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| Number | Title | Issue Date |
| 6656469 | Nicotine immunogen A 5- or 6-nicotinyl-linker-carrier protein compound and immunogen having formula (a) wherein X is --NH--CO-- or NH-- or --C.ident.C-- or --C.dbd.C-- or CH2 --; Y is --(CH2)k -- or --(CH2)m --C6 | 12/02/2003 |
| 6407203 | Cytochrome c and polynucleotides encoding cytochrome c This invention is directed to cytochrome c551 polypeptides and polynucleotides encoding the polypeptides.... | 06/18/2002 |
| 6022524 | Process for the conjugation of chelants with molecules containing amino groups A process for the preparation of macromolecular chelants characterized by a high content in chelant groups per macromolecule.... | 02/08/2000 |
| 6013623 | Use of heme-peptides to prevent or retard disease associated with oxidative stress This invention provides a method for treating a condition associated with oxidative stress in a subject which comprises administering to the subject an amount of a heme-peptide effective to treat the condition associated with oxidative stress in the subje... | 01/11/2000 |
| 5883137 | Compositions and methods for the control of smoking Compositions and methods for the control of smoking are described. The compositions according to the invention comprise: (a) a xanthine oxidase inhibitor; (b) a cytochrome P450 inhibitor; (c) a sugar; (d) a source of phosphate; and, optionally, (e) one or... | 03/16/1999 |
| 5830667 | Human P450 IID6 cytochrome-derived peptide fragments, anti-peptide fragment antibodies, applications thereof in the diagnosis of autoimmune hepatitis Human P450 IID6 cytochrome-derived peptide fragments, anti peptide anti fragment antibodies and applications thereof in the diagnosis of autoimmune hepatitis and more especially in the differential diagnosis between autoimmune hepatitis and other chronic ... | 11/03/1998 |
| 5547868 | Cholesterol disposal fusion enzymes Fusion enzymes having multiple segments of different biological activity including one segment having P450scc activity and at least one segment having electron-transfer activity for transferring electrons to P450scc are described along with genetic constr... | 08/20/1996 |
| 5466589 | Coated substrates employing oriented layers of mutant heme proteins and methods of making and using same The present invention is directed to coated substrates having a coating of biological macromolecules, preferably proteins, which are capable of being immobilized on a substrate surface and have a marker. These proteins usually are mutant proteins obtained... | 11/14/1995 |
| 5436159 | Chimeric fused monooxygenase of cytochrome P-450 and NADPH-cytochrome P-450 reductase The present invention provides a chimeric enzyme gene which codes for a monooxygenase having both monooxygenase activity derived from cytochrome P-450 and reducing power supplying ability derived from NADPH-cytochrome P-450 reductase. The present inventio... | 07/25/1995 |
| 5344777 | Structural gene of membrane-bound alcohol dehydrogenase complex, plasmid containing the same and transformed acetic acid bacteria There is provided a structural gene of membrane-bound alcohol dehydrogenase complex having a molecular size of about 7.0 kilo base which is derived from a microorganism belonging to the genus Acetobacter represented by Acetobacter altoacetigenes and shown... | 09/06/1994 |
| 5342763 | Method for producing polypeptide via bacterial fermentation A process for producing a polypeptide of interest from fermentation of bacterial host cells comprising nucleic acid encoding the polypeptide is provided. In this method, the host cells employed have an inactivated electron transport chain. Further provide... | 08/30/1994 |
| 5272257 | Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use A method for preparing phycobiliprotein/amine-reactive dye conjugates is disclosed in which the conjugates so prepared overcome the energy transfer/fluorescent quenching dilemma encountered in the use of prior art conjugates. A phycobiliprotein, for examp... | 12/21/1993 |
| 5179013 | Cytochrome P-450 enzymes Novel cytochrome P-450sca-1, P-450sca-2 and P-450sca-3 enzymes are produced by cultivation of Streptomyces carbophilus SANK 62585, and are suitable for use in hydroxylation processes.... | 01/12/1993 |
| 5114852 | Chimeric fused monooxygenase of cytochrome P-450 and NADPH-cytochrome P-450 reductase The present invention provides a chimeric enzyme gene which codes for a monooxygenase having both monooxygenase activity derived from cytochrome P-450 and reducing power supplying ability derived from NADPH-cytochrome P-450 reductase. The present inventio... | 05/19/1992 |
| 4996142 | Non-radioactive nucleic acid hybridization probes The invention relates to an adduct of a basic macromoleculer and biotin having the general formula: ##STR1## in which MM is the residue of a basic macromolecule formed by substituting the H-atom of one or more primary amino groups; alk represents an ... | 02/26/1991 |
| 4532212 | Process for the dissolution of peptides in non-aqueous and mixed non-aqueous/aqueous systems Process for the dissolution of peptides and proteins in non-aqueous and mixed non-aqueous/aqueous solvents using crown ethers, solutions thereby obtained and their use. Purification of proteins and/or enzymes, modification and optimisation of the activity... | 07/30/1985 |
| 4507233 | Colored molecular weight marker Colored proteins having a known molecular weight of 1800 to 321200 are prepared by coupling monomers of a colored protein having a known molecular weight or by coupling a colored protein having a known molecular weight with a colorless protein having a kn... | 03/26/1985 |
| 4421684 | Column for adsorption of blood proteins A column for adsorption of blood proteins is disclosed which comprises a blood inlet and a blood outlet each with a filter, and a porous material packed between both the filters, which material has a mean pore diameter (D) of 30-3,000 amgstroms with the v... | 12/20/1983 |
| 4411915 | Heme-iron-enriched amino acid and a process for the preparation of heme-iron-enriched amino acid There is disclosed heme-iron-enriched amino acid preparation consisting of aggregates of heme-protein fragments with heme bonded to histidine groups present in the fragment and a method for preparing this amino acid preparation from heme-proteins, especia... | 10/25/1983 |
| 4377482 | Mobile phase for liquid chromatography A mobile phase for use in reversed phase high performance liquid chromatography. The mobile phase is a mixture of a polar organic solvent selected from acetonitrile and methanol and an aqueous solution of a salt of a tertiary amine and phosphoric acid or ... | 03/22/1983 |
| 4356072 | Isoelectric point marker A group of compounds having the following general formula can be obtained by reacting chromoprotein and organic acid: ##STR1## wherein X is a chromophore, P is a protein, NH2 is mainly &3xb5;-amino group of lysine, n is a positive integer ... | 10/26/1982 |
| 4346174 | Process for isolating superoxide dismutase from red blood cells A process for isolating superoxide dismutase from red blood cells comprising the steps of heating hemolyzed red blood cells in the presence of at least one monovalent inorganic neutral salt and at least one transition metal salt; eliminating precipitate f... | 08/24/1982 |
| 4313871 | Antigen for early pregnancy test and contraceptive vaccine Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the ଲ-subunit of human chorionic gonadotropin which has been modified by ... | 02/02/1982 |
| 4310455 | Antigen for early pregnancy test and contraceptive vaccine Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the ଲ-subunit of human chorionic gonadotropin which has been modified by ... | 01/12/1982 |
| 4279886 | Test for pancreatic exocrine function It has been determined that ingested vitamin B12 is bound by R protein in gastric juice, but that it is not capable of absorption in this form. In a system with a normally functioning exocrine pancreas, R protein is degraded by pancreatic prote... | 07/21/1981 |
| 4268435 | Chorionic gonadotropin derived antigen for early pregnancy test and contraceptive vaccine Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the ଲ-subunit of human chorionic gonadotropin which has been modified by ... | 05/19/1981 |
| 4256629 | Antigen for early pregnancy test and contraceptive vaccine Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the ଲ-subunit of human chorionic gonadotropin which has been modified by ... | 03/17/1981 |
| 4218335 | Stabilizer for an immunochemical measuring reagent A stabilizer consisting principally of cytochrome c or a thermally modified matter of cytochrome c for maintaining constant over an extended period the sensitivity of measurement and specificity of a measuring reagent on the basis of the immunochemical ag... | 08/19/1980 |
| 4203893 | Coupling products of cytidine-diphosphocholine and amino-compounds for pharmaceutical use The products of the invention are obtained by a method which consists of: oxidizing cytidine-diphosphocholine, fixing the dialdehyde obtained by the preceding oxidation of the ribose of the cytidine on NH2 groups of the amino compound in alkali... | 05/20/1980 |
| 4192799 | Conjugates formed by reacting a prostaglandin mimic compound with a carrier molecule A method for the radioimmunoassay of PGE1 -type and PGE2 -type compounds and PGX is disclosed which utilizes antibodies formed against a prostaglandin mimic. Conjugates are disclosed which are formed by attaching a prostaglandin mimi... | 03/11/1980 |
| 4107014 | Isoelectric point markers for gel isoelectric separation Isoelectric point markers for a gel isoelectric separation are prepared to comprise at least two colored proteins of which the isoelectric point pHs are known and wherein the difference between the highest value and the lowest value among the said pHs is ... | 08/15/1978 |
| 4100149 | Method of separating proteins by ion exchange A method of separating proteins by ion exchange comprising putting a solution of proteins into contact with an ion exchange resin consisting of a porous inorganic carrier coated with a cross-linked polymer containing or carrying anion exchanging groups --... | 07/11/1978 |
| 4070459 | N-carbamylated orgotein N-carbamylated orgotein, like the native protein, possesses superoxide dismutase and anti-inflammatory activity.... | 01/24/1978 |
| 4036823 | Barbituric acid antigenic conjugates, their preparation, antibodies and use Antigenic barbituric acid conjugates are produced by coupling the hapten acid through its 3-position to an immunogenic carrier. The antigens thus produced can be used to raise antibodies in animals, the antibodies being specific to the barbituric acid hap... | 07/19/1977 |
| 4022877 | Radioactive labeled orgotein Orgotein labeled with 99M Tc, or with a radioactive iodine isotope, preferably 131 I, is useful in scintigraphy for tissue visualization, especially the kidneys.... | 05/10/1977 |
| 3975342 | Tyrosyl-class antigenic conjugates, their preparation and antibodies raised thereto Tyrosyl, thyronine, and histidyl compounds of the formulas: ##SPC1## Where R' is selected from the group consisting of --OH and --NHPp and R" is selected from the class consisting of --H and --COPp, where Pp is a polypepti... | 08/17/1976 |
| 3960720 | Gel product for separation purposes and method of using the product for hydrophobic salting out adsorption The invention concerns a gel product for chromatography based on agarose, and a method of using the product for hydrophobe salting out adsorption. The gel product is characterized in that the hydrophobe groups are bonded to the agarose with ether or esthe... | 06/01/1976 |
