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| Number | Title | Issue Date |
| 8168752 | T cell proteins and nucleotides encoding the same The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for det... | 05/01/2012 |
| 8168751 | Interferon alpha mutant and its polyethylene glycol derivative IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in vivo half-life are also provided, wherein a polyethylene glycol moiety... | 05/01/2012 |
| 8163879 | Fusion molecules and IL-15 variants The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses ... | 04/24/2012 |
| 8138312 | Compositions for regulation of tumor necrosis factor-alpha The present invention relates to compositions and methods relating to an interleukin18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In particular, the present invention provides compositions and methods for ... | 03/20/2012 |
| 8133976 | Methods of use of the TACI/TACI-L interaction The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate molecules to determine potential antagonists and agonists of the TACI/TACI-L interaction. The use of the ... | 03/13/2012 |
| 8119771 | Products for altering IL-33 activity and methods thereof Products for altering IL-33 activity including antibodies that specifically bind to an epitope with the polypeptide sequence of IL-33 such as antibodies that specifically bind to a protease cleavage region of IL-33 comprising the amino acid sequence of SEQ ID No. 17... | 02/21/2012 |
| 8106160 | N-terminal modified interferon-alpha A method of reducing formation of non-natural disulfide bonds in a mature IFN-α by adding one or more amino acid residues to its N-terminus cystein. Also disclosed herein is the IFN-α thus modified. ... | 01/31/2012 |
| 8101716 | Human interferon-beta mutein The present invention relates to a human interferon-beta mutein. In particular, the present invention relates to the human interferon-beta mutein having one or two additional sugar chains compared to natural human interferon-beta. ... | 01/24/2012 |
| 8097702 | Modified human interferon polypeptides with at least one non-naturally encoded amino acid and their uses Modified interferon polypeptides with at least one non-naturally-encoded amino acid and uses thereof are provided. ... | 01/17/2012 |
| 8093356 | Pegylated human interferon polypeptides Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids. ... | 01/10/2012 |
| 8067375 | Treatment of demyelinating disorders with soluble lymphotoxin-β-receptor Methods of treating a demyelinating disorder using inhibitors of the lymphotoxin pathway. ... | 11/29/2011 |
| 8058398 | Modified G-CSF polypeptide The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions containing hybrid molecules. ... | 11/15/2011 |
| 8048848 | Long-acting interferons and derivatives thereof and methods thereof A polypeptide and polynucleotides encoding same comprising carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an IFN protein are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of... | 11/01/2011 |
| 8048988 | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ... | 11/01/2011 |
| 8048849 | Long-acting polypeptides and methods of producing same A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of ... | 11/01/2011 |
| 8030452 | IFBM'S to promote the specific attachment of target analytes to the surface of orthopedic implants The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related materi... | 10/04/2011 |
| 8022184 | IFBM's to promote the specific attachment of target analytes to the surface of orthopedic implants The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related materi... | 09/20/2011 |
| 8022185 | IFBM's to promote the specific attachment of target analytes to the surface of orthopedic implants The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related materi... | 09/20/2011 |
| 8022183 | IFBM'S to promote the specific attachment of target analytes to the surface of orthopedic implants The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related materi... | 09/20/2011 |
| 8017733 | Polyalkylene polymer compounds and uses thereof The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepa... | 09/13/2011 |
| 7982007 | Cynomolgus toll-like receptor 3 Isolated polynucleotides encoding Cynomolgus monkey Toll-Like Receptor 3 (cynoTLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, methods and uses of these are disclosed. ... | 07/19/2011 |
| 7973133 | Inhibitor of endogenous human interferon-gamma The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity... | 07/05/2011 |
| 7956161 | Interferons of rhesus and cynomolgus origin and uses thereof Disclosed are interferons of Rhesus and Cynomolgus origin and methods of production and use thereof. ... | 06/07/2011 |
| 7951916 | Il-1 related polypeptides The present invention is directed to novel polypeptides having homology to the IL-1-like family of proteins and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric p... | 05/31/2011 |
| 7943738 | IL-17 receptor like molecules and uses thereof The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor... | 05/17/2011 |
| 7928197 | Feline IL-18 proteins The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includ... | 04/19/2011 |
| 7928198 | IL-B50 polypeptide Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided. ... | 04/19/2011 |
| 7915386 | Method of producing an interferon-β complex A method for producing an interferon-β complex includes binding interferon-β to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides having 5 or less sugar units, monosaccharides, sugar alcohols thereo... | 03/29/2011 |
| 7906622 | IL-D80 polypeptides and IL-27 Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also pr... | 03/15/2011 |
| 7893019 | G-CSF site-specific mono-conjugates Novel site-specific mono-conjugates of Granulocyte Colony Stimulating Factor (G-CSF) are hereby described, with analogues and derivatives thereof, which stimulate proliferation and differentiation of progenitor cells to mature neutrophiles. These conjugates have bee... | 02/22/2011 |
| 7893210 | Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines A method for renaturation of proteins comprising adding to a solution of denatured, chemically modified or reduced proteins a refolding buffer containing a primary, secondary or tertiary amine. Said method has been applied, for example, to interleukin-4 and bovine p... | 02/22/2011 |
| 7893211 | Mammalian genes; related reagents and methods Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided. | 02/22/2011 |
| 7888475 | Interferon alpha and interferon kappa fusion protein Herein is described a system to combat poxvirus infection wherein antagonists are developed that bind the soluble cytokine receptor but have no significant biological activity in the host, effectively blocking the virus-mediated suppressor of interferon function, th... | 02/15/2011 |
| 7879978 | ST2L Isolated polynucleotides encoding Macaca fascicularis ST2L (Cyno ST2L), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed. ... | 02/01/2011 |
| 7851596 | Myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptides There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibito... | 12/14/2010 |
| 7834152 | Antagonists of interleukin-15 Disclosed herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient. ... | 11/16/2010 |
| 7820793 | IFN-λ polypeptides and compositions A novel IFN-α/β independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely positioned genes on human chromosome 19 that encode distinct but highl... | 10/26/2010 |
| 7795396 | COOH-terminally added cysteine variant of the beta interferon The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 09/14/2010 |
| 7732572 | Cysteine variants of alpha interferon-2 The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 06/08/2010 |
| 7705128 | IL-1-like cytokine Nucleic acids encoding mammalian, e.g., primate, IL-1ζ, purified IL-1ζ polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic ... | 04/27/2010 |
