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| Number | Title | Issue Date |
| 8188230 | Method for recombinant microorganism expression and isolation of collagen-like polypeptides A composition comprising a purified collagen-like polypeptide suitable as a peptizer, said polypeptide comprising [Gly-X-Y]n repeats, wherein Gly stands for glycine, X and Y represent any amino acid and n is an integer and selected such that the length of the [Gly-X... | 05/29/2012 |
| 8173776 | Recombinant gelatins The invention concerns a recombinant CBE gelatin and recombinant gelatins having multimers of the CBE monomer sequence that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures ... | 05/08/2012 |
| 8158756 | Recombinant gelatins The invention concerns a recombinant CBE gelatin and recombinant gelatins having multimers of the CBE monomer sequence that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures ... | 04/17/2012 |
| 8119599 | Direct application of non-toxic crosslinking reagents to resist progressive spinal degeneration and deformity A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the tissue with an effective amount of a reagent that increases crosslinks in... | 02/21/2012 |
| 8084579 | Composition comprising a purified collagen-like polypeptide suitable as a peptizer A composition comprising a purified collagen-like polypeptide suitable as a peptizer, said polypeptide comprising [Gly-X-Y] repeats, wherein Gly stands for glycine, X and Y represent any amino acid and n is selected such that the length of the [Gly-X-Y] repeat is at... | 12/27/2011 |
| 8076294 | Collagen-related peptides and uses thereof The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and co... | 12/13/2011 |
| 8067374 | Adhesive hemostatic agent based on porcine atelocollagen and method for production thereof Disclosed is an adhesive hemostatic agent based on non-blood constituents including DOPA, able to strongly adhere to collagen fibers. The agent includes an antifibrinolytic agent in addition to an esterified atelocollagen which is non-immunogenic and may become posi... | 11/29/2011 |
| 8039591 | Flowable collagen material for dural closure Flowable graft materials are provided which comprise collagen powder and a liquid in an amount sufficient to impart a flowable consistency to the material. The graft materials are sufficiently formable and pliable so as to provide both superior contact with and easi... | 10/18/2011 |
| 8022038 | Composition for acceleration of type I collagen production It is an object of the present invention to provide a composition for promoting the production of type I collagen by human skin fibroblasts, and the present invention relates to a composition for promoting type I collagen production containing silybin and a peptide ... | 09/20/2011 |
| 8013121 | Isolated nature-identical collagen The present invention concerns isolated collagen, the method for its production, and isolation of the collagen from collagen-containing tissues, as well as the use of the isolated collagen in a biomatrix as an in vitro test system, tissue replacement or organ replac... | 09/06/2011 |
| 7964704 | Preparation of high purity collagen A method of preparing collagen by first producing a collagen matrix and then extracting collagen from the matrix. ... | 06/21/2011 |
| 7932354 | Process for the production of collagen material The invention relates to a process for the production of a collagen implant for wound covering, in which a suspension comprising a telopeptide-containing collagen is produced and a phosphate buffer is added. An areal structure is produced by drying the collagen-cont... | 04/26/2011 |
| 7932353 | Non-glycosylated recombinant collagen-like polypeptides The invention relates to recombinant collagen like polypeptides that are not glycosylated thereby reducing the immunogenicity of recombinant collagen-like polypeptides while at the same time preventing or reducing phosphorylation of these polypeptides. Such non-glyc... | 04/26/2011 |
| 7906623 | Defatting collagen Pig rind is one source of collagen for processing into products, such as sausage casings and films. However, it has a high fat content. The invention produces a defatted collagen paste from a collagen source by cutting the collagen into pieces, pressurising the coll... | 03/15/2011 |
| 7858748 | Method for purifying marine collagen and the processing thereof into porous sponges Methods are provided for purifying marine collagen and for processing the collagen into porous sponges. Products produced with these methods and the use of the products are also provided. ... | 12/28/2010 |
| 7838630 | Biologic replacement for fibrin clot The invention provides composition and methods for repairing a ruptured anterior cruciate ligament. ... | 11/23/2010 |
| 7834153 | Combination of insulin and ascorbate to enhance wound healing Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not ... | 11/16/2010 |
| 7820794 | Long-lasting collagen and manufacturing method thereof In a long-lasting collagen and its manufacturing method, a pig skin is gone through processes of scraping extra tissues, removing fats, imbibition, digesting, centrifugal separation, salting-out, collecting lower-layer precipitate and freeze-drying to form a collage... | 10/26/2010 |
| 7741441 | Method for producing type IV collagen An object of the invention is to provide type IV collagen without contamination by other proteins and without degradation or denaturation. The present invention provides a type IV collagen which is derived and extracted from lens capsules without the use of an enzym... | 06/22/2010 |
| 7732573 | Method for producing porous body comprising apatite/collagen composite fibers A method for producing a porous body comprising apatite/collagen composite fibers comprising the steps of gelling a dispersion comprising long apatite/collagen composite fibers having an average length of 10-75 mm, short apatite/collagen composite fibers having an a... | 06/08/2010 |
| 7700731 | Prokaryotic collagen-like proteins and uses thereof The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally... | 04/20/2010 |
| 7687604 | Method for purifying marine collagen and the processing thereof into porous sponges Methods are provided for purifying marine collagen and for processing the collagen into porous sponges. Products produced with these methods and the use of the products are also provided. ... | 03/30/2010 |
| 7579442 | Method for stromal corneal repair and refractive alteration A method and means of providing stromal repair and improved refractive correction by creating corneal stromal collagen tissue with fibril diameter and spacing that duplicates the optical transmission and diffusion characteristics of natural corneal collagen. The rep... | 08/25/2009 |
| 7544780 | Prokaryotic collagen-like proteins and uses thereof The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally... | 06/09/2009 |
| 7544781 | Polypeptide and process for producing the same A process for producing a polypeptide, by reacting a peptide component (A) represented by formula (1) below with a peptide component (B) represented by formula (2) below and optionally a compound (C) represented by formula (3) below, to obtain said polypeptide: ... | 06/09/2009 |
| 7498412 | Process for preparing porous collagen matrix from connective tissue The subject invention provides a process for preparing a porous collagen matrix from connective tissue, said process comprising: a porous structure forming step to treat said connective tissue with poring agent in situ; and a washing step to remove the impurity from... | 03/03/2009 |
| 7410770 | Method for monitoring collagen type II degradation in cartilage A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen ty... | 08/12/2008 |
| 7410947 | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art... | 08/12/2008 |
| 7396912 | Collagen production method The present invention relates to a novel collagen production method wherein the collagen-containing tissues are fermented to extract the collagen. The fermentation process employs microorganisms, including but is not limited to bacteria and yeast. The present invent... | 07/08/2008 |
| 7393437 | Photochemically crosslinked collagen scaffolds and methods for their preparation A method for producing collagen-based scaffolds with improved characteristics, which broadens the usage of collagen in tissue engineering and the products so produced are described. The method comprises reconstitution of three-dimensional collagen matrices from coll... | 07/01/2008 |
| 7393649 | Detection of specific nitrated markers Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical meas... | 07/01/2008 |
| 7374774 | Electroprocessed material made by simultaneously electroprocessing a natural protein polymer and two synthetic polymers The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination ther... | 05/20/2008 |
| 7371399 | Polymer gel containing hyaluronic acid and collagen, and its use in joints Formulations and methods for treating joints, such as temporomandibular joint disorders, osteoarthritis of the knee, hip and other types of inflammatory joint diseases. The method involves identifying specific matrix metalloproteinases (MMPs) that may be responsible... | 05/13/2008 |
| 7358284 | Particulate acellular tissue matrix A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resul... | 04/15/2008 |
| 7348005 | Oral tolerance induction by collagen to prevent allograft rejection The present invention relates to the use of collagen and MHC-like compounds to down regulate immune responses. Methods for administration of such compounds that induce immune tolerance are described. The invention is important in the context of allograft rejection, ... | 03/25/2008 |
| 7345158 | Actin related cytoskeletal protein “LACS” The present invention provides the novel L-NAME-related actin cytoskeletal protein (LACS) and genes encoding the protein. ... | 03/18/2008 |
| 7326249 | Flexible spine stabilization systems A spine stabilization system includes a flexible member attachable to a portion of the spinal column. The member includes components that are oriented and function similar to the natural fiber orientation of the anterior longitudinal ligament and annulus tissue. The... | 02/05/2008 |
| 7320962 | Hemoactive compositions and methods for their manufacture and use Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to s... | 01/22/2008 |
| 7320478 | Smart airbag for vehicular applications A smart airbag (14) is monitored by a vehicle restraint control module (24) and includes a state sensor (42) that generates an airbag state signal. A smart airbag fault circuit (40) is coupled to the state sensor (42) and includes ... | 01/22/2008 |
| 7311734 | Intervertebral spacers One embodiment of a hollow spinal spacer (10) includes a curved anterior wall (11) having opposite ends (12, 13), a posterior wall (15) having opposite ends (16, 17), two lateral walls (20, 21), each integrally connected bet... | 12/25/2007 |
