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| Number | Title | Issue Date |
| 7442774 | INGAP displacement assays An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension. ... | 10/28/2008 |
| 7435800 | Antibodies to interleukin-20 and method for inhibiting interleukin-20 induced cell proliferation Antibody to human IL-20 protein, a method for generation thereof and cells producing this antibody are disclosed. The antibody of the present invention has specificity to neutralizing hIL-20W-induced CPAE proliferation activity, and is useful for treating IL-20-indu... | 10/14/2008 |
| 7435549 | Method of identifying binding site domains that retain the capacity of binding to an epitope The present invention relates to a method of identifying binding site domains that retain the capacity of binding to an epitope when positioned C-terminal of at least one further domain in a recombinant bi- or multivalent polypeptide. The present invention further r... | 10/14/2008 |
| 7431925 | Internal image antibodies for optical imaging and therapy Methods using internal image antibodies for photodiagnosis and/or phototherapy. The internal image antibodies are conjugated with a photoactive molecule such as a dye or photosensitizer, to target specific regions, such as biological receptors. The photoactive molec... | 10/07/2008 |
| 7427664 | Antibodies to polypeptides that stimulate TNF-α release The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 09/23/2008 |
| 7413736 | Humanization of an anti-carcinoembryonic antigen anti-idiotype antibody as a tumor vaccine and for targeting applications A humanized form of an anti-idiotype antibody to CEA, e.g., hWI2, has conserved immunoreactivity. The clinical benefits of anti-CEA antibodies are maximized by using the humanized anti-idiotype as a clearing agent for anti-CEA antibodies or antibody fragments. The h... | 08/19/2008 |
| 7411045 | Autocrine growth factor receptor antibodies and methods Disclosed herein are antitumor compositions and methods of interfering with the biological activity of PC cell derived growth factor (PCDGF), anti-PCDGF receptor antibodies, fragments thereof, and methods of making anti-PCDGF receptor antibodies. The methods involve... | 08/12/2008 |
| 7399469 | Anti-LFL2 antibodies for the diagnosis, prognosis and treatment of cancer Particular anti-LFL2 antibody compositions are provided herein. These antibodies may be used for diagnosis, prognosis, therapeutic monitoring and treatment of cancer, especially breast cancer, head/neck cancer, lung cancer, ovarian cancer, stomach cancer and pancrea... | 07/15/2008 |
| 7365162 | Stabilized bioactive peptides and methods of identification, synthesis, and use An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus... | 04/29/2008 |
| 7354587 | Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using a vaccine comprising immunoconjugates that comprise antibodies and anti-idiotype antibodies that mimic an epitope of an antigen that is associated with a tu... | 04/08/2008 |
| 7335356 | Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein In this application are described Ebola GP monoclonal antibodies, epitopes recognized by these monoclonal antibodies, and the sequences of the variable regions of some of these antibodies. Also provided are mixtures of antibodies of the present invention, as well as... | 02/26/2008 |
| 7318921 | Therapeutic compositions that alter the immune response The invention is therapeutic methods and compositions that alter the immunogenicity of the host. ... | 01/15/2008 |
| 7300651 | Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1 The present invention provides methods of delaying development of CEA-associated tumors using the anti-idiotype antibody 3H1, particularly in high-risk individuals. ... | 11/27/2007 |
| 7279556 | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, ... | 10/09/2007 |
| 7267823 | peptides and immunogenic compositions containing same Using CTL epitopes to the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described. ... | 09/11/2007 |
| 7262062 | Diagnostic for scleroderma As anti-RNA polymerase (RNAP) antibodies are detected with high frequency in patients suffering from cutaneous scleroderma where skin sclerosis progresses rapidly, supervenes scleroderma renal crisis at a high rate, and associates with clinical entities whose progno... | 08/28/2007 |
| 7252954 | Sets of digital antibodies directed against short epitopes, and methods using same The present invention relates generally to sets of digital antibodies directed against short epitopes, and use thereof in methods for protein analysis. ... | 08/07/2007 |
| 7226594 | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberranty expressed in the cancers listed in Table I. Consequently, ... | 06/05/2007 |
| 7183384 | Monoclonal antibody 7H11 reactive with human cancer Novel monoclonal antibodies and binding fragments thereof specific to human breast cancer, lung cancer, colon cancer and other cancers. The monoclonal antibody does not bind to the cell surface of normal human tissues. The corresponding cancer-specific antigen with ... | 02/27/2007 |
| 7151166 | Antibody to mammalian cytokine-like polypeptide-10 A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful f... | 12/19/2006 |
| 7148330 | Binding compounds for IL-27 Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also pr... | 12/12/2006 |
| 7119175 | Antibody to mammalian cytokine-like polypeptide-10 A mammalian cytokine-like polypeptide, called Zcyto10, polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for... | 10/10/2006 |
| 7115715 | Anti-idiotype antibodies to MN proteins and MN polypeptides Herein disclosed is a novel oncogene named MN or alternatively MN/CA IX. Abnormal expression of the MN gene is shown to signify oncogenesis, and diagnostic/prognostic methods for pre-neoplastic/neoplastic disease to detect or detect and quantitate such abnormal MN g... | 10/03/2006 |
| 7109003 | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, ... | 09/19/2006 |
| 7105491 | Biosynthesis of enediyne compounds by manipulation of C-1027 gene pathway This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced by Streptomyces globisporus). Methods are provided for the biosynthesis of enediynes, enediyne analogs an... | 09/12/2006 |
| 7101674 | Anti-idiotypic anti-TNF antibodies and related immunoassay methods Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as polynucleotides coding for anti-TNF murine and chimeric antibodies, pe... | 09/05/2006 |
| 7090842 | Murine monoclonal anti-idiotype antibody 3H1 sequences for human carcinoembryonic antigen This invention provides compositions derived from the sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 3H1 and methods for using these compositions. ... | 08/15/2006 |
| 7083943 | Polynucleotides related to murine anti-idiotype antibody 11D10 and methods of use thereof The present invention provides a monoclonal and-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D1... | 08/01/2006 |
| 7078175 | Antibodies for apoptosis EI24 protein and methods of use Disclosed is the isolation and characterization of EI24, a gene whose 2.4 kb mRNA is induced following etoposide treatment. Induction of EI24 mRNA by etoposide required expression of wild-type p53. Overexpression of functional p53 was sufficient to induce expression... | 07/18/2006 |
| 7041288 | Anti-idiotypic antibodies against antibodies which inhibit the binding of immunoglobulin E to its high affinity receptors Antibodies and antibody fragments which are anti-idiotypic to an antibody that interferes with the binding of the Cε3 region of IgE to its high affinity receptor (mimobodies), particularly, which are anti-idiotypic to BSW17 (BSW17-mimobodies) are described, as well... | 05/09/2006 |
| 7026446 | Bifunctional molecules The invention relates to a chimeric antibody conjugate comprising an antigen binding region of a non-human antibody and an immunoglobulin constant region which comprises at least one CH domain or epitope thereof, with the proviso that the constant region ... | 04/11/2006 |
| 6949244 | Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof The present invention provides a monoclonal anti-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D... | 09/27/2005 |
| 6949346 | Method for binding basophils and mast cells The present invention relates to an antibody for the detection quantification, or isolation of basophils, mast cells, the precursor cells of basophils or mast cells, or a surface structure of basophils or mast cells. This antibody corresponds to an antibody with the... | 09/27/2005 |
| 6932968 | Erythropoietin (EPO) peptides and antibodies directed against these Erythropoietin (EPO) peptides and the use thereof for preparing epitope-specific anti-EPO antibodies are described. Also described are corresponding anti-EPO antibodies which take the form of polyclonal antibodies (antisera) or of monoclonal antibodies. These antibo... | 08/23/2005 |
| 6932969 | Ig fractions having immunomodulatory activity The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The in... | 08/23/2005 |
| 6927204 | Treatment of inner ear hair cells Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of ... | 08/09/2005 |
| 6916606 | Electrochemiluminescent assays Qualitative and quantitative electrochemiluminescent assays for analytes of interest present in multicomponent liquids are provided. These methods comprise contacting a sample with a reagent labeled with an electrochemiluminescent chemical moiety and capable of comb... | 07/12/2005 |
| 6916475 | Anti-idiotypic antibody and its use in regulating the composition of T cell lymphocytes The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with non-HIV-1 antibodies. The present invention provides methods of diagnosi... | 07/12/2005 |
| 6891022 | NSP molecules The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, antagonists and agonists vectors and host cells expressing, and immunoadhesions and antibodies to PRO201, PRO308 or PRO309 polypept... | 05/10/2005 |
| 6887469 | Anti-idiotypic antibodies of vascular endothelial growth factor and use thereof as drugs An anti-idiotypic vascular endothelial growth factor antibody, an Fab fragment, and pharmaceutical compositions thereof, being ligands of the human KDR receptor or of the murine flk-1 receptor and not a ligand of flt are provided. ... | 05/03/2005 |
