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Class 530/398 - Gonadatropins


Subclass of Class 530 - Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
Definition: Proteins having the structure of gonadatropins and compounds
No. of patents: 131
Last issue date: 07/26/2011


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NumberTitleIssue Date
7985732Unitary combination of FSH and hCG
A novel ovulatory induction paradigm entails administration of hCG in combination with FSH during all stages of treatment, where the ratio of FSH to hCG is adjusted to optimize ovulatory stimulation and minimize complications. The use of compositions characterized b...
07/26/2011
7964562Unitary combinations of FSH and hCG
A novel ovulatory induction paradigm entails administration of hCG in combination with FSH during all stages of treatment, where the ratio of FSH to hCG is adjusted to optimize ovulatory stimulation and minimize complications. The use of compositions characterized b...
06/21/2011
7910709β-like glycoprotein hormone polypeptide and heterodimer
Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, spec...
03/22/2011
7687610Human chorionic gonadotropin superagonists
The invention is directed toward a human glycoprotein hormone having at least one, two, three, four, or five basic amino acids in the α-subunit at positions selected from the group consisting of positions 11, 13, 14, 16, 17, and 20. The invention is also directed t...
03/30/2010
7442376Glycoprotein hormone compositions containing two β subunits
Forms of differentially acting glycoprotein hormones are disclosed. These compositions are of the formula β1-(linker1)m-α-(linker2)n-β2;  (1) β1-(linker1
10/28/2008
7405197Use of hCG in controlled ovarian hyperstimulation
The invention provides a protocol leading to improved embryo implantation rates and/or decreased miscarriage rates in which hCG, or a bio-analogue, is administered during the follicular phase. ...
07/29/2008
7361349Peptide, immunogenic composition and vaccine or medical preparation, a method to immunize animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
A peptide that comprises a modified tandem GnRH decapeptide sequence which allows for a testosterone level that is essentially nondetectable after vaccination with the peptide in a suitable dosage and/or allows for an immunogenic response that allows for the effecti...
04/22/2008
7358341Beta-like glycoprotein hormone polypeptide and heterodimer
Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, spec...
04/15/2008
7317095Mutant glycoproteins
The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the invention permits the use of lower cumulative doses of FSH to achieve ...
01/08/2008
7291339Homogeneity and secretion of a recombinant follicle stimulating hormone (FSH) in mammalian systems
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and TPO, linked to α subunit of a natural heterodimeric scaffold. Each ...
11/06/2007
7282352Homogeneity and secretion of recombinant proteins in mammalian systems
The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human ...
10/16/2007
7202215Long-acting follicle stimulating hormone analogues and uses thereof
This invention provides FSH analogues having increased serum half-life relative to FSH. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject. ...
04/10/2007
7173113Long-acting hormone and growth factor compositions and uses thereof
This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides related compositions and methods for increasing fertility, egg produc...
02/06/2007
7112341Pulmonary administration of dry powder formulations for treating infertility
Provided are stabilized follicle stimulating protein (FSP) dry powder compositions for aerosolized delivery to the deep lung, methods of preparing and administering such compositions, and methods for treating infertility involving administering the dry powders by pu...
09/26/2006
7109171Methods for treating FSH related conditions with GnRH antagonists
Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the invention generally feature administering to a subject a GnRH antagonist s...
09/19/2006
7081446Long-acting follicle stimulating hormone analogues and uses thereof
This invention provides FSH analogues having increased serum half-life relative to FSH. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject. ...
07/25/2006
7070788Follicle stimulating hormone superagonists
The invention is directed toward a human glycoprotein hormone having at least one, two, three, four, or five basic amino acids in the α-subunit at positions selected from the group consisting of positions 11, 13, 14, 16, 17, and 20. The inventions is also directed ...
07/04/2006
7022822Highly purified gonadotropin compositions and process for preparing them
Purification process of humanPurification process of human urinary gonadotropins of high biological activity and chemical purity absolutely free of foreign contaminating materials derived from the use of biological reagents or chromatography dyes, from crude of gona...
04/04/2006
6987172Multifunctional single chain glycoprotein hormones comprising three or more β subunits
Glycosylated or nonglycosylated molecules of the formula β1-(linker1)n1-β2-(linker2)n2-β3-(linker3)n
01/17/2006
6977242Two gonadotropin releasing hormones and a method to isolate the same
The present invention relates to two novel Gonadotropin releasing hormones muGnRH I and muGnRH II of amino acid SEQ ID 1 as QHWSAWRLPG, and SEQ ID 2 QHWSWGILPG respectively, useful for induced breeding in fish both in combination and alone, by activating production ...
12/20/2005
6911206Fusion proteins comprising carriers that can induce a dual immune response
The subject invention provides a fusion protein for producing a dual immune response in a vertebrate, which fusion protein comprises: (a) a first proteinaceous portion analogous to all or part of a peptide endogenously synthesized within the vertebrate, the activity...
06/28/2005
6828415Oligopeptide lyophilisate, their preparation and use
A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried. ...
12/07/2004
6761890Peptide, immunogenic composition and vaccine or medical preparation, a method to immunize animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
A peptide that comprises a modified tandem GnRH decapeptide sequence which allows for a testosterone level that is essentially non-detectable after vaccination with the peptide in a suitable dosage and/or allows for a an immunogenic response that allows for the effe...
07/13/2004
6716428Antigenic modification of polypeptides
Endogenous protein hormones, fragments thereof including epitopes, and synthetic peptides mimicking epitope regions of hormones such as human chorionic gonadotropin can be conjugated to a foreign carrier or otherwise modified so as to produce antibodies in humans ag...
04/06/2004
6706681HCG liquid formulations
The invention refers to liquid pharmaceutical compositions containing hCG stabilised with a polyalcohol or a non-reducing sugar. Preferably, the compositions are stabilised with mannitol. In the preferred embodiments such compositions are aqueous solutions in...
03/16/2004
6693074Cystine depleted glycoprotein hormones
Single-chain forms of the glycoprotein hormones LH, FSH, TSH or CG which are lacking at least one disulfide bridge in the sequence representing the ଱ and/or ଲ subunit are useful as agonists or antagonists of the native glycoprotein hormones....
02/17/2004
6689365Single-chain fertility hormones with fsh and LH activity
Glycosylated or nonglycosylated proteins of the formula FSHଲ-(linker1)n1 -LHଲ(1-X)-(linker2)n2 -଱ wherein FSHଲ is a vertebrate follicle stimulating hormone ଲ subuni...
02/10/2004
6635256Glycoprotein hormone compositions comprising two ଲ subunits and methods of use thereof
Forms of differentially acting glycoprotein hormones are disclosed. These compositions are of the formula...
10/21/2003
6620416Method for treating HIV
The present invention relates to peptides of one or more portions of the human chorionic gonadotropin ଲ-chain as well as methods for treatment and prevention of diseases, including HIV infection, using human chorionic gonadotropin, employing the &#x...
09/16/2003
6600019Polypeptides and nucleic acids encoding same
The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of ...
07/29/2003
6486303Method for making hormone heterodimers
The present invention relates to a method for preparing heterodimeric analogs of cysteine knot proteins. More specifically, the invention relates to a method for forming a subunit combination of a cysteine knot protein having an ଱-subunit and a �...
11/26/2002
6444639HCG and derivatives as matrix metalloproteases inhibitors
The use of hCG, hCG ଲ-subunit, as well as fragments and active derivatives thereof, or hCG ଲ-core in the preparation of a medicament for the prophylaxis and/or the treatment of pathologies requiring inhibition of the matrix metalloprotease (MM...
09/03/2002
6414123Method for purifying FSH
The present invention provides a method for purifying follicle stimulating hormone (FSH) from biological samples, for example, from human pituitary glands or human postmenopausal urine, wherein the FSH is contaminated with other proteins, by use of dye-li...
07/02/2002
6372711Methods for assaying human FSH using human FSH receptor
The present invention embraces essentially pure human FSH receptor, or a fragment or mutant thereof which binds FSH, DNA encoding said receptor, fragment or mutant, expression vectors comprising said DNA, cells transfected with said expression vectors, an...
04/16/2002
6251402Use of human chorionic gonadotropin in the treatment of Kaposi's sarcoma
The use of hCG Beta-core or hCG fragments, deglycosylated hCG in the treatment of Kaposi's sarcoma is described. Inhibition of tumor production or regression on a variety of KS cell lines is shown. Purified hCG preparations do not inhibit the growth of KS cell...
06/26/2001
6242580Single-chain forms of the glycoprotein hormone quartet
Single-chain forms of the glycoprotein hormone quartet, at least some members of which are found in most vertebrates, are disclosed. The ଱ and ଲ subunits of the wild-type heterodimers or their variants or their fragments are covalently linked,...
06/05/2001
6238890Single chain forms of the glycoprotein hormone quartet
Single-chain forms of the glycoprotein hormone quartet, at least some members of which are found in most vertebrates, are disclosed. The ଱ and ଲ subunits of the wild-type heterodimers or their variants or their fragments are covalently linked,...
05/29/2001
6194177DNA encoding a hybrid heterodimeric protein
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-댪nd TPO, linked to a subunit of a heterodimeric proteinac...
02/27/2001
6193972Hybrid heterodimeric protein hormone
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-ଲ and TPO, linked to a subunit of a heterodimeric proteina...
02/27/2001
6140066Methods of cancer diagnosis using a chimeric toxin
The present invention relates to methods for cancer diagnosis using a chimeric toxin. In particular, the invention relates to the use of a chimeric toxin composed of gonadotropin releasing hormone (GnRH) and Pseudomonas exotoxin A (PE) to detect a tumor-a...
10/31/2000
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