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| Number | Title | Issue Date |
| 8183350 | Compositions and methods for promoting neuronal outgrowth Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration. ... | 05/22/2012 |
| 8178657 | Polypeptide sequence involved in the modulation of the immunosuppressive effect of viral proteins The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-mo... | 05/15/2012 |
| 8153769 | Process for producing proteoglycan An efficient low-cost method of proteoglycan recovery from natural resources. There is provided a process for producing proteoglycan, comprising the steps of immersing a biological sample containing proteoglycan in an alkali solution of 0.0025 to 0.1 N and recoverin... | 04/10/2012 |
| 8129506 | Modulation of the interaction of MUC1 with MUC1 ligands The present invention provides for chimeric proteins comprising a MUC1 extracellular (MUC1-EC) polypeptide and a carrier polypeptide that function as traps for MUC1 ligands. ... | 03/06/2012 |
| 8076463 | Polymer-von Willebrand factor-conjugates The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to... | 12/13/2011 |
| 8067366 | Facilitation of resuscitation from cardiac arrest by erythropoietin The present invention relates generally to the use of erythropoietin (EPO) to facilitate resuscitation from cardiac arrest. For a mammalian subject suffering from cardiac arrest, concurrent administration of EPO with resuscitation after the onset of ventricular fibr... | 11/29/2011 |
| 8067551 | Combinatorial DNA library for producing modified -glycans in lower eukaryotes The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammal... | 11/29/2011 |
| 8026346 | Tribonectins The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint. ... | 09/27/2011 |
| 7834159 | Glycoprotein synthesis Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an un... | 11/16/2010 |
| 7829679 | Mucin-type glycoprotein and use thereof Provided is a novel mucin-type glycoprotein and a method for producing the same. Specifically, a mucin-type glycoprotein having a repeat structure including 3 to 2000 repeating units each having an amino acid sequence represented by the formula I: Val-Xaa-Glu-Thr-Th... | 11/09/2010 |
| 7825226 | Glycoprotein synthesis Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an un... | 11/02/2010 |
| 7786276 | Sequestering of glycoprotein molecules and oligosaccharide moieties in lipo-glycoprotein membranes and micelles Spontaneous formation of a coherent membrane at the interface between a non-polar liquid and an aqueous solution of glycoprotein can be used to separate proteins and carbohydrates from tissue fluid and other complex mixtures. When volatile hydrocarbons are used to i... | 08/31/2010 |
| 7786277 | Methods for introducing mannose 6-phosphate and other oligosacharides onto glycoproteins Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose 6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biolog... | 08/31/2010 |
| 7598354 | Campylobacter glycans and glycopeptides Multiple strains and species of Campylobacter share a common glycan moiety which is present in a plurality of surface-exposed glycoproteins. This glycan has the formula: GalNAc-a1, 4-GalNAc-a1,4-[Glc-β1,3]GalNAc-a1,4-GalNAc-a1,4-GalNAc-a1,3-Bac, wherein Bac is 2, 4... | 10/06/2009 |
| 7560535 | Glycoprotein synthesis Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an un... | 07/14/2009 |
| 7553939 | T cell regulatory genes and methods of use thereof A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically asso... | 06/30/2009 |
| 7470776 | Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and sialyated, fucosylated N-acetyllactosamino glycans. The glycosulfopepti... | 12/30/2008 |
| 7438915 | Immunopotentiating effect of a -derived lectin on chicken immunity and resistance to coccidiosis This study reports a novel immunopotentiating effect of a lectin (FFrL) extracted from the mushroom Fomitella fraxinea on poultry cell-mediated immunity and poultry coccidiosis. We describe the extraction of FFrL, its in vitro mitogenic activity and in vivo p... | 10/21/2008 |
| 7431921 | Interferon beta-like molecules The invention relates to a conjugate exhibiting interferon β (IFNB) activity and comprising at least one first non-polypeptide moiety covalently attached to an IFNB polypeptide, the amino acid sequence of which differs from that of wildtype human IFNB in at least o... | 10/07/2008 |
| 7427671 | Compositions of alpha platelet derived growth factor receptor nucleic acid and protein and method of making A DNA sequence which encodes a human type α platelet derived growth factor receptor protein which preferentially binds to the AA homodimer and AB heterodimer forms of platelet derived growth factor and also binds the BB homodimer at high affinity, is described. Sub... | 09/23/2008 |
| 7423130 | PRO1158 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 09/09/2008 |
| 7405198 | Glycopegylated erythropoietin The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycos... | 07/29/2008 |
| 7402562 | Composition for stabilizing corneal tissue during or after orthokeratology lens wear An orthokeratological procedure is provided that prevents or retards relaxation of corneal tissue back to the original anterior curvature of the cornea. The procedure comprises applying a stabilizing agent that comprises fibril associated collagens with interrupted ... | 07/22/2008 |
| 7399838 | Single chain class I major histo-compatibility complexes A recombinant polypeptide and nucleic acid constructs capable of expressing the recombinant polypeptide are provided. The recombinant polypeptide comprises a chimeric polypeptide including an antigenic peptide being capable of binding a human MHC class I, a function... | 07/15/2008 |
| 7399471 | Polypeptides capable of forming antigen binding structures with specificity for the Rhesus D antigens, the DNA encoding them and the process for their preparation and use Polypeptides capable of forming antigen binding structures specific for Rhesus D antigens include the sequences indicated in the FIGS. 1a to 16b. The obtained polypeptides, being Fab fragments, MAY be used directly as an active ingredient... | 07/15/2008 |
| 7396529 | Compositions and methods for regulating receptor clustering The invention relates to isolated complexes comprising one or more galectin associated with Mgat5 modified glycan or polylactosamine modified glycan, and isolated lectin-Mgt5 modified glycan lattice comprising an array of multivalent interactions among lectins, Mgat... | 07/08/2008 |
| 7388081 | Method for manufacturing glycoproteins having human-type glycosylation The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycopr... | 06/17/2008 |
| 7381804 | G-CSF analog compositions and methods The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions containing hybrid molecules. ... | 06/03/2008 |
| 7381411 | Aglyco products and methods of use Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which are immunogenic epitopes responsible for recognition of antigens by ... | 06/03/2008 |
| 7381805 | Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, compr... | 06/03/2008 |
| 7378392 | Bone and cartilage inductive proteins Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair. ... | 05/27/2008 |
| 7378506 | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes ... | 05/27/2008 |
| 7354594 | Merozoite surface protein 1 lacking glycosylation sites The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell ... | 04/08/2008 |
| 7354588 | Functional derivatives of ICAM-1 with altered ability to bind LFA-1 or HRV The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is direc... | 04/08/2008 |
| 7355017 | Blood group antigen fusion polypeptides and methods of use thereof The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection. ... | 04/08/2008 |
| 7351435 | Deglycosylated ricin toxin a-chain vaccine The present invention relates to a vaccine comprising deglycosylated ricin toxin A-chain and method for making and using the composition. ... | 04/01/2008 |
| 7351799 | Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte... | 04/01/2008 |
| 7335733 | Tissue cement proteins from The present invention relates to tissue cement proteins produced by certain species of blood-feeding ectoparasites. These proteins and compositions comprising these proteins are particularly useful for the temporary or permanent bonding of animal tissues to each oth... | 02/26/2008 |
| 7332303 | Product quality enhancement in mammalian cell culture processes for protein production The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-gal... | 02/19/2008 |
| 7329504 | Methods of preventing or treating cell migration mediated conditions or diseases The present invention relates to methods of identifying agents which modulate the activity of PIPKIγ661. Methods of using such agents to prevent or treat a cell migration-mediated condition or disease in a subject are also provided. ... | 02/12/2008 |
