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| Number | Title | Issue Date |
| 8163884 | Interleukin-21 receptor binding proteins The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in ... | 04/24/2012 |
| 8138141 | HMG1 antibody for treating inflammatory conditions There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method f... | 03/20/2012 |
| 8133980 | Antibodies and functional fragments thereof that specifically bind an RF-amide peptide or a precursor thereof The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention also relates to methods for modulating a G-protein coupled receptor and for identifying substances which ... | 03/13/2012 |
| 8110662 | Antibody directed to protein involved in maintaining differentiation of smooth muscle cells A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as... | 02/07/2012 |
| 8101724 | High-affinity human antibodies to human protease-activated receptor-2 The present invention provides antibodies that bind to protease-activated receptor-2 (PAR-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human PAR-2. The antibodies of the inven... | 01/24/2012 |
| 8093361 | Anti-perp antibody The present invention provides an antibody which specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular region. The antibody of th... | 01/10/2012 |
| 8093362 | Anti-PERP recombinant antibody An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no co... | 01/10/2012 |
| 8058403 | Antibodies to stromal cell-derived factor-1 polypeptides Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techn... | 11/15/2011 |
| 8053563 | YKL-40 monoclonal authority The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention als... | 11/08/2011 |
| 8017738 | Hemopoietin receptor protein, NR10 The inventors succeeded in isolating a novel hemopoietin receptor gene (NR10) using a sequence predicted from the extracted motif conserved in the amino acid sequences of known hemopoietin receptors. It was expected that two forms of NR10 exists, a transmembrane typ... | 09/13/2011 |
| 8017737 | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor The present invention concerns antibodies specific for the C-terminus of human hepcidin, and related methods and kits for diagnosing and/or treating a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragment... | 09/13/2011 |
| 8013127 | Antibody that binds to ER-α36 The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-α36 activity. The invention further provides methods for identifying agents that bind to such polypeptide... | 09/06/2011 |
| 8013126 | 84P2A9: a prostate and testis specific protein highly expressed in prostate cancer A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, b... | 09/06/2011 |
| 8008446 | Auto-antibodies against the melanocortin-4 receptor Disclosed are biological markers for obesity and methods for diagnosing and treating obesity and related conditions by detecting and modulating the activity of auto-antibodies against the melanocortin-4 receptor or a portion of the melanocortin-4 receptor. Also disc... | 08/30/2011 |
| 8003763 | Cripto blocking antibodies and uses thereof The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4... | 08/23/2011 |
| 8003764 | Folliculin-specific antibodies and methods of detection The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and antibodies that specifically bind to the BHD protein (folliculin). In addition, the present disclosure relates to methods of diagnosing BHD disease and related condi... | 08/23/2011 |
| 7999080 | Reagents for the detection of protein phosphorylation in signaling pathways The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of th... | 08/16/2011 |
| 7994291 | Human E3α ubiquitin ligase family The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the polypeptide. In addition,... | 08/09/2011 |
| 7985843 | Compositions and methods for the therapy and diagnosis of ovarian cancer Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, anti... | 07/26/2011 |
| 7982015 | Compositions and methods for treatment of cancer The present invention concerns compositions and methods for the treatment of disorders characterized by the overexpression of an LIV-1. More specifically, the compositions include DNA and amino acid sequences of an LIV-1, antibodies to an LIV-1, and methods for the ... | 07/19/2011 |
| 7982016 | Antigen binding proteins capable of binding thymic stromal lymphopoietin The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-T... | 07/19/2011 |
| 7973139 | Antibodies against nogo receptor The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and ... | 07/05/2011 |
| 7968689 | Antibodies to HSDEK49 polypeptides The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the presen... | 06/28/2011 |
| 7964706 | High affinity antibodies against HMGB1 and methods of use thereof Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifical... | 06/21/2011 |
| 7947810 | Kits for diagnosing a hypophosphatemic disorder The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides. ... | 05/24/2011 |
| 7935793 | Treatment of inflammatory bowel diseases with anti-IP-10 antibodies The present invention is directed to high affinity anti-human IP-10 antibodies or antigen-binding fragments of these antibodies, including chimeric, humanized or fully human antibodies. The present invention is also directed to a method of reducing the severity of a... | 05/03/2011 |
| 7932361 | Antibodies to HT5GJ57 The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote... | 04/26/2011 |
| 7932362 | Antibodies to NRIF3 proteins Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is useful in development/implementation of high throughput screens to iden... | 04/26/2011 |
| 7919595 | Antibodies to interferon-like protein Zcyto21(IL29) The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypept... | 04/05/2011 |
| 7915388 | Interleukin-13 binding proteins The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in viv... | 03/29/2011 |
| 7910705 | Stable cell lines expressing HERG1a and HERG1b A line of cultured mammalian cells includes HERG1b subunits and optionally HERG1a subunits. ... | 03/22/2011 |
| 7910704 | Human p53 splice variant displaying differential transcriptional activity Novel human p53 splice variant displaying differential transcriptional activity Described is a nucleic acid molecule encoding a p53 variant characterized in that it is capable of transactivating the p21- and 14-3-3σ-promoter but not the mdm2-, bax- and PIG3-promote... | 03/22/2011 |
| 7906626 | Immunological control of β-amyloid levels in vivo Disclosed are bispecific antibodies comprising a first antibody binding specificity which confers the ability of the bispecific antibody to cross the blood-brain barrier, and a second antibody specificity conferring the ability of the bispecific antibody to bind to ... | 03/15/2011 |
| 7888480 | Reagents for the detection of protein phosphorylation in leukemia signaling pathways The invention discloses nearly 288 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selecti... | 02/15/2011 |
| 7879982 | 19.5 polypeptide antibodies useful for diagnosing or treating psoriasis The present invention provides nucleic acid molecules, polypeptides, antibodies and methods for the diagnosis and/or treatment of psoriasis. ... | 02/01/2011 |
| 7872103 | Modulating immune responses The invention provides methods for modulating the immune system using anti-CD83 antibodies that can influence CD83 function. ... | 01/18/2011 |
| 7863424 | Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/melanoma This invention provides an isolated nucleic acid molecule which encodes immunoglobulin receptor, Immunoglobulin superfamily Receptor Translocation Associated, IRTA, protein. Provided too, are the IRTA proteins encoded by the isolated nucleic acid molecules, IRTA1, I... | 01/04/2011 |
| 7858753 | Immunoglobulins The present invention concerns immunoglobulins, such as antibodies, which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and modulate the interaction between OSM and gp130. In typical embodiments, OSM is glycosylated. The invention also concerns... | 12/28/2010 |
| 7858754 | Nel-related protein type 1 antibody The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissu... | 12/28/2010 |
| 7855278 | Antibodies to Stra6 polypeptides The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nuclei... | 12/21/2010 |
