Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 7488808 | Janus family kinases and identification of immune modulators An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or... | 02/10/2009 |
| 7410767 | HLA-E binding The invention relates to a method of testing a compound for biological activity, which method comprises providing cells expressing one of the CD94/NKG2 family of receptors, contacting the cells with recombinant HLA-E under binding conditions in the presence of the t... | 08/12/2008 |
| 7390490 | Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotox... | 06/24/2008 |
| 7288254 | Use of immunotoxins to induce immune tolerance to pancreatic islet transplantation The invention provides a method of treating diabetes in a subject, comprising administering to the diabetic subject an immunotoxin, thereby reducing the subject's T-cell population, and administering to the subject pancreatic islet cells from a donor. The immune tol... | 10/30/2007 |
| 7259138 | Anti-tumor agents A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to inhibit cell proliferation such as that associated with tumor growth... | 08/21/2007 |
| 7211257 | Methods for inducing apoptosis in ovarian carcinoma cells using an anti-regeneration and tolerance factor antibody The present invention is directed to compositions and methods to modulate inflammatory and immune responses in a subject, which includes immune activation and inhibiting inflammatory responses, by modulating the regeneration and tolerance factor (RTF). ... | 05/01/2007 |
| 7169908 | Purification of polypeptides A method for purifying a desired heterologous polypeptide from microbial fermentation broth or homogenate in which it is produced and solubilized is described. This method involves adding to the broth or homogenate an effective amount of a solution of 6,9-diamino-2-... | 01/30/2007 |
| 7119065 | Metal complex-protein composite and oxidation catalyst We claim a metal complex-protein composite comprising a salen metal complex and an apoprotein having a cavity, wherein the salen metal complex has a structure given by the following formula: R1 and R | 10/10/2006 |
| 7074403 | Immunotherapy of autoimmune disorders using antibodies which target B-cells Antibodies that bind with a B-cell antigen provide an effective means to treat autoimmune disorders. Antibodies and fragments, which may be conjugated or naked, are used alone or in multimodal therapies. The antibodies may be bispecific antibodies which may be produ... | 07/11/2006 |
| 7074409 | Polypeptides having a triggering NK activity and biological applications The invention relates to polypeptides having a triggering NK activity and an aminoacid sequence that is at least 80% identical over its entire length to the polypeptide having SEQID N°1, and any immunogenic fragments thereof, as well as to the polyclonal and monocl... | 07/11/2006 |
| 7070777 | Method for inhibiting inflammation with an antibody that binds the 5C8 protein This invention provides for methods of inhibiting inflammation with antibodies that bind the 5c8 protein. ... | 07/04/2006 |
| 7067109 | Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-t... | 06/27/2006 |
| 7060803 | Metal complex-protein composite and hydrogenation catalyst A metal complex-protein composite comprising apohemoglobin, apoheme oxygenase, apocatalase or apoferrin having cavity and a metal complex has a specific structure that the metal complex is received in the cavity of the apoprotein. The metal complex is prepared by co... | 06/13/2006 |
| 7053190 | Secreted protein HRGDF73 The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote... | 05/30/2006 |
| 7052694 | Dendritic cell potentiation A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are compositions containing the molecule and methods for using the composition... | 05/30/2006 |
| 7045128 | Antibodies against flt3-ligand Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to anti-flt3-L antibodies and enzyme-linked immunosorbent assa... | 05/16/2006 |
| 7041801 | Antibodies binding to polypeptides encoded by developmentally-regulated endothelial cell locus-1 The present invention relates to a member of a novel gene family referred to as developmentally-regulated endothelial cell locus-1 (del-1). In particularly, the invention related to del-1 nucleotide sequences, Del-1 amino acid sequences, methods of expressing a func... | 05/09/2006 |
| 7030228 | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby The invention provides antigen-binding fragments specific for dendritic cells and effective in treatment and/or diagnosing a variety of disorders. Methods of use are also provided as are methods for screening for additional such antigen-binding fragments and the pro... | 04/18/2006 |
| 7030225 | Antibodies to JTT-1 protein, cells secreting such antibodies, and methods of making such antibodies A cell surface molecule that is expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes. This molecule is involved in signal transmission of the secondary signal (costimulatory signal) essential for the activ... | 04/18/2006 |
| 7025962 | Mammalian cell surface antigens; related reagents Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.... | 04/11/2006 |
| 6979546 | Triggering receptor involved in natural cytotoxicity mediated by human natural killer cells and antibodies that identify the same The invention relates to a novel compound termed NKp30 that is selectively expressed by all mature NK cells and that is involved in human natural cytoxicity as an activatory receptor, to new antibodies that bind to the NKp30 structure, and to the pharmaceutical and ... | 12/27/2005 |
| 6949514 | Anti-tumor agents A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to inhibit cell proliferation such as that associated with tumor growth... | 09/27/2005 |
| 6783945 | Cloning and uses of the genetic locus bcl-6 This invention provides an isolated vertebrate nucleic acid molecule the bcl-6 locus. This invention also provides an isolated human nucleic acid molecule of bcl-6 locus. This invention further provides a nucleic acid molecule comprising a nucleic acid molecule of a... | 08/31/2004 |
| 6767996 | Altered antibodies and their preparation An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework... | 07/27/2004 |
| 6759519 | Antibodies to human G-protein chemokine receptor HDGNR10 (CCR5receptor) Antibodies against human G-protein chemokine receptor polypeptides, the polypeptides themselves, DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing su... | 07/06/2004 |
| 6750326 | Method for separating cells using immunorosettes The present invention relates to methods for separating cells using immunorosettes. The method involves contacting a sample containing nucleated cells and red blood cells with an antibody composition which allows immunorosettes of the nucleated cells and the red blo... | 06/15/2004 |
| 6709833 | Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4-biphosphate (PI-3,4-P2) but does not cross-react with structurally similar phospholipid antigens is advantageous for PI-3,4-P2-specific immunoassay. The gene in the variable regions of... | 03/23/2004 |
| 6692743 | Apoptosis of naive human NK cells by crosslinking of their FcγRIIIa molecules with a rat IgG2b (LO-CD2a/BTI-322) or its IgG1 humanized monoclonal antibody Although the mechanism of induction of apoptosis through antibody dependent cellular cytotoxicity (ADCC) mediated by NK cells is well understood, little is known about the fate of the reactive NK cells. Nevertheless, it has been shown that NK cells previo... | 02/17/2004 |
| 6689359 | Ligands, including antibodies, showing reactivity against endocrine cells The invention provides monoclonal and polyclonal antibodies recognising molecules on secretory cells of various tissue targets of autoimmune disease allowing a unifying method of preventing and treating autoimmune diseases and other conditions where hormo... | 02/10/2004 |
| 6677123 | Process for detecting increased risk of fetal chromosomal abnormality An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating -fetoproteins present in the body fluid of a pregnant woman, and measuring the proportion of one or more of the &... | 01/13/2004 |
| 6667036 | Methods of treatment using antibodies to P-selectin glycoprotein ligand P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [3 H]glucosamine-labeled HL-60 cell extracts on immobili... | 12/23/2003 |
| 6638506 | Method of blocking cytotoxic activity in patients with amyotrophic lateral sclerosis using antibodies to FcγRIII The present invention is directed to a method of blocking the cytotoxic activity of FcγRIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis using antibodies specific for FcγRIII receptor. In one aspect, the antibody may be... | 10/28/2003 |
| 6613327 | Methods of preventing immune-mediated abortion by inhibiting a CD28-mediated costimulatory signal Methods of inhibiting and diagnosing spontaneous abortion in a subject are provided. The subject methods are based, inter alia, on the administration of an agent that inhibits a CD28-C mediated costimulatory signal in a T cell such that spontaneous aborti... | 09/02/2003 |
| 6610834 | Human IgM antibodies to chemokine receptors Human sera from normal (i.e., non-HIV infected) individuals contain certain IgM autoantibodies reactive to chemokine and other lymphocyte-surface receptors. A subset of these IgM autoantibodies that bind to such receptors, particularly CXCR4 and CCR5 rece... | 08/26/2003 |
| 6596536 | Nucleotide sequences coding for variable regions of the alpha chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses An isolated antibody that specifically binds a peptide coded by a nucleotide sequence coding for a variable region of chain of an human T lymphocyte receptor, said nucleotide sequence having a nucleotide sequence chosen from any of: V segme... | 07/22/2003 |
| 6576236 | Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain When stimulated through the T cell receptor(TCR)/CD3 complex without requisite costimulation through the CD28/B7 interaction, T cells enter a state of antigen specific unresponsiveness or anergy. This invention is based, at least in part, on the discovery... | 06/10/2003 |
| 6566082 | T-cell antigens, and their use in diagnosis and treatment of T-cell mediated conditions The OX-40 antigen is characterized and claimed together with variants and derivatives thereof. Also described are binding agents for the antigen and the use of these in diagnosis and therapy. Examples of such use include a method for the selective depleti... | 05/20/2003 |
| 6551593 | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through 4 ଲ 7 and its ligands and madcam The invention relates to the treatment of individuals suffering from a disease associated with leukocyte recruitment to the gastrointestinal tract or other tissues as a result of binding of leukocytes to gut-associated endothelium expressing the molecule ... | 04/22/2003 |
| 6528625 | Anti-CCR5 antibodies and kits comprising same The present invention relates to an antibody or functional portion thereof which binds to a mammalian (e.g., human) chemokine receptor 5 protein (CKR-5 or CCR5) or portion of the receptor. The invention further relates to a method of inhibiting the intera... | 03/04/2003 |
| 6525180 | Antibodies to mammalian T cell surface antigen Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also pr... | 02/25/2003 |
