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| Number | Title | Issue Date |
| 7557194 | Antibody materials for an IBD-associated polypeptide The present invention provides nucleic acid and amino acid sequence of the novel I-1 and I-2 polypeptides, which are associated with human inflammatory bowel disease (IBD). Methods of diagnosing and treating inflammatory bowel disease using the IBD-associated I-1 an... | 07/07/2009 |
| 7442373 | Antibodies against protective antigen and methods of use for passive immunization and treatment of anthrax A highly efficient method for generating human antibodies using recall technology is provided. In one aspect, human antibodies which are specific to the anthrax toxin are provided. In one aspect, human peripheral blood cells that have been pre-exposed to anthrax tox... | 10/28/2008 |
| 7329639 | Peptide useful in immunomodulation The present invention provides peptides and polynucleotides, and their use for immunomodulation, immunotherapy and vaccine particularly for anti-cancer therapy, and for diagnosis purposes. The immunomodulatory effect includes induction of proliferation and activatio... | 02/12/2008 |
| 7279171 | Vaccines for infections Vaccine compositions protective against Chlamydia psittaci infections in animals, including but not limited to humans and avian species, comprising an immunogenic amount of a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions V... | 10/09/2007 |
| 7256269 | Immunogen adherence inhibitor and method of making and using same A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment or adherence of colony-forming immunogens in the rumen and... | 08/14/2007 |
| 7256270 | Immunogen adherence inhibitor and method of making and using same A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment or adherence of colony-forming immunogens in the rumen and... | 08/14/2007 |
| 7241443 | Immunogen adherence inhibitor and method of making and using same A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment or adherence of colony-forming immunogens in the rumen and... | 07/10/2007 |
| 7235644 | Vaccine against Gram-negative bacterial infections A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LP... | 06/26/2007 |
| 7230087 | mucoid exopolysaccharide specific binding peptides The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of... | 06/12/2007 |
| 7220423 | DNA immunization against infection Nucleic acid, including DNA, for immunization to generate a protective immune response in a host, including humans, to a major outer membrane protein of a strain of Chlamydia, preferably contains a nucleotide sequence encoding a MOMP or a MOMP fragment that g... | 05/22/2007 |
| 7160990 | Antibodies to a fibrinogen binding protein of staphylococcus epidermidis A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding activity and a recombinant DNA molecule coding for the protein (or f... | 01/09/2007 |
| 7122372 | Peptide useful in immunomodulation The present invention provides peptides and polynucleotides, and their use for immunomodulation, immunotherapy and vaccine particularly for anti-cancer therapy, and for diagnosis purposes. The immunomodulatory effect includes induction of proliferation and activatio... | 10/17/2006 |
| 6967240 | Congener independent detection of microcystin and nodularin congeners The present invention relates to a protienaceous compound or functionally active derivative or part thereof having a binding site for a group represented by formula (I) which is part of a group of toxins derived from various cyanobacteria, to a method for its produc... | 11/22/2005 |
| 6951925 | Processes and agents for detecting Listerias The invention relates to agents and processes for detecting bacteria of the genus Listeria, in particular L. monocytogenes. The agents according to the invention include primers whose sequence is selected from the iap gene of L. monocytogenes. I... | 10/04/2005 |
| 6913756 | Monoclonal antibodies specific for anthrax and peptides derived from the antibodies thereof The present invention provides monoclonal antibodies which are highly specific for Bacillus spores. Also provided are peptides derived from those monoclonal antibodies. Both the antibodies and peptides are highly specific and can discriminate between spores of poten... | 07/05/2005 |
| 6881410 | Treatment of E. faecium infection The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralising agents specific thereto and binding agents specific thereto for therapeutic and diagnostic use, together with diagnostic test methods, methods o... | 04/19/2005 |
| 6855513 | Quorum sensing signaling in bacteria The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginos... | 02/15/2005 |
| 6838085 | DNA immunization against Chlamydia infection Nucleic acid, including DNA, for immunization to generate a protective immune response in a host, including humans, to a major outer membrane protein of a strain of Chlamydia, preferably contains a nucleotide sequence encoding a MOMP or a MOMP fragment that g... | 01/04/2005 |
| 6838552 | Diagnosis and management of infection caused by Chlamydia The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stag... | 01/04/2005 |
| 6824992 | Histidine kinase two-component in Candida albicans The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant met... | 11/30/2004 |
| 6713059 | Antibodies raised against immunogenic conjugates of gram-negative bacterial autoinducer molecules The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals t... | 03/30/2004 |
| 6686452 | Bacillus thuringiensis CryET29 compositions toxic to coleopteran insects and ctenocephalides SPP Disclosed is a novel δ-endotoxin, designated CryET29, that exhibits insecticidal activity against siphonapteran insects, including larvae of the cat flea (Ctenocephalides felis), as well as against coleopteran insects, including the southern corn rootwor... | 02/03/2004 |
| 6680168 | Passive immunization against clostridium difficile disease The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or c... | 01/20/2004 |
| 6667035 | Amino acid sequences for therapeutic and prophylactic use against diseases due to Clostridium difficile toxins The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain of the enterotoxin (toxin A) and cytotoxin (toxin B) from Clostridium difficile, as we... | 12/23/2003 |
| 6635434 | Immunoassay for pesticides and their degradation products A hapten-polymer carrier complex was found to be useful for immunoassay purposes, specifically ELISAs, for the detection of pesticides and their degradation products in hydrosoil and ground water. The degradation products of Casoron G.RTM. (also known as ... | 10/21/2003 |
| 6607730 | Chlamydia antigens and corresponding DNA fragments and uses thereof In summary of this disclosure, the present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, ... | 08/19/2003 |
| 6605287 | Vaccines for Chlamydia psittaci infections Vaccine compositions protective against Chlamydia psittaci infections in animals, including but not limited to humans and avian species, comprising an immunogenic amount of a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 ... | 08/12/2003 |
| 6544516 | Treatment and diagnosis of infections of gram positive cocci The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralizing agents specific thereto and binding agents specific thereto for therapeutic and diagnostic use, together with diagnostic test methods... | 04/08/2003 |
| 6537550 | Use of avian antibodies The present invention relates to use of avian antibodies and/or antigen binding fragments thereof, for the production of a drug for treatment and/or prevention of respiratory tract infection. The drug is administered through local application at the oral ... | 03/25/2003 |
| 6528061 | Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions A purified immunogenic polypeptide comprises an epitope unit recognized by a protective monoclonal antibody having a high affinity and a high specificity for a surface polysaccharide of a pathogenic microorganism of bacterial, viral, or fungal origin. The... | 03/04/2003 |
| 6488929 | Candida albicans phosphomannan complex as a vaccine A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to the infection by C. albicans. The composition includes phosphomannan of C. albicans. Monoclonal antibodies for use in passive immunization a... | 12/03/2002 |
| 6458933 | Therapeutic using a bispecific antibody Multivalent, multispecific molecules having at least one specificity for a pathogen and at least one specificity for the HLA class II invariant chain (Ii) are administered to induce clearance of the pathogen. In addition to pathogens, clearance of therape... | 10/01/2002 |
| 6429189 | Cytotoxin (non-neurotoxin) for the treatment of human headache disorders and inflammatory diseases Pharmaceutical applications of a chemodenervating agent reduce pain by altering release of pain and inflammation-mediating autocoids, with a duration of action between 12-24 weeks. The limiting factor in dosing for this application is weakness and paralys... | 08/06/2002 |
| 6403090 | Peptides which mimic candida carbohydrate epitopes and their use in a vaccine A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleot... | 06/11/2002 |
| 6376658 | Proteins related to encapsulation and genes encoding the same The present invention relates to a protein related to encapsulation in immune reaction and a gene encoding the same.... | 04/23/2002 |
| 6350449 | Antibodies to meningococcal polysaccharide conjugate vaccines The invention relates to chemically-modified group B polysaccharides of Neisseria meningitidis. The invention also provides vaccines in which the respective modified polysaccharides are conjugated to a protein carrier, and the like, as well as antibodies ... | 02/26/2002 |
| 6344202 | DNA immunization against chlaymdia infection Nucleic acid, including DNA, for immunization to generate a protective immune response in a host, including humans, to a major outer membrane protein of a strain of Chlamydia, preferably contains a nucleotide sequence encoding a MOMP or a MOMP fragment th... | 02/05/2002 |
| 6322788 | Anti-bacterial antibodies and methods of use Compositions containing a purified antibody having both an antigen-binding portion specific for a bacterial antigen and a constant region that does not bind bacterial Fc-binding proteins are disclosed. Also disclosed are compositions and methods for treat... | 11/27/2001 |
| 6290960 | Vaccine and antitoxin for the treatment of C. difficile disease The present investion provides vaccines capable of protecting a vaccinated recipient from the morbidity and mortality associated with C. difficile infection. These vaccines are produced with portions of C. difficile Toxin A, or Toxin B, or both. These por... | 09/18/2001 |
| 6271017 | Genes of Heliciobacter pylori necessary for the regulation and maturation of urease and their use Oligonucletodie sequences are disclosed specific to H. pylori urease and useful as DNA probes and primers in the detection of H. pylori infection in humans.... | 08/07/2001 |
