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| Number | Title | Issue Date |
| 7612178 | Anti-IGF-1R antibodies and uses thereof The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and ... | 11/03/2009 |
| 7608691 | Antibodies against IL-16 antagonist peptides The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can ... | 10/27/2009 |
| 7608690 | IL-B30 antibodies Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided. ... | 10/27/2009 |
| 7605233 | Tumour necrosis factor binding ligands The present invention relates to ligands which bind to human tumour necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is modified. In preferred forms the ligand binds to TNF in a manner such that th... | 10/20/2009 |
| 7601813 | Anti-GL50 antibodies The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode novel GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules... | 10/13/2009 |
| 7598349 | Antibodies to peptide fragments having cell death-inhibitory activity The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence ... | 10/06/2009 |
| 7589179 | IL-7 variants with reduced immunogenicity Modified interleukin-7 (IL-7) polypeptides are disclosed. The modified IL-7 polypeptides have alterations to one or more potential T-cell epitopes, thereby to reduce a T-cell response. ... | 09/15/2009 |
| 7582733 | Humanized antibodies that recognize beta amyloid peptide The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies. ... | 09/01/2009 |
| 7582734 | Functional antibodies that specifically bind to the Chemerin receptor The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful fo... | 09/01/2009 |
| 7582735 | Feline immunoglobulin E molecules and related methods The invention relates to: nucleic acid molecules encoding the light chain and heavy chain of feline immunoglobulin E (IgE), including species-specific regions of feline IgE; proteins encoded by the nucleic acid molecules; inhibitors to the nucleic acids and proteins... | 09/01/2009 |
| 7579445 | Reagents and methods for inducing an immune response to prostate specific antigen The invention is an apparatus and method for the treatment of prostate cancer, and involves administering an antibody that specifically binds with prostate antigen. ... | 08/25/2009 |
| 7576183 | Structure-based receptor MIMICS targeted against bacterial superantigen toxins The invention provides therapeutic compositions useful in the treatment of bacterial superantigen mediated conditions, such as Toxic Shock Syndrome. The compositions comprise genetically engineered bifunctional polypeptides containing a specific T-cell receptor bind... | 08/18/2009 |
| 7576184 | Allergenic proteins of natural rubber latex, their production and use in assays This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative dete... | 08/18/2009 |
| 7576185 | PRO34128 antibodies The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molec... | 08/18/2009 |
| 7576182 | Compositions and methods for the treatment of immune related diseases The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. ... | 08/18/2009 |
| 7572896 | Antibodies to oncostatin M receptor The invention provides characterization of the disease and cancer-associated antigen, OSM-Rβ The invention also provides modulators of OSM-R.beta, including a family of monoclonal antibodies that bind to antigen OSM-R.beta, and methods of diagnosing and treating va... | 08/11/2009 |
| 7572895 | Transferrin receptor antibodies The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the transferrin receptor, methods of diagnosing and treating various human cance... | 08/11/2009 |
| 7569672 | Antibodies that bind to EphA2 and methods of use thereof Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using su... | 08/04/2009 |
| 7566770 | Humanized collagen antibodies and related methods The invention provides an antibody, or functional fragment thereof, a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain... | 07/28/2009 |
| 7560531 | Cln101 antibody compositions and methods of use alone and in combination with prostate specific antigen and other cancer markers This invention relates to a method for assessing risk of prostate and/or ovarian cancer. Specifically, in one embodiment it relates to utilizing both Cln101 and Prostate Specific Antigen (PSA) in combination to determine the risk of prostate cancer. In an alternativ... | 07/14/2009 |
| 7560532 | Smad6 and uses thereof The invention includes nucleic acids encoding the Smad6 protein, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods and produc... | 07/14/2009 |
| 7557189 | Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced versions of these antibodies, functional equivalents and improved ver... | 07/07/2009 |
| 7557190 | Optimized proteins that target Ep-CAM Humanized Ep-CAM-targeting antibodies and methods of making and using the same are provided. ... | 07/07/2009 |
| 7557191 | Sialoadhesin factor-2 antibodies Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents. ... | 07/07/2009 |
| 7544782 | Tumour necrosis factor binding ligands The present invention relates to ligands which bind to human tumor necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is modified. In preferred forms the ligand binds to TNF in a manner such that the... | 06/09/2009 |
| 7541437 | Breast cancer resistance protein (BCRP) and the DNA which encode it The Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs. ... | 06/02/2009 |
| 7541438 | Monoclonal antibody against connective tissue growth factor and medicinal uses thereof A human monoclonal antibody useful for the treatment of various diseases caused by human connective tissue growth factor (CTGF) and preventing the onset of the above diseases; medicinal uses thereof; and various monoclonal antibodies having various characteristics a... | 06/02/2009 |
| 7538194 | Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associate... | 05/26/2009 |
| 7534868 | Human antibodies to human delta like ligand 4 An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDII4) and blocks hDII4 binding to a Notch receptor. The human anti-hDII4 antibody or antibody fragment binds dimeric hDII4 with an affinity of 75 pM ... | 05/19/2009 |
| 7531633 | antibodies A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of Staphylococcus, including S. epidermidis, S. haemolyticus | 05/12/2009 |
| 7531634 | Bladder matrix protein peptides and methods of detection of bladder cancer Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also... | 05/12/2009 |
| 7528237 | Tumour necrosis factor binding ligands The present invention relates to ligands that bind to human tumour necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is modified. In preferred forms the ligand binds to TNF in a manner such that the... | 05/05/2009 |
| 7528235 | Multi-functional antibodies The present invention provides a mutant antibody comprising a reactive site not present in the wild-type of the antibody and a antigen recognition domain that specifically binds to a metal chelate, wherein the reactive site is in a position proximate to or within th... | 05/05/2009 |
| 7528236 | Humanized anti-beta7 antagonists and uses therefor The invention provides therapeutic anti-beta7 antibodies, compositions comprising, and methods of using these antibodies. ... | 05/05/2009 |
| 7524936 | Mitogenic oxygenase regulators The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfect... | 04/28/2009 |
| 7524934 | Human brain carboxypeptidase B antibodies A novel carboxypeptidase and the encoding gene thereof were successfully identified by screening a human hippocampus extract using brain-APP-cleaving activity as an index. Antibodies against the protein were also prepared. The antibodies are useful in, for example p... | 04/28/2009 |
| 7524935 | Sequences characteristic of hypoxia-regulated gene transcription There are provided polynucleotides that are modulated by hypoxic conditions. The disclosure includes such genes and proteins as well as analogs, salts and functional derivatives of such proteins, and DNA encoding such analogs, and methods of use. Methods for treatin... | 04/28/2009 |
| 7521539 | Anti-PRO4989 antibodies The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 04/21/2009 |
| 7521540 | CYR61 compositions and methods Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis, chondrogenesis, and oncogenesis, are provided. The polynucleotide compos... | 04/21/2009 |
| 7521541 | Cysteine engineered antibodies and conjugates Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody frag... | 04/21/2009 |
