Quotables
"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8071721 | Antigens and antibodies associated to pancreatic ductal adenocarcinoma The present invention provides novel human protein antigens and related antibodies that have been identified as being specifically expressed in association to human Pancreatic Ductal Adenocarcinoma (PDA). In particular, novel phosphorylated isoforms of alpha-enolase... | 12/06/2011 |
| 7982008 | Treatment of diseases and conditions mediated by increased phosphorylation The invention provides methods for the treatment of diseases and conditions mediated by increased phosphorylation, such as inflammation and cancer. The invention also provides methods for the inhibition of increased phosphorylation in cells, tissues and organs. The ... | 07/19/2011 |
| 7777005 | Compositions, kits, and methods relating to the human gene, a novel tumor suppressor gene The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions o... | 08/17/2010 |
| 7423132 | Method for the enrichment and characterization of phosphorylated peptides or proteins A method for the separation and assay of phosphorylated peptides or proteins from complex mixtures of proteins and peptides is described. The method uses a diazo moiety linked by an organic group to a substrate. Kits for performing the assay are also described. The ... | 09/09/2008 |
| 7378392 | Bone and cartilage inductive proteins Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair. ... | 05/27/2008 |
| 7312193 | Calcium phosphopeptide complexes Phosphopeptides containing the Ser(P) cluster sequence motif Ser(P)-Ser(P)-Ser(P)-Glu-Glu- can stabilize their own weight in amorphous calcium phosphate (ACP) [Ca3(PO4)1.87(HPO4)0.2xH2O] and amorphous... | 12/25/2007 |
| 7261489 | Fastener assembly for attaching a non-metal component to a metal component A fastener assembly for attaching components of dissimilar materials includes a fastener having a base portion and a protruding portion, and a mechanism for tightening the assembly. The base portion is shaped to be complementary for mating with an attachment feature... | 08/28/2007 |
| 7220568 | Nucleic acids encoding the PRO1561 polypeptide The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 05/22/2007 |
| 7198931 | Phosphorylated glyoxalase I and its use The present invention relates to a phosphorylated form of mammalian glyoxalase I. The present invention relates further to the use of phosphorylated mammalian glyoxalase I to modulate MG-modification of proteins (AGE formation) and consequent cell death, especially ... | 04/03/2007 |
| 7186797 | Polypeptide conjugates with extended circulating half-lives The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit ... | 03/06/2007 |
| 7166703 | PRO1561 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 01/23/2007 |
| 7122328 | Gene involved in mineral deposition and uses thereof The present invention features a novel human protein (ANK), nucleotide sequences encoding human ANK, and assays for ANK activity, including assays to identify therapeutics and diagnostic assays, e.g., for susceptibility to diseases such as arthritis. In related aspe... | 10/17/2006 |
| 7115269 | Attenuated strain used as a vehicle for oral immunization The present invention is directed to an attenuated Salmonella comprising a eukaryotic expression vector for delivery of the eukaryotic expression vector to a eukaryotic cell. Delivery may be to eukaryotic cells cultured in vitro or to cells in vivo, such as b... | 10/03/2006 |
| 7064186 | Cytokine zcytor17 ligand The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of... | 06/20/2006 |
| 7052916 | Polypeptide analyses using stable isotope labeling Methods for incorporating a stable isotope into a protein or peptide fragment are disclosed. The methods include providing isolated isotope-labeled protein or peptide fragments and analyzing the isolated labeld fragments. In another aspect of the invention, methods ... | 05/30/2006 |
| 7034114 | “Signalin” family of TGFβ signal transduction proteins, and uses related thereto The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in signal transduction induced by members of the TGFβ superfamily. The present invention makes available compo... | 04/25/2006 |
| 7026167 | Systems and methods for the analysis of protein phosphorylation The present invention relates to a method of applying mass spectrometry to analyzing peptides or proteins, especially in the proteome setting. More particularly, the invention relates to a mass spectrometry-based method for detection of protein/peptide phosphorylati... | 04/11/2006 |
| 6964768 | Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents A method for treating inflammatory joint diseases by inhibiting cadherin-11 mediated cellular function using a cadherin-11 modulating agent is provided. Also provided are screening assays for identifying pharmaceutical lead compounds capable of modulating cellular f... | 11/15/2005 |
| 6933127 | Substrate for PP2C The invention relates to a combination of a protein phosphatase type 2C as an enzyme and a phospho-BAD as substrate. The protein BAD is dephosphorylated in position Ser155. Furthermore, the combination is used in an in vitro screening for ligands which mo... | 08/23/2005 |
| 6924358 | 121P1F1: a tissue specific protein highly expressed in various cancers A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ova... | 08/02/2005 |
| 6818413 | Fluorescence-based high throughput screening assays for protein kinases and phosphatases The invention relates to novel fluorescence-based assays for protein kinases and phosphatases which can be used in high throughput screening. The methods of the invention utilize a competitive immunoassay to determine the amount of substrate that is phosphorylated o... | 11/16/2004 |
| 6787158 | Process for treatment of a lactic raw material A process is disclosed for extracting glycomacropeptide from a lactic raw material. This process includes the step of treating a lactic raw material containing glycomacropeptide in the presence of a weakly anionic resin wherein the glycomacropeptide is selectively a... | 09/07/2004 |
| 6780844 | Calcium phosphopeptide complexes Phosphopeptides containing the Ser(P) cluster sequence motif Ser(P)-Ser(P)-Ser(P)-Glu-Glu- can stabilize their own weight in amorphous calcium phosphate (ACP) and amorphous calcium fluoride phosphate (ACFP). The amorphous phases stabilized by the phosphopeptides are... | 08/24/2004 |
| 6753413 | P35NCK5A binding proteins The present invention concerns novel proteins capable of binding p35nck5a, and method of use of same. ... | 06/22/2004 |
| 6753158 | Assays, agents, therapy and diagnosis relating to modulation of cellular DNA repair activity A yeast homologue of mammalian DNA ligase IV is provided and a role for DNA ligase IV established in the Ku-associated DNA repair pathway. Additionally interactions between DNA ligase IV and XRCC4, and interaction between XRCC4 and DNA-PKcs/Ku are established, provi... | 06/22/2004 |
| 6747131 | Phosphorylated fusion proteins Modified proteins, modified interferons α's and β's, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-α-like proteins are provided which carry an identifiable label such as a radi... | 06/08/2004 |
| 6733989 | Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereof Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereof Expression of an SmaI fragment, which is about 1.0 kb in size, on the left-hand end of the HindIII R fragment makes it possible to synthesize, by genetic manipul... | 05/11/2004 |
| 6692962 | Plant translation methods and compositions related thereto The present invention relates to the field of plant molecular biology, in particular to translational control. The inventors herein disclose compositions and methods useful to alter plant gene translation, which methods enable genetic modification of nume... | 02/17/2004 |
| 6686450 | Immunosuppressive agents that inhibit calcineurin function and uses of these agents The present invention provides novel immunosuppressive agents. In particular, the invention provides immunosuppressive agents that bind calcineurin and/or that inhibit interaction between calcineurin and NF-AT. The invention also provides analogs of these... | 02/03/2004 |
| 6593110 | Checkpoint-activating oligonucleotides The present invention provides polypeptides (Cds1) that are involved in regulating the progression of the cell cycle. The polypeptides are activated by double-stranded DNA and phosphorylated in response to the presence of double-stranded DNA. Also provide... | 07/15/2003 |
| 6589590 | Composite material and methods of making the same A method of making artificial bone comprises providing a membrane of collagen with solutions of calcium ions and of phosphate ions on opposite sides of the membrane. The calcium ions and phosphate ions diffuse through the membrane and precipitate as a hyd... | 07/08/2003 |
| 6579969 | Goodpasture antigen binding protein The present invention provides isolated nucleic acid sequences and expression vectors encoding the Goodpasture antigen binding protein (GPBP), substantially purified GPBP, antibodies against GPBP, and methods for detecting GPBP.... | 06/17/2003 |
| 6509316 | Pharmaceutical compositions, methods, and kits for treatment and diagnosis of lung cancer The present invention relates to pharmaceutical compositions, methods and kits that provide for the early diagnosis and treatment of lung cancer. More particularly, the present invention relates to pharmaceutical compositions containing uteroglobin for pr... | 01/21/2003 |
| 6465246 | Oncogene- or virus-controlled expression systems Nucleic acid constructs for expressing an effector gene, with the nucleic acid construct comprising a promoter I (component a) which controls the expression of a transcription factor gene (component b), a transcription factor gene (component b), a promote... | 10/15/2002 |
| 6448374 | Production of phosphopeptides from casein A method for the preparation of selected phosphopeptides having anticariogenic and other activities, comprising the steps of completely digesting a soluble monovalent cation salt of casein in solution with a proteolytic enzyme, adding a mineral acid to th... | 09/10/2002 |
| 6444439 | Cloning and characterization of a cdc15-like adaptor protein (CD2BP1) A human CD2 cytoplasmic tail binding protein, CD2BP1, is described, as well as the nucleic acids encoding the protein. Also described are expression vectors and recombinant host cells comprising nucleic acids encoding the CD2BP1 protein, and methods of us... | 09/03/2002 |
| 6423684 | WD-40 derived peptides and uses thereof The present invention relates to a polypeptide composition effective to alter the activity of a first protein that interacts with a second protein, where the second protein contains at least one WD-40 region. The polypeptides of the present invention typi... | 07/23/2002 |
| 6391651 | Materials and methods for detection of insulin dependent diabetes The method and compositions of this invention provide an effective and reliable substitute for the currently employed ICA assay for diabetes. By providing a method for detecting autoantibodies to both GAD65 and IA-2 auto-antigens, the method pr... | 05/21/2002 |
| 6310181 | Adaptor protein FRS2 and related products and methods The present invention relates generally to a newly identified adaptor protein FRS2 and related products and methods. FRS2 links protein kinases to activating partners in cells. The invention also relates to nucleic acid molecules encoding portions of FRS2... | 10/30/2001 |
| 6306822 | Phosphopeptides and methods of treating bone diseases Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or weakening by administering the phosphopeptides by oral or inje... | 10/23/2001 |
