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| Number | Title | Issue Date |
| 8008440 | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery A library of macrocyclic compounds of the formula (I) where part (A) is a  bivalent radical, a â... | 08/30/2011 |
| 7820795 | N-desoxyribosyl transferases and the use thereof for enzymatic synthesis of 2′, 3′—didesoxynucleosides and 2′,3′- didehydro-2′,3′- didesoxynucleosides N-deoxyribosyl transferases of Lactobacillus fermentum and their analogues, as well their use for the enzymatic synthesis of 2′,3′-dideoxynucleosides and 2′,3′-didehydro-2′,3′-dideoxynucleosides. These transferases and their analogues include a N-... | 10/26/2010 |
| 7361495 | Polypeptide from a cellulolytic fungus having cellulolytic enhancing activity The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as wel... | 04/22/2008 |
| 7354708 | Invasion assays The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence... | 04/08/2008 |
| 7335757 | Carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same According to the present invention, there is provided a novel carbonyl reductase derived from a microbial belonging to the genus Ogataea and a DNA encoding the enzyme. By reducing ketones with the use of the carbonyl reductase, optically active alcohols, in p... | 02/26/2008 |
| 7232673 | Antimicrobial protein from The object of the present invention is to screen and identify a novel antimicrobial protein which can inhibit the growth of plant pathogenic microorganisms at a relatively low concentration such as Pyricularia oryzae and Rhizoctonia solani causative of... | 06/19/2007 |
| 7169899 | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery A library of macrocyclic compounds of the formula (I) where part (A) is a â€... | 01/30/2007 |
| 7138502 | Antibodies to the propeptide of and methods of use Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such as Candida albicans are provided which can be useful in methods for treating or preventing infections arising from such microorganisms. Microorganisms exp... | 11/21/2006 |
| 6927026 | Orotidine-5′-phosphate decarboxylase-gene, gene construct containing said gene and the utilization thereof The invention relates to an orotidine-5′-phosphate decarboxylase gene having the sequence of SEQ ID NO: 1 or its homologs, to a gene construct comprising this gene or its homologs, and to its use. The invention additionally relates to vectors or organisms comprisi... | 08/09/2005 |
| 6903193 | Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic aci... | 06/07/2005 |
| 6815169 | Identification and expression of a novel kinesin motor protein The invention provides isolated nucleic acid and amino acid sequences of TL-γ, antibodies to TL-γ, methods of screening for TL-γ modulators using biologically active TL-γ, and kits for screening for TL-γ modulators. ... | 11/09/2004 |
| 6630146 | Candida albicans phosphomannan complex as a vaccine A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans. Monoclonal antibodies for use in passive immunization again... | 10/07/2003 |
| 6558921 | Promoters of the genes glutamate deshydrogenase, ଲ-N-acetylhexosaminidase and γ-actin and their use in filamentous fungi expression, secretion and antisense systems An isolated DNA having the promoter sequence of the hex gene of P. chrysogenum or a DNA fragment that is hybridizable to the complement of the promoter sequence under stringent conditions and is capable of directing expression of DNA downstream of the fra... | 05/06/2003 |
| 6504008 | Cell based signal generation The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion ch... | 01/07/2003 |
| 6482601 | Fluorescence polarization-based homogeneous assay for fumonisin determination in grains A homogeneous assay for determining the fumonisin content in grains uses the technique of fluorescence polarization. A grain extract is prepared by shaking a crushed grain sample with a solvent. A mixture is prepared by combining the grain extract with a ... | 11/19/2002 |
| 6458930 | Aspergillus fumigatus cofilin The invention provides isolated nucleic acid and amino acid sequences of A. fumigatus cofilin, methods of screening for A. fumigatus cofilin modulators using biologically active A. fumigatus cofilin, and kits for screening for A. fumigatus cofilin modulat... | 10/01/2002 |
| 6441134 | Isolated Candida albicans oligopeptide transporter gene A Candida albicans oligopeptide transport gene, OPT1, was cloned from a C. albicans genomic library through heterologous expression in the Saccharomyces cerevisiae di-/tripeptide transport mutant PB1X-9B. When transformed with a plasmid harboring OPT1, S.... | 08/27/2002 |
| 6433137 | TUP1 sequences from Candida albicans and methods for screening agents for inhibiting virulence in Candida albicans using TUP1 The present invention provides TUP1 polynucleotides, including TUP1 polynucleotides encoding Tup1, and Tup1 polypeptides, from Candida albicans. Disruption of TUP1 function in C. albicans is associated with filamentous formation as well as low infectivity... | 08/13/2002 |
| 6420529 | Genetic selection method for identifying ligands for transmembrane proteins A chimeric protein having an (a) IRE1 or analog cytoplasmic kinase domain, (b) a transmembrane domain, and (c) a ligand binding domain of a transmembrane protein other than IRE1 is described. This protein can be used to identify and/or screen for ligands ... | 07/16/2002 |
| 6388056 | Inhibition of transglutaminase-mediated microbial interaction with a mammalian host The infection of a mammalian host by a microorganism can be prevented or treated through the administration of substrates for transglutaminases or antibodies against such substrates that inhibit the transglutaminase-mediated interaction of the microorgani... | 05/14/2002 |
| 6348577 | Regulation of aureobasidin sensitivity in fungus The present invention provides a protein regulating the sensitivity of fungus to an antimycotic aureobasidin, a gene coding for this protein, the use thereof, an antibody for the protein and the use thereof. The invention is useful in the diagnosis and tr... | 02/19/2002 |
| 6346411 | DNA encoding--candida albicans integrin-like protein An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.... | 02/12/2002 |
| 6312920 | SAM operon The invention provides isolated nucleic acid compounds encoding a novel SAM synthetase of Streptomyces fradiae. Also provided are vectors and transformed heterologous host cells for expressing the SAM synthetase and a method for preparing S-adenosylmethio... | 11/06/2001 |
| 6310186 | Purification of biological preparations This invention relates to the purification of biological preparations such as proteins and nucleic acids, especially for example proteins that have been produced by recombinant DNA techniques in bacteria. In a particular embodiment, the invention concerns... | 10/30/2001 |
| 6294651 | Gene regulating aubeobasidin sensitivity The invention is directed to isolated DNAs having nucleic acid sequences which encode proteins which regulate aureobasidin sensitivity. Also disclosed are recombinant plasmids containing the DNAs, transformants containing the plasmids, and methods of prod... | 09/25/2001 |
| 6291648 | Antitumor protein and corresponding gene sequence isolated from matsutake mushrooms An objective of the present invention is to provide an antitumor protein and a gene encoding the same. The specification discloses a protein comprising (a) an amino acid sequence of SEQ ID No.1 or (b) a modified amino acid sequence of SEQ ID No.1 which ha... | 09/18/2001 |
| 6245342 | Cosmetic preparation with a peptide addition A cosmetic preparation contains peptide derivatives from -MSH, as well as other active components. A cosmetic product has the property of activating the melanogenesis and being an anti-inflammatory and acting more efficiently. The synergetically ac... | 06/12/2001 |
| 6232095 | Recombinant helix modification recognition proteins and uses thereof Disclosed are the Hmp class of polypeptides, DNA sequences encoding those polypeptides, and uses thereof, particularly in methods and kits for mismatch (for example, mutation) detection.... | 05/15/2001 |
| 6207433 | Polypeptides having aminolevulinic acid activity and nucleic acids encoding same The present invention relates to isolated polypeptides having 5-aminolevulinic acid synthase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising ... | 03/27/2001 |
| 6200569 | Composition and method for increasing insulin activity This invention relates to potentiating insulin activity in a patient in need thereof. This invention provides a composition comprising an insulin potentiating agent; such composition comprises one or more substance derived from a water extract of Polygonu... | 03/13/2001 |
| 6172196 | DNA encoding protein complementing yeast low temperature-sensitive fermentability The present invention relates to a protein having the amino acid sequence represented by SEQ ID NO: 1, or a protein being capable of complementing the mutation exhibiting low-temperature-sensitive fermentability and having an amino acid sequence wherein o... | 01/09/2001 |
| 6160100 | Treatment for wilt diseases of trees A preventative treatment for wilt diseases in trees is disclosed which provides susceptible trees with induced resistance to wilt disease-causing organisms. The treatment comprises administering to a susceptible tree an amount of an elicitor effective to ... | 12/12/2000 |
| 6146869 | Polypeptides having phospholipase B activity and nucleic acids encoding same The present invention relates to isolated polypeptides having phospholipase B activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic aci... | 11/14/2000 |
| 6054318 | Expression of the glucose oxidase gene in transgenic organisms A genetic construct for use in production of transgenic plants with reduced susceptibility or increased resistance to pests or diseases comprises an isolated nucleotide sequence encoding the glucose oxidase enzyme of Talaromyces flavus, the nucleotide seq... | 04/25/2000 |
| 6033892 | Polypeptides having 5-aminolevulinic acid synthase activity and nucleic acids encoding same The present invention relates to isolated polypeptides having 5-aminolevulinic acid synthase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising ... | 03/07/2000 |
| 5980891 | Schizosaccharomyces-specific polypeptides The invention relates to novel Schizosaccharomyces-specific proteins and their antibodies. These proteins and antibodies can be used for identifying the yeast genus Schizosaccharomyces.... | 11/09/1999 |
| 5958687 | Nucleotide sequences and proteins conferring cycloheximide resistance The invention relates to a nucleotide sequence coding for a cycloheximide resistance protein sensitive to concatenation of amino acids A, or coding for all or part of said optionally modified concatenation A, in as much as the formed protein confers cyclo... | 09/28/1999 |
| 5955286 | Method for screening compounds for activities related to insulin receptor binding A receptor for an insulin-like polypeptide is purified from yeast membranes. This "insulin receptor-like protein" has a structure analogous to that of the mammalian insulin receptor. The insulin receptor-like protein of Saccharomyces cerevisiae is a heter... | 09/21/1999 |
| 5922585 | RNA polymerase II holoenzyme from Saccharomyces cerevisiae An RNA polymerase II holoenzyme that contains, in addition to RNA polymerase, a subset of the general transcription factors together with nine SRB proteins is described. This holoenzyme will selectively initiate transcription in vitro when supplemented wi... | 07/13/1999 |
| 5891635 | Protease assays Hybrid regulatory proteins are provided which contain amino acid sequences that are susceptible to cleavage by specific proteolytic enzymes. When acted upon by such enzymes, the hybrid regulatory proteins are rendered substantially less active, thereby al... | 04/06/1999 |
