Class 530/386 - Globulins

Subclass of Class 530 - Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
Definition: Proteins identified as globulins and compounds derived from
No. of patents: 213
Last issue date: 02/26/2008

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Number	Title	Issue Date
7335467	Breast cancer antigens The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses in breast cancer. The identified antigens can be utilized as markers f...	02/26/2008
7273924	Antibodies to the ED-B domain of fibronectin, their construction and uses A specific binding member is specific for and binds directly to the ED—B oncofoetal domain of fibronectin (FN). ...	09/25/2007
RE39789	Tumor therapy Neoplasia is treated by administering to a mammalian host a composition comprising ligands for the NKG2D receptor. In addition, other NKG2D ligands, proteins specific for the neoplastic cells and cytokines may be included to enhance the immune response. The composit...	08/21/2007
7253142	Protein solution preparation and method of stabilizing the same The present invention provides stable protein solution formulations filled in a container made from a hydrophobic resin at least for the part in direct contact with said formulation. ...	08/07/2007
7244826	Internalizing ERB2 antibodies This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F...	07/17/2007
7223844	Broadly cross-reactive neutralizing antibodies against human immunodeficiency virus selected by Env-CD4-co-receptor complexes The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody ...	05/29/2007
7183384	Monoclonal antibody 7H11 reactive with human cancer Novel monoclonal antibodies and binding fragments thereof specific to human breast cancer, lung cancer, colon cancer and other cancers. The monoclonal antibody does not bind to the cell surface of normal human tissues. The corresponding cancer-specific antigen with ...	02/27/2007
7122635	Method and composition for angiogenesis inhibition The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen but not to native triple helical forms of the collagen. Antagonists of the invention can target, for...	10/17/2006
7118924	Method for producing human antibodies in SCID mice which uses dendritic cells pulsed with antigen-antibody complexes and antigen-antibody complexes as immunizing agents An improved method for producing human antibodies in SCID mice is provided. The improvement includes the use of dendritic cells pulsed with antigen-antibody complexes and antigen-antibody complexes as immunizing agents. ...	10/10/2006
7108986	Glypican-1 in human breast cancer Glycosylphosphatidylinositol-(GPI-) anchored HSPG glypican-1 is strongly expressed in human breast and pancreatic cancer—both by the cancer cells and in the case of pancreatic cancer the adjacent fibroblasts—whereas expression of glypican-1 is low in the normal ...	09/19/2006
7097966	Detection of survivin in the biological fluids of cancer patients The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising one or more agents that detect survivin polypeptide or survivin nucl...	08/29/2006
7090983	Methods for detecting early cancer MK (midkine) was found to rise in the blood or urine of patients with various types of cancers at early stage. Based on this finding, a method for detecting early cancer, comprising the step of measuring MK in blood or urine was completed. ...	08/15/2006
7081517	Genes differentially expressed in breast cancer A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor exp...	07/25/2006
7053041	Methods and compositions useful for inhibition of αβmediated angiogenesis The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin αvβ5 antagonists. The αvβ5-mediated angiogenesis is correlated with exposure to cytokines including vascular endothelial ...	05/30/2006
7049413	MAGE-A3 peptides presented by HLA class II molecules The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocyte...	05/23/2006
7030227	Cell regulatory genes, encoded products, and uses related thereto This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably di...	04/18/2006
7022821	Antibody kit for the detection of TADG-15 protein The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression...	04/04/2006
6995246	Methods for removing suspended particles from soluble protein solutions The present invention provides soluble protein solutions, free of suspended particles in high yield. More particularly, the current invention provides a method for removing suspended particles from soluble protein solutions by filtering the soluble protein solution ...	02/07/2006
6953847	Fas antigen derivative This invention provides a novel Fas antigen derivative which comprises at least a part or entire portion of Fas antigen extracellular region polypeptide in which at least one amino acid residue is deleted from a group of amino acid residues starting from the N-termi...	10/11/2005
6936424	Materials and methods for detection and treatment of breast cancer The invention provides a wide range of methods and compositions for detecting and treating breast cancer in an individual. Specifically, the invention provides target breast cancer-associated proteins, which permit a rapid detection, preferably before metastases occ...	08/30/2005
6911316	Medical uses of scuPA/suPAR complex Methods of using a complex (scuPA/suPAR) which has thrombolytic activity under physiological conditions and in the presence of IgG, or of at least one IgG-derived peptide, which complex comprises a single chain urokinase type plasminogen activator (scuPA) and a solu...	06/28/2005
6905684	Preventives and remedies for diffuse lung diseases Preventives and remedies for diffuse lung diseases whereby apoptosis can be inhibited and thus favorable preventive/therapeutic effects can be established. These drugs contain apoptosis-inhibiting substances as the active ingredient. The above apoptosi...	06/14/2005
6891022	NSP molecules The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, antagonists and agonists vectors and host cells expressing, and immunoadhesions and antibodies to PRO201, PRO308 or PRO309 polypept...	05/10/2005
6872537	Assays for the detection of microtubule depolymerization inhibitors This invention provides methods for the screening and identification of agents having potent effects on the progression of the cell cycle. In one embodiment, the methods involve contacting a polymerized microtubule with a microtubule severing protein or a microtubul...	03/29/2005
6861509	Antibodies to Ret and RetL3 Nucleotide and amino acid sequences are provided for compounds which promote tissue growth, as well as methods for modulating tissue growth, for imaging tissues and organs, and for treating patients. ...	03/01/2005
6861510	Immunogenic compositions against gastrin peptides Immmunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharm...	03/01/2005
6858710	Compositions and methods for the therapy and diagnosis of ovarian cancer Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, anti...	02/22/2005
6846911	Methods and compositions for inhibiting inflammation and angiogenesis comprising a mammalian CD97 α subunit Isolated proteins comprising the T-cell surface antigen CD97 α are provided. Compositions and methods for making and detecting CD97 α are also provided. Further, the invention provides diagnostic and therapeutic methods and compositions for medical conditions invo...	01/25/2005
6828422	Protein/(poly)peptide libraries The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of ...	12/07/2004
6821522	Tumor Therapy Neoplasia is treated by administering to a mammalian host a composition comprising ligands for the NKG2D receptor. In addition, other NKG2D ligands, proteins specific for the neoplastic cells and cytokines may be included to enhance the immune response. The composit...	11/23/2004
6800737	Survivin, a protein that inhibits cellular apoptosis, and its modulation The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this disclosure, the present invention provides isolated Survivin protein, isola...	10/05/2004
6764827	Anti-human medullasin monoclonal antibody process for producing the same and immunoassay using the same A monoclonal antibody by which medullasin that is a kind of serine proteases existing in granulocytes, production process thereof and an immunoassay of human medullasin using the antibody are disclosed. The monoclonal antibody specifically recognizes human medullasi...	07/20/2004
6759042	Use of cross-linked, covalently bound urokinase plasminogen activator (scuPA)-urokinase plasminogen activator receptor (suPAR) complex as a fibrinolytic agent The present invention relates to the cross-linked scuPA/suPAR complex and/or tcuPA/suPAR cross-linked complex, the process of preparation of the covalently bound single compound having fibrinolytic activity and use of the cross-linked scuPA/suPAR or tcuPA/suPAR comp...	07/06/2004
6753154	Human AZU-1 gene, variants thereof and expressed gene products A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of malignancy progression and tumorigenicity reversion. Identification, ...	06/22/2004
6730301	MCP-1 receptor antibodies Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically u...	05/04/2004
6692927	Bax degradation involvement in tumor survival and progression According to the present invention, there is provided an assay for determining Bax degradation activity in a patient sample. The assay includes a labeled Bax protein which is incubated with a protein extract from the sample and a detector for detecting a ...	02/17/2004
6613377	Whey treatment process for achieving high concentration of ଱-lactalbumin A method of making an ଱-lactalbumin enriched whey protein product is described. The method involves the treatment of a whey protein product with an acid to lower the pH of the whey protein product to 4.0 or below. This pH-lowering step allows the &#...	09/02/2003
6613318	Methods for identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45...	09/02/2003
6589756	Immunoassays using anti-allotypic monoclonal antibodies The invention provides improved immunoassay techniques for detecting the presence of analytes in a liquid sample. The present immunoassay methods utilize anti-allotypic monoclonal antibodies as capture reagents for primary binding proteins specific for th...	07/08/2003
6576445	Chemokine ଱-4 The present invention relates to a novel CK଱-4 protein which is a member of the CXC chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK଱-4 protein. CK଱-4 polypeptides are also provided as a...	06/10/2003

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Class 530/386 - Globulins