin which has been modified by ... | 05/19/1981 |
| 4264766 | Immunological diagnostic reagents A water-insoluble immunological reagent being formed from discrete particles of a latex carrier to which a water-soluble polyhydroxy compound is covalently bound having condensed thereto through a covalent link an immunologically active material; process ... | 04/28/1981 |
| 4256629 | Antigen for early pregnancy test and contraceptive vaccine Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the ଲ-subunit of human chorionic gonadotropin which has been modified by ... | 03/17/1981 |
| 4237044 | Antibodies against creatinekinase-M8 and process for the production thereof Antibodies against the M subunit of CK isoenzymes having a molecular weight between about 130,000 and 210,000, and inhibiting the enzymatic activity of the M subunit, optionally also in the presence of CK substrates, without inactivating the enzymatic act... | 12/02/1980 |
| 4220722 | Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby Methods and compositions are provided for conjugating a wide variety of compounds, particularly polyfunctional compounds, having a mercapto group, either naturally present or synthetically introduced, to a polyamino compound, particularly a polypeptide (i... | 09/02/1980 |
| 4219468 | Tritiated ଲ-endorphin Tritiated ଲ-endorphin is prepared by catalytic tritiation of a [3,5-diido-Tyr]-ଲ-endorphin which in turn is readily obtained by solid phase synthesis. The tritiated ଲ-endorphin preferably [3,5-diiodo-Tyr27 ]-ଲ-endorphin ... | 08/26/1980 |
| 4192799 | Conjugates formed by reacting a prostaglandin mimic compound with a carrier molecule A method for the radioimmunoassay of PGE1 -type and PGE2 -type compounds and PGX is disclosed which utilizes antibodies formed against a prostaglandin mimic. Conjugates are disclosed which are formed by attaching a prostaglandin mimi... | 03/11/1980 |
| 4180499 | Carcinoembryonic antigens Antigens associated with carcinomas and adenocarcinomas as well as methods for isolating, identifying and detecting them are disclosed.... | 12/25/1979 |
| 4172827 | Method for concentration and purification of antigens and antibodies In carrying out a purification and/or concentration step of antigens or antibodies, a substrate is immersed in a first aqueous medium containing a specifically reacting antigen to coat said substrate with a monomolecular layer of said specifically reactin... | 10/30/1979 |
| 4146603 | Tumor specific glycoproteins and method for detecting tumorigenic cancers A new class of glycoproteins has been found to be produced by human cancer cells and is not produced by normal cells and said glycoprotein is present in the sera of cancer patients. This tumor specific glycoprotein can be characterized by its isoelectric ... | 03/27/1979 |
| 4123427 | Method for the purification of mycobacterial protein antigens and resulting product The subject invention is directed in general to a method of preparing an antigen using immunoabsorbent affinity chromotography particularly in cases where an antigen is used for the recognition and measurement of hypersensitivity and where antigenic speci... | 10/31/1978 |
| 4113712 | HBsAG Particle composed of single polypeptide subunits and the preparation procedure Hepatitis B surface antigen particles composed of single polypeptide subunits having a molecular weight of about 55,000 dalton are prepared by heating hepatitis B surface antigen in isotonic sodium chloride solution at about neutral pH containing a surfac... | 09/12/1978 |
| 4096138 | Immunological test procedure A method is described for conducting immunological tests in which a hapten or antigen is coupled to a soluble macromolecule of natural origin which complex is then aggregated into a particulate suspension which can then be used in an agglutination or indi... | 06/20/1978 |
| 4069105 | Lidocaine antigens and antibodies Derivatives of anesthetics involving anilides, lidocaine being illustrative, are provided, having an annular amino group. A difunctional linking group is provided, which provides a link to the annular amino group and an antigen, with the resulting conjuga... | 01/17/1978 |
| 4058511 | Tegretol antigens and antibodies Derivatives of dibenz[b,f]azepine drugs are provided for preparation of antigens and antibodies, the antibodies finding use in immunoassays for the dibenz[b,f]azepine drugs. Specifically, N-oxoaliphatic substituted carbamoyl dibenz[b,f]azepine compounds a... | 11/15/1977 |
| 3994870 | Purification of hepatitis B surface antigen After a polyethylene glycol purification procedure, virus particles, viral components and virus associated particles having concanavalin A binding sites are further purified by subjecting such particles or components to affinity chromatography utilizing i... | 11/30/1976 |
| 3975342 | Tyrosyl-class antigenic conjugates, their preparation and antibodies raised thereto Tyrosyl, thyronine, and histidyl compounds of the formulas: ##SPC1## Where R' is selected from the group consisting of --OH and --NHPp and R" is selected from the class consisting of --H and --COPp, where Pp is a polypepti... | 08/17/1976 |
| 3963691 | Synthetic antigens of luteinizing hormone releasing hormone Synthetic antigens related to luteinizing hormone-releasing hormone (hereinafter designated LH-RH) having the amino acid composition, pyroglutamyl-histidyl-tryptophanylseryl-tyrosyl-glycyl-leucyl-arginyl-prol yl-glycyl-poly-L-lysine (hereinafter designated... | 06/15/1976 |
| 3956258 | Carcinoembryonic antigens Antigens associated with carcinomas and adenocarcinomas as well as methods for isolating, identifying and detecting them are disclosed.... | 05/11/1976 |
| 3951937 | Large scale purification of hepatitis type B antigen using polyethylene glycol Highly purified type B hepatitis antigen (HB Ag) is produced from fluid blood material containing such antigen by subjecting blood material containing naturally occurring HB Ag to a double precipitation with polyethylene glycol. In each precipitation, the... | 04/20/1976 |
