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| Number | Title | Issue Date |
| 4694073 | Method of somatotropin solubilization and naturation using dimethylsulfoxide A method for solubilization and naturation of somatotropin protein from refractile bodies of host cells is disclosed. The method embraces the discovery that an aqueous solution of urea, or dimethylsulfone, or mixtures of urea and dimethylsulfone, can be e... | 09/15/1987 |
| 4677195 | Method for the purification of erythropoietin and erythropoietin compositions A method for purifying erythropoietin is described. The method comprises treating partially purifying erythropoietin by reverse phase high performance liquid chromatography to obtain homogeneous erythropoietin having a molecular weight of about 34,000 dal... | 06/30/1987 |
| 4667016 | Erythropoietin purification Chromatographic procedures are individually and jointly applied to the rapid and efficient isolation of biologically active proteins and especially glycoproteins such as recombinant erythropoietin present in the medium of growth of genetically transformed... | 05/19/1987 |
| 4661345 | Method for treating pertussis Method of inhibiting the adhesion of Bordetella pertussis to the cilia of human respiratory cells to treat pertussis, agents and compositions useful in the method. Agents are also useful to stimulate the production of antibodies.... | 04/28/1987 |
| 4568488 | Reverse immunoaffinity chromatography purification method One aspect of the present invention relates to a method for the purification of a protein component of a biological fluid, said method comprising: raising antibodies to impurities commonly present in crude preparations of said components; preparing an imm... | 02/04/1986 |
| 4560649 | Assaying for hLH or hCG with immobilized hormone receptors A method to obtain a substantially pure and stable hLH-hCG receptor from gonadal cells is disclosed. The characteristics of the purified receptor are disclosed. The receptor, in addition to being used as receptor in an enzyme- or dye-receptor assay for hL... | 12/24/1985 |
| 4559322 | Non-absorbable compounds of mucolytic activity, the process for their preparation, and therapeutic compositions which contain them as active principle Macromolecular compounds of mucolytic activity, non-absorbable by tissues, free from side-effects, compatible with antibiotics, and constituted by carbohydrates as their basic structure, to which enzymes and sulphydryl groups are bonded by suitable alipha... | 12/17/1985 |
| 4558005 | Monoclonal anti-erythropoietin Hybridoma tumor cell line (ATCC Number CRL 8164). A monoclonal anti-erythropoietin antibody substance, Epoclonalan, produced by said cell line. Use of Epoclonalan in immonological methods for isolation of natural erythropoietin and for quantitative detect... | 12/10/1985 |
| 4558006 | A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin Disclosed is a new mouse-mouse hybridoma tumor cell line A.T.C.C. No. HB8209. A monoclonal antibody produced by said cell line is specifically immunologically reactive with erythropoietin and with a polypeptide whose amino acid sequence is substantially d... | 12/10/1985 |
| 4558035 | Material for use in the treatment of spontaneous abortions This invention relates to a material for use in preventing recurrent spontaneous abortions in women, comprising material selected from isolated syncytiotrophoblast microvillous plasma membrane and protein- and glycoprotein-containing fractions derived the... | 12/10/1985 |
| 4534972 | Protein compositions substantially free from infectious agents Compositions containing therapeutically or immunologically active proteins are rendered substantially free from infectious agents such as viable viruses and bacteria without substantial loss of therapeutic or immunologic activity by mixing the protein com... | 08/13/1985 |
| 4522750 | Cytotoxic compositions of transferrin coupled to vinca alkaloids There is provided by this invention cell-targeting cytotoxic compositions comprising transferrin covalently coupled to vinca alkaloid.... | 06/11/1985 |
| 4518526 | Purification and activity assurance of precipitated heterologous proteins A process for isolating and purifying a precipitated heterologous protein from a host cell culture, including treating the host cell culture with a buffered solution of ionic strength suitable to solubilize most of the host protein but in which refractile... | 05/21/1985 |
| 4512922 | Purification and activity assurance of precipitated heterologous proteins A process for maintaining refractile proteins in solubilized form by replacing the strongly denaturing solution with a weakly denaturing solution.... | 04/23/1985 |
| 4511550 | 1-(p-Substituted or unsubstituted aminoalkyl)phenylpropane-1,2-dione bis(thiosemicarbazone) derivatives, and their production and use A radioactive diagnostic agent which comprises a physiologically active substance and a radioactive metallic element combined with a compound of the formula: ##STR1## wherein R, R', R1 and R2 are each a hydrogen atom or a C... | 04/16/1985 |
| 4511502 | Purification and activity assurance of precipitated heterologous proteins A process for purifying heterologous proteins from higher molecular weight components, including dissolving the heterologous protein in a strong denaturing solution and removing the higher molecular weight components using a molecular sieve or high speed ... | 04/16/1985 |
| 4511503 | Purification and activity assurance of precipitated heterologous proteins A process for dissolving refractile proteins from their insoluble form by using a strongly denaturing solution.... | 04/16/1985 |
| 4504586 | Hybridoma tumor cell lines and their monoclonal antibodies to human colony stimulating factor subclass number 1 Murine-derived hybridoma tumor cell lines and monoclonal anti-Colony Stimulating Factor Subclass Number 1 antibody substances produced by these cell lines. Use of said monoclonal antibody substances, alone or in combination, in immunological procedures fo... | 03/12/1985 |
| 4501693 | Method of preparing immunostimulant proteoglycans which induce production of interferon, proteoglycans obtained and pharmaceutical compositions containing them The present invention relates to a method of preparing bacterial membranous proteoglycans with an action which induces interferon from soluble membranous proteoglycans of a strain of gram-negative bacterium, wherein the soluble membranous proteoglycans of... | 02/26/1985 |
| 4496689 | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer There is disclosed a process for producing a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex useful for pulmonary emphysema therapy, a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex produc... | 01/29/1985 |
| 4493793 | Soluble immunoassay reagent comprising lectin covalently bonded to reactive component A lectin is covalently bonded to an immunological conjugate such as an antibody-antigen or its equivalent. Then, the lectin-conjugate is isolated from the reaction product mixture by one of a number of alternative techniques involving one or more of the f... | 01/15/1985 |
| 4482485 | Method of preparation of human urine origin colony-stimulating factor and kallikrein Human urine-origin colony-stimulating factor and kallikrein are separated in pure form, respectively, from an aqueous solution thereof, such as a urinary protein-concentrated solution by subjecting the solution added with a stabilizer such as octyl-phenox... | 11/13/1984 |
| 4478823 | Immunological preparations containing purified MHC antigens bonded to other antigens An immunologically active preparation for human or veterinary use comprises an antigenic material in combination with an MHC antigen.... | 10/23/1984 |
| 4438032 | Unique T-lymphocyte line and products derived therefrom Human T-lymphoblast cell line, Proteinaceous products produced therefrom, messenger RNA and DNA expressing the proteinaceous products. A human T-lymphoblast cell line (Mo) maintained as a continuous culture constitutively produces proteins, including immu... | 03/20/1984 |
| 4430264 | Process for the preparation of a selective anorexogenic substance regulating food intake A process is disclosed for the preparation of an endogenous anorexogenic substance obtained from blood serum. The anorexogenic substance itself is also described having a specific activity of 100 units/mg.... | 02/07/1984 |
| 4384995 | Antigenic modification of polypeptides Modified hormones or fragments of hormones are useful in producing antibodies when administered to an animal. Said antibodies in turn cause neutralization of endogenous natural protein hormones. The modification may be accomplished by attaching various ki... | 05/24/1983 |
| 4377513 | Process for the production of human erythropoietin The present invention relates to a process for the production of human erythropoietin. More precisely, the invention relates to a process for the mass production of human erythropoietin, comprising in vivo multiplication of human lymphoblastoid cells capa... | 03/22/1983 |
| 4363759 | Chemiluminescent-labeled haptens and antigens Chemiluminescent-labeled conjugates of the formula: ##STR1## wherein one of R1 and R2 is hydrogen and the other is -NR3 R4 ; R3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and... | 12/14/1982 |
| 4350687 | Platelet derived cell growth factor A purified cell growth factor is produced which comprises a substantially purified glycoproteinaceous factor from platelets which has mitogenic activity toward transformed cells, a molecular weight of 3,000-5,000 daltons and a pI of 7.8-8.3. The growth fa... | 09/21/1982 |
| 4335040 | Therapeutic product and method Described herein are compositions obtained in accordance with the procedure which comprises placing in a pressure vessel a quantity of material comprising animal tissue selected from the group consisting of fresh human placenta or other animal tissues, en... | 06/15/1982 |
| 4320111 | Immunologic compositions methods of preparation and use This invention relates to immunologic compositions comprising pyruvic aldehyde stabilized erythrocytes sensitized with an antigen by coupling of the stabilized erythrocytes to the antigen with bifunctional molecules, and to methods for preparing these com... | 03/16/1982 |
| 4303650 | Process for production of erythropoietin The invention provides a novel process for the production of erythropoietin, which is a promising medicine for curing anemia, from human urine containing the same. The inventive method comprises adjusting the pH value of the urine in the range from 6 to 8... | 12/01/1981 |
| 4297273 | Chemiluminescent phthalhydrazide-labeled protein and polypeptide conjugates Chemiluminescent-labeled conjugates of the formula: ##STR1## wherein one of R1 and R2 is hydrogen and the other is --NR3 R4 ; R3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms an... | 10/27/1981 |
| 4273865 | Insolubilized biochemical materials Stabilized, insolubilized biochemical materials are prepared by covalently bonding a biochemical material such as an antigen, antibody, hormone, or enzyme to a silicic acid heteropolycondensate layer which is applied to a mechanically stable support. The ... | 06/16/1981 |
| 4269825 | New glycoprotein and process for isolating it A new glycoprotein is characterized by a protein consisting essentially of 75&#b1;6% of -amino-acids, a carbohydrate portion of 24.6&#b1;5.2%, which contains 8.9&#b1;2% of hexoses, 7.1&#b1;1.5 of N-acetylated hexosamine, 0.2&#b1;0.2% of fucose, 8.4... | 05/26/1981 |
| 4237224 | Process for producing biologically functional molecular chimeras Method and compositions are provided for replication and expression of exogenous genes in microorganisms. Plasmids or virus DNA are cleaved to provide linear DNA having ligatable termini to which is inserted a gene having complementary termini, to provide... | 12/02/1980 |
| 4234570 | Proteinic active substances Novel biologically active substances prepared by dissociating the protein obtained from the cultivation of the microorganism Bordetella and having insulin secretion promoting action as well as glucose tolerance improving action for mammals.... | 11/18/1980 |
| 4219467 | Method for the preparation of chorionic human somatomammotropin A method is disclosed for extracting human chorionic somatomammotropin (HCS) which comprises the steps of separating from placental extract a proteinic fraction which contains such hormone, enriching the fraction so as to increase its HCS percentage conte... | 08/26/1980 |
| 4179337 | Non-immunogenic polypeptides Polypeptides such as enzymes and insulin are coupled to polyethylene glycol or polypropropylene glycol having a molecular weight of 500 to 20,000 daltons to provide a physiologically active non-immunogenic water soluble polypeptide composition. The polyet... | 12/18/1979 |
| 4129560 | Process for the purification of high molecular weight peptides using non-ionic detergents Process for the purification of high molecular weight peptides, which have a tendency to associate, by ion exchanger chromatography in aqueous buffered solvents on acid or basic ion exchangers, which comprises dissolving non ionic detergents in the buffer... | 12/12/1978 |
