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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 8076461 | Methods and compositions for determining the purity of and purifying chemically synthesized nucleic acids An antibody microarray is described comprising a plurality of antibodies immobilized on a substrate, wherein each antibody specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having an organic protecting group covalently bound there... | 12/13/2011 |
| 7432346 | Gene expressed in prostate cancer A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety of normal tissues indicates that the expression of this gene is testis... | 10/07/2008 |
| 7399589 | Immunological detection of RNA:DNA hybrids on microarrays The present invention provides a hybridization method and kit for the detection and measurement of biological molecules. A test sample containing the biological molecules of interest is hybridized with an unlabeled or optionally a detectably-labeled complementary bi... | 07/15/2008 |
| 7378091 | Antibodies against carbonic anhydrase IX (CA IX) tumor antigen The present invention relates generally to the generation and characterization of anti-CA IX monoclonal antibodies. The invention further relates to the use of such anti-CA IX antibodies in the diagnosis and treatment of disorders associated with increased activity ... | 05/27/2008 |
| 7378505 | Assay method for group transfer reactions The present invention relates to methods for detecting, quantifying and high throughput screening of donor-products and the catalytic activities generating the donor-products in group-transfer reactions catalyzed by adenosine triphosphatase (ATPase) or guanine triph... | 05/27/2008 |
| 7368293 | Liver enriched transcription factor HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes (Costa et al., 1989; Costa et al., 1990; Leff et al., 1989). We have pur... | 05/06/2008 |
| 7355010 | Assay method for group transfer reactions The present invention relates to methods for detecting, quantifying and high throughput screening of donor-products and the catalytic activities generating the donor-products in group-transfer reactions. The invention further provides immunoassays, antibodies and ki... | 04/08/2008 |
| 7256275 | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ... | 08/14/2007 |
| 7125972 | Solid carriers with peptide nucleic acid probes and methods for regeneration A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode in complex... | 10/24/2006 |
| 7071311 | Antibodies having specificity for 2′-C-allyl nucleic acids The present invention relates to antibodies, antibody conjugates, and compositions thereof, methods of antibody synthesis, and applications of antibodies useful for detecting the presence of nucleic acid molecules in vivo, such as in a clinical setting. The antibodi... | 07/04/2006 |
| 7067135 | Methods and compositions for the treatment and prevention of infections The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, Staphylococcus spp., particularly S. aureus. ... | 06/27/2006 |
| 7037894 | Stabilized proteins Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that the retain at least one functional activity. In one embodiment, the isolated polypeptide or polypeptide chains comprise at least one di-tyrosine cross-link, wherein at le... | 05/02/2006 |
| 7034109 | Intracellular delivery of biological effectors The invention relates to a sequence of amino acids with the capacity to facilitate transport of an effector across a biological membrane. More specifically, the present invention relates to novelpeptide transporters that specifically target certain cell types for th... | 04/25/2006 |
| 6998229 | Glucuronide repressors and uses thereof Clones containing a sequence encoding a glucuronide repressor are described. The nucleotide and amino acid sequences of a repressor (gusR) are presented. A glucuronide repressor is used to control expression of a transgene, detect glucuronides in a sample, and isola... | 02/14/2006 |
| 6927035 | Antiuracil monoclonal antibody A monoclonal antibody which reacts strongly with uracil and thymine but scarcely with N-carbamyl-β-alanine; a hybridoma producing this monoclonal antibody; a method of immunochemically assaying uracil or thymine characterized by using the above-described monoclonal... | 08/09/2005 |
| 6905860 | Artificial chromosome An artificial mammalian chromosome, more specifically, a clone containing a mammalian centromere sequence and a DNA replication origin with mammalian telomere sequences added to both ends of the clone, is provided by preparing a CEPH artificial yeast chromosome libr... | 06/14/2005 |
| 6827925 | Specific binding proteins including antibodies which bind to the necrotic center of tumors, and uses thereof Specific binding members, based on the third CDR of the antibody NHS76 (SEQ ID NO: 2) are provided, together with their use in methods of treatment and diagnosis. ... | 12/07/2004 |
| 6777394 | Methods and compositions for regulating imidazoline receptors The present invention relates to methods and compositions for regulating the activity of imidazoline receptors. In particular, the invention relates to pharmaceutical compositions comprising imidazoleacetic acid-ribotide (IAA-RP), imidazoleacetic acid-riboside (IAA-... | 08/17/2004 |
| 6723548 | DNA repair polypeptides and methods of use The present invention provides polypeptides having pyrimidine glycosylase activity, preferably, pyrimidine glycosylase/AP lyase activity. The polypeptides include a targeting sequence, preferably an exogenous target sequence. The invention includes polynucleotides t... | 04/20/2004 |
| 6716608 | Artificial chromosome An artificial mammalian chromosome, more specifically, a clone containing a mammalian centromere sequence and a DNA replication origin with mammalian telomere sequences added to both ends of the clone, is provided by preparing a CEPH artificial yeast chromosome libr... | 04/06/2004 |
| 6686151 | Immunological detection of RNA:DNA hybrids on microarrays The present invention provides a hybridization method and kit for the detection and measurement of biological molecules. A test sample containing the biological molecules of interest is hybridized with an unlabeled or optionally a detectably labeled compl... | 02/03/2004 |
| 6653103 | Inhibition of nucleocytoplasmic transport by vesicular stomatitis virus M protein-like polypeptides A fragment of vesicular stomatitis virus (VSV) matrix protein (M protein) and M proteins of other viral species that can inhibit nucleocytoplasmic transport of RNA, proteins and RNA-protein complexes are disclosed. These polypeptide products and related p... | 11/25/2003 |
| 6623960 | Agents that bind to and inhibit human cytochrome P450 2C8, 2C9, 2C18 and 2C19 The invention provides monoclonal antibodies to human cytochrome P450 2C8, 2C9, 2C18, and 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of the various human cytochrome P450 2C family members and lack of s... | 09/23/2003 |
| 6608034 | Immunovectors for the intracellular and intranuclear transport A product for coupling a biologically active principle with an immunovector, characterized in that the immunovector is capable of enabling the biologically active principle to be internalized into eukaryotic cells, and in that said immunovector has an aff... | 08/19/2003 |
| 6537566 | Compositions and methods for the non-invasive treatment of uterine fibroid cells The proliferation of uterine fibroid leiomyoma cells is inhibited by certain Fibroid Cell Growth Inhibitor (FGI) agents. The pharmacological doses of these FGI agents in the milieu of uterine fibroid cells can be made high enough to not only inhibit proli... | 03/25/2003 |
| 6503736 | Antibodies to crosslinkers and methods for using the same The present invention is directed to the discovery of antibodies that will react to proteins or nucleic acids bound to particular crosslinkers, but not to the free crosslinkers or free proteins or nucleic acids. Monoclonal antibodies with such binding spe... | 01/07/2003 |
| 6500672 | Liver enriched transcription factor HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes (Costa et al., 1989; Costa et al., 1990; Leff et al., 1989). ... | 12/31/2002 |
| 6399748 | In-vitro method for prognosticating the illness development of patients with carcinoma of the breast and/or for diagnosing carcinoma of the breast The present invention is directed to a method of prognosticating the illness development of patients with carcinoma of the breast and/or for diagnosing carcinoma of the breast, the method comprising a qualitative determination of T1 protein and/or T1-mRNA... | 06/04/2002 |
| 6358711 | Antibody to human testin and methods of making and using The invention provides a human testin (HTES) and polynucleotides which identify and encode HTES. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or prevent... | 03/19/2002 |
| 6355609 | Methods for stabilizing liquid nutritional products and products so stabilized Nutritional solutions and methods of making same are disclosed. The solutions include protein, lipid, and a carbohydrate source including high amylose starch and guar gum.... | 03/12/2002 |
| 6316597 | Sox-9 gene and protein and use in the regeneration of bone or cartilage An isolated DNA molecule encoding a Sox-9 gene which codes for the Sox-9 polypeptide. The human Sox-9 gene has been mapped to chromosome 17 in the same region as CMPD-1, the locus for Campomelic Dysplasia (CD). Sox-9 appears to have a role in mammalian sk... | 11/13/2001 |
| 6306588 | Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof The present invention provides methods for use in identifying, analyzing and typing polymorphic DNA fragments, particularly minisatellite, microsatellite or STR DNA fragments. In particular, the invention provides methods using DNA polymerases, more parti... | 10/23/2001 |
| 6183121 | Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an oligonucleotide, to crystallizable compositions of HCV helicase and an... | 02/06/2001 |
| 6057097 | Marker for pathologies comprising an auto-immune reaction and/or for inflammatory diseases The present invention comprises a marker for inflammatory diseases and/or pathologies comprising an autoimmune reaction, which is the plasmatic membrane and/or a portion therof, in particular the plasmatic DNA. The present invention concerns also the meth... | 05/02/2000 |
| 6022735 | Composition for introducing nucleic acid complexes into higher eucaryotic cells A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, ... | 02/08/2000 |
| 6001657 | Antibodies that selectively bind quadruplex nucleic acids Antibodies that selectively bind to quadruplex nucleic acids are described. Isolated cells that produce such antibodies, and methods utilizing these antibodies, are also described.... | 12/14/1999 |
| 5993818 | Use of autoantibodies for tumor therapy and prophylaxis A method of inhibiting the growth of a tumor cell in a mammal by administering to the mammal an autoantibody, e.g, an antinuclear autoantibody from an aged mammal, that binds to either one or both of a surface of a tumor cell and a protein released from a... | 11/30/1999 |
| 5985575 | Tethered function assay for protein function A method for determining the function of a test protein is disclosed. In a preferred embodiment, this method comprises the steps of fusing a test protein to an RNA-binding protein and exposing the fusion protein to recombinant reporter mRNA molecule that ... | 11/16/1999 |
| 5811247 | Monoclonal antibodies to nucleolar protein The invention relates to a hybridoma cell line which produces a monoclonal antibody which cross reacts with both yeast and human fibrillarin. Diagnostic kits are also described. These are useful in diagnosing diseases such as scleroderma.... | 09/22/1998 |
| 5756684 | Cloning and expression of PUR protein The present invention relates to the PUR protein, nucleotide sequences and expression vectors encoding PUR, and to methods for inhibiting PUR activity. Inhibitors of PUR activity may be used to treat hyperproliferative diseases such as cancer.... | 05/26/1998 |
