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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 8183344 | Inactivation resistant factor VIII The present invention provides novel purified and isolated nucleic acid sequences encoding procoagulant-active FVIII proteins. The nucleic acid sequences of the present invention encode amino acid sequences corresponding to known human FVIII sequences, wherein resid... | 05/22/2012 |
| 8183345 | Recombinant factor VIII having reduced inactivation by activated protein C The present invention relates to a recombinant factor VIII that is characterized by one or more mutations within a region surrounding an activated protein C cleavage site, which one or more mutations result in a reduced rate of inactivation by activated protein C. I... | 05/22/2012 |
| 8143378 | Polymer factor VIII moiety conjugates Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates,... | 03/27/2012 |
| 8133977 | Polymer-factor VIII moiety conjugates Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates,... | 03/13/2012 |
| 8124737 | Stabilized preparations of serine endopeptidases, their preparation and use The invention relates to stabilized preparations of serine endopeptidases which are suitable for use as a test reagent in a diagnostic procedure or for a therapeutic use. As a result of the addition of various additives, the preparations have improved stability and ... | 02/28/2012 |
| 8101718 | Methods of administering porcine B-domainless fVIII The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provi... | 01/24/2012 |
| 8071726 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 12/06/2011 |
| 8071727 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 12/06/2011 |
| 8071725 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 12/06/2011 |
| 8071728 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 12/06/2011 |
| 8071724 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 12/06/2011 |
| 8067543 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 11/29/2011 |
| 8058226 | Albumin-free factor VIII formulations A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent select... | 11/15/2011 |
| 8053561 | Pegylated factor VIII The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The co... | 11/08/2011 |
| 8003760 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 08/23/2011 |
| 7985838 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 07/26/2011 |
| 7985839 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 07/26/2011 |
| 7982010 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 07/19/2011 |
| 7932355 | Virally-safe factor VIII with a low content of higher multimers La present invention pertains to a composition of plasma-derived virally-safe factor VIII, obtained after nanometric filtration, said composition comprising von Willebrand factor (vWF) at a rate of 15% or less of decamers and higher multimers. Such compositions have... | 04/26/2011 |
| 7928199 | Stabilized proteins with engineered disulfide bonds The present invention relates to methods of introducing one or more cysteine residues into a polypeptide which permit the stabilization of the polypeptide by formation of at least one bond, preferably a disulfide bond, between different domains of the polypeptide. T... | 04/19/2011 |
| 7919592 | Method for separating off viruses from a protein solution by means of nanofiltration A method for separating off viruses from a protein solution by nanofiltration, comprising adding to the protein solution at least one ingredient chosen from chaotropic substances chosen from arginine, guanidine, citrulline, urea and derivatives thereof and salts the... | 04/05/2011 |
| 7888476 | Process for the preparation of a von Willebrand (FvW) factor concentrate by chromatography and a FvW concentrate thus obtainable This invention relates to a process for the preparation of a very high purity von Willebrand factor concentrate from a biological fraction containing von Willebrand factor, including a separation by anion exchange chromatography using a vinyl polymer support of weak... | 02/15/2011 |
| 7863421 | Polymer-factor VIII moiety conjugates Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates,... | 01/04/2011 |
| 7858749 | Polymer-factor VIII moiety conjugates Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates,... | 12/28/2010 |
| 7855274 | Recombinant factor VIII having increased specific activity The present invention relates to recombinant factor VIII having a specific activity that is higher than that of the corresponding wild-type factor VIII. The present invention also relates to methods of making and using the recombinant factor VIII. The present invent... | 12/21/2010 |
| 7820796 | Methods for producing Factor VIII proteins Methods are provided for purification of Factor VIII polypeptides by affinity chromatography and ion exchange chromatography, in which the eluate from the affinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent conce... | 10/26/2010 |
| 7803911 | Dried blood factor composition comprising trehalose A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed. ... | 09/28/2010 |
| 7683158 | Pegylated factor VIII The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The co... | 03/23/2010 |
| 7645860 | Factor VIII polymer conjugates The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. ... | 01/12/2010 |
| 7632921 | Site-directed modification of FVIII This invention relates to Factor VIII muteins that are covalently bound, at one or more predefined sites that are not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity, ar... | 12/15/2009 |
| 7576181 | Method of administering porcine B-domainless fVIII The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provi... | 08/18/2009 |
| 7501493 | Dried blood factor composition comprising trehalose A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed. ... | 03/10/2009 |
| 7381796 | Dried blood factor composition comprising trehalose A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed. ... | 06/03/2008 |
| 7323442 | Agents for alleviating symptoms accompanied by inflammation The present invention provides agents for alleviating symptoms resulting from inflammation, which have an activity to alleviate inflammatory symptoms caused by bacterial infection, particularly accumulation of body fluid such as bronchocavemous plasma exudation, asc... | 01/29/2008 |
| 7300922 | Modulators of pharmacological agents The biological activity of nucleic acid ligand is regulated (i.e. enhanced or inhibited) in vivo to produce a desired biological effect. This is accomplished through the administration of a modulator, or regulator, that changes the binding of the nucleic acid ligand... | 11/27/2007 |
| 7253262 | Dried blood factor composition comprising trehalose A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C. ... | 08/07/2007 |
| 7247707 | Albumin-free factor VIII formulations A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent select... | 07/24/2007 |
| 7244825 | Dried blood factor composition trehalose A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C. ... | 07/17/2007 |
| 7244824 | Dried blood factor composition comprising trehalose A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C. ... | 07/17/2007 |
| 7220836 | Dried blood factor composition comprising trehalose A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C. ... | 05/22/2007 |
