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| Number | Title | Issue Date |
| 8178656 | Silk-based drug delivery system The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. T... | 05/15/2012 |
| 8119598 | Synthetic peptide materials for joint reconstruction, repair and cushioning In joint reconstruction, repair and cushioning applications, a synthetic polypeptide material is useful that contains cross-linked polypeptides that are modeled on human elastin or other fibrous proteins. The polypeptides comprise at least three consecutive beta-she... | 02/21/2012 |
| 8101717 | Use of tropoelastin for repair or restoration of tissue The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic material from tropoelastin including heating a solution of tropoelastin having an alkaline pH to form an elast... | 01/24/2012 |
| 8071722 | Silk biomaterials and methods of use thereof The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible ma... | 12/06/2011 |
| 8048989 | Biodegradable biopolymers, method for their preparation and functional materials constituted by these biopolymers A biodegradable biopolymer material consists of silk fibroin from domesticated silkworm; silk fibroin from wild silkworm; a composite material comprising silk fibroin from domesticated silkworm and silk fibroin from wild silkworm; or a composite material comprising ... | 11/01/2011 |
| 8008439 | Biodegradable biopolymers, method for their preparation and functional materials constituted by these biopolymers A biodegradable biopolymer material consists of silk fibroin from domesticated silkworm; silk fibroin from wild silkworm; a composite material comprising silk fibroin from domesticated silkworm and silk fibroin from wild silkworm; or a composite material comprising ... | 08/30/2011 |
| 7674882 | Silk biomaterials and methods of use thereof The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible ma... | 03/09/2010 |
| 7671178 | Solubilization and reconstitution of silk using ionic liquids Silk is dissolved in an ionic liquid and is regenerated in a range of structural forms without requiring the use of harmful solvents. Silk solubility can be controlled by the selection of the ionic liquid constituents, with small cations and halide or pseudohalide a... | 03/02/2010 |
| 7635755 | Concentrated aqueous silk fibroin solution and use thereof The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further prov... | 12/22/2009 |
| 7572894 | Templated native silk smectic gels One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not misc... | 08/11/2009 |
| 7393651 | Confluence regulated adhesion molecules useful in modulating vascular permeability The invention relates to new polypeptide in isolated form belonging to a subfamily of the human Immunoglobulin Superfamily, which polypeptide shows at least 70% sequence homology with the amino acid sequence of the murine Confluency Regulated Adhesion Molecules 1 or... | 07/01/2008 |
| 7335739 | Methods for the purification and aqueous fiber spinning of spider silks and other structural proteins Methods are described for the purification and spinning of recombinant and non-recombinant proteins. Specifically, the lysis of bacteria and purification of silk proteins occur in a single solution of organic acid. Bacterial proteins are hydrolyzed while the silk pr... | 02/26/2008 |
| 7300772 | BMP products Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair. ... | 11/27/2007 |
| 7291003 | Micromachined spinneret A micromachined spinneret is disclosed which has one or more orifices through which a fiber-forming material can be extruded to form a fiber. Each orifice is surrounded by a concentric annular orifice which allows the fiber to be temporarily or permanently coated wi... | 11/06/2007 |
| 7288391 | Expression of spider silk proteins in higher plants The present invention relates to the fields of molecular biology and plant biology. Specifically, the invention is directed to the methods for expressing spider silk proteins in plants and the synthesis and purification of spider silk proteins therefrom. ... | 10/30/2007 |
| 7285637 | Method for the preparation of a non-woven silk fibroin fabrics A process for producing non-woven silk fiber fabrics comprises the following steps: a) obtaining silk fibroin, for example either from silk cocoons, or silk textiles or waste silk; b) removing the sercin layer covering the silk fibroin fibers, when present; c) break... | 10/23/2007 |
| 7241736 | Compositions and methods for treating diverticular disease Agents, compositions, and implants are provided herein for treating diverticular disease (e.g., diverticulosis and diverticulitis). In particular, fibrosis-inducing agents, hemostatic agents, and/or anti-infective agents, or compositions containing one or more of th... | 07/10/2007 |
| 7229634 | Engineered proteins, and methods of making and using The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes. ... | 06/12/2007 |
| 7226615 | Expandable foam-like biomaterials and methods Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The... | 06/05/2007 |
| 7217691 | Methods of treatment of periodontal disease Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair. ... | 05/15/2007 |
| 7211649 | Cartilage intermediate layer protein A novel, N-oligosaccharide-substituted-specific protein of approximately 91.5 kDa was purified from extracts of human articular cartilage and designated Cartilage Intermediate Layer Protein (CILP). The protein is a chondrocyte product which is deposited in the inter... | 05/01/2007 |
| 7193043 | Tropoelastin derivatives The disclosure relates to derivatives of tropoelastin and variants of those derivatives. The disclosure further provides expression products and hybrid molecules of the derivatives and variants of the invention. Methods for the production of the derivatives, variant... | 03/20/2007 |
| 7193038 | Extraction and utilization of cell growth-promoting peptides from silk protein Peptides are provided having an excellent safety, stability due to relatively low molecular weights thereof, and cell growth promotion, which are different from cell growth factors produced by abnormal cells such as tumor cells. Peptide compositions which are excell... | 03/20/2007 |
| 7176284 | Osteogenic proteins Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying... | 02/13/2007 |
| 7166570 | Medical implants and fibrosis-inducing agents Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue. ... | 01/23/2007 |
| 7134957 | Method for reducing microbial levels on the hide of an animal Disclosed is a novel method for reducing microbial levels on a hide of an animal. In one embodiment, the method comprises stunning the animal having a hide with a quantity of microorganisms on its hair, contacting the hide of the animal with an alkaline solution hav... | 11/14/2006 |
| 7129210 | Tissue adhesive sealant A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited... | 10/31/2006 |
| 7125837 | Elastin-based compositions The present invention provides screening methods that use organisms or cells that lack function in one or both elastin genes. These methods are useful in identifying drugs for the prevention and treatment of obstructive vascular diseases, such as atherosclerosis, va... | 10/24/2006 |
| 7078221 | Nucleic acid molecules encoding osteogenic proteins Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homo... | 07/18/2006 |
| 7060260 | Water-soluble silk proteins in compositions for skin care, hair care or hair coloring Skin care, hair care and hair coloring compositions comprising a water-soluble silk protein as an active ingredient are described. The water-soluble silk protein deposits onto the skin or the natural hair keratin to provide a smooth and durable film to provide added... | 06/13/2006 |
| 7049405 | α-helical protein based materials and methods for making same The invention relates to a method of producing useful materials from filament-forming α-helical proteins or filaments made of such proteins. The method comprises allowing filament-forming α-helical proteins to self-assemble into α-helix containing filaments and f... | 05/23/2006 |
| 7041797 | Precursor silk feedstock for forming filaments The application relates to a method of obtaining silk feedstock solution from a gland of a silkworm or another silk-producing arthropod in which the body of the silkworm or the other silk-producing arthropod is cut open and the gland removed. The silk feedstock solu... | 05/09/2006 |
| 7022005 | Method for reducing microbial levels on the hide of an animal Disclosed is a novel method and system for dehairing an animal, providing a system for recycling and safely disposing of chemical and biological wastes produced during such dehairing method. Included in such method are processes for handling sodium production in was... | 04/04/2006 |
| 7014807 | Process of making polypeptide fibers Process of making polypeptide fibers including the steps of contacting a polypeptide with a solution of formic acid a divalent metal ion salt, or contacting a decrystallized polypeptide with formic acid having a water content less than 3 wt % and concentrating the r... | 03/21/2006 |
| 6958223 | Methods for producing extracellular matrix proteins Incorporation of certain amino acid analogs into polypeptides produced by cells which do not ordinarily provide polypeptides containing such amino acid analogs is accomplished by subjecting the cells to growth media containing such amino acid analogs. The degree of ... | 10/25/2005 |
| 6919308 | Osteogenic devices Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying... | 07/19/2005 |
| 6852686 | Methods for ameliorating icthyosiform skin diseases The present invention relates to the discovery of a method to provide stabilized transglutaminase 1 enzyme, involucrin, and other molecules necessary for the assembly of the cell envelope to skin cells. Novel biological tools, prophylactics, therapeutics, cosmetics,... | 02/08/2005 |
| 6815427 | Sericin-containing material, process for producing the same method of using the same The object of the present invention is to elucidate a biologically active function of a component constituting undegraded sericin and to provide a novel medical material, cosmetic material, etc. utilizing the functional composition. Disclosed is a cell growth promot... | 11/09/2004 |
| 6808707 | Wound healing compositions and methods using tropoelastin and lysyl oxidase The present invention provides compositions and methods for promoting wound healing. The composition comprises virgin monomers of tropoelastin and lysyl oxidase. When the lysyl oxidase comes in contact with the tropoelastin, cross-linking of the tropoelastin monomer... | 10/26/2004 |
| 6765086 | Self-aligning peptides modeled on human elastin and other fibrous proteins A polypeptide is provided that has a secondary structure characterized by at least three beta-sheet/beta-turn structures, and that is not a naturally occurring fibrous protein. Such polypeptides, illustrated by one modeled on elastin, are useful in prosthesis. ... | 07/20/2004 |
