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| Number | Title | Issue Date |
| 7687608 | Methods for reducing the mitogenicity of lectin compositions Methods for reducing the T-cell mitogenicity of lectin compositions are provided. In one aspect this is achieved by chemically modifying mitogenic lectin compositions under optimized conditions. Additionally or alternatively, the reduction in T-cell mitogenicity is ... | 03/30/2010 |
| 7687609 | Galectin-glycosaminoglycan complex and method for controlling galectin activity A complex consisting of galectin-3 and chondroitin oligosaccharide and methods for seperating and detecting the chondroitin oligosaccharide in a sample using the immobilized complex. ... | 03/30/2010 |
| 7619072 | Purification method for recombinant glucose binding protein The present invention relates to a method for purifying a recombinant glucose binding protein, in particular the lectin Concanavalin A (Con A). The method specifically utilizes a buffer in which impurities, such as glycogen and other substances are soluble, but in w... | 11/17/2009 |
| 7332470 | Methods and compositions for treating ocular disease The use of collectins and/or surfactant proteins for the treatment and prevention of ocular disease. ... | 02/19/2008 |
| 7329739 | Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells It is intended to provide lectins and a lectin library comprising these lectins which are useful in recognizing differences in carbohydrates on cell surface (for example, sugar chains and cell surface glycoproteins) reflecting extremely subtle differences among cell... | 02/12/2008 |
| 7306821 | Process for producing a high solubility, low viscosity, isoflavone-enriched soy protein isolate and the products thereof A soy protein isolate that has increased amounts of isoflavones and saponins and a high Nitrogen Solubility Index (“NSI”) is produced by a process that involves ultrafiltration and the avoidance of isoelectric precipitation. The soy protein isolate has at least ... | 12/11/2007 |
| 7303749 | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for cancer. The present invention is directed to compositions comprising at le... | 12/04/2007 |
| 7282481 | Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing same A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method of functionalizing a natural protein having ... | 10/16/2007 |
| 7250167 | Method of treatment with anti-CD2 antibody LO-CD2b A monoclonal antibody which binds to baboon and human CD2, and in particular LO-CD2b antibody. The antibody may be employed to prevent and inhibit an immune response in human patients, such as when the immune response is mediated by the activation and proliferation ... | 07/31/2007 |
| 7169908 | Purification of polypeptides A method for purifying a desired heterologous polypeptide from microbial fermentation broth or homogenate in which it is produced and solubilized is described. This method involves adding to the broth or homogenate an effective amount of a solution of 6,9-diamino-2-... | 01/30/2007 |
| 7166458 | Assay and method for analyte sensing by detecting efficiency of radiation conversion In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid or matrix. The analyte may be glucose or any other chemical of interest. The fluid or matrix may be, for example, the fluid in a bioreactor... | 01/23/2007 |
| 7052702 | Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby reduce or preferably prevent the transmission of afferent pain signal... | 05/30/2006 |
| 7049414 | Isolation of lectins The invention relates to a process for isolating a lectin composition, in particular comprising the mannose-binding lectin (MBL), suitable for using recombinantly produced lectins as starting material, as well as methods for enriching a lectin preparation with respe... | 05/23/2006 |
| 7015313 | Lectin protein prepared from Korean marine crab Philyra pisum, process for preparing the same and the use thereof The present invention relates to a lectin protein prepared from Korean marine crab Philyra pisum, process for preparing the same and the use thereof. This protein can be used as a diagnosing agent or a carrier protein that chemically binds to various anti-can... | 03/21/2006 |
| 7005415 | Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing the same A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method for functionalizing a natural protein having... | 02/28/2006 |
| 6992178 | Agent imparting resistance to external stimuli The invention provides an agent for conferring resistance comprising a lectin as an effective component, which are able to confer resistance against external stimuli to animal cells, particularly mammalian cells, and to their cultured cells and various tissues in th... | 01/31/2006 |
| 6987022 | Leukemic cell-adsorbing material containing lectin protein from beans or soybeans An efficient method for therapeutic treatment of a leukemic patient is disclosed in which the patient's body fluid under external circulation is brought into direct contact with an adsorbent material capable of adsorbing the leukemic cells in the body fluid specific... | 01/17/2006 |
| 6979727 | Recombinant conglutinin and producing method thereof A recombinant conglutinin which contains a collagen region consisting of six amino acids containing two amino acid sequences Gly-Xaa-Xaa (SEQ ID NO:3, wherein Xaa stands for a protein-constituting amino acid), the neck region of natural conglutinin and the sugar cha... | 12/27/2005 |
| 6960652 | Compositions and methods for modifying toxic effects of proteinaceous compounds The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. | 11/01/2005 |
| 6846649 | Recombinant human mannan-binding lectin The present invention relates to methods of producing and/or isolating MBL compositions. In particular the invention relates to methods of producing and/or isolating novel recombinant human MBL preparations with high similarity to natural human MBL. The MBL preparat... | 01/25/2005 |
| 6846913 | Crude extract from Viscum album coloratum, and proteins and lectins isolated therefrom Disclosed is an extract from Korean mistletoe KM-110, which is of immunity enhancement and activity against tumor metastasis and can be used as an adjuvant material for vaccines applicable for the induction of humoral and cell-mediated immunity. Also disclosed are i... | 01/25/2005 |
| 6787639 | Collectin A gene encoding a novel collectin protein which is expected to exhibit an antibacterial activity, an antiviral activity, etc. particularly in the human body, and its amino acid sequence. ... | 09/07/2004 |
| 6774220 | Compounds having lectinic properties and their biological applications The invention relates to nucleotide sequences capable of coding for polypeptides having lectinic properties and to corresponding polypeptides of the sarcolectin type and their uses in therapeutics. In particular, the invention relates to the use of polypeptides of t... | 08/10/2004 |
| 6770758 | Polysaccharide separation method A method for the separation of polysaccharides. The method comprises conjugating a ligand to a thermo-sensitive polymer to form a conjugate, wherein the ligand specifically recognizes a polysaccharide, and the thermo-sensitive polymer features a lower critical solut... | 08/03/2004 |
| 6605699 | Galectin-11 polypeptides The present invention relates to galectin 11 proteins which are members of the galectin superfamily. In particular, the present invention relates to full-length polypeptides, fragments, and variants of galectin 11.... | 08/12/2003 |
| 6566500 | Compositions and methods for modifying toxic effects of proteinaceous compounds The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which ind... | 05/20/2003 |
| 6514716 | Detection of the end-position sialic acid groups of the human transferrin molecule The subject matter of this invention is a method of determining terminal sialic acid residues in human transferrin according to a sandwich principle, which is characterized in that the sample fluid containing the human transferrin is incubated with a firs... | 02/04/2003 |
| 6492499 | Human pancreatitis-associated protein The present invention provides a novel human C-type lectin (human PAP-2) and polynucleotides which identify and encode human PAP-2. The invention also provides expression vectors, host cells, agonists, antibodies or antagonists. The invention also provide... | 12/10/2002 |
| 6489144 | Methods for enhancing the production of interferon in cell culture Methods for enhancing the production of interferon in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production, in particular cellular levels of double-stranded-RNA-depen... | 12/03/2002 |
| 6420171 | Leukemic cell-adsorbing material containing lectin protein from Agrocybe cylindracea or jequirity plant seed An efficient method for therapeutic treatment of leukemia is provided in which a patient's body fluid during external circulation is brought into direct contact with an adsorbent material capable of specifically and selectively adsorbing leukemic cells in... | 07/16/2002 |
| 6407068 | Method of treating humans with diseases characterized by high secretion of cytokines from macrophage cells A method of treating an individual who is suffering from human immunodeficiency virus infection is disclosed. Methods of treating a human suffering from a disease characterized by high secretion of cytokines from macrophagecells and methods of reducing cy... | 06/18/2002 |
| 6306613 | Modulators of leaderless protein export and methods for identifying and using the same Methods of modulating the export of a leaderless protein from a cell by contacting the cell with a compound that alters the binding of the leaderless protein and a transport molecule are provided. Transport molecules include gastrin binding protein/alpha ... | 10/23/2001 |
| 6281197 | Cardiac glycosides and their aglycone derivatives treat complications of diabetes This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include FGF-1, FGF-2, IL-1, IL-1ଲ and factor XIIIa. These... | 08/28/2001 |
| 6156519 | (.fwdarw.)-ଲ- d-glucan binding protein, an antibody recognizing the protein and use thereof A (1.fwdarw.3)-ଲ-D-glucan binding protein obtainable by affinity chromatography or gel filtration of an extract of horseshoe crab amoebocytes and having a molecular weight of about 580 kDa, as determined by gel filtration under non-reducing conditio... | 12/05/2000 |
| 6153195 | Method of delivering drugs to cells specific for an HL-60 lectin Pharmaceutical compositions useful in the treatment of autoimmune conditions include as an active ingredient a soluble lectin having a molecular weight of about 14 kilodaltons or a fragment thereof. The lectin or fragment binds ଲ-galactoside-contain... | 11/28/2000 |
| 6117836 | Glycosylation-mediated inhibition of factor X Reagents that specifically bind a carbohydrate target wherein sialic acid is linked at the nonreducing terminus of a glycoside to a galactose or galactosamine residue through an 댒-6 linkage are able to inhibit the conversion of human Factor X to hu... | 09/12/2000 |
| 6110708 | Recombinant conglutinin and producing method thereof A recombinant conglutinin containing a collagen region comprising six amino acid residues containing two amino acid sequences Gly-Xaa-Xaa (SEQ ID) NO:3, Xaa representing a protein-constituting amino acid residue), a neck region of natural conglutinin and ... | 08/29/2000 |
| 6107283 | Cardiac glycosides inhibit proliferation of cells bearing FGF receptors This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include FGF-1, FGF-2, IL-1, IL-1ଲ and factor XIIIa. These... | 08/22/2000 |
| 6083706 | Inhibitors of leaderless protein export Methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a compound that inhibits the binding of the leaderless protein and a transport molecule are provided. Leaderless proteins include FGF-1, FGF-2, IL-1, I... | 07/04/2000 |
| 6084073 | Recombinant ricin toxin DNA sequences encoding full length precursor proteins, which proteins contain both A and B portions of two ricin isotoxins and ricin agglutinin, as well as the linker regions have been determined. These DNAs or portions or modifications thereof are expres... | 07/04/2000 |
