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| Number | Title | Issue Date |
| 8071723 | Stable D-dimer liquid preparation The invention is in the field of coagulation diagnosis and relates to a liquid, buffer-based D-dimer composition, which additionally contains fibrinogen and which is suitable as a standard material for control or calibration purposes for D-dimer test procedures.... | 12/06/2011 |
| 7968682 | Degradation-resistant fibrinogen sealants Provided are degradation-resistant fibrinogen sealants comprising a first composition comprising one or more of fibrinogen γA/γ′ heterodimers and/or fibrinogen γ′/γ′ homodimers and a second composition comprising thrombin and, optionally, degradation-resis... | 06/28/2011 |
| 7816495 | Processes for the preparation of fibrinogen The present invention relates to processes for the purification of fibrinogen, and to readily solubilised fibrinogen preparations. ... | 10/19/2010 |
| 7550567 | Fibrinogen purification The present invention relates to a process for purifying fibrinogen, which comprises one or more process steps in which one or more contaminating proteins are depleted by negative chromatography and/or negative adsorption using cation exchanger, hydrophobic gel and/... | 06/23/2009 |
| 7442308 | Process for removing viruses in fibrinogen solutions and fibrinogen obtained by said process A process for removing viruses in fibrinogen solutions and fibrinogen obtained thereof wherein the process starts with an adjusted purified fibrinogen solution, the adjusted purified solution is frozen and then thawed at a temperature between 5 and 20° C., the undi... | 10/28/2008 |
| 7353658 | Systems and methods for freezing, storing, transporting, and thawing biopharmacuetical material A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material ther... | 04/08/2008 |
| 7351422 | Hemostatic soluble cellulose fibers containing coagulating protein for treating wound and process for producing the same Proposed is a novel soluble trauma-healing and hemostatic cellulose fiber capable of absorbing and readily dissolving hemorrhaging trauma loci when applied thereto and of promoting the hemostatic action of blood platelets and fibrin and cell adhesion to the trauma s... | 04/01/2008 |
| 7348411 | Process for manufacturing fibrin membranes and fibrin membranes obtained according to this process A process for manufacturing a fibrin membrane from blood plasma that was partially depleted and subjected to coagulation by adding a solution of a physiological coagulating agent, leaving the mixture to stay until forming a gelatinous blood clot, and then dehydratin... | 03/25/2008 |
| 7335508 | Porous plasma protein matrices and methods for preparation thereof The present invention relates to porous freeze-dried plasma protein matrices having an open channel structure and a concentration gradient of plasma proteins crosslinked by the action of thrombin, and methods of producing said matrices. The compositions of the prese... | 02/26/2008 |
| 7323442 | Agents for alleviating symptoms accompanied by inflammation The present invention provides agents for alleviating symptoms resulting from inflammation, which have an activity to alleviate inflammatory symptoms caused by bacterial infection, particularly accumulation of body fluid such as bronchocavemous plasma exudation, asc... | 01/29/2008 |
| 7300428 | Tissue volume reduction Devices, compositions, and methods for achieving non-surgical lung volume reduction (e.g., bronchoscopic lung volume reduction (BLVR)) are described. BLVR can be carried out by collapsing a region of the lung, adhering one portion of the collapsed region to another,... | 11/27/2007 |
| 7229959 | Supplemented fibrin matrix delivery systems This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one... | 06/12/2007 |
| 7223848 | Methods for purifying Fc-containing proteins The present invention provides a process for dissociating Fc-containing molecules from complexes of Protein A/Fc-containing molecules or mixtures containing Fc-containing molecules and Protein A. The association, e.g., by hydrophobic interactions, between the Fc-con... | 05/29/2007 |
| 7220836 | Dried blood factor composition comprising trehalose A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C. ... | 05/22/2007 |
| 7211650 | Purification of fibrinogen from fluids by precipitation and hydrophoic chromatography The present invention provides a method for the part purification of fibrinogen from milk, the method comprising the transfer of protease enzyme which is present in the milk, into the whey phase with the removal or partition if fibrinogen into another phase of the m... | 05/01/2007 |
| 7211651 | Proteinaceous gels having visualization agents and methods of use thereof Proteinaceous gels having visualization agents and methods of use thereof are disclosed herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with c... | 05/01/2007 |
| 7196054 | Methods for treating wound tissue and forming a supplemented fibrin matrix This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antimicrobial composition. The composition may be further supplemented with,... | 03/27/2007 |
| 7189410 | Supplemented and unsupplemented tissue sealants, methods of their production and use This invention provides a fibrin sealant bandage, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiprolif... | 03/13/2007 |
| 7153830 | Method for inhibiting the formation of seromas using factor XIII Use of factor XIII for inhibiting the formation of seromas by administering factor XIII. The factor XIII can be administered locally at the site of a wound or surgery or administered systemically. If the factor XIII is administered locally, it can be activated or no... | 12/26/2006 |
| 7148190 | Haptotactic peprides We disclose haptotactic peptides having sequences homologous to specific portions of the carboxy terminal sequence of fibrinogen chains. The peptides derived from fibrinogen pre-Cγ chain possess activities of cell attraction or cell attachment to a surface to which... | 12/12/2006 |
| 7137261 | Systems and methods for freezing, mixing and thawing biopharmaceutical material A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical materi... | 11/21/2006 |
| 7122620 | Haptotactic peptides This invention is related to a novel peptide consisting of the amino acid sequence of SEQ ID NO:1, and a pharmaceutical composition comprising the peptide thereof. ... | 10/17/2006 |
| RE39321 | Supplemented and unsupplemented tissue sealants, methods of their production and use This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproli... | 10/03/2006 |
| RE39298 | Supplemented and unsupplemented tissue sealants, methods of their production and use This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compou... | 09/19/2006 |
| 7104074 | Systems and methods for freezing, storing, transporting and thawing biopharmaceutical material A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material ther... | 09/12/2006 |
| 7087722 | Fibrin binding domain polypeptides and uses and methods of producing same This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding domain of naturally-occurring human fibronectin and being capable of b... | 08/08/2006 |
| RE39192 | Supplemented and unsupplemented tissue sealants, methods of their production and use This invention provides supplemented tissue sealants, methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one cytotoxin or cell proliferation inhibiting composition. The composition may be further supplemented with,... | 07/18/2006 |
| 7045601 | Storage-stable, liquid fibrinogen formulation The present invention relates to a novel storage-stable formulation for fibrinogen in liquid or viscous liquid form comprising divalent metal ions. The fibrinogen formulation may comprise other conventional formulation ingredients and particularly preferably compris... | 05/16/2006 |
| 7008800 | Biopolymer marker indicative of disease state having a molecular weight of 1077 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopoly... | 03/07/2006 |
| 7009034 | Biocompatible crosslinked polymers Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and cros... | 03/07/2006 |
| 7009039 | Plasma protein matrices and methods for their preparation A freeze dried biocompatible matrix comprising plasma proteins, useful as implants for tissue engineering as well as in biotechnology, and methods of producing the matrix are provided. Mechanical and physical parameters can be controlled by use of auxiliary componen... | 03/07/2006 |
| 7001989 | Conjugates comprising two active agents The present invention pertains to a pharmaceutical conjugate comprising an insoluble carrier to which first and second active agents are bound, respectively via a first linker to a first functional group on the carrier and via a second linker to a second functional ... | 02/21/2006 |
| 6996995 | Systems and methods for freezing and storing biopharmaceutical material The present invention provides a system for freezing, thawing, and storing biopharmaceutical materials which includes a flexible container, a conduit, and a temperature control unit. The flexible container is adapted to receive a biopharmaceutical material therein f... | 02/14/2006 |
| 6965014 | Fibrin material and method for producing and using the same This invention describes a bioerodible fibrin material which is obtained by mixing fibrinogen and thrombin reconstituted or diluted with a particular high tonic strength medium, free of calcium. Such a fibrin-based biomaterial develops a tight structure with thin fi... | 11/15/2005 |
| 6960463 | Separation of fibrinogen from plasma proteases The present invention relates to methods for purifying fibrinogen. In one aspect, the present invention relates to a method of separating fibrinogen from plasma fraction I precipitate. In another aspect, the invention relates to the purification of fibrinogen using ... | 11/01/2005 |
| 6945056 | Systems and methods for freezing, mixing and thawing biopharmaceutical material A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical materi... | 09/20/2005 |
| 6942880 | Autologous platelet gel having beneficial geometric shapes and methods of making the same The present invention relates to the production of platelet gels formed into beneficial geometric shapes. Specifically the present invention provides a simpler way to introduce platelet gel for specific uses, such as into the cavity of a gum left after a tooth extra... | 09/13/2005 |
| 6916911 | Use of fibrinogen multimers Use of fibrinogen multimers having at least 6 fibrinogen units as an ingredient for a fibrin sealant. ... | 07/12/2005 |
| 6890903 | Method for inhibiting the formation of seromas using factor XIII Use of factor XIII for inhibiting the formation of seromas by administering factor XIII. The factor XIII can be administered locally at the site of a wound or surgery or administered systemically. If the factor XIII is administered locally, it can be activated or no... | 05/10/2005 |
| 6890763 | Biopolymer marker indicative of disease state having a molecular weight of 1350 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopoly... | 05/10/2005 |
