Bizarre Patents
Behavior Modification Wristwatch
A wristwatch including a watch band and a watch body having an octagon shaped perimeter and being red in color and having the word STOP thereon to resemble a stop sign.
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| Number | Title | Issue Date |
| 8377641 | Fluorescence quenching azo dyes, their methods of preparation and use Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition. ... | 02/19/2013 |
| 8329876 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of spec... | 12/11/2012 |
| 8188241 | Immobilized proteins and methods and uses thereof The invention relates to the field of covalently attaching proteins to a substrate, particularly to methods of immobilizing proteins by posttranslationally modifying a cysteine residue of said protein through the addition of functional groups. The invention also rel... | 05/29/2012 |
| 8138155 | Compounds for intracellular delivery of therapeutic moieties to nerve cells A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface r... | 03/20/2012 |
| 8101729 | Pegylated amino acid derivatives and the process to synthesize the same The present invention is a series of novel pegylated amino acid derivatives containing branched polyethylene glycols, which are either the same or different molecular weights. Additionally, the N-pegylated lysine derivatives are enantiomerically pure. Also disclosed... | 01/24/2012 |
| 8093365 | Biocompatible materials containing stable complexes method of TSG-6 and hyaluronan and method of using same The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable complexes of TNF-stimulated gene protein (TSG-6) and hyaluronan. ... | 01/10/2012 |
| 8039600 | Rapamycin assay Monoclonal antibodies to rapamycin and to 40-O-alkylated derivatives of rapamycin are provided, together with novel haptens, immunogenic conjugates, and processes for making them and assay kits for using them. ... | 10/18/2011 |
| 8017739 | Conjugates of hydroxyalkyl starch and a protein Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the c... | 09/13/2011 |
| 7985845 | Protein formulation The present invention relates to a new and improved low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, intended to be used as therapeutic, as propylacetic and/or as cosmeti... | 07/26/2011 |
| 7982018 | Modified corticotropin releasing factor peptides and uses thereof The present invention relates to compounds comprising modified corticotrophin releasing factor peptide and specifically urocortin and urocortin-related peptides, modified derivatives thereof, and conjugates of such modified peptides and derivatives to serum componen... | 07/19/2011 |
| 7906627 | Chimeric human sweet-umami and umami-sweet taste receptors This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably a... | 03/15/2011 |
| 7906628 | Targeting proteins to deliver therapeutic or diagnostic reagents The present invention is directed to compositions comprising an angiogenesis inhibitor coupled to a therapeutic or diagnostic agent. In a specific embodiment, the composition is a fusion gene or fusion gene product encoding the angiogenesis inhibitor coupled to a th... | 03/15/2011 |
| 7902341 | Methods and compositions for modulating somatolactogenic functions Compositions containing cyclophilin B, mutants of cyclophilin B or inhibitors of cyclophilin B and methods of using these compositions to modulate somatolactogenic function are provided. ... | 03/08/2011 |
| 7893221 | Protein folding The present invention concerns a method for folding a Transforming Growth Factor Beta, or a functional analogue thereof, into a dimeric, biologically active form. The method involves adding solubilized, unfolded monomeric growth factor to a solution containing 2-(cy... | 02/22/2011 |
| 7884194 | Soluble HER2 and HER3 splice variant proteins, splice-switching oligonucleotides, and their use in the treatment of disease Soluble epidermal growth factor receptors 2 and 3 (HER2 and HER3) splice variant proteins with HER2 and HER3 antagonist activity and anti-proliferative properties, as well as the corresponding nucleic acids, are provided for treatment of proliferative diseases, in p... | 02/08/2011 |
| 7812137 | , the receptor for leptin, nucleic acids encoding the receptor, and uses thereof The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and char... | 10/12/2010 |
| 7799902 | Receptor coupling agents and compositions thereof Receptor coupling agents, including multivalent constructs comprising anti-TNF receptor binding moieties, for treating cancer and inhibiting tumor volume in a subject are disclosed. ... | 09/21/2010 |
| 7795404 | Human soluble notch receptor ligands Novel soluble Notch receptor ligands and polynucleotides encoding such are disclosed, as well as methods for producing and using these novel nucleotides and polypeptides. These novel polypeptides or agonists or antagonists thereto modulate cellular activity, regulat... | 09/14/2010 |
| 7759468 | Bioactive peptide-based probes A method for preparing a site-specific peptide probe, wherein the peptide is specific to a receptor, includes modifying a marker to include a tether molecule and covalently binding the tether molecule to the peptide. The present invention also provides a labeled pro... | 07/20/2010 |
| 7741454 | Biological low-molecular-weight derivatives The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to li... | 06/22/2010 |
| 7741453 | Long lasting fusion peptide inhibitors for HIV infection The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), r... | 06/22/2010 |
| 7732580 | Compositions for eliciting an immune response against subspecies Provided are compositions and methods for stimulating an immune response against Mycobacterium avium subspecies paratuberculosis (MAP). The compositions include a recombinant polypeptide that contains from its N-terminus to C-terminus a C-terminal frag... | 06/08/2010 |
| 7714114 | Conjugates of an EPO moiety and a polymer Conjugates of an EPO moiety and one or more non-peptidic water-soluble polymers are provided. Typically, the non-peptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of ma... | 05/11/2010 |
| 7667008 | Fibroblast growth factor-like polypeptides and variants thereof The present invention provides novel Fibroblast Growth Factor-like (FGF-like) fusion polypeptides. ... | 02/23/2010 |
| 7662933 | N-terminally chemically modified protein compositions and methods Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modi... | 02/16/2010 |
| 7655766 | Compositions comprising positional isomers of PEGylated G-CSF A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, compr... | 02/02/2010 |
| 7626003 | Genetically engineered cDNA of rat gene and an improved protein The present invention provides an genetically engineered cDNA of the rat bcl-x gene, which has at least one substitution selected from the substitutions that change residues 22 Tyr to Phe, residues 26 Gln to Asn and residues 165 Arg to Lys, in the coding region of r... | 12/01/2009 |
| 7592432 | Polypeptide cleavage process The invention provides a palladium-promoted hydrolytic polypeptide cleavage process which selectively cleaves the polypeptide at a Cys-His cleavage site comprising solubilizing the polypeptide in a reaction mixture comprised of a palladium promoter dissolved in a hi... | 09/22/2009 |
| 7531644 | IL-6 receptor•IL-6 direct fusion protein The present invention intends to provide an IL-6R•IL-6 fusion protein and the like in which IL-6R and IL-6 are directly linked without a linker. The IL-6 receptor•IL-6 fusion protein of the present invention has a structure in which one amino acid residue... | 05/12/2009 |
| 7514540 | Functionalized carrier material containing covalently bound biomolecule via a linker The invention concerns a method for immobilizing biomolecules on a polymeric surface of a carrier material and a carrier material functionalized with a biomolecule according to the general formulas (IV) and (V), which can be produced according to the method, wherein... | 04/07/2009 |
| 7511124 | Compositions comprising phosphatidylethanolamine-binding peptides linked to anti-viral agents Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Al... | 03/31/2009 |
| 7501499 | Modified hemoglobin and methods of making same The present invention provides a hemoglobin molecule (Hb) having six ± one PEG chains, wherein two of said PEG chains are bound to Cys-93 (β) of Hb, and the remaining PEG chains are bound to thiol groups introduced on ε-NH2 of Hb. The present invention... | 03/10/2009 |
| 7488809 | Chimeric polypeptide comprising the fragment B of shiga toxin and peptides of therapeutic interest The invention pertains to methods for using chimeric polypeptides of the formula: B—X wherein B represents the B fragment of Shiga toxin or a functional equivalent thereof, and X represents one or more polypeptides of therapeutic significance. ... | 02/10/2009 |
| 7476725 | Preparation of macromolecular conjugates by four-component condensation reaction Polymer-biomolecule conjugates are prepared, generally in a site-specific or -selective manner, by a four-component condensation reaction. The method may be used to prepare conjugates having two polymer molecules attached at a single site on a biomolecule. The conju... | 01/13/2009 |
| 7470777 | Compositions and methods related to modified retroviral vectors for restricted, site specific integration Embodiments of the invention include compositions comprising and methods utilizing a retroviral integrase complex comprising a recombinant integrase having a domain comprising a non-native protein binding site, and a DNA binding protein comprising a DNA binding doma... | 12/30/2008 |
| 7449559 | Truncated EGF receptor The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TGF1. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which invo... | 11/11/2008 |
| 7449557 | Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy The present invention relates to complexes of alpha (2) macroglobulin associated with antigenic molecules for use in immunotherapy. The invention relates to methods for using such compositions in the diagnosis and treatment of immune disorders, proliferative disorde... | 11/11/2008 |
| 7449558 | Site-specific labelling of proteins An in vivo method for labelling a protein having an N-terminal cysteine is disclosed. A probe comprising a thioester group and a detectable label is introduced into a cell expressing the N-terminal cysteine protein, allowing for the N-terminal cysteine to cleave the... | 11/11/2008 |
| 7442371 | Recombinant human albumin-erythropoietin fusion proteins with long-lasting biological effects Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide h... | 10/28/2008 |
| 7439328 | Tctex-1-related polypeptides A polypeptide may include an amino acid sequence having at least about 95% identity to the amino acid sequence of SEQ ID NO: 42, wherein a residue at position 94 of the polypeptide is an amino acid other than threonine or wherein a residue at position 82 of the poly... | 10/21/2008 |
