Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 4912202 | Dihydropyridine receptor and antibodies thereto Monoclonal antibodies capable of immunoprecipitating labeled dihydropyridine receptor material from digitonin-solubilized skeletal muscle triads are disclosed. Said antibodies recognize a 170,000 dalton protein subunit of the dihydropyridine receptor.... | 03/27/1990 |
| 4900661 | Method for immunological determination of amines, monoclonal antibodies and kit of reagents for carrying out the method This method for immunological determination of amines in biological media consists of: (a) reacting a quinone (in particular, p-benzoquinone) with the amine (for example histamine) present in the test sample; (b) introducing into the medium a monoclonal a... | 02/13/1990 |
| 4891319 | Protection of proteins and the like Sensitive proteins and other macromolecules, such as enzymes, antibodies, antigens, serum complement, fluorescent proteins, vaccine components, polysaccharides such as agarose etc, can be preserved by drying at ambient temperature and at atmospheric press... | 01/02/1990 |
| 4879225 | Enhanced production of antibodies utilizing insolubilized immune complexes A method for enhancing production of antibodies through immunization with insolubilized immune complexes is disclosed. Purified antigen or heterogeneous antigen mixtures may be combined with polyclonal or monoclonal antibody and the resultant complex boun... | 11/07/1989 |
| 4849508 | Pasteurization of immunoglobulin solutions Pasteurization of immunoglobulin solutions to inactivate viruses without significantly altering the IgG molecules or their physiological activities is obtained with minimal aggregation in the absence of any stabilizer by heating this solution to mildly-el... | 07/18/1989 |
| 4842998 | Heterohybridoma screening method Human-nonhuman heterohybridomas capable of expressing IgM type antibodies can be screened to select hybridomas expressing IgM antibodies comprising human J chain components. Method comprises contacting separate samples of IgM antibodies (or IgM J chain co... | 06/27/1989 |
| 4841025 | Antibody preparations A monoclonal antibody preparation having a single binding activity, which activity is in respect of a cell surface antigen, comprises IgG antibody molecules in which only one of the two light chains will bind to said antigen, the proportion of such antibo... | 06/20/1989 |
| 4841024 | Purification of antibodies I(g)G3 antibody is purified by affinity chromatography and collection of released antibody at a pH of 9.0 to 9.6. The purification is effected in a column containing both an affinity matrix and a desalting matrix, with the column being equilibrated to a p... | 06/20/1989 |
| 4840895 | Monoclonal antibodies reactive with immune complexes A secondary monoclonal antibody against a complex of a molecule of molecular weight less than 5000 and a binding protein against said molecule which secondary monoclonal antibody is not an antibody against molecule or against its binding protein.... | 06/20/1989 |
| 4837170 | Monoclonal antibody, measuring method of glucosylated protein by utilizing the monoclonal antibody, and kit therefor For the diagnosis of diabetes, a glucosylated protein in a sample is measured by subjecting the sample to a reducing treatment and then detecting a compound, which contains one or more reduced glucosylated lysine residual groups, in accordance with an imm... | 06/06/1989 |
| 4814433 | Method for obtaining a papain-free antibody fragment preparation A method for obtaining a papain-free F(ab')2 antibody fragment preparation derived from papain digested whole IgG antibody employing an antibody to papain for binding to and removing papain-associated digestion products from the preparation. Th... | 03/21/1989 |
| 4801687 | Monoclonal antibody purification process using protein A Immunoglobins are purified by adsorption upon an immobilized protein A adsorbent using a buffer having a pH of 7.5 to 10 and containing a combination of monovalent cations and polybasic anions in a concentration of about 0.6M to 1.75M.... | 01/31/1989 |
| 4795702 | Diagnostic method for gonorrhea by assay of IgA1 fragments Method for assay of fragments produced by the reaction between the enzyme immunoglobulin A protease and its substrate immunoglobulin A, sub-class 1. IgA1, IgAP and also bacteria which secrete IgAP may be detected. The assay is especially useful in the det... | 01/03/1989 |
| 4795634 | Method for contraception by immunization against the zona pellucida This invention relates to a method for contraception comprising the active immunization of a female mammal against zona pellucida using a composition comprising an effective amount of anti-idiotypic antibodies formed against anti-zona pellucida antibodies... | 01/03/1989 |
| 4792528 | Methods for obtaining monoclonal antibodies useful in enhanced sensitivity immunoassays Mixtures of monoclonal antibodies which contain effective assaying amounts of each of at least two monoclonal antibodies that bind to different antigenic sites on the antigen and are capable under appropriate conditions of binding simultaneously to an ant... | 12/20/1988 |
| 4745183 | Use of hydroxylapatite for the analysis and preparation of purified monoclonal antibodies A novel method is disclosed for the purification of monoclonal antibodies from antibodies of the same isotype but different light chain composition which are frequently present in the fluids in which such antibodies are generated. According to the method,... | 05/17/1988 |
| 4732863 | PEG-modified antibody with reduced affinity for cell surface Fc receptors PEG-modified protein molecules characterized by reduced immunogenicity are prepared by covalent modification of the protein with PEG employing an active ester intermediate. Antibodies so modified exhibit decreased binding capacity for Fc cell surface rece... | 03/22/1988 |
| 4722892 | Monoclonal antibodies against metal chelates Monoclonal Antibodies which are specific for a complex of a chelating agent and a metallic ion are described. The antibody has an association constant (Ka) for the complex which is at least about ten times greater than the Ka for the... | 02/02/1988 |
| 4722899 | Producing highly specific, low cross-reactive antibody by immunizing with copolymer of D-glutamic acid and lysine A process for producing an antibody having a high specificity to a first antigen and a low cross-reactivity with at least one second antigen, said first antigen comprising a desired antigenic determinant and said second antigen comprising at least one ant... | 02/02/1988 |
| 4721777 | Process for the virus-inactivation of immunoglobulin Virus-contaminated immunoglobulin can be virus-inactivated by heating it in a substantially dry state at a temperature of 30° to 100° C. for a period of time sufficient for inactivating virus with maintaining original activity of the immunoglobulin. The... | 01/26/1988 |
| 4720385 | Protein compositions substantially free from infectious agents Compositions containing therapeutically or immunologically active proteins are rendered substantially free from infectious agents such as viable viruses and bacteria without substantial loss of therapeutic or immunologic activity by mixing the protein com... | 01/19/1988 |
| 4704366 | Process for binding IgG to protein A Unusually strong binding of IgG to protein A is achieved by contacting these components in the presence of a medium containing a high concentration of salt. Although such binding is of general utility, a particularly useful application is the purification... | 11/03/1987 |
| 4692416 | Monoclonal antibodies reactive with shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus The invention relates to monoclonal anti-idiotypic antibodies to human anti-DNA antibodies. Monoclonal, anti-idiotypic antibodies are produced using hybridoma technology. The antibodies are used as diagnostic reagents in methods to determine the presence ... | 09/08/1987 |
| 4690905 | Method for removal of human antibodies to native DNA from serum The invention relates to monoclonal anti-idiotypic antibodies to human anti-DNA antibodies. Monoclonal, anti-idiotypic antibodies are produced using hybridoma technology. The antibodies are used as diagnostic reagents in methods to determine the presence ... | 09/01/1987 |
| 4666697 | Radioactive diagnostic agent A radioactive diagnostic agent which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound a methyleneimine ... | 05/19/1987 |
| 4604235 | Purification of monoclonal antibodies A method of chromatographically separating monoclonal antibody type IgM from mouse ascites fluid utilizing a particular chromatographic packing of silica gel bearing bound polyethylenimine functions.... | 08/05/1986 |
| 4597966 | Histidine stabilized immunoglobulin and method of preparation Histidine-stabilized immunoglobulin preparations and a method for their manufacture are disclosed. The present invention is particularly well suited for stabilization of human gamma globulin (IgG) preparations having a relatively low protein content. Pref... | 07/01/1986 |
| 4594245 | Augmenting factors for human antibody production and process for peparing the same Augmenting factors for human antibody production having a molecular weight of 2,000-4,000 are prepared from the supernatant of cultured human lymphocytes. Nylon wool-adherent cells of human lymphocytes are separated from nylon wool-passed cells, and are t... | 06/10/1986 |
| 4585741 | Method of assay for vitamin D metabolites The vitamin D metabolite, calcitriol, is determined in blood serum by radioimmunoassay employing monoclonal antibodies in which calcitroic acid serves as the immunogen.... | 04/29/1986 |
| 4560504 | Carboxyl anchored immobilized antibodies An immobilized antibody system can be made by reacting an aminated core support with an antibody in the presence of a condensing agent which promotes the formation of the amide linkage. The immobilized antibody system is highly resistant to leaching, may ... | 12/24/1985 |
| 4543439 | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins A hybridoma cell line is disclosed that secretes monoclonal antibodies which serve as a high titer, reproducible, biological reagent useful in biological/medical research for isolating and identifying phosphotyrosine-containing proteins. In addition, the ... | 09/24/1985 |
| 4533496 | Method of isolating monoclonal antibodies from hybridoma cultures Monoclonal antibodies are isolated from spent culture medium of the in vitro growth of hybridoma cells by treating said spent cell culture medium or a concentrate thereof with a water-insoluble, cross-linked polyelectrolyte copolymer.... | 08/06/1985 |
| 4469630 | Purification of monoclonal antibodies A method of chromatographically separating monoclonal antibody type IgG from mouse ascites fluid utilizing a particular chromatographic packing of silica gel bearing bound polyethylenimine functions.... | 09/04/1984 |
| 4427653 | Method of making monoclonal antibodies Methods featuring, in one aspect, a method of preparing an antigen or mixture of antigens substantially free of antigens specific to at least two monoclonal antibodies, said method involving contacting an antigen mixture with one or more previously-isolat... | 01/24/1984 |
