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| Number | Title | Issue Date |
| 8124735 | Porous keratin construct and method of making the same The invention relates to a porous keratin construct material comprising keratin protein for use in wound healing applications. The porous keratin construct is capable of bio-absorbing into a wound to promote wound healing. The rate at which the construct bio-absorbs... | 02/28/2012 |
| 8044177 | Water-soluble keratin derivative and use thereof The present invention provides a novel water-soluble keratin derivative and applications thereof. Water-soluble keratin produced by the alkali treatment of feathers, and modified keratin, gives the following useful materials: (1) a high energy wave absorber, (2) a l... | 10/25/2011 |
| 7763715 | Extracting biopolymers from a biomass using ionic liquids Methods for using ionic liquids to extract and separate a biopolymer from a biomass containing the biopolymer are disclosed. Methods for dissolving a biopolymer in an ionic liquid are also disclosed. A recovery solvent is used to reduce the solubility of the biopoly... | 07/27/2010 |
| 7732574 | Wound care products containing keratin The invention relates to a would care product that provides a biochemical environment around a wound to promote wound healing. The wound care product includes a keratin protein fraction material in which the protein fraction is intact, is from the intermediate filam... | 06/08/2010 |
| 7226911 | Hair keratin-associated proteins The present invention relates to provide a protein group binding to keratin which is the major component of body hair, or genes encoding the same, particularly to keratin-associated proteins (KAP) which bind specifically and strongly to hair keratin or genes encodin... | 06/05/2007 |
| 7148327 | Production of soluble keratin derivaties A process for the preparation of soluble proteins of high molecular weight with little or no damage to the structural integrity of the proteins. The process is economically and environmentally acceptable by virtue of the cost of reagents that are used, and the recyc... | 12/12/2006 |
| 7134957 | Method for reducing microbial levels on the hide of an animal Disclosed is a novel method for reducing microbial levels on a hide of an animal. In one embodiment, the method comprises stunning the animal having a hide with a quantity of microorganisms on its hair, contacting the hide of the animal with an alkaline solution hav... | 11/14/2006 |
| 7094580 | Methods for producing pure perlecan and other heparan sulfate proteoglycans A method of perlecan isolation (from the EHS tumor) which produces “clean” (i.e. substantially “pure”) perlecan is disclosed. Clean perlecan is thus produced in sufficient quantities for use in a number of different in vitro and in vivo assays. In addition, ... | 08/22/2006 |
| 7022005 | Method for reducing microbial levels on the hide of an animal Disclosed is a novel method and system for dehairing an animal, providing a system for recycling and safely disposing of chemical and biological wastes produced during such dehairing method. Included in such method are processes for handling sodium production in was... | 04/04/2006 |
| 7001988 | Methods for controlling peptide solubility, chemically modified peptides, and stable solvent systems for producing same Methods for chemically modifying peptides, preferably keratinaceous feedstocks, to achieve desired solubility characteristics; stable solvent systems for preparing the modified peptides; and, the resulting chemically modified peptides. ... | 02/21/2006 |
| 7001987 | Hydrogel with controllable mechanical, chemical, and biological properties and method for making same Networks, hydrogels, and methods for networks and hydrogels comprising proteinaceous material consisting essentially of water soluble proteins and covalent interprotein crosslinks other than disulfide crosslinks. ... | 02/21/2006 |
| 6989437 | Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks Methods for producing biocompatible heterogeneous proteinaceous networks crosslinked with a heterogeneous crosslinking agent, and novel heterogeneous crosslinked networks. Preferred heterogeneous crosslinking agents are silicone-based. ... | 01/24/2006 |
| 6939849 | Recombinant PDGF A-chain homodimers and methods of use DNA encoding two forms of PDGF A-chain polypeptide, the construction of expression vectors for expressing such DNA in yeast and mammalian cells, and the expression of such DNA in yeast and mammalian cells to produce active PDGF A-chain homodimer and active PDGF A-ch... | 09/06/2005 |
| 6914126 | Methods for producing, films comprising, and methods for using heterogenous crosslinked protein networks Methods for producing biocompatible heterogeneous proteinaceous networks crosslinked with a heterogeneous crosslinking agent, and the novel crosslinked networks. ... | 07/05/2005 |
| 6827948 | Method and compositions for processing poultry feathers The present invention provides a method and compositions for processing poultry feathers. In one embodiment, the method for processing poultry feathers comprises contacting a plurality of poultry feathers having an average particle size with a detergent capable of i... | 12/07/2004 |
| 6774220 | Compounds having lectinic properties and their biological applications The invention relates to nucleotide sequences capable of coding for polypeptides having lectinic properties and to corresponding polypeptides of the sarcolectin type and their uses in therapeutics. In particular, the invention relates to the use of polypeptides of t... | 08/10/2004 |
| 6756362 | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells asso... | 06/29/2004 |
| 6749642 | Regenerated collagen fiber reduced in odor and improved in suitability for setting, process for producing the same, and method of setting The present invention provides regenerated collagen fibers which have light color and excellent touch in wet conditions and which can be formed into desirable shape with the shape being maintained properly. The present invention also provides regenerated collagen fi... | 06/15/2004 |
| 6706690 | Hemoactive compositions and methods for their manufacture and use Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to s... | 03/16/2004 |
| 6649740 | Hydratable form of keratin for use as a soil amendment A hydratable oxidized keratin composition comprising one or more metal ion species capable of absorbing water to form a hydrogel. The keratin material is useful as a soil amendment providing organic and inorganic nutrients. The keratin material is also us... | 11/18/2003 |
| 6624288 | Gamma-conopeptides This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide... | 09/23/2003 |
| 6552170 | PEGylation reagents and compounds formed therewith Compounds are disclosed having the general formula R1 -X-R2, wherein R1 and R2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R1 and R... | 04/22/2003 |
| 6379690 | Keratin-based hydrogel for biomedical applications and method of production A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide l... | 04/30/2002 |
| 6375946 | Enhanced activation of natural killer cells using an NK cell activator and a hydrogen peroxide scavenger or inhibitor A method for providing activated natural killer (NK) cells comprising the steps of administering to a population of cells which includes lymphocytes and monocytes, an effective amount of an NK cell activating cytokine or a NK cell activating flavonoid, wh... | 04/23/2002 |
| 6331621 | Isolated nucleic acid molecules which encode activin-receptor like kinases, expression vectors and cells containing these The invention involves nucleic acid molecules which encode activin like kinases, expression vectors, and cell lines.... | 12/18/2001 |
| 6316598 | Water absorbent keratin and gel formed therefrom A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a c... | 11/13/2001 |
| 6296850 | Apoptosis-related compounds and their use Apoptosis-related antigenic compounds comprising an exposed antigenic site having the amino acid sequence SEQ ID NO: 1: Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp 1 5 10 or a functionally equiva... | 10/02/2001 |
| 6254986 | Peracylated protein-based sutures and fabrics and process for making the same A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain sub... | 07/03/2001 |
| 6165496 | Keratin-based sheet material for biomedical applications and method of production A sheet wound dressing formed of cross linked keratin. An insoluble, largely Beta keratin fraction from human hair is acidified to a low pH, preferably less than about 3, which partially solubilizes the keratin by weakening hydrogen bonds. The suspension ... | 12/26/2000 |
| 6159496 | Keratin-based hydrogel for biomedical applications and method of production A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide l... | 12/12/2000 |
| 6159495 | Porous and bulk keratin bio-polymers Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separat... | 12/12/2000 |
| 6124265 | Method of making and cross-linking keratin-based films and sheets Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separat... | 09/26/2000 |
| 6110487 | Method of making porous keratin scaffolds and products of same Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separat... | 08/29/2000 |
| 6022722 | Renaturation of proteins The invention relates to a method for the renaturation of denatured proteins in which they are treated with a renaturant which has on vicinal carbon atoms a hydroxyl group and at least one fluorine atom.... | 02/08/2000 |
| 5957041 | Continuous boiler for organic materials, e.g. fish A continuous boiling apparatus (1) for organic materials, e.g., fish or offal from abattoirs, comprises at least one annular boiling zone (15) with an inlet opening (13) for the raw material and a discharge opening (4) for the heat-treated raw material. T... | 09/28/1999 |
| 5955578 | Polypeptide-polymer conjugates active in wound healing A conjugate of a synthetic polypeptide containing RGD or (dR) GD and a biodegradable polymer, such as hyaluronic acid or chondroitin sulfate is disclosed. Methods of making the conjugate and using it to aid wound healing by providing a temporary matrix ar... | 09/21/1999 |
| 5932552 | Keratin-based hydrogel for biomedical applications and method of production A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide l... | 08/03/1999 |
| 5900461 | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules A poly(ethylene glycol) derivative is disclosed that is activated with a sulfone moiety for selective attachment to thiol moieties on molecules and surfaces. The activated PEG is water soluble, hydrolytically stable for extended periods, and forms hydroly... | 05/04/1999 |
| 5821051 | E6 binding proteins An assay for screening test compounds to indentify agents which modulate the binding of an E6-BP polypeptide with a papilloma virus E6 protein. The assay includes combining, as a cell-free system, an E6-binding protein or fragment thereof which binds to t... | 10/13/1998 |
| 5772968 | Apparatus and method for hydrolyzing keratinaceous material A hydrolyzer system, apparatus, and method for effecting the continuous conversion of offal, feathers, hair, and other keratinaceous material into usable protein products for further commercial usage. The hydrolyzer system includes a feed screw conveyor, ... | 06/30/1998 |
