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| Number | Title | Issue Date |
| 8071733 | Antibodies that specifically bind hedgehog-derived polypeptides The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic do... | 12/06/2011 |
| 7741451 | Antibodies that specifically bind hedgehog-derived polypeptides The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic do... | 06/22/2010 |
| 7576189 | Antibodies to human vascular endothelial growth factor 2 and methods of using the same Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using su... | 08/18/2009 |
| 7439329 | GEF-H1b: biomarkers, complexes assays and therapeutic uses thereof The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exch... | 10/21/2008 |
| 7417124 | Antibodies specific for phosphorylation sites and screening methods using the same antibodies Polyclonal antibody specific for a phosphorylated linker region in Smad2 and/or Smad3. ... | 08/26/2008 |
| 7399636 | Diagnostic kit for predicting pregnancy outcome The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 07/15/2008 |
| 7396917 | Rationally designed antibodies Antibodies or fragments thereof having at least two CDR regions replaced or fused with biologically active peptides are described. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities. ... | 07/08/2008 |
| 7393662 | Human EPO mimetic hinge core mimetibodies, compositions, methods and uses The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hing... | 07/01/2008 |
| 7390490 | Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotox... | 06/24/2008 |
| 7390491 | Agents comprising midkine or an inhibitor thereof as active ingredient Midkine (MK), which is a retinoic acid-inducible heparin-binding growth factor, enhances neutrophilic migration and exists in an inflammatory state at a high concentration. The midkine or its inhibitors can be used for treating neutrophilic functional disorders or i... | 06/24/2008 |
| 7371384 | Compositions and methods of using angiopoietin-like 4 protein antibody ANGPTL4 compositions and methods of using such compositions, and agonists or antagonists thereof, for the diagnosis and treatment of diseases or disorders are included, including methods to modulate cell proliferation, cell adhesion, and cell migration. ... | 05/13/2008 |
| 7371377 | Antibodies to polypeptides homologous to VEGF and BMP1 The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF inclu... | 05/13/2008 |
| 7316902 | Compositions that specifically bind to colorectal cancer cells and methods of using the same A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colore... | 01/08/2008 |
| 7312319 | Neurotrophic factor (NT-4) immunoassay systems A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided herein are nucl... | 12/25/2007 |
| 7309780 | Antibodies to natural killer cell activating factor II The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to meth... | 12/18/2007 |
| 7307152 | Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 12/11/2007 |
| 7285391 | Methods for predicting pregnancy outcome in a subject by hCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 10/23/2007 |
| 7264939 | Method of detecting native proBNP The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a h... | 09/04/2007 |
| 7265211 | Anti-IL-TIF antibodies and methods of making The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for anta... | 09/04/2007 |
| 7264938 | Method of detecting native proBNP The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a h... | 09/04/2007 |
| 7261891 | Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease Methods are described for treating inflammatory bowel disease in animals, including humans. Specific avian polyclonal antibodies directed to proinflammatory cytokines (such as IL-6 and TNF) are shown to have a beneficial effect in animal models predictive of human t... | 08/28/2007 |
| 7253265 | Antibody and a method for producing an antibody that specifically binds to a full length amino acid sequence of human Delta-1 An antibody and a method for producing an antibody that specifically binds to a full length amino acid sequence of human Delta-1. ... | 08/07/2007 |
| 7226749 | Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according... | 06/05/2007 |
| 7223394 | Human antibodies that bind human TNFα Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor a (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα di... | 05/29/2007 |
| 7208584 | Fibroblast growth factor-13 The present invention relates to a novel FGF-13 protein which is a member of the fibroblast growth factor (FGF) family. In particular, isolated nucleic acid molecules are provided encoding the human FGF-13 protein. FGF-13 polypeptides are also provided as are vector... | 04/24/2007 |
| 7198954 | Methods for predicting pregnancy outcome in a subject by hCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 04/03/2007 |
| 7198790 | Growth differentiation factor-5 Growth differentiation factor-5 (GDF-5) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-5 polypeptide and polynucleotide sequences. ... | 04/03/2007 |
| 7189814 | Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 03/13/2007 |
| 7189802 | Integrin-linked kinase and its uses Methods for isolating ILK genes are provided. The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; an... | 03/13/2007 |
| 7186809 | Methods and compositions relating to anti-interleukin-4 receptor antibodies Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 antagonist to a patient afflicted with such a condition. Suitable IL-4 antagonists include, but are not limited to, IL-4 receptors (such as a soluble human IL-4 receptor),... | 03/06/2007 |
| 7183108 | Selection and uses of lactic acid bacteria strains modulating non-specific immunity The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said enterocytes. The strains can also be incorporated in food supplements such as fe... | 02/27/2007 |
| 7169759 | Tetrapeptide inhibitors of β-secretase Statine-derived peptide inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of tr... | 01/30/2007 |
| 7166285 | Anti-IL-12 antibodies and compositions The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, metho... | 01/23/2007 |
| 7160861 | Methods of inducing IL-10 production The invention provides a method of inducing IL-10 production. ... | 01/09/2007 |
| 7148025 | Method of detecting native proBNP The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a h... | 12/12/2006 |
| 7138115 | Use of IL-12 and IL-12 antagonists in the treatment of autoimmune diseases Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-γ or TNF-α. Suit... | 11/21/2006 |
| 7138498 | Antibodies to MCP-4 Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia... | 11/21/2006 |
| 7135333 | Compositions that specifically bind to colorectal cancer cells and methods of using the same A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colore... | 11/14/2006 |
| 7115263 | Compositions and methods for treating hyperimmune response in the eye The present invention comprises and utilizes methods and compositions for treating hyperimmune reactions in the eye. Compositions comprising antibodies to gamma interferon alone and in combination with other drugs are described. Also disclosed in the invention are m... | 10/03/2006 |
| 7105644 | Secreted protein HHTLF25 antibodies The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. Th... | 09/12/2006 |
