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Methods and apparatus for reducing the velocity of a rider in or on an open cockpit vehicle when the rider is thrown from the vehicle.
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| Number | Title | Issue Date |
| 8114962 | Method of detection of nucleic acids with a specific sequence composition This invention is a novel method for detecting and localizing specific nucleic acid sequences in a sample with a high degree of sensitivity and specificity. The method and novel compositions used in the method involve the use of Probe Nucleic Acids, the production o... | 02/14/2012 |
| 7956162 | Cancer-associated antigen The present invention provides a novel cancer-associated antigen that can be used in the treatment and diagnosis of cancer. Further, the invention provides amino acid and nucleic acid sequence of the novel antigen, binding proteins, and immuno-conjugates. The invent... | 06/07/2011 |
| 7691976 | BRAF35 protein and BRCA2/BRAF35 complex and methods of use An isolated nucleic acid sequence of BRAF35 and polypeptides encoded thereby are provided, as well as a multiprotein complex, and an antibody capable of binding selectively to the BRAF35 protein. Related agents and compositions which modulate interaction between BRC... | 04/06/2010 |
| 7553933 | Human p51 genes and gene products thereof Novel human genes falling within the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represe... | 06/30/2009 |
| 7368293 | Liver enriched transcription factor HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes (Costa et al., 1989; Costa et al., 1990; Leff et al., 1989). We have pur... | 05/06/2008 |
| 7361735 | LITAF binding site peptides and methods of using the same The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-α factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL, or homologs thereof. Such mo... | 04/22/2008 |
| 7303885 | Screening method for candidate drugs The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to methods for screening candidate drugs for treating or detecting MIF (macro... | 12/04/2007 |
| 7304277 | Resonator with adjustable capacitor for medical device An apparatus, system and method of a resonator device with an adjustable capacitor for allowing the resonance frequency (F) of the resonator device to continue to be matched to the Larmor frequency of the MRI system. The resonator device includes an inductor coil, a... | 12/04/2007 |
| 7304142 | Mammalian MDM2 binding proteins Isolated nucleic acid sequences encoding mammalian MDM2 binding protein and polypeptide sequences for the mammalian MDM2 binding protein are provided. Also provided are vectors containing these nucleic acid sequences, host cells which express these proteins and anti... | 12/04/2007 |
| 7279664 | Resonator for medical device A resonator device including an induction coil, a conductive member positioned adjacent the induction coil, and a dielectric layer between at least a portion of the induction coil and the conductive member to form a capacitor structure. In one embodiment, the conduc... | 10/09/2007 |
| 7262062 | Diagnostic for scleroderma As anti-RNA polymerase (RNAP) antibodies are detected with high frequency in patients suffering from cutaneous scleroderma where skin sclerosis progresses rapidly, supervenes scleroderma renal crisis at a high rate, and associates with clinical entities whose progno... | 08/28/2007 |
| 7259244 | Human homologue of the DBF4/ASK1 protein, nucleic acids, and methods related to the same The present invention provides a human polypeptide homolog of DBF4/ASK1 (for “Activator of S phase kinase”) and polynucleotides which identify and encode DRF1 (for “DBF4 Related Factor 1”). In addition, the invention provides expression vectors, host cells a... | 08/21/2007 |
| 7256260 | Human p53 mutations and a genetic system in yeast for functional identification of human p53 mutations The present invention provides isolated polypeptides of human p53 that contain mutations. These mutations can be toxic mutations, supertransactivating mutations or tox-suppressor mutations. Further provided by the invention are methods of identifying toxic, supertra... | 08/14/2007 |
| 7244604 | HDAC9 polypeptides and polynucleotides and uses thereof The present invention features substantially pure HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), an HDRP(ΔNLS) polypeptides, and isolated nucleic acid molecules encoding those polypeptides. The present invention also features vectors containing HDAC9, HDAC9a, HDAC9(Δ... | 07/17/2007 |
| 7238799 | Mustang, a gene and nuclear protein The present invention relates to a novel nucleotide sequence and the amino acid sequence encoded therein which comprise a novel gene and protein called Mustang. The present invention also relates to methods and compositions based on these sequences. These sequences ... | 07/03/2007 |
| 7189808 | Transfer compounds, production and use thereof The invention relates to the use of a carboxy-terminal fragment of the Ki-67 protein or of an active part, fragment or homologue thereof as a compound that can be used for intracellular transfer and for the introduction in and the release by the cells. The invention... | 03/13/2007 |
| 7166712 | Mammalian MDM2 binding proteins and uses thereof Isolated nucleic acid sequences encoding mammalian MDM2 binding protein and polypeptide sequences for the mammalian MDM2 binding protein are provided. Also provided are vectors containing these nucleic acid sequences, host cells which express these proteins and anti... | 01/23/2007 |
| 7148328 | Compositions and methods for regulating autolytic processes in bacteria A nucleic acid sequence required for regulating the autolytic activity of bacteria is provided. Also provided are polypeptides encoded by the gene or mutant gene as well as vector and host cells for expressing these polypeptides. Methods for identifying and using ag... | 12/12/2006 |
| 7148192 | Neuroprotective dietary supplement The invention relates to a novel dietary supplement mixture having improved neuroprotective activity and preventing, ameliorating or counteracting neurodegeneration and preventing, counteracting and/or improving cognitive function decline. It also provides a dietary... | 12/12/2006 |
| 7144581 | Compositions and methods for WT1 specific immunotherapy Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that sp... | 12/05/2006 |
| 7119169 | RelA-associated inhibitor, process for producing the same and utilization thereof Human RelA-associated inhibitor (RAI) comprises 351 amino acids and is capable of binding to p65, a subunit of the transcription factor NFκB. A process for producing RAI, a cDNA encoding it, a fragment capable of hybridizing selectively to the cDNA sequence,... | 10/10/2006 |
| 7087717 | Sp110, a polypeptide component of the nuclear body Cloning and characterization of a full length cDNA encoding Sp110 (speckled 110), a novel 110 kDa polypeptide, is disclosed. It is disclosed that Sp110 is a component of the nuclear body, is expressed in leukocytes, and is also expressed in other types of cells, inc... | 08/08/2006 |
| 7074578 | Methods and means of histone methylation This invention relates to the methylation of histones, in particular to a previously uncharacterised group of histone H3 methylases which comprise a SET domain and which methylate either lysine 4 within the amino tail of histone H3 or within the histone H3 core. Met... | 07/11/2006 |
| 7070928 | Evolving new molecular function Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecul... | 07/04/2006 |
| 7056683 | Genetically encoded fluorescent reporters of kinase, methyltransferase, and acetyl-transferase activities The invention provides fusion protein reporter molecules that can be used to monitor protein modifications (e.g., histone modifications) in living cells, and methods of using the fusion reporter molecules for diagnosing protein-modification-associated disorders (e.g... | 06/06/2006 |
| 7038022 | Multimeric forms of members of the steroid/thyroid superfamily of receptors In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact to form multimeric species comprising a complex of more than one receptor. Accordingly, the interaction of a first rece... | 05/02/2006 |
| 7030224 | Human cytoplasmic polyadenylation element binding protein and uses thereof The present invention provides genomic and cDNA encoding human cytoplasmic polyadenylation element binding protein, expression vectors comprising human cytoplasmic polyadenylation element binding protein cDNA and host cells that contain the expression vectors. Also ... | 04/18/2006 |
| 6979725 | Rad2/FEN-1 orthologues and uses thereof The invention provides isolated Rad2/FEN-1 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering Rad2/FEN-1 concentration and/or composition of plants. The invention further provides recombinant expres... | 12/27/2005 |
| 6953834 | Transcription factors related to TFIIA The invention provides human polynucleotide sequences that encode transcription factor polypeptides that are termed ALF and SALF, and an alternative C-terminal sequence. The invention includes ALF, SALF and alternative C-terminus polypeptides, peptides, fusion prote... | 10/11/2005 |
| 6949624 | Cloning of the human nuclear receptor co-repressor gene The present invention relates to the discovery of the human nuclear receptor co-repressor gene and the human nuclear receptor co-repressor protein, a molecule that recruits a complex of proteins that alters chromatin structure and mediates transcriptional repression... | 09/27/2005 |
| 6946259 | Compositions and methods for treating cells having double minute DNA This invention provides methods by which test substances can be screened for their ability to inhibit, enhance or eliminate double minute (DM) or extrachromosomal DNA by micronucleation in cells. This invention also provides a method for inducing maturation or death... | 09/20/2005 |
| 6927278 | Peptide scaffolds for transfer of molecules into eukaryotic cells Compositions and methods of using compositions with a nuclear targeting peptide containing a nonclassical nuclear localization signal to deliver selected molecules to the nucleus of eukaryotic cells are provided. The compositions are useful for gene transfer. ... | 08/09/2005 |
| 6921813 | DNA Molecules The present invention provides novel nucleic acid molecules coding for sigma subunits of Mycobacterium tuberculosis RNA polymerase. It also relates to polypeptides, referred to as SigA and SigB, encoded by such nucleic acid molecules, as well as to vectors an... | 07/26/2005 |
| 6897293 | Growth arrest homeobox gene A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafte... | 05/24/2005 |
| 6897054 | Human H37 proteins and cDNA encoding the same This application provides human H37 protein having an amino acid sequence of SEQ ID NO: 1 or NO: 2; human gene encoding the protein; cDNA of the human gene which has a base sequence of SEQ ID NO: 3 or NO: 4; DNA fragment comprising a partial sequence of the cDNA; re... | 05/24/2005 |
| 6897026 | Array imaging method A method for imaging molecules contained in an array of discrete reaction sites on the surface of a solid support comprises: (i) imaging the array and detecting a first molecule located on the solid support at a known position with... | 05/24/2005 |
| 6884873 | Kit for determining DNA double-stranded breaks with anti-γ-H2A antibodies The present invention provides an isolated or purified antibody or antigenically-reactive fragment thereof that specifically binds to a C-terminal phosphorylated serine in an H2A histone protein and a product comprising the same. The present invention further provid... | 04/26/2005 |
| 6884423 | Antimicrobial histone H1 compositions, kits, and methods of use thereof The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic bacteria. Th... | 04/26/2005 |
| 6867027 | RNA polymerase Disclosed are RNA polymerases consisting of a wild type RNA polymerase provided that at least one of amino acids in the wild type RNA polymerase has been modified to enhance its ability for incorporating 3′-deoxyribonucleotides and derivatives thereof in compariso... | 03/15/2005 |
| 6852832 | Single stranded DNA binding proteins from archaea The invention provides ssDNA-binding proteins from three species of archaeons, Methanococcus jannaschii, Methanobacter theromoautotrophicum, and Archaeoglobus fulgidus, as well as the ability to identify ssDNA-binding proteins from other archaeons. The... | 02/08/2005 |
