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| Number | Title | Issue Date |
| 8188235 | Antibodies to IL-6 and their uses Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such ... | 05/29/2012 |
| 8188232 | Compositions and methods for modulating lymphocyte activity The invention derives from the identification of HVEM as the native ligand for BTLA. The invention provides compositions and methods for modulating BTLA-HVEM interactions and BTLA and HVEM activity, which are useful for modulating immune responses. Agonists and anta... | 05/29/2012 |
| 8188234 | 1D05 PCSK9 antagonists Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associa... | 05/29/2012 |
| 8188233 | 1B20 PCSK9 antagonists Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associa... | 05/29/2012 |
| 8188237 | Binding domain-immunoglobulin fusion proteins The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglo... | 05/29/2012 |
| 8188231 | Optimized FC variants The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. ... | 05/29/2012 |
| 8188236 | Eta-1 gene and methods for use The present application relates to osteopontin (Eta-1) polypeptides, nucleic acids that encode Eta-1, antibodies that specifically bind to Eta-1, and methods for enhancing an immune response in an animal. ... | 05/29/2012 |
| 8183346 | Anti-ferroportin 1 monoclonal antibodies and uses thereof Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the leve... | 05/22/2012 |
| 8173778 | Antibody to a guanine nucleotide exchange factor A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ... | 05/08/2012 |
| 8173601 | Activin-ActRIIa antagonists and uses for treating multiple myeloma In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma. ... | 05/08/2012 |
| 8168755 | Antibodies specific to heterodimers of Bcl-2 family and uses thereof Isolated antibodies specifically binding to heterodimers of the Bcl-2 family and uses thereof for detecting presence of Bcl-2 heterodimers in a patient. ... | 05/01/2012 |
| 8168757 | PD-1 binding proteins The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immuni... | 05/01/2012 |
| 8168756 | Levetiracetam immunoassays Methods, compositions and kits are disclosed directed at levetiracetam derivatives, immunogens, signal generating moieties, antibodies that bind levetiracetam and immunoassays for detection of levetiracetam. ... | 05/01/2012 |
| 8163882 | Polypeptide variants with altered effector function The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc reg... | 04/24/2012 |
| 8163883 | Gene encoding labyrinthin, a marker for cancer A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use ... | 04/24/2012 |
| 8163881 | Immunoglobulin molecules with improved characteristics The present invention provides for IgG1 molecules with improved characteristics. In particular, substitution mutations are provided that, in combination, facilitate improved placental transfer, improved serum half-life and improved FcRn binding. Substitution mutatio... | 04/24/2012 |
| 8153583 | Toll like receptor 3 antagonists, methods and uses Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists, and methods of making and using the foregoing are disclosed. ... | 04/10/2012 |
| 8138313 | Treatment of tumors using specific anti-L1 antibody The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment. ... | 03/20/2012 |
| 8133867 | Method for treating rheumatoid arthritis with an antibody that binds to a hepatocyte growth factor receptor A therapeutic agent for rheumatoid arthritis, particularly a therapeutic agent for ameliorating an inflammatory symptom or bone deformity in rheumatoid arthritis, which comprises an antibody that binds to a hepatocyte growth factor receptor as an active ingredient. | 03/13/2012 |
| 8129503 | Agents that bind a target in pulmonary tissue for targeting respiratory diseases Disclosed is the use of an agent (e.g., antibody fragment, antagonist, ligand, dAb monomer) that binds a target in pulmonary tissue for the manufacture of a long action or long therapeutic window formulation for local delivery to pulmonary tissue, and methods for ad... | 03/06/2012 |
| 8129502 | Cancerous disease modifying antibodies The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of... | 03/06/2012 |
| 8124739 | Antibody to human Zcyto10 polypeptide A mammalian cytokine-like polypeptide, called Zcyto10, polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for... | 02/28/2012 |
| 8124738 | Human monoclonal antibodies to CD70 The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods ... | 02/28/2012 |
| 8114966 | Peptide-based passive immunization therapy for treatment of atherosclerosis The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B in the manufacture of a pharmaceutical composition for therapeutical... | 02/14/2012 |
| 8114965 | Compositions of PSMA antibodies The invention includes antibodies or antigen-binding fragments thereof which bind specifically to conformational epitopes on the extracellular domain of PSMA, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybri... | 02/14/2012 |
| 8114964 | Anti-MCP-1 antibodies, compositions, methods and uses The present invention relates to at least one novel anti-MCP-1 antibody, including isolated nucleic acids that encode at least one anti-MCP-1 antibody, MCP-1, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including thera... | 02/14/2012 |
| 8110661 | Anti-IP-10 antibodies and methods of use thereof The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-10, CXCL10), thereby modulating the interaction between IP-10 and its receptor, CXCR3, and/or modulating the biological activities of IP-10. The ... | 02/07/2012 |
| 8106161 | Binding domain-immunoglobulin fusion proteins The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglo... | 01/31/2012 |
| 8101720 | Immunoglobulin insertions, deletions and substitutions An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide. ... | 01/24/2012 |
| 8101721 | Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof The present invention is related to antibodies with binding affinity to fibroblast growth factor receptor 2 (FGFR2) optionally with binding affinity to other FGF receptors, which block both ligand-dependent and constitutive ligand independent receptor activation. Sp... | 01/24/2012 |
| 8101719 | Humanized anti-CD47 antibody The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host ce... | 01/24/2012 |
| 8097704 | Antibody specifically binding to DR5 and composition for preventing or treating cancers comprising the same The present invention provides an antibody specifically binding to death receptor 5 (DR5), which is selected from the group consisting of: an antibody comprising a heavy chain variable region (VH) having the amino acid sequences of SEQ ID NOs: 1 to 3 at c... | 01/17/2012 |
| 8097703 | CD19 antibodies and their uses The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressin... | 01/17/2012 |
| 8093358 | Methods of treatment using anti-erbb antibody-maytansinoid conjugates The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anri-ErbB rece... | 01/10/2012 |
| 8093357 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 01/10/2012 |
| 8093359 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 01/10/2012 |
| 8088896 | Generation and profiling of fully human gold-derived therapeutic antibodies specific for human CD38 The present invention provides novel antibodies and functional fragments thereof specific for CD38, and methods for using the same. These antibodies as well as the novel methods for using those antibodies can be used to treat, for example, hematological malignancies... | 01/03/2012 |
| 8088897 | Assay method for group transfer reactions An isolated antibody produced against a donor product of an enzymatically catalyzed group transfer reaction is disclosed. In one aspect, the antibody has the ability to preferentially recognize the donor-product guanosine diphosphate (GDP), in the presence of the do... | 01/03/2012 |
| 8088895 | Antibodies that bind CXCR7 epitopes Antibodies that bind CXCR7 epitopes, as well as methods of identifying CXCR7 modulators are described. ... | 01/03/2012 |
| 8084583 | RS7 antibodies This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an e... | 12/27/2011 |
