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| Number | Title | Issue Date |
| 8093364 | Enhanced purification of antibodies and antibody fragments by apatite chromatography Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparati... | 01/10/2012 |
| 8063189 | Protein purification by citrate precipitation The invention provides methods for isolating proteins in purified form from mixtures by precipitation with citrate. The methods are advantageous in that they effectively separate a protein from lower molecular weight contaminants, including fragments or portions of ... | 11/22/2011 |
| 8058407 | Purification of acidic proteins using ceramic hydroxyapatite chromatography The present invention provides a method of removing product-related inactive or partially active species, high molecular weight aggregates, as well as other process-related impurities from preparations of acidic proteins by using ceramic hydroxyapatite chromatograph... | 11/15/2011 |
| 7947813 | Polyelectrolyte precipitation and purification of proteins Methods are presented for isolating and purifying proteins by adding a polyelectrolyte to a cell culture fluid, such as a harvested cell culture fluid, and precipitating a protein-polyelectrolyte complex or a complex of impurities and the polyelectrolyte. ... | 05/24/2011 |
| 7928205 | Methods for refolding of recombinant antibodies The present invention is generally directed to methods of producing an increase in the enrichment or recovery of preferred forms of IgG proteins. More particularly, the invention relates to subjecting preparations of such recombinant IgG proteins with a reduction/ox... | 04/19/2011 |
| 7847071 | Antibody purification by protein a and ion exchange chromatography A novel method for selectively removing leaked protein A from antibody purified by means of protein A affinity chromatography is disclosed. ... | 12/07/2010 |
| 7820799 | Methods of purifying Fc region containing proteins The present application provides methods of purifying polypeptides having a Fc region, for example, antibodies or antibody fusions, by adsorbing the polypeptides to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent ... | 10/26/2010 |
| 7714112 | Method of antibody purification The present invention relates to a method of separating antibodies from other compound(s) in a liquid sample, wherein a mobile phase comprising said sample is contacted with a multi-modal separation matrix to adsorb undesired compounds while the antibodies remain fr... | 05/11/2010 |
| 7700743 | Immobilised affinity medium and its use in separation A chromatography media such as silica controlled pore glass or agarose containing an affinity ligand such as 2-Aminobenzimidazole (ABI) or aminomethylbenzimidazole (AMBI). The ligand is present in density of from about 30 to about 80 μmole/ml. ... | 04/20/2010 |
| 7385040 | Antibody purification The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support to which multi-modal ligands have been immobilised, wherein a multi-... | 06/10/2008 |
| 7368542 | Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can... | 05/06/2008 |
| RE40070 | Antibody purification This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecule proteins.The questions raised in reexamination request, 09/006,966 filed Mar. 12, 2004 have been considered and th... | 02/19/2008 |
| 7186410 | Method for preparing human immunoglobulin concentrates for therapeutic use The invention concerns a method for preparing human immunoglobulin concentrates for therapeutic use, from plasma or a plasma fraction. The method comprises pre-purification and a single anion-exchange chromatography carried out at alkaline pH, thereby enabling the i... | 03/06/2007 |
| 7183391 | Kunitz domain polypeptide zkun10 We claim the proteinase inhibitors comprising a Kunitz domain, wherein the Kunitz domain comprises amino acid residues 57–107 of SEQ ID NO: 2. We also claim a fusion protein comprising said Kunitz domain. In addition, we claim a method of inhibiting protease degra... | 02/27/2007 |
| 7138120 | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products The present invention relates to a process for purifying immunoglobulin G from a crude immunoglobulin-containing plasma protein fraction. Said process includes a number of steps of which the anion exchange chromatography and the cation exchange chromatography are pr... | 11/21/2006 |
| 7118675 | Process for removing protein aggregates and virus from a protein solution A process is provided for selectively removing protein aggregates from a protein solution in a normal flow (NFF) filtration process. Preferably, it relates to a process for selectively removing protein aggregates from a protein solution in a normal flow (NFF) filtra... | 10/10/2006 |
| 7041798 | Method for the chromatographic fractionation of plasma or serum, preparations, so obtained, and their use The invention relates to the fractionation of plasma or serum into at least one albumin fraction and one immunoglobulin fraction by hydrophobic interaction chromatography. The fractionation is carried out using an incremental salt gradient, especially an ammonium su... | 05/09/2006 |
| 6893639 | Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates The method for immune serum globulin purification relates to the purification of immune globulins from blood plasma with a high degree of efficiency and a high rate of recovery. The immune globulin source is Cohn's fraction I+II+III or II+III prepared from plasma or... | 05/17/2005 |
| 6875432 | Reduced-viscosity concentrated protein formulations The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.... | 04/05/2005 |
| 6875848 | Process for the production of virus-inactivated human gammaglobulin G The gammaglobulin is extracted from a fraction isolated by fractionation with ethanol in the presence of a carbohydrate, and after reducing the content of contaminants with PEG, it is applied to an anionic resin exchange column, an effluent being obtained in which t... | 04/05/2005 |
| 6737405 | Stabilized protein preparation and process for its preparation A stabilized protein preparation is described which contains no antithrombin III and is protected against loss of activity during pasteurization by the addition of stabilizers which comprise one or more saccharides as a mixture with more than 0.5 mol/l of one or mor... | 05/18/2004 |
| 6709655 | Pharmaceutical composition of F(ab1)2 antibody fragments and a process for the preparation thereof The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically ... | 03/23/2004 |
| 6646108 | Process for isolating IgG and IgA A method for the separation of IgG and IgA from an immunoglobulin-containing starting material is described, whereby the method is characterized in that (i) IgG and optionally IgA are adsorbed to a solid inorganic carrier material, (ii) IgA is isolated fr... | 11/11/2003 |
| 6504012 | Method for preparing dual virally inactivated immune globulin for intravenous administration A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by fractionating an impure gamma globulin solution and then treating the purified gamma globulin, in any order, with a solvent-deter... | 01/07/2003 |
| 6485725 | Room temperature storable immunoglobulin preparation for intravenous injection A method for producing an immunoglobulin preparation for intravenous injection, which comprises the steps of: fractionating an immunoglobulin-containing solution with 4 to 10 w/v% of polyethylene glycol having a molecular weight of from 1,000 to 10,000, a... | 11/26/2002 |
| 6307028 | Chromatographic method for high yield purification and viral inactivation of antibodies An improved process for the purification of antibodies from human plasma or other sources is disclosed. The process involves suspension of the antibodies at pH 3.8 to 4.5 followed by addition of caprylic acid and a pH shift to pH 5.0 to 5.2. A precipitate... | 10/23/2001 |
| 6281336 | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products The present invention relates to a process for purifying immunoglobulin G from a crude immunoglobulin-containing plasma protein fraction. Said process includes a number of steps of which the anion exchange chromatography and the cation exchange chromatogr... | 08/28/2001 |
| 6252055 | Concentrated antibody preparation Concentrated monoclonal antibody preparations for administration to humans are described in which the antibody is present at a concentration of greater than 100 mg/ml and as high as 350 mg/ml.... | 06/26/2001 |
| 6177548 | Enhanced aggregate removal from bulk biologicals using ion exchange chromatography Disclosed are methods and processes for removing aggregates and other impurities from partially purified protein bulk product, in particular, from partially purified monoclonal antibody, using anion exchange chromatography. In such methods and processes, ... | 01/23/2001 |
| 6165467 | Stabilized human monoclonal antibody preparation A stabilized human monoclonal antibody preparation containing 1 to 20 mg of D-mannitol per 1 mg of a human monoclonal antibody. This preparation is excellent in stability in a solution state, a freeze drying state and a freezing state, particularly stabil... | 12/26/2000 |
| 6162904 | Manufacturing method for intraveneously administrable immune globulin and resultant product A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by heat treating for viral inactivation and fractionating an impure gamma globulin solution and then treating the purified gamma glo... | 12/19/2000 |
| 6159471 | Room temperature storable immunoglobulin preparation for intravenous injection A method for producing an immunoglobulin preparation for intravenous injection, which comprises the steps of: fractionating an immunoglobulin-containing solution with 4 to 10 w/v % of polyethylene glycol having a molecular weight of from 1,000 to 10,000, ... | 12/12/2000 |
| 6136312 | Method for producing an IgM preparation for intravenous application In the method for producing an immunoglobulin solution suitable for intravenous application with an IgM proportion of more than 5% by weight with respect to the immunoglobulin proportion, an IgM-containing immunoglobulin solution is treated with a proteas... | 10/24/2000 |
| 6124437 | Immunoglobulin preparation and preparation process thereof An immunoglobulin preparation comprising an immunoglobulin, wherein the preparation contains, as a contaminant, serum albumin in an amount not greater than 10 μg per 50 mg of immunoglobulin; and/or wherein the preparation is free of fine particles which ... | 09/26/2000 |
| 6090380 | Treatment of rheumatoid arthritis by oral administration of pooled human immunoglobulin Pooled human immunoglobulin may be administered orally to rheumatoid arthritis patients to treat the rheumatoid arthritic condition of those patients. Oral administration of pooled human immunoglobulin can result in significant clinical improvement in the... | 07/18/2000 |
| 5972632 | Anticomplement activity assays Immunoassays for complement components, complement activation products or, preferably both, can be used to determine an acceptable level of anticomplement activity (AC) in plasma derived biologically active products intended for infusion into a mammal. In... | 10/26/1999 |
| 5945098 | Stable intravenously-administrable immune globulin preparation Stable, intravenously-administrable immune globulin preparations are stabilized against aggregation and polymerization and rendered isotonic with amino acid(s) and non-ionic detergents, polysorbate and polyethylene glycol. The immunoglobulins are derived ... | 08/31/1999 |
| 5917021 | Stabilized monomeric protein compositions The present invention relates to a stabilized protein composition comprising a monomeric protein and a storage-stabilizing amount of sucrose, histidine or glycine, which is sufficient to inhibit aggregation of the protein molecules during freeze/thaw cycl... | 06/29/1999 |
| 5889157 | Humanized B3 antibody fragments, fusion proteins, and uses thereof This invention provides for recombinant single chain antibodies capable of specifically binding to a LewisY -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for humanized c... | 03/30/1999 |
| 5886154 | Chromatographic method for high yield purification and viral inactivation of antibodies An improved process for the purification of antibodies from human plasma or other sources is disclosed. The process involves suspension of the antibodies at pH 3.8 to 4.5 followed by addition of caprylic acid and a pH shift to pH 5.0 to 5.2. A precipitate... | 03/23/1999 |
