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| Number | Title | Issue Date |
| 7439331 | Inhibition of complement activation The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including ... | 10/21/2008 |
| 7390490 | Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotox... | 06/24/2008 |
| 7291333 | Blockade of protein C activation reduces microvascular surgical blood loss A method of inhibiting microvascular bleeding is provided. Antibody to protein C administered to a patient in a pharmaceutically acceptable carrier prevents anticoagulation by greater than 90% of activated protein C in human plasma. ... | 11/06/2007 |
| 7279158 | Methods for the treatment of inflammatory joint disease The use of compounds that block complement component C5 or its active fragments C5a and/or C5b (such compounds collectively referred to as “C5 blockers”) to treat established joint inflammation (arthritis) is disclosed. Administration of such C5 bl... | 10/09/2007 |
| 7279161 | Factor IX/factor IXa activating antibodies and antibody derivatives An antibody or antibody derivative against factor IX/activated factor IX (FIXa) which increases the procoagulant activity of FIXa. ... | 10/09/2007 |
| 7273925 | Methods and products for regulating lectin complement pathway associated complement activation The invention relates to methods and products for regulating lectin complement pathway associated complement activation. The methods include both in vitro and in vivo methods for inhibiting lectin complement pathway associated complement activation. The methods are ... | 09/25/2007 |
| 7244580 | Epsilon immunoglobulin chain derived peptides for induction of anti-IgE antibodies The present invention relates to identification of polypeptides useful for generating antibodies specific for non-human IgE, particularly equine IgE. The invention, therefore, also relates to antibodies that specifically bind to IgE and methods to detect IgE using t... | 07/17/2007 |
| 7122322 | Endometriosis-specific secretory protein A method and kit of diagnosing endometriosis in a female patient suspected of having endometriosis. The method includes obtaining a sample from the patient. The sample is analyzed to detect the presence of a purified and isolated endometriotic haptoglobin designated... | 10/17/2006 |
| 7112327 | Inhibition of complement activation The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including ... | 09/26/2006 |
| 7098036 | Antibodies to lipoproteins and apolipoproteins and methods of use thereof Compositions and methods using antibodies which are immunoreactive with specific apolipoproteins to determine the concentrations of lipoproteins such as HDL and LDL, and/or apolipoproteins in human blood, serum or plasma sample, are described. Monoclonal antibodies ... | 08/29/2006 |
| 7083786 | MASP-2, a complement-fixing enzyme, and uses for it The invention relates to the discovery and characterization of mannan binding lectin-associated serine protease-2 (MASP-2), a new serine protease that acts in the MBLectin complement fixation pathway. ... | 08/01/2006 |
| 7060268 | Protein formulation A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibod... | 06/13/2006 |
| 7052855 | Anti-APO-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring APO-B-48 using the same A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100. ... | 05/30/2006 |
| 7049407 | Heparanase specific antibodies and their use in research and medical applications A variety of heparanase specific antibodies which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific antibodies for detection of the presence, absence or level of heparana... | 05/23/2006 |
| 7033590 | Factor IX/factor IXa activating antibodies and antibody derivatives An antibody or antibody derivative against factor IX/activated factor IX (FIXa) which increases the procoagulant activity of FIXa. ... | 04/25/2006 |
| 7022775 | Resins based on polystyrene-functionalized methyl esters groups of L-tyrosine and their uses The present invention relates to resins based on functionalized polystyrene, to the method for the production thereof, to the use thereof for producing columns for purifying anti-factor VIII antibodies, and also to a method for purifying anti-factor VIII antibodies ... | 04/04/2006 |
| 6998469 | Platelet membrane glycoprotein VI (GPVI) DNA and protein sequences, and uses thereof The present invention comprises a method of purifying GPVI, GPVI peptides, cDNA and protein sequence, and methods for using GPVI and antibodies directed against GPVI. ... | 02/14/2006 |
| 6953667 | Antibodies against human protein HUVDJ43 The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote... | 10/11/2005 |
| 6936424 | Materials and methods for detection and treatment of breast cancer The invention provides a wide range of methods and compositions for detecting and treating breast cancer in an individual. Specifically, the invention provides target breast cancer-associated proteins, which permit a rapid detection, preferably before metastases occ... | 08/30/2005 |
| 6932969 | Ig fractions having immunomodulatory activity The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The in... | 08/23/2005 |
| 6914129 | Anti-IgE antibodies The present invention describes IgE antagonists (including variant anti-IgE antibodies) and their use in diagnosis, therapy or prophylaxis of allergic and other IgE-mediated disorders, including asthma, food allergies, hypersensitivity and anaphylactic reactions. | 07/05/2005 |
| 6893831 | Immunoassay of PIVKA-II The present invention provides an immunoassay for specifically measuring with high sensitivity PIVKA-II in serum or plasma through antigen-antibody reaction by adding an animal serum containing thrombin and/or an antibody reacting with human fibrin-like related subs... | 05/17/2005 |
| 6866845 | Compositions and methods for the treatment of sepsis The present invention relates to compositions and methods for the prevention and treatment of blood-borne and toxin mediated diseases, and in particular anti-C5a antibodies for the prevention and treatment of sepsis in humans as well as other animals. The present in... | 03/15/2005 |
| 6858438 | Peptides immunoreactive with autoantibodies from patients with rheumatoid arthritis The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine res... | 02/22/2005 |
| 6855508 | ELISA for VEGF The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA method and kits for VEG... | 02/15/2005 |
| 6828114 | Monoclonal antibody against apolipoprotein A-I The present invention is drawn to a monoclonal antibody reacting specfically with (1) apoA-I occurring in HDL containing no apoA-II and having a molecular weight of 150,000 or less; and (2) apoA-I not binding to a lipid; a hybridoma producing this antibody; a method... | 12/07/2004 |
| 6689570 | Methods of identifying agents which bind GPR-9-6 The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The invention also relates to a method of identifying agents (molecu... | 02/10/2004 |
| 6673561 | Diagnostic test for thrombotic or thromboembolic disease Thrombotic or thromboembolic disease is detected or monitored by determining the presence or amount B in a urine sample.... | 01/06/2004 |
| 6673346 | Compositions and methods for the treatment of sepsis The present invention relates to compositions and methods for the prevention and treatment of blood-borne and toxin mediated diseases, and in particular anti-C5a antibodies for the prevention and treatment of sepsis in humans as well as other animals. The... | 01/06/2004 |
| 6656746 | Antibodies to human kunitz-type inhibitor The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA... | 12/02/2003 |
| 6632615 | Method for isolating a target biological material, capture phase, detecting phase and reagent containing them The invention concerns a method for isolating a target biological material contained in a sample, which consists in providing a capture phase comprising an organic molecule having at least a reactive function and at least a protein material capable of rec... | 10/14/2003 |
| 6613537 | Pyrrolopyridinium derivatives The present invention is drawn to pyrrolopyridinium derivatives having a new structural skeleton, preferably containing an intramolecular hemiacetal, which is clearly different from any known Advanced Glycation Endproduct (AGE) and which, when present in ... | 09/02/2003 |
| 6582603 | Method for purifying thrombin substrate and/or inhibitors or method for eliminating the same A method for the refinement of a thrombin substrate, characterized by comprising therein a step of affinity chromatography formed by using an affinity adsorbent having as a ligand a thrombin or thrombin analogue deprived of nucleophilicity (activity) with... | 06/24/2003 |
| 6579682 | Methods and tools for identifying compounds which modulate atherosclerosis by impacting LDL-proteoglycan binding The present invention relates to the study and control of atherosclerosis through the modulation of LDL-proteoglycan binding at Site B (amino acids 3359-3369) of the apo-B100 protein in LDL. The invention encompasses methods of identifying compounds which... | 06/17/2003 |
| 6538113 | Methods of obtaining antibody directed against prothrombin fragments F2/F1+2 The invention relates to synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic, to the use thereof for the immunization of an animal and for the purification o... | 03/25/2003 |
| 6534323 | Compositions and methods for early detection of heart disease The invention relates to methods, compositions, kits, and devices for detecting cardiac ischemia, hypoxia, or other causes of heart failure in a mammal by obtaining a test sample from a mammal, measuring a level of a non-polypeptidic cardiac marker in the... | 03/18/2003 |
| 6514716 | Detection of the end-position sialic acid groups of the human transferrin molecule The subject matter of this invention is a method of determining terminal sialic acid residues in human transferrin according to a sandwich principle, which is characterized in that the sample fluid containing the human transferrin is incubated with a firs... | 02/04/2003 |
| 6500630 | Marker for inflammatory conditions Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.... | 12/31/2002 |
| 6500428 | Antibodies to a lymphocyte surface receptor that binds CAML and methods of use thereof A novel lymphocyte receptor protein, its DNA sequence, and its role in the calcium activation pathway is described. The protein, or genetically engineered constructs encoding it, are shown to increase lymphocyte response, and to identify ligands of the pr... | 12/31/2002 |
| 6451547 | Process for differential diagnosis of Alzheimer's dementia and device therefor A method for diagnosing Alzheimer's disease(AD) is disclosed. The method involves directly detecting the presence of a biochemical marker, specifically human glutamine synthetase, in bodily fluid, preferably blood or a blood product. The detection is by a... | 09/17/2002 |
