Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8133865 | von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided. ... | 03/13/2012 |
| 8119772 | MART-1 T cell receptors T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma. ... | 02/21/2012 |
| 7977460 | Compositions comprising coagulation factors IXA and VIII for the treatment of haemophilia A or B The present invention relates to the use of FIXa and FVIII in the preparation of a composition for the treatment of haemophilia A or haemophilia B in a subject which does not present with anti-FVIII antibodies. The present invention further relates to a composition ... | 07/12/2011 |
| 7772371 | Stimulators of Factor X activated (FXa) as new topical antihemorrhagic agents The activated coagulation Factor X (FXa) stimulating agents may be used in the treatment of hemorrhages in a subject. Compounds and combinations are described which are particularly useful for the topical treatment of hemorrhaging in healthy subjects or in patients ... | 08/10/2010 |
| 7714107 | Freeze-dried fibrin matrices and methods for preparation thereof The present invention relates to porous freeze-dried fibrin matrices substantially devoid of external anti-fibrinolytic agents, and methods of producing such matrices. Resilient matrices, also known as sponges, that are particularly beneficial for supporting three d... | 05/11/2010 |
| 7700733 | Factor VII or VIIa polypeptide variants The present invention relates to novel polypeptide variants of factor VII (FVII) or factor VIIa (FVIIa) polypeptides, where said variants comprise an amino acid substitution in position 10 and 32 and where said variants further comprise a sugar moiety covalently att... | 04/20/2010 |
| 7459534 | Inactivation resistant factor VIII The present invention provides novel purified and isolated nucleic acid sequences encoding procoagulant-active FVIII proteins. The nucleic acid sequences of the present invention encode amino acid sequences corresponding to known human FVIII sequences, wherein resid... | 12/02/2008 |
| 7419948 | Treatment of hemophilia with human Factor IX produced in mammary tissue of transgenic mammals Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by intro... | 09/02/2008 |
| 7419949 | Single-dose administration of factor VIIa The present invention provides methods for preventing and/or treating bleeding episodes by administering a single dose of Factor VIIa or a Factor VIIa equivalent. Preferably, the single dose comprises between about 150 and about 500 μg/kg Factor VIIa or Factor VIIa... | 09/02/2008 |
| 7390488 | Compositions and methods for producing vascular occlusion The present invention relates generally to methods and compositions for targeting, delivering, and activating platelet-dependent vascular occlusion agents. In particular, antibodies carrying platelet binding agents are targeted to hyperplastic cells or tissues, such... | 06/24/2008 |
| 7381796 | Dried blood factor composition comprising trehalose A method for preparing a stable dried composition of blood factor product containing a stabilizing amount of trehalose in the absence of a stabilizing amount of albumin is disclosed. ... | 06/03/2008 |
| 7375084 | Highly phosphorylated and sulfated recombinant factor IX The present invention relates to a purified recombinant blood coagulation factor IX (rFIX) preparation, wherein at least 25% of the rFIX in the preparation is fully phosphorylated and sulfated, a cell culture expressing a rFIX resulting in said preparation, a pharma... | 05/20/2008 |
| 7348411 | Process for manufacturing fibrin membranes and fibrin membranes obtained according to this process A process for manufacturing a fibrin membrane from blood plasma that was partially depleted and subjected to coagulation by adding a solution of a physiological coagulating agent, leaving the mixture to stay until forming a gelatinous blood clot, and then dehydratin... | 03/25/2008 |
| 7332577 | Therapeutic human albumin solutions with low prekallikrein activator (PKA) activity and process for obtaining them The invention discloses a purified albumin solution of human origin with low prekallicrein activator (PKA) activity and stability over time characterised in that it has an antithrombin content equal to or greater than 0.03 mg/g of albumin, and a process for producti... | 02/19/2008 |
| 7300922 | Modulators of pharmacological agents The biological activity of nucleic acid ligand is regulated (i.e. enhanced or inhibited) in vivo to produce a desired biological effect. This is accomplished through the administration of a modulator, or regulator, that changes the binding of the nucleic acid ligand... | 11/27/2007 |
| 7276590 | Ion exchange chromatography of proteins and peptides The present invention relates to an ion exchange chromatography process for purifying a peptide from a mixture containing the peptide and related impurities, and to an industrial method including such ion exchange chromatography process. ... | 10/02/2007 |
| 7276235 | Tissue glue with improved antiadhesive properties The use of a tissue glue comprising a stabilized fibrinogen preparation, which can be stored in the liquid or frozen state and comprises a chaotropic substance, and a thrombin preparation, for reducing or preventing tissue adhesions, is described. ... | 10/02/2007 |
| 7268110 | Agents for preventing and treating thrombocytopenia Method of increasing blood platelet formation by administering a parathyroid hormone (PTH) or at least one PTH derivative as an active ingredient. ... | 09/11/2007 |
| 7253262 | Dried blood factor composition comprising trehalose A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C. ... | 08/07/2007 |
| 7247451 | Antithrombin protein and DNA sequences from black fly The invention is drawn to anti-thrombin proteins from the salivary glands of the species, Simulium. Methods for recombinant production of the protein as well as biomedical uses are provided. ... | 07/24/2007 |
| 7244824 | Dried blood factor composition comprising trehalose A stable blood factor composition contains a stabilizing amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C. ... | 07/17/2007 |
| 7244825 | Dried blood factor composition trehalose A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C. ... | 07/17/2007 |
| 7235638 | Coagulation factor VII derivatives The present invention relates to novel human coagulation Factor VII polypeptides, Factor VII derivatives as well as polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions... | 06/26/2007 |
| 7229959 | Supplemented fibrin matrix delivery systems This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one... | 06/12/2007 |
| 7220836 | Dried blood factor composition comprising trehalose A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C. ... | 05/22/2007 |
| 7220837 | Modified vitamin K-dependent polypeptides The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described. ... | 05/22/2007 |
| 7220747 | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer This invention provides methods for treating cellular blood components and other cells containing mitochondria to improve vital qualities of the cells by contacting the cells with a mitochondrial enhancer to the cells. Mitochondrial enhancers prevent damage to and r... | 05/22/2007 |
| 7217794 | Compounds and methods for treatment of thrombosis The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods f... | 05/15/2007 |
| 7211644 | Diagnostic markers of human female infertility Methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility, compounds and methods for contraception. Methods and compounds are based on the levels of ebaf in endometri... | 05/01/2007 |
| 7208179 | Methods for treating disease and forming a supplemented fibrin matrix This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one oligonucleotide. The composition may be further supplemented with, for examp... | 04/24/2007 |
| 7196054 | Methods for treating wound tissue and forming a supplemented fibrin matrix This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antimicrobial composition. The composition may be further supplemented with,... | 03/27/2007 |
| 7189411 | Peptide/lipid complex formation by co-lyophilization The invention relates to the formation of peptide/lipid vesicles and complexes through the co-lyophilization of peptides, preferably that are able to adopt an amphipathic alphahelical conformation, and one or more lipids. A single solution which solubilizes both the... | 03/13/2007 |
| 7176288 | Human coagulation factor VII variants The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as nucleic acid constructs encoding such variants, vectors and host cells comprising and expressing the nucleic acid, pharmaceutical compositions, uses an... | 02/13/2007 |
| 7169573 | Method for monitoring coagulability and hypercoagulable states The assay of soluble endothelial protein C receptor (sEPCR) is useful to monitor effective thrombin levels and a hypercoagulable state. An assay for sEPCR is therefore useful to monitor ongoing effectiveness of anticoagulant therapy. A sEPCR ELISA assay is particula... | 01/30/2007 |
| 7153830 | Method for inhibiting the formation of seromas using factor XIII Use of factor XIII for inhibiting the formation of seromas by administering factor XIII. The factor XIII can be administered locally at the site of a wound or surgery or administered systemically. If the factor XIII is administered locally, it can be activated or no... | 12/26/2006 |
| 7125846 | Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide, and factor V or a factor V-related polypeptide, and the use thereof for treating bleeding episodes. ... | 10/24/2006 |
| RE39321 | Supplemented and unsupplemented tissue sealants, methods of their production and use This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproli... | 10/03/2006 |
| 7115559 | Method for treating coumarin-induced hemorrhage Use of factor XIII for treating coumarin-induced hemorrhage or bleeding. The coumarin may be warfarin or dicoumarol. A patient having coumarin-induced bleeding is treated with factor XIII alone or in conjunction with vitamin K. ... | 10/03/2006 |
| RE39298 | Supplemented and unsupplemented tissue sealants, methods of their production and use This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compou... | 09/19/2006 |
| 7094378 | Method and apparatus for inactivation of biological contaminants using photosensitizers Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein, blood and blood constituents are provided. The methods comprise adjusti... | 08/22/2006 |
